The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions (original) (raw)
Petrie, H.T. & Zuniga-Pflucker, J.C. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu. Rev. Immunol.25, 649–679 (2007). ArticleCAS Google Scholar
Rothenberg, E.V. & Anderson, M.K. Elements of transcription factor network design for T-lineage specification. Dev. Biol.246, 29–44 (2002). ArticleCAS Google Scholar
Bendelac, A., Savage, P.B. & Teyton, L. The biology of NKT cells. Annu. Rev. Immunol.25, 297–336 (2007). ArticleCAS Google Scholar
Bendelac, A. & Medzhitov, R. Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J. Exp. Med.195, F19–F23 (2002). ArticleCAS Google Scholar
Kronenberg, M. Toward an understanding of NKT cell biology: progress and paradoxes. Annu. Rev. Immunol.23, 877–900 (2005). ArticleCAS Google Scholar
Matsuda, J.L. et al. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med.192, 741–754 (2000). ArticleCAS Google Scholar
Kronenberg, M. & Engel, I. On the road: progress in finding the unique pathway of invariant NKT cell differentiation. Curr. Opin. Immunol.19, 186–193 (2007). ArticleCAS Google Scholar
Gadue, P., Morton, N. & Stein, P.L. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J. Exp. Med.190, 1189–1196 (1999). ArticleCAS Google Scholar
Dao, T. et al. Development of CD1d-restricted NKT cells in the mouse thymus. Eur. J. Immunol.34, 3542–3552 (2004). ArticleCAS Google Scholar
Eberl, G., Lowin-Kropf, B. & MacDonald, H.R. Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice. J. Immunol.163, 4091–4094 (1999). CASPubMed Google Scholar
Veillette, A. Immune regulation by SLAM family receptors and SAP-related adaptors. Nat. Rev. Immunol.6, 56–66 (2006). ArticleCAS Google Scholar
Borowski, C. & Bendelac, A. Signaling for NKT cell development: the SAP-FynT connection. J. Exp. Med.201, 833–836 (2005). ArticleCAS Google Scholar
Chung, B., Aoukaty, A., Dutz, J., Terhorst, C. & Tan, R. Signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J. Immunol.174, 3153–3157 (2005). ArticleCAS Google Scholar
Pasquier, B. et al. Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J. Exp. Med.201, 695–701 (2005). ArticleCAS Google Scholar
Egawa, T. et al. Genetic evidence supporting selection of the Vα14i NKT cell lineage from double-positive thymocyte precursors. Immunity22, 705–716 (2005). ArticleCAS Google Scholar
Kelly, K.F. & Daniel, J.M. POZ for effect–POZ-ZF transcription factors in cancer and development. Trends Cell Biol.16, 578–587 (2006). ArticleCAS Google Scholar
Dent, A.L., Shaffer, A.L., Yu, X., Allman, D. & Staudt, L.M. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science276, 589–592 (1997). ArticleCAS Google Scholar
He, X. et al. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature433, 826–833 (2005). ArticleCAS Google Scholar
Sun, G. et al. The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat. Immunol.6, 373–381 (2005). ArticleCAS Google Scholar
Maeda, T. et al. Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science316, 860–866 (2007). ArticleCAS Google Scholar
McConnell, M.J. & Licht, J.D. The PLZF gene of t(11;17)-associated APL. Curr. Top. Microbiol. Immunol.313, 31–48 (2007). CASPubMed Google Scholar
Barna, M., Hawe, N., Niswander, L. & Pandolfi, P.P. Plzf regulates limb and axial skeletal patterning. Nat. Genet.25, 166–172 (2000). ArticleCAS Google Scholar
Exley, M.A. et al. Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR α-chain CDR3 loop. Eur. J. Immunol.38, 1756–1766 (2008). ArticleCAS Google Scholar
Matsuda, J.L. & Gapin, L. Developmental program of mouse Vα14i NKT cells. Curr. Opin. Immunol.17, 122–130 (2005). ArticleCAS Google Scholar
Zelent, A., Guidez, F., Melnick, A., Waxman, S. & Licht, J.D. Translocations of the RARα gene in acute promyelocytic leukemia. Oncogene20, 7186–7203 (2001). ArticleCAS Google Scholar
Koken, M.H. et al. Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proc. Natl. Acad. Sci. USA94, 10255–10260 (1997). ArticleCAS Google Scholar
Townsend, M.J. et al. T-bet regulates the terminal maturation and homeostasis of NK and Vα14i NKT cells. Immunity20, 477–494 (2004). ArticleCAS Google Scholar
Costoya, J.A. et al. Essential role of Plzf in maintenance of spermatogonial stem cells. Nat. Genet.36, 653–659 (2004). ArticleCAS Google Scholar
Pellicci, D.G. et al. DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. J. Immunol.175, 4416–4425 (2005). ArticleCAS Google Scholar
Mendiratta, S.K. et al. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity6, 469–477 (1997). ArticleCAS Google Scholar
Davis, M.M. & Bjorkman, P.J. T-cell antigen receptor genes and T-cell recognition. Nature334, 395–402 (1988). ArticleCAS Google Scholar
Benlagha, K., Wei, D.G., Veiga, J., Teyton, L. & Bendelac, A. Characterization of the early stages of thymic NKT cell development. J. Exp. Med.202, 485–492 (2005). ArticleCAS Google Scholar
Gapin, L., Matsuda, J.L., Surh, C.D. & Kronenberg, M. NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat. Immunol.2, 971–978 (2001). ArticleCAS Google Scholar
Gumperz, J.E., Miyake, S., Yamamura, T. & Brenner, M.B. Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J. Exp. Med.195, 625–636 (2002). ArticleCAS Google Scholar
Hammond, K.J. et al. NKT cells are phenotypically and functionally diverse. Eur. J. Immunol.29, 3768–3781 (1999). ArticleCAS Google Scholar
Stetson, D.B. et al. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J. Exp. Med.198, 1069–1076 (2003). ArticleCAS Google Scholar
Benlagha, K., Kyin, T., Beavis, A., Teyton, L. & Bendelac, A. A thymic precursor to the NK T cell lineage. Science296, 553–555 (2002). ArticleCAS Google Scholar
Falk, I., Potocnik, A.J., Barthlott, T., Levelt, C.N. & Eichmann, K. Immature T cells in peripheral lymphoid organs of recombinase-activating gene-1/-2-deficient mice. Thymus dependence and responsiveness to anti-CD3 epsilon antibody. J. Immunol.156, 1362–1368 (1996). CASPubMed Google Scholar
Pellicci, D.G. et al. A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1−CD4+ CD1d-dependent precursor stage. J. Exp. Med.195, 835–844 (2002). ArticleCAS Google Scholar
Nichols, K.E. et al. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat. Med.11, 340–345 (2005). ArticleCAS Google Scholar
Griewank, K. et al. Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity27, 751–762 (2007). ArticleCAS Google Scholar
Bezbradica, J.S. et al. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity25, 487–497 (2006). ArticleCAS Google Scholar
Felices, M. & Berg, L.J. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J. Immunol.180, 3007–3018 (2008). ArticleCAS Google Scholar
Au-Yeung, B.B. & Fowell, D.J. A key role for Itk in both IFN-γ and IL-4 production by NKT cells. J. Immunol.179, 111–119 (2007). ArticleCAS Google Scholar
Broussard, C. et al. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity25, 93–104 (2006). ArticleCAS Google Scholar
Horai, R. et al. Requirements for selection of conventional and innate T lymphocyte lineages. Immunity27, 775–785 (2007). ArticleCAS Google Scholar
Hu, J., Sahu, N., Walsh, E. & August, A. Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk. Eur. J. Immunol.37, 2892–2899 (2007). ArticleCAS Google Scholar
Berg, L.J. Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development. Nat. Rev. Immunol.7, 479–485 (2007). ArticleCAS Google Scholar
Hu, J. & August, A. Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development. J. Immunol.180, 6544–6552 (2008). ArticleCAS Google Scholar
Phan, R.T. & Dalla-Favera, R. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature432, 635–639 (2004). ArticleCAS Google Scholar
Barna, M. et al. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev. Cell3, 499–510 (2002). ArticleCAS Google Scholar
Filipponi, D. et al. Repression of kit expression by Plzf in germ cells. Mol. Cell. Biol.27, 6770–6781 (2007). ArticleCAS Google Scholar
Shiraishi, K. et al. Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression. Oncogene26, 339–348 (2007). ArticleCAS Google Scholar
Quaranta, M.T. et al. PLZF-mediated control on VLA-4 expression in normal and leukemic myeloid cells. Oncogene25, 399–408 (2006). ArticleCAS Google Scholar
McConnell, M.J. et al. Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-Myc expression. Mol. Cell. Biol.23, 9375–9388 (2003). ArticleCAS Google Scholar
Parrado, A. et al. The promyelocytic leukemia zinc finger protein down-regulates apoptosis and expression of the proapoptotic BID protein in lymphocytes. Proc. Natl. Acad. Sci. USA101, 1898–1903 (2004). ArticleCAS Google Scholar
Szabo, S.J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell100, 655–669 (2000). ArticleCAS Google Scholar
Ivanov, I.I. et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell126, 1121–1133 (2006). ArticleCAS Google Scholar
Kronenberg, M. & Rudensky, A. Regulation of immunity by self-reactive T cells. Nature435, 598–604 (2005). ArticleCAS Google Scholar
Yu, K.O. et al. Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand α-galactosylceramide bound to mouse CD1d. J. Immunol. Methods323, 11–23 (2007). ArticleCAS Google Scholar
Liu, Y. et al. A modified α-galactosyl ceramide for staining and stimulating natural killer T cells. J. Immunol. Methods312, 34–39 (2006). ArticleCAS Google Scholar
Lamb, T.J., Graham, A.L. & Petrie, A. T testing the immune system. Immunity28, 288–292 (2008). ArticleCAS Google Scholar