Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival (original) (raw)

• Romero, P. et al. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes. J. Exp. Med. 188, 1641–1650 (1998).
  Article CAS Google Scholar
• Lee, P.P. et al. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat. Med. 5, 677–685 (1999).
  Article CAS Google Scholar
• Salio, M. et al. Mature dendritic cells prime functionally superior melan-A–specific CD8+ lymphocytes as compared with nonprofessional APC. J. Immunol. 167, 1188–1197 (2001).
  Article CAS Google Scholar
• Dunbar, P.R. et al. A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response. J. Immunol. 165, 6644–6652 (2000).
  Article CAS Google Scholar
• Curiel, T.J. et al. Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity. Nat. Med. 9, 562–567 (2003).
  Article CAS Google Scholar
• Yee, C., Riddell, S.R. & Greenberg, P.D. Prospects for adoptive T cell therapy. Curr. Opin. Immunol. 9, 702–708 (1997).
  Article CAS Google Scholar
• Maio, M. & Parmiani, G. Melanoma immunotherapy: new dreams or solid hopes? Immunol. Today 17, 405–407 (1996).
  Article CAS Google Scholar
• Maeurer, M.J., Storkus, W.J., Kirkwood, J.M. & Lotze, M.T. New treatment options for patients with melanoma: review of melanoma-derived T-cell epitope–based peptide vaccines. Melanoma Res. 6, 11–24 (1996).
  Article CAS Google Scholar
• Pardoll, D. Does the immune system see tumors as foreign or self? Annu. Rev. Immunol. 21, 807–839 (2003).
  Article CAS Google Scholar
• Pardoll, D. T cells and tumours. Nature 411, 1010–1012 (2001).
  Article CAS Google Scholar
• Schreiber, H., Wu, T.H., Nachman, J. & Kast, W.M. Immunodominance and tumor escape. Semin. Cancer Biol. 12, 25–31 (2002).
  Article CAS Google Scholar
• Munn, D.H. et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 297, 1867–1870 (2002).
  Article CAS Google Scholar
• Khong, H.T. & Restifo, N.P. Natural selection of tumor variants in the generation of 'tumor escape' phenotypes. Nat. Immunol. 3, 999–1005 (2002).
  Article CAS Google Scholar
• Shevach, E.M. CD4+CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2, 389–400 (2002).
  Article CAS Google Scholar
• Wood, K.J. & Sakaguchi, S. Regulatory lymphocytes: regulatory T cells in transplantation tolerance. Nat. Rev. Immunol. 3, 199–210 (2003).
  Article CAS Google Scholar
• Von Herrath, M.G. & Harrison, L.C. Regulatory lymphocytes: antigen-induced regulatory T cells in autoimmunity. Nat. Rev. Immunol. 3, 223–232 (2003).
  Article CAS Google Scholar
• Bach, J.F. Regulatory lymphocytes: regulatory T cells under scrutiny. Nat. Rev. Immunol. 3, 189–198 (2003).
  Article Google Scholar
• Read, S. & Powrie, F. CD4+ regulatory T cells. Curr. Opin. Immunol. 13, 644–649 (2001).
  Article CAS Google Scholar
• Dieckmann, D., Plottner, H., Berchtold, S., Berger, T. & Schuler, G. Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood. J. Exp. Med. 193, 1303–1310 (2001).
  Article CAS Google Scholar
• Ng, W.F. et al. Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells. Blood 98, 2736–2744 (2001).
  Article CAS Google Scholar
• Levings, M.K., Sangregorio, R. & Roncarolo, M.G. Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 193, 1295–1302 (2001).
  Article CAS Google Scholar
• Woo, E.Y. et al. Regulatory CD4+CD25+ T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 61, 4766–4772 (2001).
  CAS PubMed Google Scholar
• Woo, E.Y. et al. Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J. Immunol. 168, 4272–4276 (2002).
  Article CAS Google Scholar
• Liyanage, U.K. et al. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169, 2756–2761 (2002).
  Article CAS Google Scholar
• Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057–1061 (2003).
  Article CAS Google Scholar
• Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330–336 (2003).
  Article CAS Google Scholar
• Khattri, R., Cox, T., Yasayko, S.A. & Ramsdell, F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4, 337–342 (2003).
  Article CAS Google Scholar
• Sakaguchi, S. et al. Immunologic tolerance maintained by CD25+CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182, 18–32 (2001).
  Article CAS Google Scholar
• Baecher-Allan, C., Brown, J.A., Freeman, G.J. & Hafler, D.A. CD4+CD25hi regulatory cells in human peripheral blood. J. Immunol. 167, 1245–1253 (2001).
  Article CAS Google Scholar
• Zou, W. et al. Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat. Med. 7, 1339–1346 (2001).
  Article CAS Google Scholar
• Knutson, K.L., Schiffman, K. & Disis, M.L. Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients. J. Clin. Invest. 107, 477–484 (2001).
  Article CAS Google Scholar
• Baecher-Allan, C., Viglietta, V. & Hafler, D.A. Inhibition of human CD4+CD25hi regulatory T cell function. J. Immunol. 169, 6210–6217 (2002).
  Article CAS Google Scholar
• Markman, M. Optimizing primary chemotherapy in ovarian cancer. Hematol. Oncol. Clin. North Am. 17, 957–968, viii (2003).
  Article Google Scholar
• Shevach, E.M. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18, 423–449 (2000).
  Article CAS Google Scholar
• Taylor, P.A., Noelle, R.J. & Blazar, B.R. CD4+CD25+ immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 193, 1311–1318 (2001).
  Article CAS Google Scholar
• Taylor, P.A., Lees, C.J. & Blazar, B.R. The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99, 3493–3499 (2002).
  Article CAS Google Scholar
• Shimizu, J., Yamazaki, S. & Sakaguchi, S. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163, 5211–5218 (1999).
  CAS PubMed Google Scholar
• Steitz, J., Bruck, J., Lenz, J., Knop, J. & Tuting, T. Depletion of CD25+CD4+ T cells and treatment with tyrosinase-related protein 2–transduced dendritic cells enhance the interferon α–induced, CD8+ T-cell-dependent immune defense of B16 melanoma. Cancer Res. 61, 8643–8646 (2001).
  CAS PubMed Google Scholar
• Piccirillo, C.A. & Shevach, E.M. Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J. Immunol. 167, 1137–1140 (2001).
  Article CAS Google Scholar
• van Maurik, A., Herber, M., Wood, K.J. & Jones, N.D. Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J. Immunol. 169, 5401–5404 (2002).
  Article CAS Google Scholar
• Iellem, A. et al. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4+CD25+ regulatory T cells. J. Exp. Med. 194, 847–853 (2001).
  Article CAS Google Scholar
• Wu, M., Fang, H. & Hwang, S.T. Cutting edge: CCR4 mediates antigen-primed T cell binding to activated dendritic cells. J. Immunol. 167, 4791–4795 (2001).
  Article CAS Google Scholar
• Tang, H.L. & Cyster, J.G. Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells. Science 284, 819–822 (1999).
  Article CAS Google Scholar
• Zhang, L. et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N. Engl. J. Med. 348, 203–213 (2003).
  Article CAS Google Scholar
• Bieche, I. et al. Quantification of estrogen receptor α and β expression in sporadic breast cancer. Oncogene 20, 8109–8115 (2001).
  Article CAS Google Scholar
• Zou, W. et al. Quantification of cytokine gene expression by competitive PCR using a colorimetric assay. Eur. Cytokine Netw. 6, 257–264 (1995).
  CAS PubMed Google Scholar
• Zou, W. et al. Macrophage-derived dendritic cells have strong Th1-polarizing potential mediated by β-chemokines rather than IL-12. J. Immunol. 165, 4388–4396 (2000).
  Article CAS Google Scholar
• Lecoeur, H., Fevrier, M., Garcia, S., Riviere, Y. & Gougeon, M.L. A novel flow cytometric assay for quantitation and multiparametric characterization of cell-mediated cytotoxicity. J. Immunol. Methods 253, 177–187 (2001).
  Article CAS Google Scholar