Cancer, cadmium and genome integrity (original) (raw)
- News & Views
- Published: 01 July 2003
Nature Genetics volume 34, pages 239–241 (2003)Cite this article
- 662 Accesses
- 153 Citations
- Metrics details
The direct inhibition of DNA mismatch repair by cadmium provides a molecular mechanism for cadmium toxicity with profound implications for human health, risk assessment and biological understanding of environmental mutagens. Alteration of key DNA damage response pathways may prove even more important than direct DNA damage by mutagens.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Figure 1: A beautiful toxin.
Corel royalty-free art photo image 523028
Figure 2: Cadmium poisoning of MMR enzymes and resulting mutations.
Katie Ris
References
- Jin, Y.H. et al. Nat. Genet. 34, 326–329 (2003).
Article CAS Google Scholar - Hayes, R.B. Cancer Causes Control, 8 371–385 (1997).
Article CAS Google Scholar - Hengstler, J.G. et al. Carcinogenesis 24, 63–73 (2003).
Article CAS Google Scholar - Friedberg, E.C. Nature 421, 436–440 (2003).
Article Google Scholar - Hoeijmakers, J.H. Nature 411, 366–374 (2001).
Article CAS Google Scholar - Kolodner, R.D., Putnam. C.D. & Myung, K. Science 297, 552–557 (2002).
Article CAS Google Scholar - Drotschmann, K. et al. J. Biol. Chem. 383, 969–975 (2002).
CAS Google Scholar - McMurray, C.T. Lancet 358, S37 (2001).
Article Google Scholar - Kovtun, I.V. & McMurray, C.T. Nat. Genet. 27, 407–411 (2001).
Article CAS Google Scholar - Thilly, W.G. Nat. Genet. 34, 255–259 (2003).
Article CAS Google Scholar - Castagnetto, J.M. et al. Nucleic Acids Res. 30, 379–382 (2002).
Article CAS Google Scholar - Hopfner, K.P. et al. Nature 418, 562–566 (2002).
Article CAS Google Scholar - Laity, J.H., Lee, B.M. & Wright, P.E. Curr. Opin. Struct. Biol. 11, 39–46 (2001).
Article CAS Google Scholar - Hopfner, K.-P. & Tainer, J.A. Curr. Opin. Struct. Biol. 13, 249–255 (2003).
Article CAS Google Scholar - McMurray, C.T. Trends Neurol. Sci. 24, S32–S38 (2001).
Article CAS Google Scholar
Author information
Authors and Affiliations
- Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Rochester, 55905, Minnesota, USA
Cynthia T McMurray - Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, 92037, California, USA
John A Tainer - Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, 94720, California, USA
John A Tainer
Authors
- Cynthia T McMurray
You can also search for this author inPubMed Google Scholar - John A Tainer
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
McMurray, C., Tainer, J. Cancer, cadmium and genome integrity.Nat Genet 34, 239–241 (2003). https://doi.org/10.1038/ng0703-239
- Issue Date: 01 July 2003
- DOI: https://doi.org/10.1038/ng0703-239