Mapping cis- and trans-regulatory effects across multiple tissues in twins (original) (raw)

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Acknowledgements

The MuTHER Study was funded by a program grant from the Wellcome Trust (081917/Z/07/Z) and by core funding for the Wellcome Trust Centre for Human Genetics (090532). Additional funding came from the European Community's Seventh Framework Programme (FP7/2007-2013), ENGAGE project and grant agreement HEALTH-F4-2007-201413, the Swiss National Science Foundation and the NCCR Frontiers in Genetics, the Louis-Jeantet Foundation and a US National Institutes of Health–NIMH grant (GTEx project). Additional details on the funding for the participating studies and investigators are provided in the Supplementary Note.

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Author notes

1. Stephen B Montgomery
   Present address: Present address: Department of Pathology, Stanford University School of Medicine, Stanford, California, USA, and Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.,
2. Elin Grundberg, Kerrin S Small, Åsa K Hedman, Alexandra C Nica and Alfonso Buil: These authors contributed equally to this work.

Authors and Affiliations

1. Wellcome Trust Sanger Institute, Hinxton, UK
   Elin Grundberg, Kerrin S Small, Tsun-Po Yang, Eshwar Meduri, James Nisbett, Magdalena Sekowska, Alicja Wilk, So-Youn Shin, Catherine Ingle, Leopold Parts, Simon Potter, Loukia Tsaprouni, Richard Durbin, Nicole Soranzo & Panos Deloukas
2. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
   Elin Grundberg, Kerrin S Small, Jordana T Bell, Eshwar Meduri, Daniel Glass, Gabriela Surdulescu, Veronique Bataille, Kourosh R Ahmadi & Tim D Spector
3. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
   Åsa K Hedman, Sarah Keildson, Jordana T Bell, Josine L Min, Cecilia M Lindgren, Krina T Zondervan & Mark I McCarthy
4. Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
   Alexandra C Nica, Alfonso Buil, Antigone S Dimas, Stephen B Montgomery & Emmanouil T Dermitzakis
5. Institute of Genetics and Genomics in Geneva, University of Geneva, Geneva, Switzerland
   Alexandra C Nica, Alfonso Buil, Antigone S Dimas, Stephen B Montgomery & Emmanouil T Dermitzakis
6. Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
   Amy Barrett, Mary Travers, Neelam Hassanali & Mark I McCarthy
7. Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social and Community Medicine, University of Bristol, Bristol, UK
   Sue Ring, Karen Ho & George Davey Smith
8. deCODE genetics, Reykjavik, Iceland
   Gudmar Thorleifsson, Augustine Kong, Unnur Thorsteindottir & Kari Stefansson
9. Faculty of Medicine, University of Iceland, Reykjavík, Iceland
   Unnur Thorsteindottir & Kari Stefansson
10. Department of Informatics, School of Natural and Mathematical Sciences, King's College London, London, UK
    Chrysanthi Ainali & Sophia Tsoka
11. Department of Engineering, University of Cambridge, Cambridge, UK
    David Knowles
12. European Bioinformatics Institute, Hinxton, UK
    Maria Krestyaninova
13. University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
    Christopher E Lowe & Stephen O'Rahilly
14. Cambridge National Institute for Health Research (NIHR) Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, UK
    Christopher E Lowe & Stephen O'Rahilly
15. St. John's Institute of Dermatology, King's College London, London, UK
    Paola Di Meglio & Frank O Nestle
16. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA
    Eric E Schadt
17. Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK
    Mark I McCarthy

Authors

1. Elin Grundberg
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2. Kerrin S Small
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3. Åsa K Hedman
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4. Alexandra C Nica
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5. Alfonso Buil
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6. Sarah Keildson
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7. Jordana T Bell
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8. Tsun-Po Yang
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9. Eshwar Meduri
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10. Amy Barrett
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11. James Nisbett
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12. Magdalena Sekowska
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13. Alicja Wilk
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14. So-Youn Shin
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15. Daniel Glass
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16. Mary Travers
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17. Josine L Min
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18. Sue Ring
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19. Karen Ho
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20. Gudmar Thorleifsson
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21. Augustine Kong
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22. Unnur Thorsteindottir
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23. Chrysanthi Ainali
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24. Antigone S Dimas
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25. Neelam Hassanali
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26. Catherine Ingle
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27. David Knowles
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28. Maria Krestyaninova
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29. Christopher E Lowe
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30. Paola Di Meglio
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31. Stephen B Montgomery
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32. Leopold Parts
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33. Simon Potter
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34. Gabriela Surdulescu
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35. Loukia Tsaprouni
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36. Sophia Tsoka
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37. Veronique Bataille
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38. Richard Durbin
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39. Frank O Nestle
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40. Stephen O'Rahilly
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41. Nicole Soranzo
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42. Cecilia M Lindgren
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43. Krina T Zondervan
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44. Kourosh R Ahmadi
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45. Eric E Schadt
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46. Kari Stefansson
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47. George Davey Smith
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48. Mark I McCarthy
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49. Panos Deloukas
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50. Emmanouil T Dermitzakis
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51. Tim D Spector
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Consortia

The Multiple Tissue Human Expression Resource (MuTHER) Consortium

Contributions

K.R.A., M.I.M., P.D., E.T.D. and T.D.S. conceived the study. E.G., K.S.S., Å.K.H., A.C.N., A. Buil and S.K. analyzed data. T.-P.Y., E.M., S.-Y.S., J.L.M., K.T.Z., S.R., K.H., G.T., A.K., U.T., S.P., N.S., E.E.S., K.S. and G.D.S. contributed reagents, materials, or analysis tools. A. Barrett, J.N., M.S., A.W., D.G., M.T., N.H., C.I., M.K. and G.S. performed wet lab experiments or collected samples. J.T.B., C.A., A.S.D., D.K., C.E.L., P.D.M., S.B.M., L.P., L.T., S.T., V.B., R.D., F.O.N., S.O. and C.M.L. contributed experimental and technical support as well as discussion. E.G. prepared the manuscript, with contributions from K.S.S., Å.K.H., A.C.N., A. Buil, M.I.M., P.D., E.T.D. and T.D.S. All authors read and approved the manuscript.

Corresponding authors

Correspondence toMark I McCarthy, Panos Deloukas, Emmanouil T Dermitzakis or Tim D Spector.

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Competing interests

The authors declare no competing financial interests.

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A full list of members and affiliations is provided in the Supplementary Note.

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Grundberg, E., Small, K., Hedman, Å. et al. Mapping _cis_- and _trans_-regulatory effects across multiple tissues in twins.Nat Genet 44, 1084–1089 (2012). https://doi.org/10.1038/ng.2394

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• Received: 04 January 2012
• Accepted: 08 August 2012
• Published: 02 September 2012
• Issue Date: October 2012
• DOI: https://doi.org/10.1038/ng.2394