Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG (original) (raw)

• Boya, P. et al. Inhibition of macroautophagy triggers apoptosis. Mol. Cell Biol. 25, 1025–1040 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Klionsky, D. J. The molecular machinery of autophagy: unanswered questions. J. Cell Sci. 118, 7–18 (2005).
  Article CAS PubMed Google Scholar
• Levine, B. Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell 120, 159–162 (2005).
  CAS PubMed Google Scholar
• Levine, B. & Klionsky, D. J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 6, 463–477 (2004).
  Article CAS PubMed Google Scholar
• Lum, J. J., DeBerardinis, R. J. & Thompson, C. B. Autophagy in metazoans: cell survival in the land of plenty. Nature Rev. Mol. Cell Biol. 6, 439–448 (2005).
  Article CAS Google Scholar
• Kihara, A., Noda, T., Ishihara, N. & Ohsumi, Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152, 519–530 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Suzuki, K. et al. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J. 20, 5971–5981 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Furuya N., Yu J., Byfield M., Pattingre S & B., L. The evolutionarily conserved domain of beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1, 46–52 (2005).
  Article CAS PubMed Google Scholar
• Aita, V. M. et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 59, 59–65 (1999).
  Article CAS PubMed Google Scholar
• Liang, X. H. et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672–676 (1999).
  Article CAS PubMed Google Scholar
• Qu, X. et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 112, 1809–1820 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Yue, Z., Jin, S., Yang, C., Levine, A. J. & Heintz, N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl Acad. Sci. USA 100, 15077–15082 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Gozuacik, D. & Kimchi, A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23, 2891–2906 (2004).
  Article CAS PubMed Google Scholar
• Jia, L. et al. Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. Br. J. Haematol. 98, 673–685 (1997).
  Article CAS PubMed Google Scholar
• Mills, K. R., Reginato, M., Debnath, J., Queenan, B. & Brugge, J. S. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc. Natl Acad. Sci. USA 101, 3438–3443 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Thorburn, J. et al. Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol. Biol. Cell 16, 1189–1199 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Arico, S. et al. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 276, 35243–35246 (2001).
  Article CAS PubMed Google Scholar
• Pattingre, S. et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122, 927–939 (2005).
  Article CAS PubMed Google Scholar
• Shimizu, S. et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nature Cell Biol. 6, 1221–1228 (2004).
  Article CAS PubMed Google Scholar
• Virgin, H. W. t. et al. Complete sequence and genomic analysis of murine gammaherpesvirus 68. J. Virol. 71, 5894–5904 (1997).
  CAS PubMed PubMed Central Google Scholar
• Polster, B. M., Pevsner, J. & Hardwick, J. M. Viral Bcl-2 homologs and their role in virus replication and associated diseases. Biochim. Biophys. Acta. 1644, 211–227 (2004).
  Article CAS PubMed Google Scholar
• Roy, D. J., Ebrahimi, B. C., Dutia, B. M., Nash, A. A. & Stewart, J. P. Murine gammaherpesvirus M11 gene product inhibits apoptosis and is expressed during virus persistence. Arch. Virol. 145, 2411–2420 (2000).
  Article CAS PubMed Google Scholar
• Wang, G. H., Garvey, T. L. & Cohen, J. I. The murine gammaherpesvirus-68 M11 protein inhibits Fas- and TNF-induced apoptosis. J. Gen. Virol. 80, 2737–2740 (1999).
  Article CAS PubMed Google Scholar
• de Lima, B. D., May, J. S., Marques, S., Simas, J. P. & Stevenson, P. G. Murine gammaherpesvirus 68 bcl-2 homologue contributes to latency establishment in vivo. J. Gen. Virol. 86, 31–40 (2005).
  Article CAS PubMed Google Scholar
• Gangappa, S., van Dyk, L. F., Jewett, T. J., Speck, S. H. & Virgin, H. W. IV. Identification of the in vivo role of a viral bcl-2. J. Exp. Med. 195, 931–940 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Bekri, S. et al. Detailed map of a region commonly amplified at 11q13->q14 in human breast carcinoma. Cytogenet. Cell. Genet. 79, 125–131 (1997).
  Article CAS PubMed Google Scholar
• Perelman, B. et al. Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. Genomics 41, 397–405 (1997).
  Article CAS PubMed Google Scholar
• Goi, T. et al. Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: report of a case. Surg. Today 33, 702–706 (2003).
  Article PubMed Google Scholar
• Ionov, Y., Nowak, N., Perucho, M., Markowitz, S. & Cowell, J. K. Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability. Oncogene 23, 639–645 (2004).
  Article CAS PubMed Google Scholar
• Liang, X. H. et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72, 8586–8596 (1998).
  CAS PubMed PubMed Central Google Scholar
• Loh, J. et al. A surface groove essential for viral bcl-2 function during chronic infection in vivo. PLoS Pathog. 1, e10 (2005).
  Article PubMed PubMed Central Google Scholar
• Tanida, I., Ueno, T. & Kominami, E. LC3 conjugation system in mammalian autophagy. Int. J. Biochem. Cell. Biol. 36, 2503–2518 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T. & Ohsumi, Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15, 1101–1111 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720–5728 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Vieira, O. V. et al. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J. Cell Biol. 155, 19–25 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Levine, B. & Yuan, J. Autophagy in cell death: an innocent convict? J. Clin. Invest. 115, 2679–2688 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Iida, A. et al. Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation. Hum. Genet. 106, 277–287 (2000).
  Article CAS PubMed Google Scholar
• Lum, J. J. et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237–248 (2005).
  Article CAS PubMed Google Scholar
• Nobukuni, T. et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc. Natl Acad. Sci. USA 102, 14238–14243 (2005).
  Article CAS PubMed PubMed Central Google Scholar