Laminin 332 in squamous-cell carcinoma (original) (raw)

• Miller, D. L. & Weinstock, M. A. Nonmelanoma skin cancer in the United States: incidence. J. Am. Acad. Dermatol. 30, 774–778 (1994).
  Article CAS PubMed Google Scholar
• Czarnecki, D., Staples, M., Mar, A., Giles, G. & Meehan, C. Metastases from squamous cell carcinoma of the skin in southern Australia. Dermatology 189, 52–54 (1994).
  Article CAS PubMed Google Scholar
• McGowan, K. A. & Marinkovich, M. P. Laminins and human disease. Microsc. Res. Tech. 51, 262–279 (2000).
  Article CAS PubMed Google Scholar
• Keene, D. R., Marinkovich, M. P. & Sakai, L. Y. Immunodissection of the connective tissue matrix in human skin. Microsc. Res. Tech. 38, 394–406 (1997).
  Article CAS PubMed Google Scholar
• Beauvais, D. M. & Rapraeger, A. C. Syndecans in tumor cell adhesion and signaling. Reprod. Biol. Endocrinol. 2, 3 (2004).
  Article PubMed PubMed Central Google Scholar
• Guo, W. & Giancotti, F. G. Integrin signalling during tumour progression. Nature Rev. Mol. Cell Biol. 5, 816–826 (2004).
  Article CAS Google Scholar
• Hornebeck, W. & Maquart, F. X. Proteolyzed matrix as a template for the regulation of tumor progression. Biomed. Pharmacother. 57, 223–230 (2003).
  Article CAS PubMed Google Scholar
• Mareel, M. & Leroy, A. Clinical, cellular, and molecular aspects of cancer invasion. Physiol. Rev. 83, 337–376 (2003).
  Article CAS PubMed Google Scholar
• Liotta, L. A., Rao, C. N. & Wewer, U. M. Biochemical interactions of tumor cells with basement membrane. Ann. Rev. Biochem. 55, 1037–1057 (1986).
  Article CAS PubMed Google Scholar
• Liotta, L. A. et al. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 284, 67–68 (1980).
  Article CAS PubMed Google Scholar
• Sasaki, T., Fassler, R. & Hohenester, E. Laminin: the crux of basement membrane assembly. J. Cell Biol. 164, 959–963 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Ryan, M. C. et al. The functions of laminins: lessons from in vivo studies. Matrix Biol. 15, 369–381 (1996).
  Article CAS PubMed Google Scholar
• Marinkovich, M. P. et al. The basement membrane proteins kalinin and nicein are structurally and immunologically identical. Lab. Invest. 69, 295–299 (1993).
  CAS PubMed Google Scholar
• Meneguzzi, G. et al. Kalinin is abnormally expressed in epithelial basement membranes of Herlitz's junctional epidermolysis bullosa patients. Exp. Dermatol. 1, 221–229 (1992).
  Article CAS PubMed Google Scholar
• Pulkkinen, L. et al. A homozygous nonsense mutation in the beta 3 chain gene of laminin 5 (LAMB3) in Herlitz junctional epidermolysis bullosa. Genomics 24, 357–360 (1994).
  Article CAS PubMed Google Scholar
• Aberdam, D. et al. Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the gamma 2 subunit of nicein/kalinin (LAMININ-5). Nature Genet. 6, 299–304 (1994).
  Article CAS PubMed Google Scholar
• Martin, G. R. & Timpl, R. Laminin and other basement membrane components. Annu. Rev. Cell Biol. 3, 57–85 (1987).
  Article CAS PubMed Google Scholar
• Kallunki, P. et al. A truncated laminin chain homologous to the B2 chain: structure, spacial expression, and chromosomal assignment. J. Cell Biol. 119, 679–694 (1992). Identification of laminin 332 as a member of the laminin family.
  Article CAS PubMed Google Scholar
• Mizushima, H. et al. Differential expression of laminin-5/ladsin subunits in human tissues and cancer cell lines and their induction by tumor promoter and growth factors. J. Biochem. (Tokyo) 120, 1196–1202 (1996).
  Article CAS Google Scholar
• Pyke, C. et al. Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res. 55, 4132–4139 (1995). Early extensive survey of laminin 332 in human carcinomas.
  CAS PubMed Google Scholar
• Tani, T. et al. Pancreatic carcinomas deposit laminin-5, preferably adhere to laminin-5, and migrate on the newly deposited basement membrane. Am. J. Pathol. 151, 1289–1302 (1997).
  CAS PubMed PubMed Central Google Scholar
• Berndt, A., Hyckel, P., Könneker, A., Katenkamp, D. & Kosmehl, H. Oral squamous cell carcinoma invasion is associated with a laminin-5 matrix re-organization but independent of basement membrane and hemidesmosome formation. Clues from an in vitro invasion model. Invasion Metastasis 17, 251–258 (1997).
  CAS PubMed Google Scholar
• Orian-Rousseau, V. et al. Human colonic cancer cells synthesize and adhere to laminin-5. Their adhesion to laminin-5 involves multiple receptors among which is integrin alpha2beta1. J. Cell Sci. 111, 1993–2004 (1998).
  CAS PubMed Google Scholar
• Skyldberg, B. et al. Laminin-5 as a marker of invasiveness in cervical lesions. J. Natl Cancer Inst. 91, 1882–1887 (1999).
  Article CAS PubMed Google Scholar
• Ono, Y. et al. Clinocopathologic significance of laminin-5 γ2 chain expression in squamous cell carcinoma of the tongue: immunohistochemical analysis of 67 lesions. Cancer 85, 2315–2321 (1999).
  Article CAS PubMed Google Scholar
• Lohi, J. et al. Basement membrane laminin-5 is deposited in colorectal adenomas and carcinomas and serves as a ligand for α3β1 integrin. APMIS 108, 161–172 (2000).
  Article CAS PubMed Google Scholar
• Nordemar, S. et al. Laminin-5 as a predictor of invasiveness in cancer in situ lesions of the larynx. Anticancer Res. 21, 509–512 (2001).
  CAS PubMed Google Scholar
• Lenander, C. et al. Laminin-5 gamma 2 chain expression correlates with unfavorable prognosis in colon carcinomas. Anal. Cell. Pathol. 22, 201–209 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Calaluce, R. et al. Laminin-5-mediated gene expression in human prostate carcinoma cells. Mol. Carcinog. 30, 119–129 (2001).
  Article CAS PubMed Google Scholar
• Nordemar, S., Hogmo, A., Lindholm, J., Auer, G. & Munck-Wikland, E. Laminin-5 gamma 2: a marker to identify oral mucosal lesions at risk for tumor development? Anticancer Res. 23, 4985–4989 (2003).
  PubMed Google Scholar
• Giannelli, G., Fransvea, E., Bergamini, C., Marinosci, F. & Antonaci, S. Laminin-5 chains are expressed differentially in metastatic and nonmetastatic hepatocellular carcinoma. Clin. Cancer Res. 9, 3684–3691 (2003).
  CAS PubMed Google Scholar
• Yamamoto, H., Itoh, F., Iku, S., Hosokawa, M. & Imai, K. Expression of the γ (2) chain of laminin-5 at the invasive front is associated with recurrence and poor prognosis in human esophageal squamous cell carcinoma. Clin. Cancer Res. 7, 896–900 (2001).
  CAS PubMed Google Scholar
• Nordstrom, B. et al. Laminin-5 gamma 2 chain as an invasivity marker for uni- and multifocal lesions in the lower anogenital tract. Int. J. Gynecol. Cancer 12, 105–109 (2002).
  Article PubMed Google Scholar
• Giannelli, G. & Antonaci, S. Biological and clinical relevance of Laminin-5 in cancer. Clin. Exp. Metastasis 18, 439–443 (2000).
  Article CAS PubMed Google Scholar
• Katayama, M., Sanzen, N., Funakoshi, A. & Sekiguchi, K. Laminin γ2-chain fragment in the circulation: a prognostic indicator of epithelial tumor invasion. Cancer Res. 63, 222–229 (2003).
  CAS PubMed Google Scholar
• Shinto, E. et al. Prognostic implication of laminin-5 gamma 2 chain expression in the invasive front of colorectal cancers, disclosed by area-specific four-point tissue microarrays. Lab. Invest. 85, 257–266 (2005).
  Article CAS PubMed Google Scholar
• Savoia, P., Trusolino, L., Pepino, E. & Marchisio, P. C. Expression and topography of integrins and basement membrane proteins in epidermal carcinomas: basal but not squamous cell carcinomas display loss of alpha 6 beta 4 and BM-600/nicein. J. Invest. Dermatol. 101, 352–358 (1993).
  Article CAS PubMed Google Scholar
• Martin, K. J. et al. Down-regulation of laminin-5 in breast carcinoma cells. Mol. Med. 4, 602–613 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Holler, E. Laminin isoform expression in breast tumors. Breast Cancer Res. 7, 166–167 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Hao, J. et al. Investigation into the mechanism of the loss of laminin 5 (α3β3γ2) expression in prostate cancer. Am. J. Pathol. 158, 1129–135. (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Janes, S. M. & Watt, F. M. New roles for integrins in squamous-cell carcinoma. Nature Rev. Cancer 3, 175–183 (2006).
  Article CAS Google Scholar
• Li, J. et al. Laminin-10 is crucial for hair morphogenesis. EMBO J. 22, 2400–2410 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Fan, H. & Khavari, P. A. Sonic hedgehog opposes epithelial cell cycle arrest. J. Cell Biol. 147, 71–76 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Shaw, L. M. Tumor cell invasion assays. Methods Mol. Biol. 294, 97–105 (2005).
  PubMed Google Scholar
• Malinda, K. M. In vivo matrigel migration and angiogenesis assays. Methods Mol. Med. 78, 329–335 (2003).
  PubMed Google Scholar
• Mullen, P. The use of Matrigel to facilitate the establishment of human cancer cell lines as xenografts. Methods Mol. Med. 88, 287–292 (2004).
  CAS PubMed Google Scholar
• Ekblom, P., Lonai, P. & Talts, J. F. Expression and biological role of laminin-1. Matrix Biol. 22, 35–47 (2003).
  Article CAS PubMed Google Scholar
• Rousselle, P., Lunstrum, G. P., Keene, D. R. & Burgeson, R. E. Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J. Cell Biol. 114, 567–576 (1991). Characterization of the role of laminin 332 in epidermal adhesion.
  Article CAS PubMed Google Scholar
• Carter, W. G., Ryan, M. C. & Gahr, P. J. Epiligrin, a new cell adhesion ligand for integrin-3–1 in epithelial basement membranes. Cell 65, 559–610 (1991). Characterization of laminin 332 integrin specificity.
  Article Google Scholar
• Carter, W. G., Kaur, P., Gil, S. G., Gahr, P. J. & Wayner, E. A. Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J. Cell Biol. 111, 3141–3154 (1990).
  Article CAS PubMed Google Scholar
• Hood, J. D. & Cheresh, D. A. Role of integrins in cell invasion and migration. Nature Rev. Cancer 2, 91–100 (2002).
  Article Google Scholar
• Nievers, M. G., Schaapveld, R. Q. & Sonnenberg, A. Biology and function of hemidesmosomes. Matrix Biol. 18, 5–17 (1999).
  Article CAS PubMed Google Scholar
• Litjens, S. H., de Pereda, J. M. & Sonnenberg, A. Current insights into the formation and breakdown of hemidesmosomes. Trends Cell Biol. 16, 376–383 (2006).
  Article CAS PubMed Google Scholar
• Geuijen, C. A. & Sonnenberg, A. Dynamics of the α6β4 Integrin in keratinocytes. Mol. Biol. Cell 13, 3845–3858 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Salo, S. et al. Laminin-5 promotes adhesion and migration of epithelial cells: identification of a migration-related element in the γ2 chain gene (LAMC2) with activity in transgenic mice. Matrix Biol. 18, 197–210 (1999).
  Article CAS PubMed Google Scholar
• Giannelli, G., Falk-Marzillier, J., Schiraldi, O., Stetler-Stevenson, W. G. & Quaranta, V. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Science 277, 225–228 (1997). Shows the association between laminin 332 processing and carcinoma cell migration.
  Article CAS PubMed Google Scholar
• Zhang, K. & Kramer, R. H. Laminin 5 deposition promotes keratinocyte motility. Exp. Cell Res. 227, 309–322 (1996).
  Article CAS PubMed Google Scholar
• Miyazaki, K., Kikkawa, Y., Nakamura, A., Yasumitsu, H. & Umeda, M. A large cell-adhesive scatter factor secreted by human gastric carcinoma cells. Proc. Natl Acad. Sci. USA 90, 11767–1171 (1993). Demonstration of the role of laminin 332 in tumour-cell migration.
  Article CAS PubMed PubMed Central Google Scholar
• Kariya, Y. & Miyazaki, K. The basement membrane protein laminin-5 acts as a soluble cell motility factor. Exp. Cell Res. 297, 508–520 (2004).
  Article CAS PubMed Google Scholar
• Nguyen, B. P., Gil, S. G. & Carter, W. G. Deposition of laminin 5 by keratinocytes regulates integrin adhesion and signaling. J. Biol. Chem. 275, 31896–31907 (2000).
  Article CAS PubMed Google Scholar
• Nguyen, B. P., Ren, X. D., Schwartz, M. A. & Carter, W. G. Ligation of integrin α3β1 by laminin 5 at the wound edge activates Rho-dependent adhesion of leading keratinocytes on collagen. J. Biol. Chem. 276, 43860–43870 (2001).
  Article CAS PubMed Google Scholar
• Zhou, H. & Kramer, R. H. Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1. J. Biol. Chem. 280, 10624–10635 (2005).
  Article CAS PubMed Google Scholar
• Russell, A. J. et al. Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. J. Cell Sci. 116, 3543–3556 (2003).
  Article CAS PubMed Google Scholar
• Pullar, C. E. et al. β4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1. Mol. Biol. Cell 17, 4925–4935 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Sehgal, B. U. et al. Integrin β4 regulates migratory behavior of keratinocytes by determining laminin-332 organization. J. Biol. Chem. 46, 35487–35498 (2006).
  Article CAS Google Scholar
• Zahir, N. et al. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors. J. Cell Biol. 163, 1397–1407 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Hamelers, I. H. et al. The Rac activator Tiam1 is required for α3β1-mediated laminin-5 deposition, cell spreading, and cell migration. J. Cell Biol. 171, 871–881 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Malliri, A. et al. Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature 417, 867–871 (2002).
  Article CAS PubMed Google Scholar
• Danen, E. H. et al. Integrins control motile strategy through a Rho-cofilin pathway. J. Cell Biol. 169, 515–526 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Marinkovich, M. P., Lunstrum, G. P. & Burgeson, R. E. The anchoring filament protein kalinin is synthesized and secreted as a high molecular weight precursor. J. Biol. Chem. 267, 17900–17906 (1992). Characterization of the proteolytic processing of laminin 332.
  CAS PubMed Google Scholar
• Amano, S. et al. Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 g 2 chain. J. Biol. Chem. 275, 22728–22735 (2000).
  Article CAS PubMed Google Scholar
• Gerecke, D. R., Gordon, M. K., Wagman, W. W., Champliaud, M. F. & Burgeson, R. E. in Extracellular matrix assembly and structure (eds Mecham, R. P., Birk, D. E. & Yurchenko, P. D.) 417–439 (Academic Press, San Diego, USA, 1994).
  Book Google Scholar
• Schenk, S. et al. Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. J. Cell Biol. 161, 197–209 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Decline, F. & Rousselle, P. Keratinocyte migration requires alpha2beta1 integrin-mediated interaction with the laminin 5 γ2 chain. J. Cell Sci. 114, 811–823 (2001).
  CAS PubMed Google Scholar
• Gagnoux-Palacios, L. et al. The short arm of the laminin γ2 chain plays a pivotal role in the incorporation of laminin 5 into the extracellular matrix and in cell adhesion. J. Cell Biol. 153, 835–850. (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Sigle, R. O. et al. Globular domains 4/5 of the laminin α3 chain mediate deposition of precursor laminin 5. J. Cell Sci. 117, 4481–4494 (2004).
  Article CAS PubMed Google Scholar
• Dajee, M. et al. NFκB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 421, 639–643 (2003). Demonstration of the requirement for laminin 332 and α6β4 integrin in human SCC tumours.
  Article CAS PubMed Google Scholar
• Waterman, E. A. et al. A laminin-collagen complex drives human epidermal carcinogenesis through phosphoinositol-3 kinase activation. Cancer Res. (in the press 2007).
• Nakashima, Y., Kariya, Y., Yasuda, C. & Miyazaki, K. Regulation of cell adhesion and type VII collagen binding by the β3 chain short arm of laminin-5: effect of its proteolytic cleavage. J. Biochem. (Tokyo) 138, 539–552 (2005).
  Article CAS Google Scholar
• McGrath, J. A., Schofield, O. M., Mayou, B. J., McKee, P. H. & Eady, R. A. Epidermolysis bullosa complicated by squamous cell carcinoma: report of 10 cases. J. Cut. Pathol. 19, 116–123 (1992).
  Article CAS Google Scholar
• Newman, C., Wagner, R. F. Jr., Tyring, S. K. & Spigel, G. T. Squamous cell carcinoma secondary to recessive dystrophic epidermolysis bullosa. A report of 4 patients with 17 primary cutaneous alignancies. J. Dermatol. Surg. Oncol. 18, 301–305 (1992).
  Article CAS PubMed Google Scholar
• Ortiz-Urda, S. et al. Type VII collagen is required for Ras-driven human epidermal tumorigenesis. Science 307, 1773–1776 (2005). Demonstration of collagen VII requirement in human SCC tumours.
  Article CAS PubMed Google Scholar
• Guo, W. et al. β4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 126, 489–502 (2006).
  Article CAS PubMed Google Scholar
• Trusolino, L., Bertotti, A. & Comoglio, P. M. A signaling adapter function for α6β4 integrin in the control of HGF-dependent invasive growth. Cell 5, 643–654 (2001).
  Article Google Scholar
• Okamoto, O. et al. Normal human keratinocytes bind to the α3LG4/5 domain of unprocessed laminin-5 through the receptor syndecan-1. J. Biol. Chem. 278, 44168–44177 (2003).
  Article CAS PubMed Google Scholar
• Tsubota, Y. et al. Isolation and activity of proteolytic fragment of laminin-5 α3 chain. Biochem. Biophys. Res. Commun. 278, 614–620 (2000).
  Article CAS PubMed Google Scholar
• Veitch, D. P. et al. Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin. J. Biol. Chem. 278, 15661–15668 (2003).
  Article CAS PubMed Google Scholar
• Hintermann, E. & Quaranta, V. Epithelial cell motility on laminin-5: regulation by matrix assembly, proteolysis, integrins and erbB receptors. Matrix Biol. 23, 75–85 (2004).
  Article CAS PubMed Google Scholar
• Marinkovich, M. P., Keene, D. R., Rimberg, C. S. & Burgeson, R. E. Cellular origin of the dermal-epidermal basement membrane. Dev. Dyn. 197, 255–267 (1993).
  Article CAS PubMed Google Scholar
• Timpl, R. et al. Laminin-a glycoprotein from basement membranes. J. Biol. Chem. 254, 9933–9937 (1979).
  CAS PubMed Google Scholar
• Takagi, J., Yang, Y., Liu, J. H., Wang, J. H. & Springer, T. A. Complex between nidogen and laminin fragments reveals a paradigmatic β-propeller interface. Nature 424, 969–974 (2003).
  Article CAS PubMed Google Scholar
• Cheng, Y. S., Champliaud, M. F., Burgeson, R. E., Marinkovich, M. P. & Yurchenco, P. D. Self-assembly of laminin isoforms. J. Biol. Chem. 272, 31525–31532 (1997).
  Article CAS PubMed Google Scholar
• Champliaud, M. F. et al. Human amnion contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment. J. Cell Biol. 132, 1189–1198 (1996).
  Article CAS PubMed Google Scholar
• Rousselle, P. et al. Laminin 5 binds the NC-1 domain of type VII collagen. J. Cell Biol. 138, 719–728 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Chen, M. et al. Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. J. Biol. Chem. 272, 14516–14522 (1997).
  Article CAS PubMed Google Scholar
• Koshikawa, N., Giannelli, G., Cirulli, V., Miyazaki, K. & Quaranta, V. Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5. J. Cell Biol. 148, 615–624 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Goldfinger, L. E., Stack, M. S. & Jones, J. C. Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator. J. Cell Biol. 141, 255–265 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Timpl, R. et al. Structure and function of laminin LG modules. Matrix Biol. 19, 309–317. (2000).
  Article CAS PubMed Google Scholar
• Hynes, R. O. Integrins: bidirectional, allosteric signaling machines. Cell 110, 673–687 (2002).
  Article CAS PubMed Google Scholar
• Sung, U., O'Rear, J. J. & Yurchenco, P. D. Localization of heparin binding activity in recombinant laminin G domain. Eur. J. Biochem. 250, 138–143 (1997).
  Article CAS PubMed Google Scholar
• Henry, M. D. & Campbell, K. P. A role for dystroglycan in basement membrane assembly. Cell 95, 859–870 (1998).
  Article CAS PubMed Google Scholar
• Geerts, D. et al. Binding of integrin α6β4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding. J. Cell Biol. 147, 417–434 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Nievers, M. G., Kuikman, I., Geerts, D., Leigh, I. M. & Sonnenberg, A. Formation of hemidesmosome-like structures in the absence of ligand binding by the α6β4 integrin requires binding of HD1/plectin to the cytoplasmic domain of the β4 integrin subunit. J. Cell Sci. 113, 963–973 (2000).
  CAS PubMed Google Scholar
• Sterk, L. M. et al. The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin α6β4 and may regulate the spatial organization of hemidesmosomes. J. Cell Biol. 149, 969–982 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Sterk, L. M. et al. Association of the tetraspanin CD151 with the laminin-binding integrins α3β1, α6β1, α6β4 and α7β1 in cells in culture and in vivo. J. Cell Sci. 115, 1161–1173 (2002).
  CAS PubMed Google Scholar