Dissociation of the Pharmacological Effects of THC by mTOR Blockade (original) (raw)
Bellocchio L, Lafenêtre P, Cannich A, Cota D, Puente N, Grandes P et al (2010). Bimodal control of stimulated food intake by the endocannabinoid system. Nat Neurosci13: 281–283. ArticleCAS Google Scholar
Blundell J, Kouser M, Powell CM (2008). Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation. Neurobiol Learn Mem90: 28–35. ArticleCAS Google Scholar
Boucher AA, Vivier L, Metna-Laurent M, Brayda-Bruno L, Mons N, Arnold JC et al (2009). Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain. Behav Pharmacol20: 45–55. ArticleCAS Google Scholar
Bruel-Jungerman E, Rampon C, Laroche S (2007). Adult hippocampal neurogenesis, synaptic plasticity and memory: facts and hypotheses. Rev Neurosci18: 93–114. ArticleCAS Google Scholar
Busquets-Garcia A, Puighermanal E, Pastor A, de la Torre R, Maldonado R, Ozaita A (2011). Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. Biol Psychiatry70: 479–486. ArticleCAS Google Scholar
Castellano C, Rossi-Arnaud C, Cestari V, Costanzi M (2003). Cannabinoids and memory: animal studies. Curr Drug Targets CNS Neurol Disord2: 389–402. ArticleCAS Google Scholar
Dancey JE (2005). Inhibitors of the mammalian target of rapamycin. Expert Opin Investig Drugs14: 313–328. ArticleCAS Google Scholar
Derkinderen P, Valjent E, Toutant M, Corvol JC, Enslen H, Ledent C et al (2003). Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. J Neurosci23: 2371–2382. ArticleCAS Google Scholar
Dobashi Y, Watanabe Y, Miwa C, Suzuki S, Koyama S (2011). Mammalian target of rapamycin: a central node of complex signaling cascades. Int J Clin Exp Pathol4: 476–495. CASPubMedPubMed Central Google Scholar
Ehninger D, Han S, Shilyansky C, Zhou Y, Li W, Kwiatkowski DJ et al (2008). Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis. Nat Med14: 843–848. ArticleCAS Google Scholar
Fan N, Yang H, Zhang J, Chen C (2010). Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for in vivo Delta9-THC exposure-impaired hippocampal synaptic plasticity. J Neurochem112: 691–702. ArticleCAS Google Scholar
Guertin DA, Sabatini DM (2009). The pharmacology of mTOR inhibition. Sci Signal2: 24. Article Google Scholar
Hoeffer CA, Klann E (2010). mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci33: 67–75. ArticleCAS Google Scholar
Hoffman AF, Oz M, Yang R, Lichtman AH, Lupica CR (2007). Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation. Learn Mem14: 63–74. ArticleCAS Google Scholar
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A et al (2007). Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med356: 2271–2281. ArticleCAS Google Scholar
Hutcheson DM, Tzavara ET, Smadja C, Valjent E, Roques BP, Hanoune J et al (1998). Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol. Br J Pharmacol125: 1567–1577. ArticleCAS Google Scholar
Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X et al (2006). TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell126: 955–968. ArticleCAS Google Scholar
Jaworski J, Sheng M (2006). The growing role of mTOR in neuronal development and plasticity. Mol Neurobiol34: 205–219. ArticleCAS Google Scholar
Jefferies HB, Fumagalli S, Dennis PB, Reinhard C, Pearson RB, Thomas G (1997). Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k. EMBO J16: 3693–3704. ArticleCAS Google Scholar
Katona I, Sperlágh B, Sík A, Käfalvi A, Vizi ES, Mackie K et al (1999). Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J Neurosci19: 4544–4558. ArticleCAS Google Scholar
Katona I, Urbán GM, Wallace M, Ledent C, Jung KM, Piomelli D et al (2006). Molecular composition of the endocannabinoid system at glutamatergic synapses. J Neurosci26: 5628–5637. ArticleCAS Google Scholar
Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M et al (2006). The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum. J Neurosci26: 2991–3001. ArticleCAS Google Scholar
Kim HJ, Waataja JJ, Thayer SA (2008). Cannabinoids inhibit network-driven synapse loss between hippocampal neurons in culture. J Pharmacol Exp Ther325: 850–858. ArticleCAS Google Scholar
Krab LC, Goorden SM, Elgersma Y (2008). Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases. Trends Genet24: 498–510. ArticleCAS Google Scholar
Mackie K (2005). Distribution of cannabinoid receptors in the central and peripheral nervous system. Handb Exp Pharmacol168: 299–325. ArticleCAS Google Scholar
Maldonado R, Berrendero F, Ozaita A, Robledo P (2011). Neurochemical basis of cannabis addiction. Neuroscience181: 1–17. ArticleCAS Google Scholar
Marsicano G, Lafenêtre P (2009). Roles of the endocannabinoid system in learning and memory. Curr Top Behav Neurosci1: 201–230. ArticleCAS Google Scholar
Marsicano G, Lutz B (1999). Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain. Eur J Neurosci11: 4213–4225. ArticleCAS Google Scholar
Martin BR, Sim-Selley LJ, Selley DE (2004). Signaling pathways involved in the development of cannabinoid tolerance. Trends Pharmacol Sci25: 325–330. ArticleCAS Google Scholar
Milligan G, Smith NJ (2007). Allosteric modulation of heterodimeric G-protein-coupled receptors. Trends Pharmacol Sci28: 615–620. ArticleCAS Google Scholar
Monory K, Blaudzun H, Massa F, Kaiser N, Lemberger T, Schütz G et al (2007). Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice. PLoS Biol5: e269. Article Google Scholar
Monory K, Massa F, Egertová M, Eder M, Blaudzun H, Westenbroek R et al (2006). The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron51: 455–466. ArticleCAS Google Scholar
Navé BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR (1999). Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J344: 427–431. Article Google Scholar
Ozaita A, Puighermanal E, Maldonado R (2007). Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. J Neurochem102: 1105–1114. ArticleCAS Google Scholar
Pertwee RG (2001). Cannabinoid receptors and pain. Prog Neurobiol63: 569–611. ArticleCAS Google Scholar
Pertwee RG (2009). Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol156: 397–411. ArticleCAS Google Scholar
Pertwee RG (2012). Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities. Philos Trans R Soc Lond B Biol Sci367: 3353–3363. ArticleCAS Google Scholar
Piomelli D (2005). The endocannabinoid system: a drug discovery perspective. Curr Opin Investig Drugs6: 672–679. CASPubMed Google Scholar
Puighermanal E, Busquets-Garcia A, Maldonado R, Ozaita A (2012). Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. Philos Trans R Soc Lond B Biol Sci367: 3254–3263. ArticleCAS Google Scholar
Puighermanal E, Marsicano G, Busquets-Garcia A, Lutz B, Maldonado R, Ozaita A (2009). Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nat Neurosci12: 1152–1158. ArticleCAS Google Scholar
Rey AA, Purrio M, Viveros MP, Lutz B (2012). Biphasic effects of cannabinoids in anxiety responses: CB1 and GABA(B) receptors in the balance of GABAergic and glutamatergic neurotransmission. Neuropsychopharmacology34: 2624–2634. Article Google Scholar
Richter JD, Klann E (2009). Making synaptic plasticity and memory last: mechanisms of translational regulation. Genes Dev23: 1–11. ArticleCAS Google Scholar
Rini BI (2008). Temsirolimus, an inhibitor of mammalian target of rapamycin. Clin Cancer Res14: 1286–1290. ArticleCAS Google Scholar
Rubino T, Sala M, Viganò D, Braida D, Castiglioni C, Limonta V et al (2007). Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats. Neuropsychopharmacology32: 2036–2045. ArticleCAS Google Scholar
Rubino T, Viganò D, Premoli F, Castiglioni C, Bianchessi S, Zippel R et al (2006). Changes in the expression of G protein-coupled receptor kinases and beta-arrestins in mouse brain during cannabinoid tolerance: a role for RAS-ERK cascade. Mol Neurobiol33: 199–213. ArticleCAS Google Scholar
Ruehle S, Rey AA, Remmers F, Lutz B (2012). The endocannabinoid system in anxiety, fear memory and habituation. J Psychopharmacol26: 23–39. ArticleCAS Google Scholar
Sharma A, Hoeffer CA, Takayasu Y, Miyawaki T, McBride SM, Klann E et al (2010). Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci30: 694–702. ArticleCAS Google Scholar
Shire D, Carillon C, Kaghad M, Calandra B, Rinaldi-Carmona M, Le Fur G et al (1995). An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J Biol Chem270: 3726–3731. ArticleCAS Google Scholar
Sim-Selley LJ (2003). Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids. Crit Rev Neurobiol15: 91–119. ArticleCAS Google Scholar
Skosnik PD, Edwards CR, O'Donnell BF, Steffen A, Steinmetz JE, Hetrick WP (2008). Cannabis use disrupts eyeblink conditioning: evidence for cannabinoid modulation of cerebellar-dependent learning. Neuropsychopharmacology33: 1432–1440. ArticleCAS Google Scholar
Smith TH, Sim-Selley LJ, Selley DE (2010). Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? Br J Pharmacol160: 454–466. ArticleCAS Google Scholar
Steindel F, Lerner R, Häring M, Ruehle S, Marsicano G, Lutz B et al (2013). Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus. J Neurochem (e-pub ahead of print 5 January 2013; doi:10.1111/jnc.12137).
Thorat SN, Bhargava HN (1994). Evidence for a bidirectional cross-tolerance between morphine and delta 9-tetrahydrocannabinol in mice. Eur J Pharmacol260: 5–13. ArticleCAS Google Scholar
Troca-Marín JA, Alves-Sampaio A, Montesinos ML (2012). Deregulated mTOR-mediated translation in intellectual disability. Prog Neurobiol96: 268–282. Article Google Scholar
Viveros MP, Marco EM, File SE (2005). Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav81: 331–342. ArticleCAS Google Scholar
Wager-Miller J, Westenbroek R, Mackie K (2002). Dimerization of G protein-coupled receptors: CB1 cannabinoid receptors as an example. Chem Phys Lipids121: 83–89. ArticleCAS Google Scholar
Wilson RI, Nicoll RA (2002). Endocannabinoid signaling in the brain. Science296: 678–682. ArticleCAS Google Scholar
Zanettini C, Panlilio LV, Alicki M, Goldberg SR, Haller J, Yasar S (2011). Effects of endocannabinoid system modulation on cognitive and emotional behavior. Front Behav Neurosci5: 57. ArticleCAS Google Scholar