VHL loss causes spindle misorientation and chromosome instability (original) (raw)
Frew, I. J. et al. pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation. EMBO J.27, 1747–1757 (2008). ArticleCAS Google Scholar
Thoma, C. R. et al. pVHL and GSK3beta are components of a primary cilium-maintenance signalling network. Nature Cell Biol.9, 588–595 (2007). ArticleCAS Google Scholar
McAinsh, A. D., Meraldi, P., Draviam, V. M., Toso, A. & Sorger, P. K. The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. EMBO J.25, 4033–4049 (2006). ArticleCAS Google Scholar
Toyoshima, F., Matsumura, S., Morimoto, H., Mitsushima, M. & Nishida, E. PtdIns(3, 4, 5)P3 regulates spindle orientation in adherent cells. Dev. Cell13, 796–811 (2007). ArticleCAS Google Scholar
Toyoshima, F. & Nishida, E. Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner. EMBO J.26, 1487–1498 (2007). ArticleCAS Google Scholar
Lolkema, M. P. et al. The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Lett.581, 4571–4576 (2007). ArticleCAS Google Scholar
Hergovich, A., Lisztwan, J., Barry, R., Ballschmieter, P. & Krek, W. Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nature Cell Biol.5, 64–70 (2003). ArticleCAS Google Scholar
Li, L. et al. Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations. Mol. Cell Biol.27, 5381–5392 (2007). ArticleCAS Google Scholar
Rieder, C. L., Cole, R. W., Khodjakov, A. & Sluder, G. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J. Cell Biol.130, 941–948 (1995). ArticleCAS Google Scholar
Musacchio, A. & Salmon, E. D. The spindle-assembly checkpoint in space and time. Nature Rev. Mol. Cell Biol.8, 379–393 (2007). ArticleCAS Google Scholar
Weaver, B. A., Silk, A. D., Montagna, C., Verdier-Pinard, P. & Cleveland, D. W. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell11, 25–36 (2007). ArticleCAS Google Scholar
Tanudji, M. et al. Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay. Mol. Biol. Cell15, 3771–3781 (2004). ArticleCAS Google Scholar
Michel, L. S. et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature409, 355–359 (2001). ArticleCAS Google Scholar
Abou-Rebyeh, H., Borgmann, V., Nagel, R. & Al-Abadi, H. DNA ploidy is a valuable predictor for prognosis of patients with resected renal cell carcinoma. Cancer92, 2280–2285 (2001). ArticleCAS Google Scholar
Pepe, S. et al. Nuclear DNA content-derived parameters correlated with heterogeneous expression of p53 and bcl-2 proteins in clear cell renal carcinomas. Cancer89, 1065–1075 (2000). ArticleCAS Google Scholar
Fischer, E. et al. Defective planar cell polarity in polycystic kidney disease. Nature Genet.38, 21–23 (2006). ArticleCAS Google Scholar
Solomon, D. & Schwartz, A. Renal pathology in von Hippel-Lindau disease. Hum. Pathol.19, 1072–1079 (1988). ArticleCAS Google Scholar
Mandriota, S. J. et al. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell1, 459–468 (2002). ArticleCAS Google Scholar
Krek, W. & Nigg, E. A. Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J.10, 3331–3341 (1991). ArticleCAS Google Scholar
De Antoni, A. et al. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr. Biol.15, 214–225 (2005). ArticleCAS Google Scholar
Frew, I. J. et al. Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. Mol. Cell Biol.28, 4536–4548 (2008). ArticleCAS Google Scholar
McClelland, S. E. et al. The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity. EMBO J.26, 5033–5047 (2007). ArticleCAS Google Scholar
Meraldi, P., Draviam, V. M. & Sorger, P. K. Timing and checkpoints in the regulation of mitotic progression. Dev. Cell7, 45–60 (2004). ArticleCAS Google Scholar
Salinas, S. et al. Human spastin has multiple microtubule-related functions. J. Neurochem.95, 1411–1420 (2005). ArticleCAS Google Scholar
Mertz, K. D. et al. Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer. Int. J. Cancer123, 569–576 (2008). ArticleCAS Google Scholar
Staller, P. et al. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature425, 307–311 (2003). ArticleCAS Google Scholar
Dalquen, P. et al. DNA aneuploidy, _S_-phase fraction, nuclear p53 positivity, and survival in non-small-cell lung carcinoma. Virchows Arch.431, 173–179 (1997). ArticleCAS Google Scholar