- Buck, M.D., O'Sullivan, D. & Pearce, E.L. T cell metabolism drives immunity. J. Exp. Med. 212, 1345–1360 (2015).
CAS PubMed PubMed Central Google Scholar
- O'Sullivan, D. & Pearce, E.L. Targeting T cell metabolism for therapy. Trends Immunol. 36, 71–80 (2015).
CAS PubMed PubMed Central Google Scholar
- Waickman, A.T. & Powell, J.D. mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol. Rev. 249, 43–58 (2012).
CAS PubMed PubMed Central Google Scholar
- Michalek, R.D. et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299–3303 (2011).
CAS PubMed Google Scholar
- Jacobs, S.R. et al. Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J. Immunol. 180, 4476–4486 (2008).
CAS PubMed Google Scholar
- Cham, C.M. & Gajewski, T.F. Glucose availability regulates IFN-γ production and p70S6 kinase activation in CD8+ effector T cells. J. Immunol. 174, 4670–4677 (2005).
CAS PubMed Google Scholar
- Chang, C.H. et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, 1239–1251 (2013).
CAS PubMed PubMed Central Google Scholar
- Doedens, A.L. et al. Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen. Nat. Immunol. 14, 1173–1182 (2013).
CAS PubMed PubMed Central Google Scholar
- Shi, L.Z. et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367–1376 (2011).
CAS PubMed PubMed Central Google Scholar
- Wang, R. et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871–882 (2011).
CAS PubMed PubMed Central Google Scholar
- Villena, J.A. & Kralli, A. ERRa: a metabolic function for the oldest orphan. Trends Endocrinol. Metab. 19, 269–276 (2008).
CAS PubMed PubMed Central Google Scholar
- Michalek, R.D. et al. Estrogen-related receptor-a is a metabolic regulator of effector T-cell activation and differentiation. Proc. Natl. Acad. Sci. USA 108, 18348–18353 (2011).
CAS PubMed PubMed Central Google Scholar
- Man, K. et al. The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat. Immunol. 14, 1155–1165 (2013).
CAS PubMed Google Scholar
- Yao, S. et al. Interferon regulatory factor 4 sustains CD8+ T cell expansion and effector differentiation. Immunity 39, 833–845 (2013).
CAS PubMed Google Scholar
- MacIver, N.J. et al. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J. Immunol. 187, 4187–4198 (2011).
CAS PubMed Google Scholar
- Chang, C.H. et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell 162, 1229–1241 (2015).
CAS PubMed PubMed Central Google Scholar
- Ho, P.C. et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell 162, 1217–1228 (2015).
CAS PubMed PubMed Central Google Scholar
- Blagih, J. et al. The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity 42, 41–54 (2015).
CAS PubMed Google Scholar
- Mayer, A., Denanglaire, S., Viollet, B., Leo, O. & Andris, F. AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function. Eur. J. Immunol. 38, 948–956 (2008).
CAS PubMed Google Scholar
- Berod, L. et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat. Med. 20, 1327–1333 (2014).
CAS PubMed Google Scholar
- Ananieva, E.A., Patel, C.H., Drake, C.H., Powell, J.D. & Hutson, S.M. Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells. J. Biol. Chem. 289, 18793–18804 (2014).
CAS PubMed PubMed Central Google Scholar
- Lee, J. et al. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J. Immunol. 192, 3190–3199 (2014).
CAS PubMed Google Scholar
- Fischer, K. et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109, 3812–3819 (2007).
CAS PubMed Google Scholar
- Haas, R. et al. Lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and effector functions. PLoS Biol. 13, e1002202 (2015).
PubMed PubMed Central Google Scholar
- Munn, D.H. et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 22, 633–642 (2005).
CAS PubMed Google Scholar
- Opitz, C.A. et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478, 197–203 (2011).
CAS PubMed Google Scholar
- Mezrich, J.D. et al. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J. Immunol. 185, 3190–3198 (2010).
CAS PubMed Google Scholar
- Sharma, M.D. et al. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J. Clin. Invest. 117, 2570–2582 (2007).
CAS PubMed PubMed Central Google Scholar
- Pearce, E.L. et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460, 103–107 (2009).
CAS PubMed PubMed Central Google Scholar
- Araki, K. et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108–112 (2009).
CAS PubMed PubMed Central Google Scholar
- van der Windt, G.J. et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36, 68–78 (2012).
CAS PubMed Google Scholar
- Rolf, J. et al. AMPKa1: a glucose sensor that controls CD8 T-cell memory. Eur. J. Immunol. 43, 889–896 (2013).
CAS PubMed PubMed Central Google Scholar
- van der Windt, G.J. et al. CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc. Natl. Acad. Sci. USA 110, 14336–14341 (2013).
CAS PubMed PubMed Central Google Scholar
- Fraser, K.A., Schenkel, J.M., Jameson, S.C., Vezys, V. & Masopust, D. Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting. Immunity 39, 171–183 (2013).
CAS PubMed PubMed Central Google Scholar
- O'Sullivan, D. et al. Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity 41, 75–88 (2014).
CAS PubMed PubMed Central Google Scholar
- Cui, G. et al. IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T Cell longevity. Cell 161, 750–761 (2015).
CAS PubMed PubMed Central Google Scholar
- Maekawa, Y. et al. Notch controls the survival of memory CD4+ T cells by regulating glucose uptake. Nat. Med. 21, 55–61 (2015).
CAS PubMed Google Scholar
- Wang, Y., Wang, X.Y., Subjeck, J.R., Shrikant, P.A. & Kim, H.L. Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines. Br. J. Cancer 104, 643–652 (2011).
CAS PubMed PubMed Central Google Scholar
- Chaoul, N. et al. Rapamycin impairs antitumor CD8+ T-cell responses and vaccine-induced tumor eradication. Cancer Res. 75, 3279–3291 (2015).
CAS PubMed Google Scholar
- Gattinoni, L., Klebanoff, C.A. & Restifo, N.P. Pharmacologic induction of CD8+ T cell memory: better living through chemistry. Sci. Transl. Med. 1, 11ps12 (2009).
PubMed PubMed Central Google Scholar
- Patsoukis, N. et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat. Commun. 6, 6692 (2015).
CAS PubMed Google Scholar
- Calvaresi, E.C. et al. Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. ChemBioChem 14, 2263–2267 (2013).
CAS PubMed PubMed Central Google Scholar
- Lameris, R. et al. Bispecific antibody platforms for cancer immunotherapy. Crit. Rev. Oncol. Hematol. 92, 153–165 (2014).
PubMed Google Scholar
- Mundra, V., Li, W. & Mahato, R.I. Nanoparticle-mediated drug delivery for treating melanoma. Nanomedicine (Lond.) 10, 2613–2633 (2015).
CAS Google Scholar
- Gerriets, V.A. et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J. Clin. Invest. 125, 194–207 (2015).
PubMed Google Scholar
- Sinclair, L.V. et al. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat. Immunol. 14, 500–508 (2013).
CAS PubMed PubMed Central Google Scholar
- Maus, M.V. et al. Adoptive immunotherapy for cancer or viruses. Annu. Rev. Immunol. 32, 189–225 (2014).
CAS PubMed PubMed Central Google Scholar
- Sukumar, M. et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J. Clin. Invest. 123, 4479–4488 (2013).
CAS PubMed PubMed Central Google Scholar
- Sukumar, M. et al. Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy. Cell Metab. 23, 63–76 (2015).
PubMed PubMed Central Google Scholar
- Simpson, T.R. et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti CTLA-4 therapy against melanoma. J. Exp. Med. 210, 1695–1710 (2015).
Google Scholar