T cells use two directionally distinct pathways for cytokine secretion (original) (raw)

• Bromley, S.K. et al. The immunological synapse. Annu. Rev. Immunol. 19, 375–396 (2001).
  Article CAS PubMed Google Scholar
• Monks, C.R., Freiberg, B.A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82–86 (1998).
  Article CAS PubMed Google Scholar
• Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221–227 (1999).
  Article CAS PubMed Google Scholar
• Sancho, D. et al. Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions. Immunol. Rev. 189, 84–97 (2002).
  Article CAS PubMed Google Scholar
• Kupfer, A. & Singer, S.J. Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. Annu. Rev. Immunol. 7, 309–337 (1989).
  Article CAS PubMed Google Scholar
• Davis, S.J. & van der Merwe, P.A. The immunological synapse: required for T cell receptor signalling or directing T cell effector function? Curr. Biol. 11, R289–R291 (2001).
  Article CAS PubMed Google Scholar
• Stinchcombe, J.C., Bossi, G., Booth, S. & Griffiths, G.M. The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity 15, 751–761 (2001).
  Article CAS PubMed Google Scholar
• Kupfer, A., Mosmann, T.R. & Kupfer, H. Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. Proc. Natl. Acad. Sci. USA 88, 775–779 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Kupfer, H., Monks, C.R. & Kupfer, A. Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions. J. Exp. Med. 179, 1507–1515 (1994).
  Article CAS PubMed Google Scholar
• Reichert, P., Reinhardt, R.L., Ingulli, E. & Jenkins, M.K. Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells. J. Immunol. 166, 4278–4281 (2001).
  Article CAS PubMed Google Scholar
• Poo, W.J., Conrad, L. & Janeway, C.A., Jr. Receptor-directed focusing of lymphokine release by helper T cells. Nature 332, 378–380 (1988).
  Article CAS PubMed Google Scholar
• Pagan, J.K. et al. The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Curr. Biol. 13, 156–160 (2003).
  Article CAS PubMed Google Scholar
• Bock, J.B., Matern, H.T., Peden, A.A. & Scheller, R.H. A genomic perspective on membrane compartment organization. Nature 409, 839–841 (2001).
  Article CAS PubMed Google Scholar
• Segev, N. Ypt and Rab GTPases: insight into functions through novel interactions. Curr. Opin. Cell Biol. 13, 500–511 (2001).
  Article CAS PubMed Google Scholar
• Zerial, M. & McBride, H. Rab proteins as membrane organizers. Nat. Rev. Mol. Cell Biol. 2, 107–117 (2001).
  Article CAS PubMed Google Scholar
• Jahn, R., Lang, T. & Sudhof, T.C. Membrane fusion. Cell 112, 519–533 (2003).
  Article CAS PubMed Google Scholar
• Parlati, F. et al. Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. Proc. Natl. Acad. Sci. USA 99, 5424–5429 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Allenspach, E.J. et al. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15, 739–750 (2001).
  Article CAS PubMed Google Scholar
• Morales-Tirado, V. et al. Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells. J. Immunol. 173, 726–730 (2004).
  Article CAS PubMed Google Scholar
• Chen, D.S. et al. Marked differences in human melanoma antigen-specific T cell responsiveness following peptide vaccination using a functional microarray. PloS Med. 2, e265 (2005) published online 20 September 2005 (10.1371/journal.pmed.0020265).
  Article CAS PubMed PubMed Central Google Scholar
• Catalfamo, M. et al. Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation. Immunity 20, 219–230 (2004).
  Article CAS PubMed Google Scholar
• Darchen, F. & Goud, B. Multiple aspects of Rab protein action in the secretory pathway: focus on Rab3 and Rab6. Biochimie 82, 375–384 (2000).
  Article CAS PubMed Google Scholar
• Riedel, D. et al. Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol. Cell. Biol. 22, 6487–6497 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Wendler, F. & Tooze, S. Syntaxin 6: the promiscuous behaviour of a SNARE protein. Traffic 2, 606–611 (2001).
  Article CAS PubMed Google Scholar
• Masuda, E.S. et al. Rab37 is a novel mast cell specific GTPase localized to secretory granules. FEBS Lett. 470, 61–64 (2000).
  Article CAS PubMed Google Scholar
• Antonin, W. et al. A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. EMBO J. 19, 6453–6464 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Hirst, J., Miller, S.E., Taylor, M.J., von Mollard, G.F. & Robinson, M.S. EpsinR is an adaptor for the SNARE protein Vti1b. Mol. Biol. Cell 15, 5593–5602 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Chidambaram, S., Mullers, N., Wiederhold, K., Haucke, V. & von Mollard, G.F. Specific interaction between SNAREs and epsin N-terminal homology (ENTH) domains of epsin-related proteins in trans-Golgi network to endosome transport. J. Biol. Chem. 279, 4175–4179 (2004).
  Article CAS PubMed Google Scholar
• Murray, R.Z., Wylie, F.G., Khromykh, T., Hume, D.A. & Stow, J.L. Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-α. J. Biol. Chem. 280, 10478–10483 (2005).
  Article CAS PubMed Google Scholar
• Huber, L.A., Dupree, P. & Dotti, C.G. A deficiency of the small GTPase rab8 inhibits membrane traffic in developing neurons. Mol. Cell. Biol. 15, 918–924 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Ang, A.L., Folsch, H., Koivisto, U.M., Pypaert, M. & Mellman, I. The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells. J. Cell Biol. 163, 339–350 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Stinchcombe, J.C. et al. Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J. Cell Biol. 152, 825–834 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Butz, E.A. & Bevan, M.J. Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity 8, 167–175 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177–187 (1998).
  Article CAS PubMed Google Scholar
• Boehm, U., Klamp, T., Groot, M. & Howard, J.C. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15, 749–795 (1997).
  Article CAS PubMed Google Scholar
• Pestka, S. et al. Interleukin-10 and related cytokines and receptors. Annu. Rev. Immunol. 22, 929–979 (2004).
  Article CAS PubMed Google Scholar
• Grouard, G. et al. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J. Exp. Med. 185, 1101–1111 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Locksley, R.M., Killeen, N. & Lenardo, M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104, 487–501 (2001).
  Article CAS PubMed Google Scholar
• Sallusto, F., Mackay, C.R. & Lanzavecchia, A. The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol. 18, 593–620 (2000).
  Article CAS PubMed Google Scholar
• Schmitz, J. et al. Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells. J. Exp. Med. 179, 1349–1353 (1994).
  Article CAS PubMed Google Scholar
• Glimcher, L.H. & Murphy, K.M. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14, 1693–1711 (2000).
  CAS PubMed Google Scholar
• Okada, T. et al. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Bio 3, e150 (2005) published online 3 May 2005 (10.1371/journal.pbio.0030150).
  Article CAS Google Scholar
• Croft, M. & Swain, S.L. B cell response to fresh and effector T helper cells. Role of cognate T-B interaction and the cytokines IL-2, IL-4, and IL-6. J. Immunol. 146, 4055–4064 (1991).
  CAS PubMed Google Scholar
• Calderhead, D.M., Kosaka, Y., Manning, E.M. & Noelle, R.J. CD40–CD154 interactions in B-cell signaling. Curr. Top. Microbiol. Immunol. 245, 73–99 (2000).
  CAS PubMed Google Scholar
• Boisvert, J., Edmondson, S. & Krummel, M.F. Immunological synapse formation licenses CD40–CD40L accumulations at T-APC contact sites. J. Immunol. 173, 3647–3652 (2004).
  Article CAS PubMed Google Scholar
• Maldonado, R.A., Irvine, D.J., Schreiber, R. & Glimcher, L.H. A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431, 527–532 (2004).
  Article CAS PubMed Google Scholar
• Taylor, P.C., Williams, R.O. & Feldmann, M. Tumour necrosis factor α as a therapeutic target for immune-mediated inflammatory diseases. Curr. Opin. Biotechnol. 15, 557–563 (2004).
  Article CAS PubMed Google Scholar
• Kontoyiannis, D., Pasparakis, M., Pizarro, T.T., Cominelli, F. & Kollias, G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10, 387–398 (1999).
  Article CAS PubMed Google Scholar
• Grivennikov, S.I. et al. Distinct and nonredundant in vivo functions of TNF produced by T cells and macrophages/neutrophils: protective and deleterious effects. Immunity 22, 93–104 (2005).
  CAS PubMed Google Scholar
• Steinman, L. Immune therapy for autoimmune diseases. Science 305, 212–216 (2004).
  Article CAS PubMed Google Scholar
• Spiliotis, E.T. & Nelson, W.J. Spatial control of exocytosis. Curr. Opin. Cell Biol. 15, 430–437 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Boniface, J.J., Reich, Z., Lyons, D.S. & Davis, M.M. Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning. Proc. Natl. Acad. Sci. USA 96, 11446–11451 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Purbhoo, M.A., Irvine, D.J., Huppa, J.B. & Davis, M.M. T cell killing does not require the formation of a stable mature immunological synapse. Nat. Immunol. 5, 524–530 (2004).
  Article CAS PubMed Google Scholar
• Irvine, D.J., Purbhoo, M.A., Krogsgaard, M. & Davis, M.M. Direct observation of ligand recognition by T cells. Nature 419, 845–849 (2002).
  Article CAS PubMed Google Scholar