- Mosmann, T.R. & Coffman, R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145–173 (1989).
Article CAS PubMed Google Scholar
- O'Garra, A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8, 275–283 (1998).
Article CAS PubMed Google Scholar
- Park, H. et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6, 1133–1141 (2005).
Article CAS PubMed PubMed Central Google Scholar
- Harrington, L.E. et al. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123–1132 (2005).
Article CAS PubMed Google Scholar
- Aujla, S.J., Dubin, P.J. & Kolls, J.K. Th17 cells and mucosal host defense. Semin. Immunol. 19, 377–382 (2007).
Article CAS PubMed PubMed Central Google Scholar
- LeibundGut-Landmann, S. et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 8, 630–638 (2007).
Article CAS PubMed Google Scholar
- Murphy, C.A. et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198, 1951–1957 (2003).
Article CAS PubMed PubMed Central Google Scholar
- Bettelli, E. et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235–238 (2006).
Article CAS PubMed Google Scholar
- Langrish, C.L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233–240 (2005).
Article CAS PubMed PubMed Central Google Scholar
- Mangan, P.R. et al. Transforming growth factor-β induces development of the TH17 lineage. Nature 441, 231–234 (2006).
Article CAS PubMed Google Scholar
- Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179–189 (2006).
Article CAS PubMed Google Scholar
- Zhou, L. et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8, 967–974 (2007).
Article CAS PubMed Google Scholar
- Nurieva, R. et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448, 480–483 (2007).
Article CAS PubMed Google Scholar
- Korn, T. et al. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells. Nature 448, 484–487 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Wei, L., Laurence, A., Elias, K.M. & O'Shea, J.J. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J. Biol. Chem. 282, 34605–34610 (2007).
Article CAS PubMed Google Scholar
- Liang, S.C. et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271–2279 (2006).
Article CAS PubMed PubMed Central Google Scholar
- McGeachy, M.J. et al. TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology. Nat. Immunol. 8, 1390–1397 (2007).
Article CAS PubMed Google Scholar
- Acosta-Rodriguez, E.V., Napolitani, G., Lanzavecchia, A. & Sallusto, F. Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells. Nat. Immunol. 8, 942–949 (2007).
Article CAS PubMed Google Scholar
- Wilson, N.J. et al. Development, cytokine profile and function of human interleukin 17–producing helper T cells. Nat. Immunol. 8, 950–957 (2007).
Article CAS PubMed Google Scholar
- Chen, Z., Tato, C.M., Muul, L., Laurence, A. & O'Shea, J.J. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 56, 2936–2946 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Evans, H.G., Suddason, T., Jackson, I., Taams, L.S. & Lord, G.M. Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc. Natl. Acad. Sci. USA 104, 17034–17039 (2007).
Article CAS PubMed PubMed Central Google Scholar
- van Beelen, A.J. et al. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27, 660–669 (2007).
Article CAS PubMed Google Scholar
- Laurence, A. & O'Shea, J.J. TH-17 differentiation: of mice and men. Nat. Immunol. 8, 903–905 (2007).
Article CAS PubMed Google Scholar
- Weaver, C.T., Hatton, R.D., Mangan, P.R. & Harrington, L.E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25, 821–852 (2007).
Article CAS PubMed Google Scholar
- Wang, Y.H. et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J. Exp. Med. 204, 1837–1847 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Ivanov, I.I. et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121–1133 (2006).
Article CAS PubMed Google Scholar
- Ivanov, I.I., Zhou, L. & Littman, D.R. Transcriptional regulation of Th17 cell differentiation. Semin. Immunol. 19, 409–417 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Ringner, M. What is principal component analysis? Nat. Biotechnol. 26, 303–304 (2008).
Article CAS PubMed Google Scholar
- Zaba, L.C. et al. Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J. Exp. Med. 204, 3183–3194 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Yen, D. et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 116, 1310–1316 (2006).
Article CAS PubMed PubMed Central Google Scholar
- Khader, S.A. et al. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat. Immunol. 8, 369–377 (2007).
Article CAS PubMed Google Scholar
- Amadi-Obi, A. et al. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat. Med. 13, 711–718 (2007).
Article CAS PubMed Google Scholar
- Chen, Z. & O'Shea, J.J. Th17 cells: a new fate for differentiating helper T cells. Immunol. Res. published online 3 January 2008 (doi:10.1007/s12026-007-8014-9).
Article CAS PubMed Google Scholar
- Kastelein, R.A., Hunter, C.A. & Cua, D.J. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu. Rev. Immunol. 25, 221–242 (2007).
Article CAS PubMed Google Scholar
- Veldhoen, M., Hocking, R.J., Flavell, R.A. & Stockinger, B. Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat. Immunol. 7, 1151–1156 (2006).
Article CAS PubMed Google Scholar
- Xie, M.H. et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2–4 and IL-22R. J. Biol. Chem. 275, 31335–31339 (2000).
Article CAS PubMed Google Scholar
- Gurney, A.L. IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues. Int. Immunopharmacol. 4, 669–677 (2004).
Article CAS PubMed Google Scholar
- Zenewicz, L.A. et al. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27, 647–659 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Kreymborg, K. et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J. Immunol. 179, 8098–8104 (2007).
Article CAS PubMed Google Scholar
- Leonard, W.J. & Spolski, R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 5, 688–698 (2005).
Article CAS PubMed Google Scholar
- Moore, K.W., de Waal Malefyt, R., Coffman, R.L. & O'Garra, A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19, 683–765 (2001).
Article CAS PubMed Google Scholar
- Ito, T. et al. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med. 202, 1213–1223 (2005).
Article CAS PubMed PubMed Central Google Scholar
- Trinchieri, G. Interleukin-10 production by effector T cells: Th1 cells show self control. J. Exp. Med. 204, 239–243 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Jankovic, D. & Trinchieri, G. IL-10 or not IL-10: that is the question. Nat. Immunol. 8, 1281–1283 (2007).
Article CAS PubMed Google Scholar
- O'Garra, A. & Vieira, P. TH1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 7, 425–428 (2007).
Article CAS PubMed Google Scholar
- Lin, J.T., Martin, S.L., Xia, L. & Gorham, J.D. TGF-β1 uses distinct mechanisms to inhibit IFN-γ expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet. J. Immunol. 174, 5950–5958 (2005).
Article CAS PubMed Google Scholar
- Gorelik, L., Constant, S. & Flavell, R.A. Mechanism of transforming growth factor β-induced inhibition of T helper type 1 differentiation. J. Exp. Med. 195, 1499–1505 (2002).
Article CAS PubMed PubMed Central Google Scholar
- Manel, N., Unutmaz, D. & Littman, D.R. Human TH-17 differentiation requires transforming growth factor-β and induction of the nuclear receptor RORγt. Nat. Immunol. (in the press).