Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk (original) (raw)

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Acknowledgements

S.R. is supported by a US National Institutes of Health (NIH) Career Development Award (1K08AR055688-01A1) and an American College of Rheumatology Bridge Grant. R.M.P. is supported by a K08 grant from the NIH (AI55314-3), a private donation from the Fox Trot Fund, the William Randolph Hearst Fund of Harvard University, the American College of Rheumatology 'Within Our Reach' campaign and holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund. M.J.D. is supported by NIH grants through the U01 (HG004171, DK62432) and R01 (DK083756-1, DK64869) mechanisms. The Broad Institute Center for Genotyping and Analysis is supported by grant U54 RR020278 from the National Center for Research Resources. The Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS) Registry is supported by a grant from Millennium Pharmaceuticals and Biogen-Idec. The North American Rheumatoid Arthritis Consortium (NARAC) is supported by the NIH (NO1-AR-2-2263 and RO1 AR44422). This research was also supported in part by the Intramural Research Program of the National Institute of Arthritis, Musculoskeletal and Skin Diseases of the NIH. This research was also supported in part by grants to KAS from the Canadian Institutes for Health Research (MOP79321 and IIN - 84042) and the Ontario Research Fund (RE01061) and by a Canada Research Chair. We acknowledge the help of C.E. van der Schoot for healthy control samples for the Genetics Network Rheumatology Amsterdam (GENRA) and the help of B.A.C. Dijkmans, D. van Schaardenburg, A.S. Peña, P.L. Klarenbeek, Z. Zhang, M.T. Nurmohammed, W.F. Lems, R.R.J. van de Stadt, W.H. Bos, J. Ursum, M.G.M. Bartelds, D.M. Gerlag, M.G.H. van der Sande, C.A. Wijbrandts and M.M.J. Herenius in gathering GENRA patient samples and data. We thank the Myocardial Infarction Genetics Consortium (MIGen) study for the use of genotype data from their healthy controls in our study. The MIGen study was funded by the US NIH and National Heart, Lung, and Blood Institute's SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data (STAMPEED) genomics research program R01HL087676 and a grant from the National Center for Research Resources. We thank the Johanna Seddon Progression of AMD Study, AMD Registry Study, Family Study of AMD, The US Twin Study of AMD and the Age-Related Eye Disease Study (AREDS) for use of genotype data from their healthy controls in our study. We thank D. Hafler and the Multiple Sclerosis collaborative for use of genotype data from their healthy controls recruited at Brigham and Women's Hospital.

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Authors and Affiliations

1. Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA
   Soumya Raychaudhuri, Eli A Stahl, Robert Chen, Jonathan Coblyn, Karen H Costenbader, Jing Cui, Fina A S Kurreeman, Nancy A Shadick, Michael E Weinblatt, Elizabeth W Karlson & Robert M Plenge
2. Broad Institute, Cambridge, Massachusetts, USA
   Soumya Raychaudhuri, Brian P Thomson, Candace Guiducci, Kristin G Ardlie, Noel P Burtt, Phillip L De Jager, David Altshuler, Mark J Daly & Robert M Plenge
3. Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
   Soumya Raychaudhuri, David Altshuler & Mark J Daly
4. Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, US National Institutes of Health, Bethesda, Maryland, USA
   Elaine F Remmers & Daniel L Kastner
5. Arthritis Research Campaign (arc)–Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
   Stephen Eyre, Anne Hinks, Anne Barton, John Bowes, Edward Flynn, Xiayi Ke, Paul Martin, Wendy Thomson & Jane Worthington
6. Celera, Alameda, California, USA
   Joseph J Catanese, Monica Chang, Yonghong Li & Ann B Begovich
7. Department of Medicine, University of Toronto, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada
   Gang Xie, Xiangdong Liu & Katherine A Siminovitch
8. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
   Lars Alfredsson & Bo Ding
9. University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
   Christopher I Amos
10. Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, California, USA
    Lindsey A Criswell
11. Department of Pathology, Laboratory of Immunogenetics, VU University Medical Center, Amsterdam, The Netherlands
    J Bart A Crusius
12. Department of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA
    Phillip L De Jager
13. National Institute for Health Research-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, United Kingdom
    Paul Emery & Ann W Morgan
14. University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, United Kingdom
    Pille Harrison & Paul Wordsworth
15. Division of Applied Medicine, Musculoskeletal and Genetics Section, University of Aberdeen, United Kingdom
    Lynne J Hocking & David M Reid
16. Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Tom W J Huizinga, Fina A S Kurreeman, Annette H M van der Helm-van Mil & Rene E M Toes
17. The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, USA
    Annette T Lee & Peter K Gregersen
18. Department of Medicine, Rheumatology Unit, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
    Leonid Padyukov & Lars Klareskog
19. Genome Institute of Singapore, Singapore
    Mark Seielstad
20. Rowe Program in Genetics, University of California at Davis, Davis, California, USA
    Michael F Seldin
21. Clinical and Academic Rheumatology, Kings College Hospital National Health Service Foundation Trust, Denmark Hill, London, United Kingdom
    Sophia Steer
22. Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Paul P Tak & Niek de Vries
23. Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    Irene E van der Horst-Bruinsma
24. School of Medicine and Biomedical Sciences, Sheffield University, Sheffield, United Kingdom
    Anthony G Wilson
25. Jan van Breemen Institute, Amsterdam, The Netherlands
    Gert Jan Wolbink
26. Sanquin Research Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gert Jan Wolbink
27. Roche Diagnostics, Pleasanton, California, USA
    Ann B Begovich

Authors

1. Soumya Raychaudhuri
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2. Brian P Thomson
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3. Elaine F Remmers
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4. Stephen Eyre
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5. Anne Hinks
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6. Candace Guiducci
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7. Joseph J Catanese
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8. Gang Xie
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9. Eli A Stahl
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10. Robert Chen
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11. Lars Alfredsson
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12. Christopher I Amos
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13. Kristin G Ardlie
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14. Anne Barton
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15. John Bowes
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16. Noel P Burtt
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17. Monica Chang
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18. Jonathan Coblyn
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19. Karen H Costenbader
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20. Lindsey A Criswell
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21. J Bart A Crusius
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22. Jing Cui
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23. Phillip L De Jager
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24. Bo Ding
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25. Paul Emery
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26. Edward Flynn
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27. Pille Harrison
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28. Lynne J Hocking
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29. Tom W J Huizinga
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30. Daniel L Kastner
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31. Xiayi Ke
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32. Fina A S Kurreeman
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33. Annette T Lee
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34. Xiangdong Liu
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35. Yonghong Li
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36. Paul Martin
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37. Ann W Morgan
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38. Leonid Padyukov
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39. David M Reid
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40. Mark Seielstad
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41. Michael F Seldin
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42. Nancy A Shadick
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43. Sophia Steer
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44. Paul P Tak
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45. Wendy Thomson
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46. Annette H M van der Helm-van Mil
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47. Irene E van der Horst-Bruinsma
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48. Michael E Weinblatt
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49. Anthony G Wilson
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50. Gert Jan Wolbink
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51. Paul Wordsworth
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52. David Altshuler
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53. Elizabeth W Karlson
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54. Rene E M Toes
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55. Niek de Vries
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56. Ann B Begovich
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57. Katherine A Siminovitch
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58. Jane Worthington
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59. Lars Klareskog
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60. Peter K Gregersen
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61. Mark J Daly
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62. Robert M Plenge
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Consortia

BIRAC Consortium

YEAR Consortium

Contributions

S.R., M.J.D., D.A. and R.M.P. designed the study, conducted the statistical analysis, interpreted the primary data and wrote the initial manuscript. All authors contributed to the final manuscript. B.P.T., E.F.R., S.E., A.H., C.G., J.J.C., G.X., E.A.S., R.C., N.P.B. and M.S. were involved directly in genotyping samples or extracting genotypes for this study. The BRASS genetic study was coordinated by E.A.S., P.L.d.J., J.C., S.R. and R.M.P. under the direction of M.E.W. and N.A.S. The CANADA genetic study was coordinated by C.I.A., X.L. and G.X. under the direction of K.A.S. The Epidemiological Investigation of Rheumatoid Arthritis (EIRA) genetic study was coordinated by L.A., B.D., L.P. and M.S. under the direction of L.K. The Genomics Collaborative Initiative (GCI) genetic study was coordinated by K.G.A., J.J.C., M.C. and Y.L. under the direction of A.B.B. The GENRA genetic study was coordinated by J.B.A.C., P.P.T., I.E.v.d.H.-B. and G.J.W. under the direction of N.d.V. The Leiden University Medical Center (LUMC) genetic study was coordinated by T.W.J.H., F.A.S.K., Y.L. and A.H.M.v.d.H.-v.M. under the direction of R.E.M.T. The NARAC genetic study was coordinated by E.F.R., C.I.A., M.C., L.A.C., D.L.K., A.T.L. and M.F.S. under the direction of P.K.G. The NHS genetic study was coordinated by K.H.C. and J.C. under the direction of E.W.K. The UK Rheumatoid Arthritis Genetics (UKRAG) genetic study was coordinated by S.E., B.I.R.A.C., A.B., J.B., P.E., E.F., P.H., A.H., L.J.H., X.K., P.M., A.W.M., D.M.R., S.S., W.T., A.G.W., P.W. and Y.E.A.R. under the direction of J.W.

Corresponding authors

Correspondence toSoumya Raychaudhuri or Robert M Plenge.

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A full list of members is provided in the Supplementary Note.

A full list of members is provided in the Supplementary Note.

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Raychaudhuri, S., Thomson, B., Remmers, E. et al. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.Nat Genet 41, 1313–1318 (2009). https://doi.org/10.1038/ng.479

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• Received: 13 May 2009
• Accepted: 21 September 2009
• Published: 08 November 2009
• Issue Date: December 2009
• DOI: https://doi.org/10.1038/ng.479