- Roncarolo, M.G. et al. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev. 212, 28–50 (2006).
Article CAS PubMed Google Scholar
- Pflanz, S. et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity 16, 779–790 (2002).
Article CAS PubMed Google Scholar
- Villarino, A. et al. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19, 645–655 (2003).
Article CAS PubMed Google Scholar
- Batten, M. et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7, 929–936 (2006).
Article CAS PubMed Google Scholar
- Awasthi, A. et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8, 1380–1389 (2007).
Article CAS PubMed Google Scholar
- Stumhofer, J.S. et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8, 1363–1371 (2007).
Article CAS PubMed Google Scholar
- Fitzgerald, D.C. et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8, 1372–1379 (2007).
Article CAS PubMed Google Scholar
- Murugaiyan, G. et al. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J. Immunol. 183, 2435–2443 (2009).
Article CAS PubMed Google Scholar
- Pot, C. et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 183, 797–801 (2009).
Article CAS PubMed Google Scholar
- Spolski, R., Kim, H.P., Zhu, W., Levy, D.E. & Leonard, W.J. IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 182, 2859–2867 (2009).
Article CAS PubMed Google Scholar
- Pot, C., Apetoh, L., Awasthi, A. & Kuchroo, V.K. Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells. J. Interferon Cytokine Res. 30, 381–388 (2010).
Article CAS PubMed PubMed Central Google Scholar
- Wurster, A.L. et al. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J. Exp. Med. 196, 969–977 (2002).
Article CAS PubMed PubMed Central Google Scholar
- Zhou, L. et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8, 967–974 (2007).
Article CAS PubMed Google Scholar
- Bauquet, A.T. et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 10, 167–175 (2009).
Article CAS PubMed Google Scholar
- Korn, T. et al. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells. Nature 448, 484–487 (2007).
Article CAS PubMed PubMed Central Google Scholar
- Coquet, J.M., Chakravarti, S., Smyth, M.J. & Godfrey, D.I. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J. Immunol. 180, 7097–7101 (2008).
Article CAS PubMed Google Scholar
- Xu, J. et al. c-Maf regulates IL-10 expression during Th17 polarization. J. Immunol. 182, 6226–6236 (2009).
Article CAS PubMed Google Scholar
- Veldhoen, M. et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453, 106–109 (2008).
Article CAS PubMed Google Scholar
- Quintana, F.J. et al. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor. Nature 453, 65–71 (2008).
Article CAS PubMed Google Scholar
- Jones, P.B., Galeazzi, D.R., Fisher, J.M. & Whitlock, J.P. Jr. Control of cytochrome P1–450 gene expression by dioxin. Science 227, 1499–1502 (1985).
Article CAS PubMed Google Scholar
- Sun, J., Madan, R., Karp, C.L. & Braciale, T.J. Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat. Med. 15, 277–284 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Kerkvliet, N.I. et al. Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3 T cells in pancreatic lymph nodes. Immunotherapy 1, 539–547 (2009).
CAS PubMed Google Scholar
- Funatake, C.J., Marshall, N.B., Steppan, L.B., Mourich, D.V. & Kerkvliet, N.I. Cutting edge: activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+CD25+ cells with characteristics of regulatory T cells. J. Immunol. 175, 4184–4188 (2005).
Article CAS PubMed Google Scholar
- Hibbert, L., Pflanz, S., De Waal Malefyt, R. & Kastelein, R.A. IL-27 and IFN-α signal via Stat1 and Stat3 and induce T-bet and IL-12Rβ2 in naive T cells. J. Interferon Cytokine Res. 23, 513–522 (2003).
Article CAS PubMed Google Scholar
- Whitlock, J.P. Jr. Induction of cytochrome P4501A1. Annu. Rev. Pharmacol. Toxicol. 39, 103–125 (1999).
Article CAS PubMed Google Scholar
- Chiaro, C.R., Morales, J.L., Prabhu, K.S. & Perdew, G.H. Leukotriene A4 metabolites are endogenous ligands for the Ah receptor. Biochemistry 47, 8445–8455 (2008).
Article CAS PubMed Google Scholar
- Kim, D.W. et al. The RelA NF-κB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells. Oncogene 19, 5498–5506 (2000).
Article CAS PubMed Google Scholar
- Klinge, C.M., Kaur, K. & Swanson, H.I. The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. Arch. Biochem. Biophys. 373, 163–174 (2000).
Article CAS PubMed Google Scholar
- Kamanaka, M. et al. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity 25, 941–952 (2006).
Article CAS PubMed Google Scholar
- Okey, A.B., Vella, L.M. & Harper, P.A. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1–450 by 3-methylcholanthrene. Mol. Pharmacol. 35, 823–830 (1989).
CAS PubMed Google Scholar
- Fitzgerald, D.C. et al. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 179, 3268–3275 (2007).
Article CAS PubMed Google Scholar
- Nicholson, L.B., Greer, J.M., Sobel, R.A., Lees, M.B. & Kuchroo, V.K. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3, 397–405 (1995).
Article CAS PubMed Google Scholar
- Morari, J. et al. The role of proliferator-activated receptor γ coactivator-1α in the fatty-acid-dependent transcriptional control of interleukin-10 in hepatic cells of rodents. Metabolism 59, 215–223 (2010).
Article CAS PubMed Google Scholar
- Monteiro, P. et al. AhR- and c-maf-dependent induction of β7-integrin expression in human macrophages in response to environmental polycyclic aromatic hydrocarbons. Biochem. Biophys. Res. Commun. 358, 442–448 (2007).
Article CAS PubMed Google Scholar
- Manel, N., Unutmaz, D. & Littman, D.R. The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. Nat. Immunol. 9, 641–649 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Wolk, K., Witte, E., Witte, K., Warszawska, K. & Sabat, R. Biology of interleukin-22. Semin. Immunopathol. 32, 17–31 (2010).
Article CAS PubMed Google Scholar
- Heath-Pagliuso, S. et al. Activation of the Ah receptor by tryptophan and tryptophan metabolites. Biochemistry 37, 11508–11515 (1998).
Article CAS PubMed Google Scholar
- Kobayashi, S. et al. A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis. Rheumatology (Oxford) 47, 1317–1322 (2008).
Article CAS Google Scholar
- Kong, L.Y., Luster, M.I., Dixon, D., O'Grady, J. & Rosenthal, G.J. Inhibition of lung immunity after intratracheal instillation of benzo(a)pyrene. Am. J. Respir. Crit. Care Med. 150, 1123–1129 (1994).
Article CAS PubMed Google Scholar
- Allan, L. & Sherr, D. Suppression of plasma cell differentiation by benzo[_a_]pyrene, an environmental pollutant. Environ Health J. 9, 15 (2010).
Article Google Scholar
- Camacho, I.A., Nagarkatti, M. & Nagarkatti, P.S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces Fas-dependent activation-induced cell death in superantigen-primed T cells. Arch. Toxicol. 76, 570–580 (2002).
Article CAS PubMed Google Scholar
- Head, J.L. & Lawrence, B.P. The aryl hydrocarbon receptor is a modulator of anti-viral immunity. Biochem. Pharmacol. 77, 642–653 (2009).
Article CAS PubMed Google Scholar
- Marshall, N.B., Vorachek, W.R., Steppan, L.B., Mourich, D.V. & Kerkvliet, N.I. Functional characterization and gene expression analysis of CD4+CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Immunol. 181, 2382–2391 (2008).
Article CAS PubMed Google Scholar
- Ryu, H.Y. et al. Environmental chemical-induced bone marrow B cell apoptosis: death receptor-independent activation of a caspase-3 to caspase-8 pathway. Mol. Pharmacol. 68, 1087–1096 (2005).
Article CAS PubMed Google Scholar
- Schneider, D., Manzan, M.A., Yoo, B.S., Crawford, R.B. & Kaminski, N. Involvement of Blimp-1 and AP-1 dysregulation in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated suppression of the IgM response by B cells. Toxicol. Sci. 108, 377–388 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Singh, N.P., Nagarkatti, M. & Nagarkatti, P. Primary peripheral T cells become susceptible to 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated apoptosis in vitro upon activation and in the presence of dendritic cells. Mol. Pharmacol. 73, 1722–1735 (2008).
Article CAS PubMed Google Scholar
- Gandhi, R. et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells. Nat. Immunol. advance online publication, doi:10.1038/ni.1915 (1 August 2010).
- Ho, I.C., Lo, D. & Glimcher, L.H. c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J. Exp. Med. 188, 1859–1866 (1998).
Article CAS PubMed PubMed Central Google Scholar
- Schmidt, J.V., Su, G.H., Reddy, J.K., Simon, M.C. & Bradfield, C.A. Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc. Natl. Acad. Sci. USA 93, 6731–6736 (1996).
Article CAS PubMed PubMed Central Google Scholar
- Tone, Y. et al. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat. Immunol. 9, 194–202 (2008).
Article CAS PubMed Google Scholar
- Quintana, F.J. et al. Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish. PLoS One 5, e9478 (2010).
Article PubMed PubMed Central Google Scholar