The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells (original) (raw)

• Cheng, J. et al. Hematopoietic defects in mice lacking the sialomucin CD34. Blood 87, 479–490 (1996).
  CAS PubMed Google Scholar
• Antonchuk, J., Hyland, C.D., Hilton, D.J. & Alexander, W.S. Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors. Blood 104, 1306–1313 (2004).
  Article CAS PubMed Google Scholar
• Ballmaier, M. et al. c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia. Blood 97, 139–146 (2001).
  Article CAS PubMed Google Scholar
• Ihara, K. et al. Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia. Proc. Natl. Acad. Sci. USA 96, 3132–3136 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Kimura, S., Roberts, A.W., Metcalf, D. & Alexander, W.S. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc. Natl. Acad. Sci. USA 95, 1195–1200 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Hrabe de Angelis, M.H. et al. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat. Genet. 25, 444–447 (2000).
  Article CAS PubMed Google Scholar
• Kile, B.T. et al. Functional genetic analysis of mouse chromosome 11. Nature 425, 81–86 (2003).
  Article CAS PubMed Google Scholar
• Nelms, K.A. & Goodnow, C.C. Genome-wide ENU mutagenesis to reveal immune regulators. Immunity 15, 409–418 (2001).
  Article CAS PubMed Google Scholar
• Nolan, P.M. et al. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat. Genet. 25, 440–443 (2000).
  Article CAS PubMed Google Scholar
• Duterque-Coquillaud, M., Niel, C., Plaza, S. & Stehelin, D. New human erg isoforms generated by alternative splicing are transcriptional activators. Oncogene 8, 1865–1873 (1993).
  CAS PubMed Google Scholar
• Shimizu, K. et al. An ets-related gene, ERG, is rearranged in human myeloid leukemia with t(16;21) chromosomal translocation. Proc. Natl. Acad. Sci. USA 90, 10280–10284 (1993).
  Article CAS PubMed PubMed Central Google Scholar
• Sorensen, P.H. et al. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat. Genet. 6, 146–151 (1994).
  Article CAS PubMed Google Scholar
• Baldus, C.D. et al. Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes. Proc. Natl. Acad. Sci. USA 101, 3915–3920 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Marcucci, G. et al. Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. J. Clin. Oncol. 23, 9234–9242 (2005).
  Article CAS PubMed Google Scholar
• Mullighan, C.G. et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446, 758–764 (2007).
  Article CAS PubMed Google Scholar
• Tomlins, S.A. et al. Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature 448, 595–599 (2007).
  Article CAS PubMed Google Scholar
• Tomlins, S.A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644–648 (2005).
  Article CAS PubMed Google Scholar
• Alexander, W.S., Roberts, A.W., Nicola, N.A., Li, R. & Metcalf, D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 87, 2162–2170 (1996).
  CAS PubMed Google Scholar
• Reddy, E.S. & Rao, V.N. Erg, an ets-related gene, codes for sequence-specific transcriptional activators. Oncogene 6, 2285–2289 (1991).
  CAS PubMed Google Scholar
• Liang, H. et al. Solution structure of the ets domain of Fli-1 when bound to DNA. Nat. Struct. Biol. 1, 871–875 (1994).
  Article CAS PubMed Google Scholar
• Andersson, L.C., Nilsson, K. & Gahmberg, C.G. K562–a human erythroleukemic cell line. Int. J. Cancer 23, 143–147 (1979).
  Article CAS PubMed Google Scholar
• Rainis, L. et al. The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res. 65, 7596–7602 (2005).
  Article CAS PubMed Google Scholar
• Carrere, S., Verger, A., Flourens, A., Stehelin, D. & Duterque-Coquillaud, M. Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains. Oncogene 16, 3261–3268 (1998).
  Article CAS PubMed Google Scholar
• Spyropoulos, D.D. et al. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol. Cell. Biol. 20, 5643–5652 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Hart, A. et al. Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity 13, 167–177 (2000).
  Article CAS PubMed Google Scholar
• Loder, F. et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190, 75–89 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Anderson, M.K., Hernandez-Hoyos, G., Diamond, R.A. & Rothenberg, E.V. Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage. Development 126, 3131–3148 (1999).
  CAS PubMed Google Scholar
• Okada, S. et al. In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood 80, 3044–3050 (1992).
  CAS PubMed Google Scholar
• Kiel, M.J. et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121, 1109–1121 (2005).
  Article CAS PubMed Google Scholar
• Yang, L. et al. Identification of Lin−Sca1+kit+CD34+Flt3− short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood 105, 2717–2723 (2005).
  Article CAS PubMed Google Scholar
• Buttice, G. et al. Erg, an Ets-family member, differentially regulates human collagenase1 (MMP1) and stromelysin1 (MMP3) gene expression by physically interacting with the Fos/Jun complex. Oncogene 13, 2297–2306 (1996).
  CAS PubMed Google Scholar
• McLaughlin, F. et al. Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation. Blood 98, 3332–3339 (2001).
  Article CAS PubMed Google Scholar
• Pimanda, J.E. et al. Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer. Blood 107, 4737–4745 (2006).
  Article CAS PubMed Google Scholar
• Forsberg, E.C. et al. Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet. 1, e28 (2005).
  Article PubMed PubMed Central Google Scholar
• Bryder, D., Rossi, D.J. & Weissman, I.L. Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am. J. Pathol. 169, 338–346 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Okuda, T., van Deursen, J., Hiebert, S.W., Grosveld, G. & Downing, J.R. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321–330 (1996).
  Article CAS PubMed Google Scholar
• Nottingham, W.T. et al. Runx1-mediated hematopoietic stem cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer. Blood 110, 4188–4197 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Hollenhorst, P.C., Shah, A.A., Hopkins, C. & Graves, B.J. Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 21, 1882–1894 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Ichikawa, M. et al. AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat. Med. 10, 299–304 (2004).
  Article CAS PubMed Google Scholar
• Pimanda, J.E. et al. Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc. Natl. Acad. Sci. USA 104, 17692–17697 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Robb, L. et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc. Natl. Acad. Sci. USA 92, 7075–7079 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Shivdasani, R.A., Mayer, E.L. & Orkin, S.H. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 373, 432–434 (1995).
  Article CAS PubMed Google Scholar
• Porcher, C. et al. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell 86, 47–57 (1996).
  Article CAS PubMed Google Scholar
• Mikkola, H.K. et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature 421, 547–551 (2003).
  Article CAS PubMed Google Scholar
• Hitzler, J.K. & Zipursky, A. Origins of leukaemia in children with Down syndrome. Nat. Rev. Cancer 5, 11–20 (2005).
  Article CAS PubMed Google Scholar
• Hitzler, J.K., Cheung, J., Li, Y., Scherer, S.W. & Zipursky, A. GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome. Blood 101, 4301–4304 (2003).
  Article CAS PubMed Google Scholar
• Mundschau, G. et al. Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood 101, 4298–4300 (2003).
  Article CAS PubMed Google Scholar
• Wechsler, J. et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat. Genet. 32, 148–152 (2002).
  Article CAS PubMed Google Scholar
• Miyoshi, H. et al. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc. Natl. Acad. Sci. USA 88, 10431–10434 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Kirsammer, G. et al. Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood 111, 767–775 (2007).
  Article PubMed Google Scholar
• Bode, V.C. Ethylnitrosourea mutagenesis and the isolation of mutant alleles for specific genes located in the T region of mouse chromosome 17. Genetics 108, 457–470 (1984).
  CAS PubMed PubMed Central Google Scholar
• O'Reilly, L.A. et al. Tissue expression and subcellular localization of the pro-survival molecule Bcl-w. Cell Death Differ. 8, 486–494 (2001).
  Article CAS PubMed Google Scholar
• Alexander, W.S., Metcalf, D. & Dunn, A.R. Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity. EMBO J. 14, 5569–5578 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Darzynkiewicz, Z., Juan, G. & Srour, E. in Current Protocols in Cytometry. (ed. Robinson, J.P.) 7.3.1–7.3.16 (John Wiley and Sons, Hoboken, NJ, 2004).
  Google Scholar
• Voss, A.K., Thomas, T. & Gruss, P. Mice lacking HSP90β fail to develop a placental labyrinth. Development 127, 1–11 (2000).
  CAS PubMed Google Scholar
• Ma, Q., Chen, Z., del Barco Barrantes, I., de la Pompa, J.L. & Anderson, D.J. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20, 469–482 (1998).
  Article CAS PubMed Google Scholar
• Lin, S.M., Du, P., Huber, W. & Kibbe, W.A. Model-based variance-stabilizing transformation for Illumina microarray data. Nucleic Acids Res. 36, e11 (2008).
  Article PubMed PubMed Central Google Scholar
• Smyth, G.K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3 Issue 1, Article 3 (2004).
  Article Google Scholar