SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion (original) (raw)

• Kinzler, K.W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159–170 (1996).
  Article CAS Google Scholar
• Moustakas, A. & Heldin, C.-H. Non-Smad TGF-β signals. J. Cell Sci. 118, 3573–3584 (2005).
  Article CAS Google Scholar
• Salovaara, R. et al. Frequent loss of SMAD4/DPC4 protein in colorectal cancers. Gut 51, 56–59 (2002).
  Article CAS Google Scholar
• Parsons, R. et al. Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer. Cancer Res. 55, 5548–5550 (1995).
  CAS PubMed Google Scholar
• Mori, Y. et al. Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability. Cancer Res. 61, 6046–6049 (2001).
  CAS PubMed Google Scholar
• Takaku, K. et al. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92, 645–656 (1998).
  Article CAS Google Scholar
• Oshima, H., Oshima, M., Kobayashi, M., Tsutsumi, M. & Taketo, M.M. Morphological and molecular processes of polyp formation in Apc Δ716 knockout mice. Cancer Res. 57, 1644–1649 (1997).
  CAS PubMed Google Scholar
• Mueller, M.M. & Fusenig, N.E. Friends or foes–bipolar effects of the tumor stroma in cancer. Nat. Rev. Cancer 4, 839–849 (2004).
  Article CAS Google Scholar
• Coussens, L.M., Tinkle, C.L., Hanahan, D. & Werb, Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103, 481–490 (2000).
  Article CAS Google Scholar
• Olumi, A.F. et al. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59, 5002–5011 (1999).
  CAS PubMed Google Scholar
• Orimo, A. et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121, 335–348 (2005).
  Article CAS Google Scholar
• Lin, E.Y., Nguyen, A.V., Russel, R.G. & Pollard, J.W. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193, 727–739 (2001).
  Article CAS Google Scholar
• Friedl, P. & Wolf, K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer 3, 362–374 (2003).
  Article CAS Google Scholar
• Bhowmick, N.A., Neilson, E.G. & Moses, H.L. Stromal fibroblasts in cancer initiation and progression. Nature 432, 332–337 (2004).
  Article CAS Google Scholar
• Pollard, J.W. Tumor-educated macrophages promote tumour progression and metastasis. Nat. Rev. Cancer 4, 71–78 (2004).
  Article CAS Google Scholar
• Seno, H. et al. Cyclooxygenase 2- and prostaglandin E2 receptor EP2-dependent angiogenesis in Apc Δ716 mouse intestinal polyps. Cancer Res. 62, 506–511 (2002).
  CAS PubMed Google Scholar
• Akashi, K., Traver, D., Miyamoto, T. & Weissman, I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193–197 (2000).
  Article CAS Google Scholar
• Krause, D.S., Fackler, M.J., Civin, C.I. & May, W.S. CD34: structure, biology, and clinical utility. Blood 87, 1–13 (1996).
  CAS PubMed Google Scholar
• Zhao, X. et al. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J. Immunol. 171, 2797–2830 (2003).
  Article CAS Google Scholar
• Yang, M. & Odgren, P.R. Molecular cloning and characterization of rat CCL9 (MIP-1γ), the ortholog of mouse CCL9. Cytokine 31, 94–102 (2005).
  Article CAS Google Scholar
• Chen, C.-R., Kang, Y., Siegel, P.M. & Massagué, J. E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression. Cell 110, 19–32 (2002).
  Article CAS Google Scholar
• Matsuo, S.E., Leoni, S.G., Colquhoun, A. & Kimura, E.T. Transforming growth factor-β1 and activin A generate antiproliferative signaling in thyroid cancer cells. J. Endocrinol. 190, 141–150 (2006).
  Article CAS Google Scholar
• Gao, J.-L. et al. Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J. Exp. Med. 185, 1959–1968 (1997).
  Article CAS Google Scholar
• Greaves, D.R. & Schall, T.J. Chemokines and myeloid cell recruitment. Microbes Infect. 2, 331–336 (2000).
  Article CAS Google Scholar
• Robinson, S.C. et al. A chemokine receptor antagonist inhibits experimental breast tumor growth. Cancer Res. 63, 8360–8365 (2003).
  CAS PubMed Google Scholar
• Janowska-Wieczorek, A. et al. Growth factors and cytokines upregulate gelatinase expression in bone marrow CD34+ cells and their transmigration through reconstituted basement membrane. Blood 93, 3379–3390 (1999).
  CAS PubMed Google Scholar
• Mook, O.R.F., Frederiks, W.M. & Van Noorden, C.J.F. The role of gelatinases in colorectal cancer progression and metastasis. Biochim. Biophys. Acta 1705, 69–89 (2004).
  CAS PubMed Google Scholar
• Markowitz, S. TGF-β receptors and DNA repair genes, coupled targets in a pathway of human colon carcinogenesis. Biochim. Biophys. Acta 1470, M13–M20 (2000).
  CAS PubMed Google Scholar
• Direkze, N.C. et al. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res. 64, 8492–8495 (2004).
  Article CAS Google Scholar
• Garmy-Susini, B. & Varner, J.A. Circulating endothelial progenitor cells. Br. J. Cancer 93, 855–858 (2005).
  Article CAS Google Scholar
• Kaplan, R.N. et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438, 820–827 (2005).
  Article CAS Google Scholar
• Wyckoff, J. et al. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res. 64, 7022–7029 (2004).
  Article CAS Google Scholar
• Lewis, C.E. & Pollard, J.W. Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66, 605–612 (2006).
  Article CAS Google Scholar
• Kusmartsev, S. & Gabrilovich, D.I. Role of immature myeloid cells in mechanisms of immune evasion in cancer. Cancer Immunol. Immunother. 55, 237–245 (2006).
  Article Google Scholar
• Han, I.-S. et al. Differentiation of CD34+ cells from human cord blood and murine bone marrow is suppressed by C6 β-chemokines. Mol. Cells 15, 176–180 (2003).
  CAS PubMed Google Scholar
• Balkwill, F. Cancer and the chemokine network. Nat. Rev. Cancer 4, 540–550 (2004).
  Article CAS Google Scholar
• Forssmann, U. et al. CKβ8, a novel CC chemokine that predominantly acts on monocytes. FEBS Lett. 408, 211–216 (1997).
  Article CAS Google Scholar
• Paglinawan, R. et al. TGFβ directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes. Glia 44, 219–231 (2003).
  Article Google Scholar
• Scotton, C., Milliken, D., Wilson, J., Raju, S. & Balkwill, F. Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br. J. Cancer 85, 891–897 (2001).
  Article CAS Google Scholar
• Bergers, G. et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat. Cell Biol. 2, 737–744 (2000).
  Article CAS Google Scholar
• Collins, H.M., Morris, T.M. & Watson, S.A. Spectrum of matrix metalloproteinase expression in primary and metastatic colon cancer: relationship to the tissue inhibitors of metalloproteinases and membrane type-1-matrix metalloproteinase. Br. J. Cancer 84, 1664–1670 (2001).
  Article CAS Google Scholar
• Zavadil, J. & Böttinger, E.P. TGF-β and epithelial-to-mesenchymal transitions. Oncogene 24, 5764–5774 (2005).
  Article CAS Google Scholar
• Grady, W.M. et al. Mutation of the type II transforming growth factor-β receptor is coincident with the transformation of human colon adenomas to malignant carcinomas. Cancer Res. 58, 3101–3104 (1998).
  CAS PubMed Google Scholar
• Ishiguro, K., Yoshida, T., Yagishita, H., Numata, Y. & Okayasu, T. Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas. Gut 55, 695–702 (2006).
  Article CAS Google Scholar
• Bhowmick, N.A. et al. TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303, 848–851 (2004).
  Article CAS Google Scholar
• Oshima, M. et al. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc. Natl. Acad. Sci. USA 92, 4482–4486 (1995).
  Article CAS Google Scholar
• Oshima, H., Oshima, M., Inaba, K. & Taketo, M.M. Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice. EMBO J. 23, 1669–1678 (2004).
  Article CAS Google Scholar
• Brubaker, P.L. & Vranic, M. Fetal rat intestinal cells in monolayer culture: a new in vitro system to study the glucagon-like immunoreactive peptides. Endocrinology 120, 1976–1985 (1987).
  Article CAS Google Scholar
• Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T. & Nishimune, Y. 'Green mice' as a source of ubiquitous green cells. FEBS Lett. 407, 313–319 (1997).
  Article CAS Google Scholar
• Mook, O.R.F., van Overbeek, C., Ackema, E.G., van Maldegem, F. & Fredericks, W.M. In situ localization of gelatinolytic activity in the extracellular matrix of metastasis of colon cancer in rat liver using quenched fluorogenic DQ-gelatin. J. Histochem. Cytochem. 51, 821–829 (2003).
  Article CAS Google Scholar