- American Cancer Society. Breast Cancer Facts & Figures 2011–2012. <http://www.cancer.org/Research/CancerFactsFigures/BreastCancerFactsFigures/breast-cancer-facts-and-figures-2011-2012> (2012).
- Fehm, T. et al. Tumor cell dormancy: implications for the biology and treatment of breast cancer. APMIS 116, 742–753 (2008).
Article CAS PubMed Google Scholar
- Eckhardt, B.L., Francis, P.A., Parker, B.S. & Anderson, R.L. Strategies for the discovery and development of therapies for metastatic breast cancer. Nat. Rev. Drug Discov. 11, 479–497 (2012).
Article CAS PubMed Google Scholar
- Dunn, G.P., Bruce, A.T., Ikeda, H., Old, L.J. & Schreiber, R.D. Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 3, 991–998 (2002).
Article CAS PubMed Google Scholar
- Dunn, G.P. et al. A critical function for type I interferons in cancer immunoediting. Nat. Immunol. 6, 722–729 (2005).
Article CAS PubMed Google Scholar
- Koebel, C.M. et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 450, 903–907 (2007).
Article CAS PubMed Google Scholar
- Schreiber, R.D., Old, L.J. & Smyth, M.J. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331, 1565–1570 (2011).
Article CAS PubMed Google Scholar
- Vesely, M.D., Kershaw, M.H., Schreiber, R.D. & Smyth, M.J. Natural innate and adaptive immunity to cancer. Annu. Rev. Immunol. 29, 235–271 (2011).
Article CAS PubMed Google Scholar
- Honda, K. et al. IRF-7 is the master regulator of type-I interferon–dependent immune responses. Nature 434, 772–777 (2005).
Article CAS PubMed Google Scholar
- Wathelet, M.G. et al. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo. Mol. Cell 1, 507–518 (1998).
Article CAS PubMed Google Scholar
- Darnell, J.E. Jr., Kerr, I.M. & Stark, G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415–1421 (1994).
Article CAS PubMed Google Scholar
- Samarajiwa, S.A., Forster, S., Auchettl, K. & Hertzog, P.J. INTERFEROME: the database of interferon regulated genes. Nucleic Acids Res. 37, D852–D857 (2009).
Article CAS PubMed Google Scholar
- Eckhardt, B.L. et al. Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix. Mol. Cancer Res. 3, 1–13 (2005).
CAS PubMed Google Scholar
- Lelekakis, M. et al. A novel orthotopic model of breast cancer metastasis to bone. Clin. Exp. Metastasis 17, 163–170 (1999).
Article CAS PubMed Google Scholar
- Parker, B.S. et al. Primary tumour expression of the cysteine cathepsin inhibitor Stefin A inhibits distant metastasis in breast cancer. J. Pathol. 214, 337–346 (2008).
Article CAS PubMed Google Scholar
- Culhane, A.C. et al. GeneSigDB—a curated database of gene expression signatures. Nucleic Acids Res. 38, D716–D725 (2010).
Article CAS PubMed Google Scholar
- Lu, R., Au, W.C., Yeow, W.S., Hageman, N. & Pitha, P.M. Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon snd silencing by hypermethylation. J. Biol. Chem. 275, 31805–31812 (2000).
Article CAS PubMed Google Scholar
- Sheehan, K.C. et al. Blocking monoclonal antibodies specific for mouse IFN-α/β receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfection. J. Interferon Cytokine Res. 26, 804–819 (2006).
Article CAS PubMed Google Scholar
- Hwang, S.Y. et al. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses. Proc. Natl. Acad. Sci. USA 92, 11284–11288 (1995).
Article CAS PubMed PubMed Central Google Scholar
- Yang, L. et al. Abrogation of TGFβ signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 13, 23–35 (2008).
Article CAS PubMed PubMed Central Google Scholar
- DuPre', S.A. & Hunter, K.W. Jr. Mouse mammary carcinoma 4T1 induces a leukemoid reaction with splenomegaly: association with tumor-derived growth factors. Exp. Mol. Pathol. 82, 12–24 (2007).
Article CAS PubMed Google Scholar
- Youn, J.I., Nagaraj, S., Collazo, M. & Gabrilovich, D.I. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J. Immunol. 181, 5791–5802 (2008).
Article CAS PubMed Google Scholar
- Waight, J.D., Hu, Q., Miller, A., Liu, S. & Abrams, S.I. Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell–dependent mechanism. PLoS ONE 6, e27690 (2011).
Article CAS PubMed PubMed Central Google Scholar
- Adeegbe, D. et al. In vivo induction of myeloid suppressor cells and CD4+Foxp3+ T regulatory cells prolongs skin allograft survival in mice. Cell Transplant. 20, 941–954 (2011).
Article CAS PubMed Google Scholar
- Hervas-Stubbs, S. et al. Direct effects of type I interferons on cells of the immune system. Clin. Cancer Res. 17, 2619–2627 (2011).
Article CAS PubMed Google Scholar
- Wu, J.M. et al. Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin. Cancer Res. 14, 1938–1946 (2008).
Article CAS PubMed PubMed Central Google Scholar
- Minn, A.J. et al. Genes that mediate breast cancer metastasis to lung. Nature 436, 518–524 (2005).
Article CAS PubMed PubMed Central Google Scholar
- Harrell, J.C. et al. Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse. Breast Cancer Res. Treat. 132, 523–535 (2012).
Article CAS PubMed Google Scholar
- Hayakawa, Y. & Smyth, M.J. CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J. Immunol. 176, 1517–1524 (2006).
Article CAS PubMed Google Scholar
- Maher, S.G., Romero-Weaver, A.L., Scarzello, A.J. & Gamero, A.M. Interferon: cellular executioner or white knight? Curr. Med. Chem. 14, 1279–1289 (2007).
Article CAS PubMed Google Scholar
- Noppert, S.J., Fitzgerald, K.A. & Hertzog, P.J. The role of type I interferons in TLR responses. Immunol. Cell Biol. 85, 446–457 (2007).
Article CAS PubMed Google Scholar
- Swann, J.B. et al. Type I IFN contributes to NK cell homeostasis, activation, and antitumor function. J. Immunol. 178, 7540–7549 (2007).
Article CAS PubMed Google Scholar
- Dunn, G.P., Koebel, C.M. & Schreiber, R.D. Interferons, immunity and cancer immunoediting. Nat. Rev. Immunol. 6, 836–848 (2006).
Article CAS PubMed Google Scholar
- Chin, A.I. et al. Toll-like receptor 3–mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res. 70, 2595–2603 (2010).
Article CAS PubMed PubMed Central Google Scholar
- Savitsky, D., Tamura, T., Yanai, H. & Taniguchi, T. Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol. Immunother. 59, 489–510 (2010).
Article CAS PubMed Google Scholar
- Coppin, C., Le, L., Porzsolt, F. & Wilt, T. Targeted therapy for advanced renal cell carcinoma. Cochrane Database Syst. Rev. CD006017 (2008).
- Garbe, C. et al. Evidence and interdisciplinary consensus-based German guidelines: surgical treatment and radiotherapy of melanoma. Melanoma Res. 18, 61–67 (2008).
Article PubMed Google Scholar
- Bi, X. et al. Loss of interferon regulatory factor 5 (IRF5) expression in human ductal carcinoma correlates with disease stage and contributes to metastasis. Breast Cancer Res. 13, R111 (2011).
Article CAS PubMed PubMed Central Google Scholar
- Peranzoni, E. et al. Myeloid-derived suppressor cell heterogeneity and subset definition. Curr. Opin. Immunol. 22, 238–244 (2010).
Article CAS PubMed Google Scholar
- Ribechini, E., Greifenberg, V., Sandwick, S. & Lutz, M.B. Subsets, expansion and activation of myeloid-derived suppressor cells. Med. Microbiol. Immunol. 199, 273–281 (2010).
Article CAS PubMed Google Scholar
- Vuk-Pavlovié, S. et al. Immunosuppressive CD14+HLA-DRlow/− monocytes in prostate cancer. Prostate 70, 443–455 (2010).
Article Google Scholar
- Lin, E.Y., Nguyen, A.V., Russell, R.G. & Pollard, J.W. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193, 727–740 (2001).
Article CAS PubMed PubMed Central Google Scholar
- Melani, C., Chiodoni, C., Forni, G. & Colombo, M.P. Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity. Blood 102, 2138–2145 (2003).
Article CAS PubMed Google Scholar
- Bunt, S.K., Sinha, P., Clements, V.K., Leips, J. & Ostrand-Rosenberg, S. Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression. J. Immunol. 176, 284–290 (2006).
Article CAS PubMed Google Scholar
- Penn, I. Tumors of the immunocompromised patient. Annu. Rev. Med. 39, 63–73 (1988).
Article CAS PubMed Google Scholar
- Oruc, M.T., Soran, A., Jain, A.K., Wilson, J.W. & Fung, J. De novo breast cancer in patients with liver transplantation: University of Pittsburgh's experience and review of the literature. Liver Transpl. 10, 1–6 (2004).
Article PubMed Google Scholar
- DeNardo, D.G. et al. CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16, 91–102 (2009).
Article CAS PubMed PubMed Central Google Scholar
- Chen, Q., Zhang, X.H. & Massague, J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20, 538–549 (2011).
Article CAS PubMed PubMed Central Google Scholar
- Filipazzi, P. et al. Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor–based antitumor vaccine. J. Clin. Oncol. 25, 2546–2553 (2007).
Article CAS PubMed Google Scholar
- Diaz-Montero, C.M. et al. Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol. Immunother. 58, 49–59 (2009).
Article CAS PubMed Google Scholar
- van 't Veer, L.J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530–536 (2002).
Article CAS PubMed Google Scholar
- Weigelt, B. et al. Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer. Cancer Res. 65, 9155–9158 (2005).
Article CAS PubMed Google Scholar
- Coleman, R.E. et al. Breast-cancer adjuvant therapy with zoledronic acid. N. Engl. J. Med. 365, 1396–1405 (2011).
Article CAS PubMed Google Scholar
- Gnant, M. et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol. 12, 631–641 (2011).
Article CAS PubMed Google Scholar
- Hu, Z. et al. The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 7, 96 (2006).
Article PubMed PubMed Central Google Scholar
- Repetto, L. et al. Tamoxifen and interferon-β for the treatment of metastatic breast cancer. Breast Cancer Res. Treat. 39, 235–238 (1996).
Article CAS PubMed Google Scholar
- Hadden, J.W. The immunology and immunotherapy of breast cancer: an update. Int. J. Immunopharmacol. 21, 79–101 (1999).
Article CAS PubMed Google Scholar
- Frith, M.C. et al. Detection of functional DNA motifs via statistical over-representation. Nucleic Acids Res. 32, 1372–1381 (2004).
Article CAS PubMed PubMed Central Google Scholar
- Matys, V. et al. TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res. 34, D108–D110 (2006).
Article CAS PubMed Google Scholar
- Parker, B.S. et al. Alterations in vascular gene expression in invasive breast carcinoma. Cancer Res. 64, 7857–7866 (2004).
Article CAS PubMed Google Scholar
- St Croix, B. et al. Genes expressed in human tumor endothelium. Science 289, 1197–1202 (2000).
Article CAS PubMed Google Scholar
- Haibe-Kains, B. et al. A three-gene model to robustly identify breast cancer molecular subtypes. J. Natl. Cancer Inst. 104, 311–325 (2012).
Article CAS PubMed PubMed Central Google Scholar
- Cimino, A. et al. Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases. Breast Cancer Res. Treat. 123, 701–708 (2010).
Article CAS PubMed Google Scholar
- Wu, L., Patten, N., Yamashiro, C.T. & Chui, B. Extraction and amplification of DNA from formalin-fixed, paraffin-embedded tissues. Appl. Immunohistochem. Mol. Morphol. 10, 269–274 (2002).
CAS PubMed Google Scholar
- Mikeska, T., Felsberg, J., Hewitt, C.A. & Dobrovic, A. Analyzing DNA methylation using bisulfite pyrosequencing. Methods Mol. Biol. 791, 33–53 (2011).
Article CAS PubMed Google Scholar
- Wojdacz, T.K. & Dobrovic, A. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res. 35, e41 (2007).
Article PubMed PubMed Central Google Scholar