Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior (original) (raw)

• Brown, D.A. & Adams, P.R. Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone. Nature 283, 673–676 (1980).
  Article CAS Google Scholar
• Brown, D.A. M-currents: an update. Trends Neurosci. 11, 294–299 (1988).
  Article CAS Google Scholar
• Halliwell, J.V. & Adams, P.R. Voltage-clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res. 250, 71–92 (1982).
  Article CAS Google Scholar
• Storm, J.F. Potassium currents in hippocampal pyramidal cells. Prog. Brain Res. 83, 161–187 (1990).
  Article CAS Google Scholar
• Jentsch, T.J. Neuronal KCNQ potassium channels: physiology and role in disease. Nat. Rev. Neurosci. 1, 21–30 (2000).
  Article CAS Google Scholar
• Ryan, S.G. et al. Benign familial neonatal convulsions: evidence for clinical and genetic heterogeneity. Ann. Neurol. 29, 469–473 (1991).
  Article CAS Google Scholar
• Dedek, K., Fusco, L., Teloy, N. & Steinlein, O.K. Neonatal convulsions and epileptic encephalopathy in an Italian family with a missense mutation in the fifth transmembrane region of KCNQ2. Epilepsy Res. 54, 21–27 (2003).
  Article CAS Google Scholar
• Borgatti, R. et al. A novel mutation in KCNQ2 associated with BFNC, drug resistant epilepsy, and mental retardation. Neurology 63, 57–65 (2004).
  Article CAS Google Scholar
• Dedek, K. et al. Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel. Proc. Natl. Acad. Sci. USA 98, 12272–12277 (2001).
  Article CAS Google Scholar
• Marrion, N.V. Control of M-current. Annu. Rev. Physiol. 59, 483–504 (1997).
  Article CAS Google Scholar
• Wang, H.S. et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282, 1890–1893 (1998).
  Article CAS Google Scholar
• Selyanko, A.A. et al. Inhibition of KCNQ1–4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors. J. Physiol. (Lond.) 522, 349–355 (2000).
  Article CAS Google Scholar
• Hadley, J.K. et al. Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium. J. Neurosci. 23, 5012–5019 (2003).
  Article CAS Google Scholar
• Cooper, E.C. et al. Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc. Natl. Acad. Sci. USA 97, 4914–4919 (2000).
  Article CAS Google Scholar
• Shah, M.M., Mistry, M., Marsh, S.J., Brown, D.A. & Delmas, P. Molecular correlates of the M-current in cultured rat hippocampal neurons. J. Physiol. (Lond.) 544, 29–37 (2002).
  Article CAS Google Scholar
• Cooper, E.C., Harrington, E., Jan, Y.N. & Jan, L.Y. M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J. Neurosci. 21, 9529–9540 (2001).
  Article CAS Google Scholar
• Devaux, J.J., Kleopa, K.A., Cooper, E.C. & Scherer, S.S. KCNQ2 is a nodal K+ channel. J. Neurosci. 24, 1236–1244 (2004).
  Article CAS Google Scholar
• Storm, J.F. An after-hyperpolarization of medium duration in rat hippocampal pyramidal cells. J. Physiol. (Lond.) 409, 171–190 (1989).
  Article CAS Google Scholar
• Madison, D.V. & Nicoll, R.A. Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro. J. Physiol. (Lond.) 354, 319–331 (1984).
  Article CAS Google Scholar
• Malenka, R.C., Madison, D.V., Andrade, R. & Nicoll, R.A. Phorbol esters mimic some cholinergic actions in hippocampal pyramidal neurons. J. Neurosci. 6, 475–480 (1986).
  Article CAS Google Scholar
• Watanabe, H. et al. Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability. J. Neurochem. 75, 28–33 (2000).
  Article CAS Google Scholar
• Yang, Y. et al. Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Hum. Mol. Genet. 12, 975–984 (2003).
  Article CAS Google Scholar
• Gossen, M. & Bujard, H. Tight control of gene expression in mammalian cells by tetracycline- responsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547–5551 (1992).
  Article CAS Google Scholar
• Tremblay, P. et al. Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc. Natl. Acad. Sci. USA 95, 12580–12585 (1998).
  Article CAS Google Scholar
• Schroeder, B.C., Kubisch, C., Stein, V. & Jentsch, T.J. Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Nature 396, 687–690 (1998).
  Article CAS Google Scholar
• Hu, H., Vervaeke, K. & Storm, J.F. Two forms of electrical resonance at theta frequencies, generated by M-current, h-current and persistent Na+ current in rat hippocampal pyramidal cells. J. Physiol. (Lond.) 545, 783–805 (2002).
  Article CAS Google Scholar
• Nitecka, L. et al. Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae. Neuroscience 13, 1073–1094 (1984).
  Article CAS Google Scholar
• Mello, L.E. et al. Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 34, 985–995 (1993).
  Article CAS Google Scholar
• Holmes, G.L. & Ben-Ari, Y. Seizures in the developing brain: perhaps not so benign after all. Neuron 21, 1231–1234 (1998).
  Article CAS Google Scholar
• Stocker, M., Krause, M. & Pedarzani, P. An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neurons. Proc. Natl. Acad. Sci. USA 96, 4662–4667 (1999).
  Article CAS Google Scholar
• Hutcheon, B. & Yarom, Y. Resonance, oscillation and the intrinsic frequency preferences of neurons. Trends Neurosci. 23, 216–222 (2000).
  Article CAS Google Scholar
• Pike, F.G. et al. Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents. J. Physiol. (Lond.) 529, 205–213 (2000).
  Article CAS Google Scholar
• Leung, L.S. & Yu, H.W. Theta-frequency resonance in hippocampal CA1 neurons in vitro demonstrated by sinusoidal current injection. J. Neurophysiol. 79, 1592–1596 (1998).
  Article CAS Google Scholar
• Hutcheon, B., Miura, R.M. & Puil, E. Subthreshold membrane resonance in neocortical neurons. J. Neurophysiol. 76, 683–697 (1996).
  Article CAS Google Scholar
• Morris, R.G., Garrud, P., Rawlins, J.N. & O'Keefe, J. Place navigation impaired in rats with hippocampal lesions. Nature 297, 681–683 (1982).
  Article CAS Google Scholar
• Buzsaki, G. Theta oscillations in the hippocampus. Neuron 33, 325–340 (2002).
  Article CAS Google Scholar
• Sah, P. Ca(2+)-activated K+ currents in neurones: types, physiological roles and modulation. Trends Neurosci. 19, 150–154 (1996).
  Article CAS Google Scholar
• Schroeder, B.C., Hechenberger, M., Weinreich, F., Kubisch, C. & Jentsch, T.J. KCNQ5, a novel potassium channel broadly expressed in brain, mediates M- type currents. J. Biol. Chem. 275, 24089–24095 (2000).
  Article CAS Google Scholar
• Vergara, C., Latorre, R., Marrion, N.V. & Adelman, J.P. Calcium-activated potassium channels. Curr. Opin. Neurobiol. 8, 321–329 (1998).
  Article CAS Google Scholar
• Bond, C.T. et al. Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. J. Neurosci. 24, 5301–5306 (2004).
  Article CAS Google Scholar
• Williamson, A. & Alger, B.E. Characterization of an early afterhyperpolarization after a brief train of action potentials in rat hippocampal neurons in vitro. J. Neurophysiol. 63, 72–81 (1990).
  Article CAS Google Scholar
• Raghavachari, S. et al. Gating of human theta oscillations by a working memory task. J. Neurosci. 21, 3175–3183 (2001).
  Article CAS Google Scholar
• Kahana, M.J., Seelig, D. & Madsen, J.R. Theta returns. Curr. Opin. Neurobiol. 11, 739–744 (2001).
  Article CAS Google Scholar
• Sarnthein, J., Petsche, H., Rappelsberger, P., Shaw, G.L. & von Stein, A. Synchronization between prefrontal and posterior association cortex during human working memory. Proc. Natl. Acad. Sci. USA 95, 7092–7096 (1998).
  Article CAS Google Scholar
• Blümcke, I., Thom, M. & Wiestler, O.D. Ammon's horn sclerosis: a maldevelopmental disorder associated with temporal lobe epilepsy. Brain Pathol. 12, 199–211 (2002).
  PubMed Google Scholar
• Khazipov, R. et al. Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. Eur. J. Neurosci. 19, 590–600 (2004).
  Article Google Scholar
• Ben-Ari, Y. Excitatory actions of GABA during development: the nature of the nurture. Nat. Rev. Neurosci. 3, 728–739 (2002).
  Article CAS Google Scholar
• Lechner, S.G., Mayer, M. & Boehm, S. Activation of M1 muscarinic receptors triggers transmitter release from rat sympathetic neurons through an inhibition of M-type K+ channels. J. Physiol. (Lond.) 553, 789–802 (2003).
  Article CAS Google Scholar
• Martire, M. et al. M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. J. Neurosci. 24, 592–597 (2004).
  Article CAS Google Scholar
• Noebels, J.L. The biology of epilepsy genes. Annu. Rev. Neurosci. 26, 599–625 (2003).
  Article CAS Google Scholar