Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex (original) (raw)

• Liang, X. H. et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672–676 (1999).
  Article CAS Google Scholar
• Liang, X. H. et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72, 8586–8596 (1998).
  CAS PubMed PubMed Central Google Scholar
• Yue, Z., Jin, S., Yang, C., Levine, A. J. & Heintz, N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl Acad. Sci. USA 100, 15077–15082 (2003).
  Article CAS Google Scholar
• Qu, X. et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 112, 1809–1820 (2003).
  Article CAS Google Scholar
• Edinger, A. L. & Thompson, C. B. Defective autophagy leads to cancer. Cancer Cell 4, 422 (2003).
  Article CAS Google Scholar
• Yue, Z. et al. A novel protein complex linking the δ2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 35, 921–933 (2002).
  Article CAS Google Scholar
• Shibata, M. et al. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J. Biol. Chem. 281, 14474–14485 (2006).
  Article CAS Google Scholar
• Pacheco, C. D., Kunkel, R. & Lieberman, A. P. Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects. Hum. Mol. Genet. 16, 1495–1503 (2007).
  Article CAS Google Scholar
• Kihara, A., Kabeya, Y., Ohsumi, Y. & Yoshimori, T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2, 330–335 (2001).
  Article CAS Google Scholar
• Kihara, A., Noda, T., Ishihara, N. & Ohsumi, Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152, 519–530 (2001).
  Article CAS Google Scholar
• Zeng, X., Overmeyer, J. H. & Maltese, W. A. Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J. Cell Sci. 119, 259–270 (2006).
  Article CAS Google Scholar
• Stack, J. H., DeWald, D. B., Takegawa, K. & Emr, S. D. Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J. Cell Biol. 129, 321–334 (1995).
  Article CAS Google Scholar
• Liang, C. et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nature Cell Biol. 8, 688–699 (2006).
  Article CAS Google Scholar
• Fimia, G. M. et al. Ambra1 regulates autophagy and development of the nervous system. Nature 447, 1121–1125 (2007).
  CAS PubMed Google Scholar
• Takahashi, Y. et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nature Cell Biol. 9, 1142–1151 (2007).
  Article CAS Google Scholar
• Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720–5728 (2000).
  Article CAS Google Scholar
• Ichimura, Y. et al. A ubiquitin-like system mediates protein lipidation. Nature 408, 488–492 (2000).
  Article CAS Google Scholar
• Kabeya, Y. et al. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J. Cell Sci. 117, 2805–2812 (2004).
  Article CAS Google Scholar
• Wang, Q. J. et al. Induction of autophagy in axonal dystrophy and degeneration. J. Neurosci. 26, 8057–8068 (2006).
  Article CAS Google Scholar
• Yue, Z. Regulation of neuronal autophagy in axon: implication of autophagy in axonal function and dysfunction/degeneration. Autophagy 3, 139–141 (2007).
  Article CAS Google Scholar
• Komatsu, M. et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131, 1149–1163 (2007).
  Article CAS Google Scholar
• Hara, T. et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885–889 (2006).
  Article CAS Google Scholar
• Komatsu, M. et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880–884 (2006).
  Article CAS Google Scholar
• Yan, Y., Flinn, R. J., Wu, H., Schnur, R. S. & Backer, J. M. hVps15 but not calcium/calmodulin is required for the activity and regulation of hVps34 in mammalian cells. Biochem. J. 417, 747–755 (2009).
  Article CAS Google Scholar
• Arsov, I. et al. BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development. Cell Death Differ. 15, 1385–1395 (2008).
  Article CAS Google Scholar
• Pankiv, S. et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitatedegradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282, 24131–24145 (2007).
  Article CAS Google Scholar
• Kobayashi, T. et al. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function. Nature 392, 193–197 (1998).
  Article CAS Google Scholar
• Katzmann, D. J., Odorizzi, G. & Emr, S. D. Receptor downregulation and multivesicular-body sorting. Nature Rev. Mol. Cell Biol. 3, 893–905 (2002).
  Article CAS Google Scholar
• Stenmark, H., Aasland, R. & Driscoll, P. C. The phosphatidylinositol 3-phosphate-binding FYVE finger. FEBS Lett. 513, 77–84 (2002).
  Article CAS Google Scholar
• Gong, S., Yang, X. W., Li, C. & Heintz, N. Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication. Genome Res. 12, 1992–1998 (2002).
  Article CAS Google Scholar
• Miled, N. et al. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317, 239–242 (2007).
  Article CAS Google Scholar
• Gronostajski, R. M. & Pardee, A. B. Protein degradation in 3T3 cells and tumorigenic transformed 3T3 cells. J. Cell Physiol. 119, 127–132 (1984).
  Article CAS Google Scholar
• Komatsu, M. et al. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc. Natl Acad. Sci. USA 104, 14489–14494 (2007).
  Article CAS Google Scholar