Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo (original) (raw)

• Janeway, C.A.J. & Bottomly, K. Signals and signs for lymphocyte responses. Cell 76, 275–285 (1994).
  Article CAS Google Scholar
• Weiss, A. & Littman, D.R. Signal transduction by lymphocyte antigen receptors. Cell 76, 263–274 (1994).
  Article CAS Google Scholar
• Kisielow, P. & von Boehmer, H. Development and selection of T cells: facts and puzzles. Adv. Immunol. 58, 87–209 (1995).
  Article CAS Google Scholar
• Taniuchi, I. et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111, 621–633 (2002).
  Article CAS Google Scholar
• Hogquist, K.A. Signal strength in thymic selection and lineage commitment. Curr. Opin. Immunol. 13, 225–231 (2001).
  Article CAS Google Scholar
• Singer, A. New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision. Curr. Opin. Immunol. 14, 207–215 (2002).
  Article CAS Google Scholar
• Germain, R.N. T-cell development and the CD4-CD8 lineage decision. Nat. Rev. Immunol. 2, 309–322 (2002).
  Article CAS Google Scholar
• Itano, A. et al. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183, 731–741 (1996).
  Article CAS Google Scholar
• Matechak, E.O., Killeen, N., Hedrick, S.M. & Fowlkes, B.J. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4, 337–347 (1996).
  Article CAS Google Scholar
• Sharp, L.L., Schwarz, D.A., Bott, C.M., Marshall, C.J. & Hedrick, S.M. The influence of the MAPK pathway on T cell lineage commitment. Immunity 7, 609–618 (1997).
  Article CAS Google Scholar
• Bommhardt, U., Cole, M.S., Tso, J.Y. & Zamoyska, R. Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus. Eur. J. Immunol. 27, 1152–1163 (1997).
  Article CAS Google Scholar
• Sharp, L.L. & Hedrick, S.M. Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and lck signaling. J. Immunol. 163, 6598–6605 (1999).
  CAS PubMed Google Scholar
• Hernandez-Hoyos, G., Sohn, S.J., Rothenberg, E.V. & Alberola-Ila, J. Lck activity controls CD4/CD8 T cell lineage commitment. Immunity 12, 313–322 (2000).
  Article CAS Google Scholar
• Wilkinson, B. & Kaye, J. Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model. Cell. Immunol. 211, 86–95 (2001).
  Article CAS Google Scholar
• Shores, E.W. et al. Role of TCR ζ chain in T cell development and selection. Science 266, 1047–1050 (1994).
  Article CAS Google Scholar
• Fischer, K.D. et al. Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CD8+ thymocytes. Nature 374, 474–477 (1995).
  Article CAS Google Scholar
• Tarakhovsky, A. et al. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374, 467–470 (1995).
  Article CAS Google Scholar
• Zhang, R., Alt, F.W., Davidson, L., Orkin, S.H. & Swat, W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374, 470–473 (1995).
  Article CAS Google Scholar
• Hashimoto, K. et al. Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection. J. Exp. Med. 184, 931–943 (1996).
  Article CAS Google Scholar
• Shores, E.W. et al. Role of the multiple T cell receptor (TCR)-ζ chain signaling motifs in selection of the T cell repertoire. J. Exp. Med. 185, 893–900 (1997).
  Article CAS Google Scholar
• Turner, M. et al. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity 7, 451–460 (1997).
  Article CAS Google Scholar
• Yasutomo, K., Doyle, C., Miele, L., Fuchs, C. & Germain, R.N. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. Nature 404, 506–510 (2000).
  Article CAS Google Scholar
• Brugnera, E. et al. Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells. Immunity 13, 59–71 (2000).
  Article CAS Google Scholar
• Bosselut, R., Guinter, T.I., Sharrow, S.O. & Singer, A. Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes “paradoxically” appear as CD4+8lo transitional cells during positive selection of CD8+ T cells. J. Exp. Med. 197, 1709–1719 (2003).
  Article CAS Google Scholar
• Chan, A.C., Iwashima, M., Turck, C.W. & Weiss, A. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR ζ chain. Cell 71, 649–662 (1992).
  Article CAS Google Scholar
• Iwashima, M., Irving, B.A., van Oers, N.S., Chan, A.C. & Weiss, A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263, 1136–1139 (1994).
  Article CAS Google Scholar
• Negishi, I. et al. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376, 435–438 (1995).
  Article CAS Google Scholar
• Kadlecek, T.A. et al. Differential requirements for ZAP-70 in TCR signaling and T cell development. J. Immunol. 161, 4688–4694 (1998).
  CAS PubMed Google Scholar
• Liu, X. et al. Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection. J. Exp. Med. 197, 363–373 (2003).
  Article CAS Google Scholar
• Aronow, B. et al. Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene. Genes Dev. 3, 1384–1400 (1989).
  Article CAS Google Scholar
• Lundberg, K., Heath, W., Kontgen, F., Carbone, F.R. & Shortman, K. Intermediate steps in positive selection: differentiation of CD4+8intTCRint thymocytes into CD4−8+TCRhi thymocytes. J. Exp. Med. 181, 1643–1651 (1995).
  Article CAS Google Scholar
• Suzuki, H., Punt, J.A., Granger, L.G. & Singer, A. Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. Immunity 2, 413–425 (1995).
  Article CAS Google Scholar
• Swat, W., Dessing, M., von Boehmer, H. & Kisielow, P. CD69 expression during selection and maturation of CD4+8+ thymocytes. Eur. J. Immunol. 23, 739–746 (1993).
  Article CAS Google Scholar
• Sebzda, E., Choi, M., Fung-Leung, W.P., Mak, T.W. & Ohashi, P.S. Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner. Immunity 6, 643–653 (1997).
  Article CAS Google Scholar
• Bhandoola, A., Kithiganahalli, B., Granger, L. & Singer, A. Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8+ T cell differentiation in the thymus. Int. Immunol. 12, 1035–1040 (2000).
  Article CAS Google Scholar
• Woolf, E. et al. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc. Natl. Acad. Sci. USA 100, 7731–7736 (2003).
  Article CAS Google Scholar
• Linette, G.P. et al. Bcl-2 is upregulated at the CD4+CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1, 197–205 (1994).
  Article CAS Google Scholar
• Hernandez-Hoyos, G., Anderson, M.K., Wang, C., Rothenberg, E.V. & Alberola-Ila, J. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity 19, 83–94 (2003).
  Article CAS Google Scholar
• Pai, S.Y. et al. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 19, 863–875 (2003).
  Article CAS Google Scholar
• Lucas, B. & Germain, R.N. Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. Immunity 5, 461–477 (1996).
  Article CAS Google Scholar
• Bhandoola, A. et al. Positive selection as a developmental progression initiated by αβ TCR signals that fix TCR specificity prior to lineage commitment. Immunity 10, 301–311 (1999).
  Article CAS Google Scholar
• Yasutomo, K., Lucas, B. & Germain, R.N. TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type. J. Immunol. 165, 3015–3022 (2000).
  Article CAS Google Scholar
• Kaye, J. et al. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341, 746–749 (1989).
  Article CAS Google Scholar
• Kaye, J., Vasquez, N.J. & Hedrick, S.M. Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J. Immunol. 148, 3342–3353 (1992).
  CAS PubMed Google Scholar
• Sentman, C.L., Shutter, J.R., Hockenbery, D., Kanagawa, O. & Korsmeyer, S.J. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67, 879–888 (1991).
  Article CAS Google Scholar
• Azzam, H.S. et al. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188, 2301–2311 (1998).
  Article CAS Google Scholar
• Jones, R.G. et al. Protein kinase B regulates T lymphocyte survival, nuclear factor κB activation, and Bcl-XL levels in vivo . J. Exp. Med. 191, 1721–1734 (2000).
  Article CAS Google Scholar
• Tarakhovsky, A. et al. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269, 535–537 (1995).
  Article CAS Google Scholar
• Pena-Rossi, C. et al. Negative regulation of CD4 lineage development and responses by CD5. J. Immunol. 163, 6494–6501 (1999).
  CAS PubMed Google Scholar
• Samelson, L.E. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu. Rev. Immunol. 20, 371–394 (2002).
  Article CAS Google Scholar
• Azzam, H.S. et al. Fine tuning of TCR signaling by CD5. J. Immunol. 166, 5464–5472 (2001).
  Article CAS Google Scholar
• Sosinowski, T., Killeen, N. & Weiss, A. The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity 15, 457–466 (2001).
  Article CAS Google Scholar
• Gao, E.K., Lo, D., Cheney, R., Kanagawa, O. & Sprent, J. Abnormal differentiation of thymocytes in mice treated with cyclosporin A. Nature 336, 176–179 (1988).
  Article CAS Google Scholar
• Bosselut, R., Feigenbaum, L., Sharrow, S.O. & Singer, A. Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes. Immunity 14, 483–494 (2001).
  Article CAS Google Scholar
• Fung-Leung, W.P. et al. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65, 443–449 (1991).
  Article CAS Google Scholar
• Schmedt, C. et al. Csk controls antigen receptor-mediated development and selection of T-lineage cells. Nature 394, 901–904 (1998).
  Article CAS Google Scholar
• Sohn, S.J., Forbush, K.A., Pan, X.C. & Perlmutter, R.M. Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes. J. Immunol. 166, 2209–2217 (2001).
  Article CAS Google Scholar
• Yu, Q., Erman, B., Bhandoola, A., Sharrow, S.O. & Singer, A. In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells. J. Exp. Med. 197, 475–487 (2003).
  Article CAS Google Scholar
• Chong, M.M. et al. Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity 18, 475–487 (2003).
  Article CAS Google Scholar
• Chan, S., Waltzinger, C., Tarakhovsky, A., Benoist, C. & Mathis, D. An influence of CD5 on the selection of CD4-lineage T cells. Eur. J. Immunol. 29, 2916–2922 (1999).
  Article CAS Google Scholar
• Wilkinson, B. et al. TOX: an HMG box protein implicated in the regulation of thymocyte selection. Nat. Immunol. 3, 272–280 (2002).
  Article CAS Google Scholar
• Davis, C.B., Killeen, N., Crooks, M.E., Raulet, D. & Littman, D.R. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73, 237–247 (1993).
  Article CAS Google Scholar
• Baron, A., Hafen, K. & von Boehmer, H. A human CD4 transgene rescues CD4−CD8+ cells in β2-microglobulin-deficient mice. Eur. J. Immunol. 24, 1933–1936 (1994).
  Article CAS Google Scholar
• Leung, R.K. et al. Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment. Nat. Immunol. 2, 1167–1173 (2001).
  Article CAS Google Scholar
• Zijlstra, M. et al. β2-microglobulin deficient mice lack CD4−8+ cytolytic T cells. Nature 344, 742–746 (1990).
  Article CAS Google Scholar
• June, C.H. & Rabinovitch, P.S. in Current Protocols in Immunology (eds. Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. & Strober, W., eds.) 5.5.1–5.5.15 (Wiley Class Interscience, New York, New York, 1991).
  Google Scholar