Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population (original) (raw)

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Acknowledgements

We thank all the individuals who participated in the study and also thank the collaborating physicians for helping with sample collection. We are grateful to the members of BioBank Japan and the Rotary Club of Osaka-Midosuji District 2660 Rotary International in Japan for supporting our study. We thank M.T. Shimizu, H. Sekiguchi, A.I. Jodo, N. Kawaraichi and the technical staff of the Center for Genomic Medicine for providing technical assistance and K. Barrymore for proofreading this manuscript. This work was conducted as part of the BioBank Japan Project, which is supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan. This work was also partly supported by grants from the Ministry of Health, Labour and Welfare, Japan.

Author information

Authors and Affiliations

  1. Laboratory for Respiratory Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Tomomitsu Hirota, Shota Tanaka & Mayumi Tamari
  2. Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Minato-ku, Japan
    Atsushi Takahashi
  3. Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Michiaki Kubo
  4. Laboratory for Medical Informatics, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Tatsuhiko Tsunoda
  5. Department of Otorhinolaryngology, Fukui Medical University, Matsuoka, Japan
    Kaori Tomita, Masafumi Sakashita, Takechiyo Yamada & Shigeharu Fujieda
  6. Department of Otolaryngology–Head and Neck Surgery, University of Yamanashi, Faculty of Medicine, Chuo, Japan
    Shota Tanaka
  7. Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Japan
    Satoru Doi
  8. Miyatake Asthma Clinic, Osaka, Japan
    Akihiko Miyatake
  9. Nonprofit Organization (NPO) Japan Health Promotion Supporting Network, Wakayama, Japan
    Tadao Enomoto
  10. Atopy Research Center, Juntendo University School of Medicine, Bunkyo-ku, Japan
    Chiharu Nishiyama, Nobuhiro Nakano, Keiko Maeda, Ko Okumura & Hideoki Ogawa
  11. Department of Dermatology, Juntendo University School of Medicine, Bunkyo-ku, Japan
    Shigaku Ikeda
  12. Department of Medical Genetics, Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Emiko Noguchi
  13. Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), Saitama, Japan
    Emiko Noguchi
  14. Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Tohru Sakamoto & Nobuyuki Hizawa
  15. Department of Dermatology, Takao Hospital, Kyoto, Japan
    Koji Ebe
  16. Department of Dermatology, Jikei University School of Medicine, Minato-ku, Japan
    Hidehisa Saeki
  17. Department of Dermatology, Keio University School of Medicine, Shinjuku-ku, Japan
    Takashi Sasaki, Tamotsu Ebihara & Masayuki Amagai
  18. Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Satoshi Takeuchi & Masutaka Furue
  19. Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Japan
    Yusuke Nakamura

Authors

  1. Tomomitsu Hirota
  2. Atsushi Takahashi
  3. Michiaki Kubo
  4. Tatsuhiko Tsunoda
  5. Kaori Tomita
  6. Masafumi Sakashita
  7. Takechiyo Yamada
  8. Shigeharu Fujieda
  9. Shota Tanaka
  10. Satoru Doi
  11. Akihiko Miyatake
  12. Tadao Enomoto
  13. Chiharu Nishiyama
  14. Nobuhiro Nakano
  15. Keiko Maeda
  16. Ko Okumura
  17. Hideoki Ogawa
  18. Shigaku Ikeda
  19. Emiko Noguchi
  20. Tohru Sakamoto
  21. Nobuyuki Hizawa
  22. Koji Ebe
  23. Hidehisa Saeki
  24. Takashi Sasaki
  25. Tamotsu Ebihara
  26. Masayuki Amagai
  27. Satoshi Takeuchi
  28. Masutaka Furue
  29. Yusuke Nakamura
  30. Mayumi Tamari

Contributions

T.H. and M.T. designed the study and drafted the manuscript. A.T. and T.T. analyzed the GWAS data. T.H., K.T., S. Tanaka and M.K. performed the genotyping for the GWAS. M.S., T.Y., S.F., S.D., A.M., T. Enomoto, C.N., N.N., K.M., S.I., K.O., H.O., E.N., T. Sakamoto, N.H., K.E., H.S., T. Sasaki, T. Ebihara, M.A., S. Takeuchi and M.F. recruited subjects and participated in the diagnostic evaluations. M.T. wrote the manuscript. M.K. and Y.N. contributed to the overall GWAS study design.

Corresponding author

Correspondence toMayumi Tamari.

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Competing interests

The authors declare no competing financial interests.

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Hirota, T., Takahashi, A., Kubo, M. et al. Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.Nat Genet 44, 1222–1226 (2012). https://doi.org/10.1038/ng.2438

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