TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 (original) (raw)
Pflanz, S. et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity16, 779–790 (2002). ArticleCAS Google Scholar
Hunter, C.A. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol.5, 521–531 (2005). ArticleCAS Google Scholar
Trinchieri, G., Pflanz, S. & Kastelein, R.A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity19, 641–644 (2003). ArticleCAS Google Scholar
Trinchieri, G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol.3, 133–146 (2003). ArticleCAS Google Scholar
Cua, D.J. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature421, 744–748 (2003). ArticleCAS Google Scholar
Yen, D. et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest.116, 1310–1316 (2006). ArticleCAS Google Scholar
Cua, D.J. & Kastelein, R.A. TGF-β, a 'double agent' in the immune pathology war. Nat. Immunol.7, 557–559 (2006). ArticleCAS Google Scholar
Weaver, C.T., Harrington, L.E., Mangan, P.R., Gavrieli, M. & Murphy, K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity24, 677–688 (2006). ArticleCAS Google Scholar
Nussenblatt, R.B. Bench to bedside: new approaches to the immunotherapy of uveitic disease. Int. Rev. Immunol.21, 273–289 (2002). Article Google Scholar
Jabs, D.A. et al. Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel. Am. J. Ophthalmol.130, 492–513 (2000). ArticleCAS Google Scholar
Nussenblatt, R.B. et al. Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial. Proc. Natl. Acad. Sci. USA22, 7462–7466 (1999). Article Google Scholar
Becker, M.D., Garman, K., Whitcup, S.M., Planck, S.R. & Rosenbaum, J.T. Inhibition of leukocyte sticking and infiltration, but not rolling, by antibodies to ICAM-1 and LFA-1 in murine endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci.42, 2563–2566 (2001). CASPubMed Google Scholar
Nussenblatt, R.B. Proctor lecture. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indications. Invest. Ophthalmol. Vis. Sci.32, 3131–3141 (1991). CASPubMed Google Scholar
Crane, I.J. et al. Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis. J. Leukoc. Biol.79, 435–443 (2006). ArticleCAS Google Scholar
Tarrant, T.K., Silver, P.B., Chan, C.C., Wiggert, B. & Caspi, R.R. Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. J. Immunol.161, 122–127 (1998). CASPubMed Google Scholar
Tarrant, T.K. et al. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J. Exp. Med.189, 219–230 (1999). ArticleCAS Google Scholar
Caspi, R.R. et al. Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response. J. Immunol.157, 2668–2675 (1996). CASPubMed Google Scholar
Cho, M.L. et al. STAT3 and NF-κB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J. Immunol.176, 5652–5661 (2006). ArticleCAS Google Scholar
Komiyama, Y. et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol.177, 566–573 (2006). ArticleCAS Google Scholar
Nakae, S., Nambu, A., Sudo, K. & Iwakura, Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol.171, 6173–6177 (2003). ArticleCAS Google Scholar
Nakae, S. et al. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc. Natl. Acad. Sci. USA100, 5986–5990 (2003). ArticleCAS Google Scholar
Yu, C.R. et al. Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling. J. Immunol.173, 737–746 (2004). ArticleCAS Google Scholar
Egwuagu, C.E. et al. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J. Immunol.168, 3181–3187 (2002). ArticleCAS Google Scholar
Stumhofer, J.S. et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol.7, 937–945 (2006). ArticleCAS Google Scholar
Takase, H. et al. Induction of suppressors of cytokine signaling (SOCS) in the retina during experimental autoimmune uveitis (EAU): potential neuroprotective role of SOCS proteins. J. Neuroimmunol.168, 118–127 (2005). ArticleCAS Google Scholar
Caspi, R.R. et al. A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol.140, 1490–1495 (1988). CASPubMed Google Scholar
Weaver, C.T., Hatton, R.D., Mangan, P.R. & Harrington, L.E. IL-17 Family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol.25, 821–852 (2007). ArticleCAS Google Scholar
Owaki, T. et al. A role for IL-27 in early regulation of Th1 differentiation. J. Immunol.175, 2191–2200 (2005). ArticleCAS Google Scholar
Villarino, A.V. et al. IL-27 limits IL-2 production during Th1 differentiation. J. Immunol.176, 237–247 (2006). ArticleCAS Google Scholar
Batten, M. et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol.7, 929–936 (2006). ArticleCAS Google Scholar
Yoshimura, T. et al. Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J. Immunol.177, 5377–5385 (2006). ArticleCAS Google Scholar
Jovanovic, D.V. et al. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-β and TNF-α, by human macrophages. J. Immunol.160, 3513–3521 (1998). CASPubMed Google Scholar
Watford, W.T. et al. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol. Rev.202, 139–156 (2004). ArticleCAS Google Scholar
Villarino, A.V. & Hunter, C.A. Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27. Arthritis Res. Ther.6, 225–233 (2004). ArticleCAS Google Scholar
Chen, Z. et al. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc. Natl. Acad. Sci. USA103, 8137–8142 (2006). ArticleCAS Google Scholar
Tato, C.M., Laurence, A. & O'Shea, J.J. Helper T cell differentiation enters a new era: le roi est mort; vive le roi!. J. Exp. Med.203, 809–812 (2006). ArticleCAS Google Scholar
Li, J., Gran, B., Zhang, G.X., Rostami, A. & Kamoun, M. IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis. J. Neurol. Sci.232, 3–9 (2005). ArticleCAS Google Scholar
Sonobe, Y. et al. Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations. Brain Res.1040, 202–207 (2005). ArticleCAS Google Scholar
Hamzaoui, K. et al. Cytokine profile in Behcet's disease patients. Relationship with disease activity. Scand. J. Rheumatol.31, 205–210 (2002). Article Google Scholar
Saruhan-Direskeneli, G., Yentur, S.P., Akman-Demir, G., Isik, N. & Serdaroglu, P. Cytokines and chemokines in neuro-Behcet's disease compared to multiple sclerosis and other neurological diseases. J. Neuroimmunol.145, 127–134 (2003). ArticleCAS Google Scholar
Okhravi, N., Odufuwa, B., McCluskey, P. & Lightman, S. Scleritis. Surv. Ophthalmol.50, 351–363 (2005). Article Google Scholar
Deuter, C.M., Kotter, I., Gunaydin, I., Zierhut, M. & Stubiger, N. Ocular involvement in Behcet's disease: first 5-year-results for visual development after treatment with interferon alfa-2a. Ophthalmologe101, 129–134 (2004). ArticleCAS Google Scholar
Calguneri, M. et al. Effects of interferon alpha treatment on the clinical course of refractory Behcet's disease: an open study. Ann. Rheum. Dis.62, 492–493 (2003). ArticleCAS Google Scholar
Nussenblatt, R.B. et al. Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration. J. Autoimmun.21, 283–293 (2003). ArticleCAS Google Scholar
Egwuagu, C.E., Yu, C.R., Li, Z. & Nussenblatt, R.B. SOCS5 mRNA levels in peripheral blood mononuclear cells (PBMC): a potential bio-marker for monitoring response of uveitis patients to Daclizumab therapy. J. Autoimmun.24, 39–46 (2005). ArticleCAS Google Scholar
Hofmann, H., Schulz-key, S., Hertle, D. & Kirsch, M. Orgaotypic cultures of the rat retina. in New Methods for Culturing Cells from Nervous Tissues—Bio Valley Monogr. Vol. 1 (eds. Poindron, P., Piguet, P. & Forster, E.) 58–73 (Karger, Basel, Switzerland, 2005). Chapter Google Scholar