Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76 (original) (raw)

• Monks, C.R., Freiberg, B.A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82–86 (1998).
  Article CAS Google Scholar
• Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221–227 (1999).
  Article CAS Google Scholar
• Huppa, J.B. & Davis, M.M. T-cell-antigen recognition and the immunological synapse. Nat. Rev. Immunol. 3, 973–983 (2003).
  Article CAS Google Scholar
• Dustin, M.L. & Cooper, J.A. The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat. Immunol. 1, 23–29 (2000).
  Article CAS Google Scholar
• Vicente-Manzanares, M. & Sanchez-Madrid, F. Role of the cytoskeleton during leukocyte responses. Nat. Rev. Immunol. 4, 110–122 (2004).
  Article CAS Google Scholar
• Freiberg, B.A. et al. Staging and resetting T cell activation in SMACs. Nat. Immunol. 3, 911–917 (2002).
  Article CAS Google Scholar
• Allenspach, E.J. et al. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15, 739–750 (2001).
  Article CAS Google Scholar
• Blanchard, N., Di Bartolo, V. & Hivroz, C. In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern. Immunity 17, 389–399 (2002).
  Article CAS Google Scholar
• Delon, J., Kaibuchi, K. & Germain, R.N. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity 15, 691–701 (2001).
  Article CAS Google Scholar
• Lee, K.H. et al. T cell receptor signaling precedes immunological synapse formation. Science 295, 1539–1542 (2002).
  Article CAS Google Scholar
• Irvine, D.J., Purbhoo, M.A., Krogsgaard, M. & Davis, M.M. Direct observation of ligand recognition by T cells. Nature 419, 845–849 (2002).
  Article CAS Google Scholar
• Harriague, J. & Bismuth, G. Imaging antigen-induced PI3K activation in T cells. Nat. Immunol. 3, 1090–1096 (2002).
  Article CAS Google Scholar
• Costello, P.S., Gallagher, M. & Cantrell, D.A. Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse. Nat. Immunol. 3, 1082–1089 (2002).
  Article CAS Google Scholar
• Lee, K.H. et al. The immunological synapse balances T cell receptor signaling and degradation. Science 302, 1218–1222 (2003).
  Article CAS Google Scholar
• Purtic, B., Pitcher, L.A., van Oers, N.S. & Wulfing, C. T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells. Proc. Natl. Acad. Sci. USA 102, 2904–2909 (2005).
  Article CAS Google Scholar
• Bunnell, S.C. et al. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J. Cell Biol. 158, 1263–1275 (2002).
  Article CAS Google Scholar
• Huppa, J.B., Gleimer, M., Sumen, C. & Davis, M.M. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat. Immunol. 4, 749–755 (2003).
  Article CAS Google Scholar
• Dustin, M.L. & Shaw, A.S. Costimulation: building an immunological synapse. Science 283, 649–650 (1999).
  Article CAS Google Scholar
• Stoll, S., Delon, J., Brotz, T.M. & Germain, R.N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296, 1873–1876 (2002).
  Article Google Scholar
• Miller, M.J., Wei, S.H., Parker, I. & Cahalan, M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296, 1869–1873 (2002).
  Article CAS Google Scholar
• Hailman, E., Burack, W.R., Shaw, A.S., Dustin, M.L. & Allen, P.M. Immature CD4+CD8+ thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity 16, 839–848 (2002).
  Article CAS Google Scholar
• Heissmeyer, V. et al. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5, 255–265 (2004).
  Article CAS Google Scholar
• Iezzi, G., Karjalainen, K. & Lanzavecchia, A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8, 89–95 (1998).
  Article CAS Google Scholar
• van Stipdonk, M.J. et al. Dynamic programming of CD8+ T lymphocyte responses. Nat. Immunol. 4, 361–365 (2003).
  Article CAS Google Scholar
• Faroudi, M., Zaru, R., Paulet, P., Muller, S. & Valitutti, S. Cutting edge: T lymphocyte activation by repeated immunological synapse formation and intermittent signaling. J. Immunol. 171, 1128–1132 (2003).
  Article CAS Google Scholar
• Depoil, D. et al. Immunological synapses are versatile structures enabling selective T cell polarization. Immunity 22, 185–194 (2005).
  Article CAS Google Scholar
• Bunnell, S.C., Kapoor, V., Trible, R.P., Zhang, W. & Samelson, L.E. Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity 14, 315–329 (2001).
  Article CAS Google Scholar
• Barda-Saad, M. et al. Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat. Immunol. 6, 80–89 (2004).
  Article Google Scholar
• Krummel, M.F. & Davis, M.M. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr. Opin. Immunol. 14, 66–74 (2002).
  Article CAS Google Scholar
• Krummel, M.F., Sjaastad, M.D., Wulfing, C. & Davis, M.M. Differential clustering of CD4 and CD3ζ during T cell recognition. Science 289, 1349–1352 (2000).
  Article CAS Google Scholar
• Brossard, C. et al. Multifocal structure of the T cell - dendritic cell synapse. Eur. J. Immunol. 35, 1741–1753 (2005).
  Article CAS Google Scholar
• Gelkop, S. & Isakov, N. T cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins. J. Biol. Chem. 274, 21519–21527 (1999).
  Article CAS Google Scholar
• Sasahara, Y. et al. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol. Cell 10, 1269–1281 (2002).
  Article CAS Google Scholar
• Zeng, R. et al. SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J. Immunol. 171, 1360–1368 (2003).
  Article CAS Google Scholar
• Griffiths, E.K. & Penninger, J.M. Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr. Opin. Immunol. 14, 317–322 (2002).
  Article CAS Google Scholar
• Krause, M. et al. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J. Cell Biol. 149, 181–194 (2000).
  Article CAS Google Scholar
• Dustin, M.L. Stop and go traffic to tune T cell responses. Immunity 21, 305–314 (2004).
  Article CAS Google Scholar
• Maldonado, R.A., Irvine, D.J., Schreiber, R. & Glimcher, L.H. A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431, 527–532 (2004).
  Article CAS Google Scholar
• Valitutti, S., Muller, S., Cella, M., Padovan, E. & Lanzavecchia, A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148–151 (1995).
  Article CAS Google Scholar
• Davis, S.J. & van der Merwe, P.A. The immunological synapse: required for T cell receptor signalling or directing T cell effector function? Curr. Biol. 11, R289–R291 (2001).
  Article CAS Google Scholar
• Delon, J. & Germain, R.N. Information transfer at the immunological synapse. Curr. Biol. 10, R923–R933 (2000).
  Article CAS Google Scholar
• Wulfing, C. et al. Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat. Immunol. 3, 42–47 (2002).
  Article CAS Google Scholar
• Campbell, R.E. et al. A monomeric red fluorescent protein. Proc. Natl. Acad. Sci. USA 99, 7877–7882 (2002).
  Article CAS Google Scholar
• Axelrod, D. Cell-substrate contacts illuminated by total internal reflection fluorescence. J. Cell Biol. 89, 141–145 (1981).
  Article CAS Google Scholar
• Tokunaga, M., Kitamura, K., Saito, K., Iwane, A.H. & Yanagida, T. Single molecule imaging of fluorophores and enzymatic reactions achieved by objective-type total internal reflection fluorescence microscopy. Biochem. Biophys. Res. Commun. 235, 47–53 (1997).
  Article CAS Google Scholar