Tissue-specific transcriptional regulation has diverged significantly between human and mouse (original) (raw)

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Acknowledgements

We are grateful to S. Strom and K. Dorko (University of Pittsburgh) for human liver samples (DK92310); T. DiCesare, S. Gupta, R. Kumar, J. Rodriguez and K. Walker for technical assistance and R. Young and G. Gerber for discussions. This work was supported by funding from US National Institutes of Health (grants DK68655 and DK70813 (D.T.O.) and DK076284 (R.D.D.)), Cancer Research UK (D.T.O.) and the Whitaker Foundation (E.F.).

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Author notes

  1. Duncan T Odom & Caitlin M Conboy
    Present address: Present address: Cancer Research UK–Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.,
  2. Duncan T Odom and Robin D Dowell: These authors contributed equally to this work.

Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, 02142, Massachusetts, USA
    Duncan T Odom, Elizabeth S Jacobsen, Caitlin M Conboy & David K Gifford
  2. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA
    Robin D Dowell, Timothy W Danford, P Alexander Rolfe, David K Gifford & Ernest Fraenkel
  3. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA
    William Gordon & Ernest Fraenkel
  4. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA
    Kenzie D MacIsaac

Authors

  1. Duncan T Odom
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  2. Robin D Dowell
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  3. Elizabeth S Jacobsen
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  4. William Gordon
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  5. Timothy W Danford
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  6. Kenzie D MacIsaac
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  7. P Alexander Rolfe
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  8. Caitlin M Conboy
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  9. David K Gifford
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  10. Ernest Fraenkel
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Contributions

D.T.O., R.D.D. and E.F. designed experiments; R.D.D. designed the arrays; D.T.O., E.S.J., W.G. and C.M.C. performed experiments; R.D.D., T.W.D, K.D.M., P.A.R. and E.F. analyzed the data and D.T.O, R.D.D., D.K.G. and E.F. created the manuscript.

Corresponding author

Correspondence toErnest Fraenkel.

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The authors declare no competing financial interests.

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Odom, D., Dowell, R., Jacobsen, E. et al. Tissue-specific transcriptional regulation has diverged significantly between human and mouse.Nat Genet 39, 730–732 (2007). https://doi.org/10.1038/ng2047

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