Polycomb CBX7 has a unifying role in cellular lifespan (original) (raw)

• Hayflick, L. The limited in vitro lifespan of human diploid cell strains. Exp. Cell Res. 37, 614–621 (1965).
  Article CAS Google Scholar
• Campisi, J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11, S27–S31 (2001).
  Article CAS Google Scholar
• Hanahan, D. & Weinberg, R.A. The hallmarks of cancer. Cell 100, 57–70 (2000).
  Article CAS Google Scholar
• Kiyono, T. et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396, 84–88 (1998).
  Article CAS Google Scholar
• Jacobs, J.J. et al. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. Nature Genet. 26, 291–299 (2000).
  Article CAS Google Scholar
• Jacobs, J.J.L., Kieboom, K., Marino, S., DePinho, R.A. & van Lohuizen, M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397, 164–168 (1999).
  Article CAS Google Scholar
• Hannon, G.J. et al. MaRX: an approach to genetics in mammalian cells. Science 283, 1129–1130 (1999).
  Article CAS Google Scholar
• Maestro, R. et al. Twist is a potential oncogene that inhibits apoptosis. Genes Dev. 13, 2207–2217 (1999).
  Article CAS Google Scholar
• Kamijo, T.F. et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649–659 (1997).
  Article CAS Google Scholar
• Paro, R. & Hogness, D.S. The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila. Proc. Natl Acad. Sci. USA 88, 263–267 (1991).
  Article CAS Google Scholar
• Min, J., Zhang, Y. & Xu, R.-M. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. 17, 1823–1828 (2003).
  Article CAS Google Scholar
• Jones, D.O., Cowell, I.G. & Singh, P.B. Mammalian chromodomain proteins: their role in genome organisation and expression. Bioessays 22, 124–137 (2000).
  Article CAS Google Scholar
• Satijn, D.P. & Otte, A.P. Polycomb group protein complexes: do different complexes regulate distinct target genes? Biochim. Biophys. Acta 1447, 1–16 (1999).
  Article CAS Google Scholar
• Satijn, D.P. et al. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. Mol Cell Biol. 17, 4105–4113 (1997).
  Article CAS Google Scholar
• Saurin, A.J. et al. The human polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain. J. Cell Biol. 142, 887–898 (1998).
  Article CAS Google Scholar
• Jacobs, J.J. & van Lohuizen, M. Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim. Biophys. Acta 1602, 151–161 (2002).
  CAS PubMed Google Scholar
• Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D. & Lowe, S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593–602 (1997).
  Article CAS Google Scholar
• Quelle, D.E., Zindy, F., Ashmun, R.A. & Sherr, C.J. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83, 993–1000 (1995).
  Article CAS Google Scholar
• Zhang, Y., Xiong, Y. & Yarbrough, W.G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92, 725–734 (1998).
  Article CAS Google Scholar
• Serrano, M. et al. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85, 27–37 (1996).
  Article CAS Google Scholar
• Sharpless, N.E. & DePinho, R.A. The INK4A/ARF locus and its two gene products. Curr. Opin. Genet. Dev. 9, 22–30 (1999).
  Article CAS Google Scholar
• Alkema, M.J., Jacobs, H., van Lohuizen, M. & Berns, A. Perturbation of B and T cell development and predisposition to lymphomagenesis in E-Bmi1 transgenic mice require the Bmi1 RING finger. Oncogene 15, 899–910 (1997).
  Article CAS Google Scholar
• Sewalt, R.G. et al. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes. Mol. Cell Biol. 18, 3586–3595 (1998).
  Article CAS Google Scholar
• Varambally, S. et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624–629 (2002).
  Article CAS Google Scholar
• Gunster, M.J. et al. Differential expression of human Polycomb group proteins in various tissues and cell types. J. Cell Biochem. 81, 129–143 (2001).
  Article Google Scholar
• Itahana, K. et al. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol. Cell Biol. 23, 389–401 (2003).
  Article CAS Google Scholar
• Dimri, G.P. et al. The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res. 62, 4736–4745 (2002).
  CAS PubMed Google Scholar
• Satijn, D.P. et al. Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. Mol. Cell Biol. 17, 6076–6086 (1997).
  Article CAS Google Scholar
• Carnero, A., Hudson, J.D., Hannon, G.J. & Beach, D.H. Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model. Nucleic Acids Res. 28, 2234–2241 (2000).
  Article CAS Google Scholar
• Brummelkamp, T.R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550–553 (2002).
  Article CAS Google Scholar