Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor (original) (raw)

• Lanier, L.L. NK cell recognition. Annu. Rev. Immunol. 23, 225–274 (2005).
  Article CAS Google Scholar
• Raulet, D.H. Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3, 781–790 (2003).
  Article CAS Google Scholar
• Vivier, E., Nunes, J.A. & Vely, F. Natural killer cell signaling pathways. Science 306, 1517–1519 (2004).
  Article CAS Google Scholar
• Mathew, P.A. et al. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J. Immunol. 151, 5328–5337 (1993).
  CAS PubMed Google Scholar
• Valiante, N.M. & Trinchieri, G. Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes. J. Exp. Med. 178, 1397–1406 (1993).
  Article CAS Google Scholar
• Veillette, A. & Latour, S. The SLAM family of immune-cell receptors. Curr. Opin. Immunol. 15, 277–285 (2003).
  Article CAS Google Scholar
• Engel, P., Eck, M.J. & Terhorst, C. The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nat. Rev. Immunol. 3, 813–821 (2003).
  Article CAS Google Scholar
• Kumar, V. & McNerney, M.E. A new self: MHC-class-I-independent natural-killer-cell self-tolerance. Nat. Rev. Immunol. 5, 363–374 (2005).
  Article CAS Google Scholar
• Brown, M.H. et al. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. J. Exp. Med. 188, 2083–2090 (1998).
  Article CAS Google Scholar
• Latchman, Y., McKay, P.F. & Reiser, H. Identification of the 2B4 molecule as a counter-receptor for CD48. J. Immunol. 161, 5809–5812 (1998).
  CAS PubMed Google Scholar
• Veillette, A. SLAM family receptors regulate immunity with and without SAP-related adaptors. J. Exp. Med. 199, 1175–1178 (2004).
  Article CAS Google Scholar
• Lee, K.M. et al. 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. J. Exp. Med. 199, 1245–1254 (2004).
  Article CAS Google Scholar
• Vaidya, S.V. et al. Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells. J. Immunol. 174, 800–807 (2005).
  Article CAS Google Scholar
• Nichols, K.E., Ma, C.S., Cannons, J.L., Schwartzberg, P.L. & Tangye, S.G. Molecular and cellular pathogenesis of X-linked lymphoproliferative disease. Immunol. Rev. 203, 180–199 (2005).
  Article CAS Google Scholar
• Latour, S. & Veillette, A. The SAP family of adaptors in immune regulation. Semin. Immunol. 16, 409–419 (2004).
  Article CAS Google Scholar
• Nakajima, H. et al. Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity. Eur. J. Immunol. 30, 3309–3318 (2000).
  Article CAS Google Scholar
• Parolini, S. et al. X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells. J. Exp. Med. 192, 337–346 (2000).
  Article CAS Google Scholar
• Tangye, S.G., Phillips, J.H., Lanier, L.L. & Nichols, K.E. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. J. Immunol. 165, 2932–2936 (2000).
  Article CAS Google Scholar
• Benoit, L., Wang, X., Pabst, H.F., Dutz, J. & Tan, R. Defective NK cell activation in X-linked lymphoproliferative disease. J. Immunol. 165, 3549–3553 (2000).
  Article CAS Google Scholar
• Bloch-Queyrat, C. et al. Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. J. Exp. Med. 202, 181–192 (2005).
  Article CAS Google Scholar
• Chen, R. et al. Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors. Mol. Cell. Biol. 24, 5144–5156 (2004).
  Article CAS Google Scholar
• Thompson, A.D. et al. EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Oncogene 13, 2649–2658 (1996).
  CAS PubMed Google Scholar
• Morra, M. et al. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J. 20, 5840–5852 (2001).
  Article CAS Google Scholar
• Nichols, K.E. et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc. Natl. Acad. Sci. USA 95, 13765–13770 (1998).
  Article CAS Google Scholar
• Coffey, A.J. et al. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat. Genet. 20, 129–135 (1998).
  Article CAS Google Scholar
• Latour, S. et al. Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat. Cell Biol. 5, 149–154 (2003).
  Article CAS Google Scholar
• Chan, B. et al. SAP couples Fyn to SLAM immune receptors. Nat. Cell Biol. 5, 155–160 (2003).
  Article CAS Google Scholar
• Sivori, S. et al. Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc. Natl. Acad. Sci. USA 99, 4526–4531 (2002).
  Article CAS Google Scholar
• Eissmann, P. et al. Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244). Blood 105, 4722–4729 (2005).
  Article CAS Google Scholar
• Colucci, F. et al. Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat. Immunol. 3, 288–294 (2002).
  Article CAS Google Scholar
• Huntington, N.D., Xu, Y., Nutt, S.L. & Tarlinton, D.M. A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells. J. Exp. Med. 201, 1421–1433 (2005).
  Article CAS Google Scholar
• Veillette, A., Thibaudeau, E. & Latour, S. High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages. J. Biol. Chem. 273, 22719–22728 (1998).
  Article CAS Google Scholar
• Davidson, D. & Veillette, A. PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates. EMBO J. 20, 3414–3426 (2001).
  Article CAS Google Scholar
• Lutz, M.B. et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223, 77–92 (1999).
  Article CAS Google Scholar
• Nakamura, M.C. et al. Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. J. Exp. Med. 189, 493–500 (1999).
  Article CAS Google Scholar
• Latour, S. et al. Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat. Immunol. 2, 681–690 (2001).
  Article CAS Google Scholar
• Davidson, D. et al. Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in TH2 cytokine regulation. Immunity 21, 707–717 (2004).
  Article CAS Google Scholar
• Davidson, D., Chow, L.M., Fournel, M. & Veillette, A. Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn. J. Exp. Med. 175, 1483–1492 (1992).
  Article CAS Google Scholar
• Veillette, A., Bookman, M.A., Horak, E.M. & Bolen, J.B. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55, 301–308 (1988).
  Article CAS Google Scholar