Rapid optical control of nociception with an ion-channel photoswitch (original) (raw)

References

  1. Yizhar, O., Fenno, L.E., Davidson, T.J., Mogri, M. & Deisseroth, K. Optogenetics in neural systems. Neuron 71, 9–34 (2011).
    Article CAS Google Scholar
  2. Kramer, R.H., Fortin, D. & Trauner, D. New photochemical tools for controlling neuronal activity. Curr. Opin. Neurobiol. 19, 544–552 (2009).
    Article CAS Google Scholar
  3. Fehrentz, T., Schönberger, M. & Trauner, D. Optochemical genetics. Angew. Chem. Int. Edn. 50, 12156–12182 (2011).
    Article CAS Google Scholar
  4. Fortin, D. et al. Photochemical control of endogenous ion channels and cellular excitability. Nat. Methods 5, 331–338 (2008).
    Article CAS Google Scholar
  5. Banghart, M.R. et al. Photochromic blockers of voltage-gated potassium channels. Angew. Chem. Int. Ed. 48, 9097–9101 (2009).
    Article CAS Google Scholar
  6. Mourot, A. et al. Tuning photochromic ion channel blockers. ACS Chem. Neurosci. 2, 536–543 (2011).
    Article CAS Google Scholar
  7. Basbaum, A.I., Bautista, D.M., Scherrer, G. & Julius, D. Cellular and molecular mechanisms of pain. Cell 139, 267–284 (2009).
    Article CAS Google Scholar
  8. Cavanaugh, D.J. et al. Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J. Neurosci. 31, 5067–5077 (2011).
    Article CAS Google Scholar
  9. Chung, M.-K., Güler, A.D. & Caterina, M.J. TRPV1 shows dynamic ionic selectivity during agonist stimulation. Nat. Neurosci. 11, 555–564 (2008).
    Article CAS Google Scholar
  10. Binshtok, A.M., Bean, B.P. & Woolf, C.J. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 449, 607–610 (2007).
    Article CAS Google Scholar
  11. Binshtok, A.M. et al. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology 111, 127–137 (2009).
    Article CAS Google Scholar
  12. Scholz, A. Mechanisms of (local) anaesthetics on voltage-gated sodium and other ion channels. Br. J. Anaesth. 89, 52–61 (2002).
    Article CAS Google Scholar
  13. Hille, B. Ion Channels of Excitable Membranes 3rd edn. (Sinauer Associates, 2001).
  14. Strichartz, G.R. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J. Gen. Physiol. 62, 37–57 (1973).
    Article CAS Google Scholar
  15. Kawaguchi, A. et al. Enhancement of sodium current in NG108–15 cells during neural differentiation is mainly due to an increase in NaV1.7 expression. Neurochem. Res. 32, 1469–1475 (2007).
    Article CAS Google Scholar
  16. Rogawski, M.A., Inoue, K., Suzuki, S. & Barker, J.L. A slow calcium-dependent chloride conductance in clonal anterior pituitary cells. J. Neurophysiol. 59, 1854–1870 (1988).
    Article CAS Google Scholar
  17. Hoshi, T., Zagotta, W.N. & Aldrich, R.W. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250, 533–538 (1990).
    Article CAS Google Scholar
  18. Khakh, B.S., Bao, X.R., Labarca, C. & Lester, H.A. Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat. Neurosci. 2, 322–330 (1999).
    Article CAS Google Scholar
  19. Virginio, C., MacKenzie, A., Rassendren, F.A., North, R.A. & Surprenant, A. Pore dilation of neuronal P2X receptor channels. Nat. Neurosci. 2, 315–321 (1999).
    Article CAS Google Scholar
  20. Wang, H. et al. Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. J. Neurosci. 25, 7986–7992 (2005).
    Article CAS Google Scholar
  21. Bautista, D.M. et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124, 1269–1282 (2006).
    Article CAS Google Scholar
  22. Voets, T. et al. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430, 748–754 (2004).
    Article CAS Google Scholar
  23. de Castro, F., Silos-Santiago, I., López de Armentia, M., Barbacid, M. & Belmonte, C. Corneal innervation and sensitivity to noxious stimuli in trkA knockout mice. Eur. J. Neurosci. 10, 146–152 (1998).
    Article CAS Google Scholar
  24. Rózsa, A.J. & Beuerman, R.W. Density and organization of free nerve endings in the corneal epithelium of the rabbit. Pain 14, 105–120 (1982).
    Article Google Scholar
  25. Wenk, H.N. & Honda, C.N. Silver nitrate cauterization: characterization of a new model of corneal inflammation and hyperalgesia in rat. Pain 105, 393–401 (2003).
    Article CAS Google Scholar
  26. Zhang, F. et al. Multimodal fast optical interrogation of neural circuitry. Nature 446, 633–639 (2007).
    Article CAS Google Scholar
  27. Chow, B.Y. et al. High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature 463, 98–102 (2010).
    Article CAS Google Scholar
  28. Zhang, F., Aravanis, A.M., Adamantidis, A.R., de Lecea, L. & Deisseroth, K. Circuit-breakers: optical technologies for probing neural signals and systems. Nat. Rev. Neurosci. 8, 577–581 (2007).
    Article CAS Google Scholar
  29. Malin, S.A., Davis, B.M. & Molliver, D.C. Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticity. Nat. Protoc. 2, 152–160 (2007).
    Article CAS Google Scholar
  30. McKemy, D.D., Neuhausser, W.M. & Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52–58 (2002).
    Article CAS Google Scholar

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