Epigenetic ontogeny of the Igk locus during B cell development (original) (raw)

• Krangel, M.S. Gene segment selection in V(D)J recombination: accessibility and beyond. Nat. Immunol. 4, 624–630 (2003).
  Article CAS Google Scholar
• Bergman, Y., Fisher, A.G. & Cedar, H. Epigenetic mechanisms that regulate antigen receptor gene expression. Curr. Opin. Immunol. 15, 176–181 (2003).
  Article CAS Google Scholar
• Schatz, D.G., Oettinger, M.A. & Baltimore, D. The V(D)J recombination activating gene, RAG-1. Cell 59, 1035–1048 (1989).
  Article CAS Google Scholar
• Oettinger, M.A., Schatz, D.G., Gorka, C. & Baltimore, D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517–1523 (1990).
  Article CAS Google Scholar
• Gellert, M. A new view of V(D)J recombination. Genes Cells 1, 269–275 (1996).
  Article CAS Google Scholar
• Corcoran, A.E., Riddell, A., Krooshoop, D. & Venkitaraman, A.R. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature 391, 904–907 (1998).
  Article CAS Google Scholar
• Lewis, S.A. The mechanism of V(D)J joining: lessons from molecular, immunological and comparative analyses. Adv. Immunol. 56, 27–150 (1994).
  Article CAS Google Scholar
• Sleckman, B.P., Gorman, J.R. & Alt, F.W. Accessibility control of antigen-receptor variable-region gene assembly: role of _cis_-acting elements. Annu. Rev. Immunol. 14, 459–481 (1996).
  Article CAS Google Scholar
• Brown, K.E. et al. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91, 845–854 (1997).
  Article CAS Google Scholar
• Brown, K.E., Baxter, J., Graf, D., Merkenschlager, M. & Fisher, A.G. Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. Mol. Cell 3, 207–217 (1999).
  Article CAS Google Scholar
• Skok, J.A. et al. Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes. Nat. Immunol. 2, 848–854 (2001).
  Article CAS Google Scholar
• Mather, E.L. & Perry, R.P. Methylation status and DNaseI sensitivity of immunoglobulin genes: changes associated with rearrangement. Proc. Natl. Acad. Sci. USA 80, 4689–4693 (1983).
  Article CAS Google Scholar
• Goldmit, M., Schlissel, M., Cedar, H. & Bergman, Y. Differential accessibility at the kappa chain locus plays a role in allelic exclusion. EMBO J. 21, 5255–5261 (2002).
  Article CAS Google Scholar
• Mostoslavsky, R. et al. κ chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 12, 1801–1811 (1998).
  Article CAS Google Scholar
• Chowdhury, D. & Sen, R. Stepwise activation of the immunoglobulin μ heavy chain gene locus. EMBO J. 20, 6394–6403 (2001).
  Article CAS Google Scholar
• Maës, J. et al. Chromatin remodeling at the Ig loci prior to V(D)J recombination. J. Immunol. 167, 866–874 (2001).
  Article Google Scholar
• Morshead, K.B., Ciccone, D.N., Taverna, S.D., Allis, C.D. & Oettinger, M.A. Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc. Natl. Acad. Sci. USA 100, 11577–11582 (2003).
  Article CAS Google Scholar
• Kosak, S.T. et al. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science 296, 158–162 (2002).
  Article CAS Google Scholar
• Kirillov, A. et al. A role for nuclear NF-κB in B-cell-specific demethylation of the Igκ locus. Nat. Genet. 13, 435–441 (1996).
  Article CAS Google Scholar
• Rolink, A., Kudo, A., Karasuyama, H., Kikuchi, Y. & Melchers, F. Long-term proliferating early pre-B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. EMBO J. 10, 327–336 (1991).
  Article CAS Google Scholar
• Mostoslavsky, R. et al. Asynchronous replication and allelic exclusion in the immune system. Nature 414, 221–225 (2001).
  Article CAS Google Scholar
• Azuara, V. et al. Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication. Nat. Cell Biol. 5, 668–674 (2003).
  Article CAS Google Scholar
• Maison, C. & Almouzni, G. HP1 and the dynamics of heterochromatin maintenance. Nat. Rev. Mol. Cell Biol. 5, 296–304 (2004).
  Article CAS Google Scholar
• Dillon, N. & Festenstein, R. Unravelling heterochromatin: competition between positive and negative factors regulates accessibility. Trends Genet. 18, 252–258 (2002).
  Article CAS Google Scholar
• Sabbattini, P. et al. Binding of Ikaros to the λ5 promoter silences transcription through a mechanism that does not require heterochromatin formation. EMBO J. 20, 2812–2822 (2001).
  Article CAS Google Scholar
• Mostoslavsky, R. et al. Demethylation and the establishment of κ allelic exclusion. Cold Spring Harb. Symp. Quant. Biol. 64, 197–206 (1999).
  Article CAS Google Scholar
• Hashimshony, T., Zhang, J., Keshet, I., Bustin, M. & Cedar, H. The role of DNA methylation in setting up chromatin structure during development. Nat. Genet. 34, 187–192 (2003).
  Article CAS Google Scholar
• Smale, S.T. The establishment and maintenance of lymphocyte identity through gene silencing. Nat. Immunol. 4, 607–615 (2003).
  Article CAS Google Scholar
• Fisher, A.G. & Merkenschlager, M. Gene silencing, cell fate and nuclear organisation. Curr. Opin. Genet. Dev. 12, 193–197 (2002).
  Article CAS Google Scholar
• Martin, D.J. van Ness, B.G. Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells. Mol. Cell. Biol. 10, 1950–1958 (1990).
  Article CAS Google Scholar
• Singh, N., Bergman, Y., Cedar, H. & Chess, A. Biallelic germline transcription at the κ immunoglobulin locus. J. Exp. Med. 197, 743–750 (2003).
  Article CAS Google Scholar
• Georgopoulos, K. Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat. Rev. Immunol. 2, 162–174 (2002).
  Article CAS Google Scholar
• Smale, S.T. & Fisher, A.G. Chromatin structure and gene regulation in the immune system. Annu. Rev. Immunol. 20, 427–462 (2002).
  Article CAS Google Scholar
• Sun, L., Liu, A. & Georgopoulos, K. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J. 15, 5358–5369 (1996).
  Article CAS Google Scholar
• Cobb, B.S. et al. Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. Genes Dev. 14, 2146–2160 (2000).
  Article CAS Google Scholar
• Strom, L., Lundgren, M. & Severinson, E. Binding of Ikaros to germline Ig heavy chain γ1 and ε promoters. Mol. Immunol. 39, 771–782 (2003).
  Article CAS Google Scholar
• Harker, N. et al. The CD8α gene locus is regulated by the Ikaros family of proteins. Mol. Cell 10, 1403–1415 (2002).
  Article CAS Google Scholar
• Trinh, L.A. et al. Down-regulation of TDT transcription in CD4+CD8+ thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes Dev. 15, 1817–1832 (2001).
  Article CAS Google Scholar
• McBlane, F. & Boyes, J. Stimulation of V(D)J recombination by histone acetylation. Curr. Biol. 10, 483–486 (2000).
  Article CAS Google Scholar
• Su, I.H. et al. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat. Immunol. 4, 124–131 (2003).
  Article CAS Google Scholar
• Johnson, K., Angelin-Duclos, C., Park, S. & Calame, K.L. Changes in histone acetylation are associated with differences in accessibility of V(H) gene segments to V-DJ recombination during B-cell ontogeny and development. Mol. Cell. Biol. 23, 2438–2450 (2003).
  Article CAS Google Scholar
• Su, R.C. et al. Dynamic assembly of silent chromatin during thymocyte maturation. Nat. Genet. 36, 502–506 (2004).
  Article CAS Google Scholar
• Liang, H-E., Hsu, L-Y., Cado, D. & Schlissel, M.S. Variegated transcriptional activation of the immunoglobulin κ locus in pre-B cells contributes to the allelic exclusion of light-chain expression. Cell 118, 19–29 (2004).
  Article CAS Google Scholar
• Southern, E.M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98, 503–517 (1975).
  Article CAS Google Scholar
• Hebbes, T.R., Clayton, A.L., Thorne, A.W. & Crane-Robinson, C. Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken β-globin chromosomal domain. EMBO J. 13, 1823–1830 (1994).
  Article CAS Google Scholar
• Ji, Y., Zhang, J., Lee, A.I., Cedar, H. & Bergman, Y. A multistep mechanism for the activation of rearrangement in the immune system. Proc. Natl. Acad. Sci. USA 100, 7557–7562 (2003).
  Article CAS Google Scholar
• Lichtenstein, M., Keini, G., Cedar, H. & Bergman, Y. B-cell specific demethylation: a novel role for the intronic κ-chain enhancer sequence. Cell 76, 913–923 (1994).
  Article CAS Google Scholar