Paria, B. C., Reese, J., Das, S. K. & Dey, S. K. Deciphering the cross-talk of implantation: advances and challenges. Science296, 2185–2188 (2002). ArticleCASPubMed Google Scholar
Red-Horse, K. et al. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J. Clin. Invest.114, 744–754 (2004). ArticleCASPubMedPubMed Central Google Scholar
Enders, A. C. & Schlafke, S. A morphological analysis of early implantation stages in the rat. Am. J. Anat.120, 195–226 (1967). Article Google Scholar
Nothias, J. Y., Majumder, S., Kaneko, K. J. & DePamphilis, M. L. Regulation of gene expression at the beginning of mammalian development. J. Biol. Chem.270, 22077–22080 (1995). ArticleCASPubMed Google Scholar
Latham, K. E., Garrels, J. I., Chang, C. & Solter, D. Quantitative analysis of protein synthesis in mouse embryos. I. Extensive reprogramming at the one- and two-cell stages. Development112, 921–932 (1991). CASPubMed Google Scholar
Shi, C. Z. et al. Protein databases for compacted eight-cell and blastocyst-stage mouse embryos. Mol. Reprod. Dev.37, 34–47 (1994). ArticleCASPubMed Google Scholar
Zimmermann, J. W. & Schultz, R. M. Analysis of gene expression in the preimplantation mouse embryo: use of mRNA differential display. Proc. Natl Acad. Sci. USA91, 5456–5460 (1994). ArticleCASPubMedPubMed Central Google Scholar
Ko, M. S. et al. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development127, 1737–1749 (2000). PubMed Google Scholar
Hamatani, T., Carter, M. G., Sharov, A. A. & Ko, M. S. Dynamics of global gene expression changes during mouse preimplantation development. Dev. Cell6, 117–131 (2004). This study, together with the work described in reference 12, shows that mouse preimplantation embryo development is a dynamic molecular process that is governed by waves of gene expression. ArticleCASPubMed Google Scholar
Wang, Q. T. et al. A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev. Cell6, 133–144 (2004). ArticleCASPubMed Google Scholar
Zeng, F., Baldwin, D. A. & Schultz, R. M. Transcript profiling during preimplantation mouse development. Dev. Biol.272, 483–496 (2004). ArticleCASPubMed Google Scholar
Tong, Z. B. et al. Mater, a maternal effect gene required for early embryonic development in mice. Nature Genet.26, 267–268 (2000). ArticleCASPubMed Google Scholar
Johnson, M. H. & McConnell, J. M. Lineage allocation and cell polarity during mouse embryogenesis. Semin. Cell Dev. Biol.15, 583–597 (2004). ArticleCASPubMed Google Scholar
Rossant, J. Lineage development and polar asymmetries in the peri-implantation mouse blastocyst. Semin. Cell Dev. Biol.15, 573–581 (2004). ArticlePubMed Google Scholar
Nichols, J. et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell95, 379–391 (1998). This study shows that expression ofOct4in inside cells of mouse preimplantation embryos is required for the generation of pluripotent cells. The other key molecules for cell-lineage differentiation during preimplantation development are described in references 18–24. ArticleCASPubMed Google Scholar
Niwa, H., Miyazaki, J. & Smith, A. G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genet.24, 372–376 (2000). ArticleCASPubMed Google Scholar
Mitsui, K. et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell113, 631–642 (2003). ArticleCASPubMed Google Scholar
Chambers, I. et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell113, 643–655 (2003). ArticleCASPubMed Google Scholar
Strumpf, D. et al. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development132, 2093–2102 (2005). ArticleCASPubMed Google Scholar
Russ, A. P. et al. Eomesodermin is required for mouse trophoblast development and mesoderm formation. Nature404, 95–99 (2000). ArticleCASPubMed Google Scholar
Paria, B. C., Huet-Hudson, Y. M. & Dey, S. K. Blastocyst's state of activity determines the “window” of implantation in the receptive mouse uterus. Proc. Natl Acad. Sci. USA90, 10159–10162 (1993). This study, which uses a delayed-implantation mouse model, showed for the first time that the receptive state of the uterus alone is not sufficient for successful implantation, but that blastocysts must also achieve implantation competency. The differential roles of oestrogen and catecholoestrogens in establishing the window of implantation are highlighted in references 26 and 32. ArticleCASPubMedPubMed Central Google Scholar
Ma, W. G., Song, H., Das, S. K., Paria, B. C. & Dey, S. K. Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc. Natl Acad. Sci. USA100, 2963–2968 (2003). ArticleCASPubMedPubMed Central Google Scholar
Lopes, F. L., Desmarais, J. A. & Murphy, B. D. Embryonic diapause and its regulation. Reproduction128, 669–678 (2004). ArticleCASPubMed Google Scholar
Hamatani, T. et al. Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation. Proc. Natl Acad. Sci. USA101, 10326–10331 (2004). This study analyses global gene expression in dormant and activated mouse blastocysts, providing evidence that gene-expression patterns are distinct at these two different physiological states of the embryo. ArticleCASPubMedPubMed Central Google Scholar
Paria, B. C., Das, S. K., Andrews, G. K. & Dey, S. K. Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation. Proc. Natl Acad. Sci. USA90, 55–59 (1993). ArticleCASPubMedPubMed Central Google Scholar
Raab, G. et al. Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor. Development122, 637–645 (1996). CASPubMed Google Scholar
Paria, B. C. et al. Coordination of differential effects of primary estrogen and catecholestrogen on two distinct targets mediates embryo implantation in the mouse. Endocrinology139, 5235–5246 (1998). ArticleCASPubMed Google Scholar
Guo, Y. et al. N–acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. J. Biol. Chem.280, 23429–23432 (2005). ArticleCASPubMed Google Scholar
Paria, B. C., Das, S. K. & Dey, S. K. The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Proc. Natl Acad. Sci. USA92, 9460–9464 (1995). This work provided the first evidence for the presence of the G-protein-coupled cannabinoid receptors CB1 and CB2 in preimplantation mouse embryos. The differential roles of endocannabinoids in embryo–uterine interactions during implantation are further illustrated in references 33 and 35–37. ArticleCASPubMedPubMed Central Google Scholar
Wang, H. et al. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nature Med.10, 1074–1080 (2004). ArticleCASPubMed Google Scholar
Wang, H. et al. Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. Proc. Natl Acad. Sci. USA100, 14914–14919 (2003). ArticleCASPubMedPubMed Central Google Scholar
Paria, B. C. et al. Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation. J. Biol. Chem.276, 20523–20528 (2001). ArticleCASPubMed Google Scholar
Wang, J., Mayernik, L., Schultz, J. F. & Armant, D. R. Acceleration of trophoblast differentiation by heparin-binding EGF-like growth factor is dependent on the stage-specific activation of calcium influx by ErbB receptors in developing mouse blastocysts. Development127, 33–44 (2000). CASPubMed Google Scholar
Stachecki, J. J. & Armant, D. R. Transient release of calcium from inositol 1,4,5-trisphosphate-specific stores regulates mouse preimplantation development. Development122, 2485–2496 (1996). CASPubMed Google Scholar
Wang, Y. et al. Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos. Dev. Dyn.231, 72–87 (2004). ArticleCASPubMed Google Scholar
Riley, J. K. et al. The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo. Dev. Biol.284, 377–386 (2005). ArticleCASPubMed Google Scholar
Lubahn, D. B. et al. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc. Natl Acad. Sci. USA90, 11162–11166 (1993). ArticleCASPubMedPubMed Central Google Scholar
Curtis, S. W., Clark, J., Myers, P. & Korach, K. S. Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor a knockout mouse uterus. Proc. Natl Acad. Sci. USA96, 3646–3651 (1999). ArticleCASPubMedPubMed Central Google Scholar
Paria, B. C., Tan, J., Lubahn, D. B., Dey, S. K. & Das, S. K. Uterine decidual response occurs in estrogen receptor-a-deficient mice. Endocrinology140, 2704–2710 (1999). ArticleCASPubMed Google Scholar
Lydon, J. P. et al. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev.9, 2266–2278 (1995). ArticleCASPubMed Google Scholar
Mulac-Jericevic, B., Mullinax, R. A., DeMayo, F. J., Lydon, J. P. & Conneely, O. M. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B-isoform. Science289, 1751–1754 (2000). ArticleCASPubMed Google Scholar
Song, H., Lim, H., Das, S. K., Paria, B. C. & Dey, S. K. Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice. Mol. Endocrinol.14, 1147–1161 (2000). ArticleCASPubMed Google Scholar
Stewart, C. L. et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature359, 76–79 (1992). This study provided the first evidence thatLifis expressed in mouse uterine glands and is essential for implantation. The stromal expression ofLifsurrounding the blastocyst at the time of attachment was also found to be important for implantation, as described in reference 47. ArticleCASPubMed Google Scholar
Ernst, M. et al. Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J. Exp. Med.194, 189–203 (2001). ArticleCASPubMedPubMed Central Google Scholar
Benson, G. V. et al. Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Development122, 2687–2696 (1996). CASPubMed Google Scholar
Hsieh-Li, H. M. et al. Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility. Development121, 1373–1385 (1995). CASPubMed Google Scholar
Lim, H., Ma, L., Ma, W. G., Maas, R. L. & Dey, S. K. Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse. Mol. Endocrinol.13, 1005–1017 (1999). ArticleCASPubMed Google Scholar
Satokata, I., Benson, G. & Maas, R. Sexually dimorphic sterility phenotypes in _Hoxa10_-deficient mice. Nature374, 460–463 (1995). This paper was the first to show female infertility in mice that lackHoxa10. It was later shown that defective decidualization is the cause of this female infertility, as described in references 50 and 52. ArticleCASPubMed Google Scholar
Daikoku, T. et al. Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: evidence for a novel cytokine-homeobox-Wnt signaling in implantation. Mol. Endocrinol.18, 1238–1250 (2004). This work was the first to provide evidence that cytokines, homeotic proteins and morphogens in the mouse uterus constitute a molecular circuitry that is crucial to implantation. ArticleCASPubMed Google Scholar
Gendron, R. L. et al. Abnormal uterine stromal and glandular function associated with maternal reproductive defects in Hoxa-11 null mice. Biol. Reprod.56, 1097–1105 (1997). ArticleCASPubMed Google Scholar
Taylor, H. S., Arici, A., Olive, D. & Igarashi, P. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J. Clin. Invest.101, 1379–1384 (1998). ArticleCASPubMedPubMed Central Google Scholar
Wang, W., Van De Water, T. & Lufkin, T. Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development125, 621–634 (1998). CASPubMed Google Scholar
Borthwick, J. M. et al. Determination of the transcript profile of human endometrium. Mol. Hum. Reprod.9, 19–33 (2003). ArticleCASPubMed Google Scholar
Carson, D. D. et al. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol. Hum. Reprod.8, 871–879 (2002). ArticleCASPubMed Google Scholar
Kao, L. C. et al. Global gene profiling in human endometrium during the window of implantation. Endocrinology143, 2119–2138 (2002). ArticleCASPubMed Google Scholar
Mirkin, S. et al. In search of candidate genes critically expressed in the human endometrium during the window of implantation. Hum. Reprod.20, 2104–2117 (2005). ArticleCASPubMed Google Scholar
Riesewijk, A. et al. Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology. Mol. Hum. Reprod.9, 253–264 (2003). ArticleCASPubMed Google Scholar
Satokata, I. & Maas, R. Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nature Genet.6, 348–356 (1994). ArticleCASPubMed Google Scholar
Takamoto, N., Zhao, B., Tsai, S. Y. & DeMayo, F. J. Identification of Indian hedgehog as a progesterone-responsive gene in the murine uterus. Mol. Endocrinol.16, 2338–2348 (2002). ArticleCASPubMed Google Scholar
Matsumoto, H., Zhao, X., Das, S. K., Hogan, B. L. & Dey, S. K. Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. Dev. Biol.245, 280–290 (2002). ArticleCASPubMed Google Scholar
Paria, B. C. et al. Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Proc. Natl Acad. Sci. USA98, 1047–1052 (2001). This article provides a comprehensive account of the expression of morphogens, including HH, BMP, WNT and FGF signalling in the mouse uterus during the periimplantation period. The evidence that HH signalling in the uterine epithelial–mesenchymal interaction is important for implantation was later reported in references 64 and 65. ArticleCASPubMedPubMed Central Google Scholar
Parr, B. A. & McMahon, A. P. Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature395, 707–710 (1998). ArticleCASPubMed Google Scholar
Daikoku, T. et al. Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus. Mol. Endocrinol.19, 683–697 (2005). ArticleCASPubMed Google Scholar
Tranguch, S. et al. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc. Natl Acad. Sci. USA102, 14326–14331 (2005). ArticleCASPubMedPubMed Central Google Scholar
Das, S. K. et al. Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation. Development120, 1071–1083 (1994). The role of HB-EGF as an early initiator of molecular crosstalk between the blastocyst and uterus before attachment was first illustrated in this study. CASPubMed Google Scholar
Iwamoto, R. et al. Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc. Natl Acad. Sci. USA100, 3221–3226 (2003). ArticleCASPubMedPubMed Central Google Scholar
Chobotova, K. et al. Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. Mech. Dev.119, 137–144 (2002). ArticleCASPubMed Google Scholar
Genbacev, O. D. et al. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science299, 405–408 (2003). This study shows that, in humans, selectin oligosaccharide ligands are expressed in the receptive uterine lining, while the Tr cell surface is decorated with L-selectin. Further evidence indicates that this ligand–receptor signalling is important for human implantation. ArticleCASPubMed Google Scholar
Fouladi-Nashta, A. A. et al. Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice. Dev. Biol.281, 1–21 (2005). ArticleCASPubMed Google Scholar
Lim, H. et al. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell91, 197–208 (1997). This study shows that ovulation, fertilization, implantation and decidualization are defective in mice lacking COX2-derived prostaglandins. ArticleCASPubMed Google Scholar
Lim, H. et al. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ. Genes Dev.13, 1561–1574 (1999). ArticleCASPubMedPubMed Central Google Scholar
Wang, H. et al. Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup. J. Biol. Chem.279, 10649–10658 (2004). ArticleCASPubMed Google Scholar
Kim, J. J. et al. Expression of cyclooxygenase-1 and-2 in the baboon endometrium during the menstrual cycle and pregnancy. Endocrinology140, 2672–2678 (1999). ArticleCASPubMed Google Scholar
Song, H. et al. Cytosolic phospholipase A2α is crucial for “on-time” embryo implantation that directs subsequent development. Development129, 2879–2889 (2002). This work shows that mouse uteri that lack cPLA2α transiently defer on-time implantation, creating an adverse ripple effect throughout the course of pregnancy and leading to poor pregnancy outcome. A similar phenotype is observed inlpA3-null mice, as reported in reference 80. The importance of on-time implantation in human pregnancy outcome is presented in reference 81. CASPubMed Google Scholar
Wilcox, A. J., Baird, D. D. & Weinberg, C. R. Time of implantation of the conceptus and loss of pregnancy. N. Engl. J. Med.340, 1796–1799 (1999). ArticleCASPubMed Google Scholar
Hogan, B. L. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev.10, 1580–1594 (1996). ArticleCASPubMed Google Scholar
Pfendler, K. C., Yoon, J., Taborn, G. U., Kuehn, M. R. & Iannaccone, P. M. Nodal and bone morphogenetic protein 5 interact in murine mesoderm formation and implantation. Genesis28, 1–14 (2000). ArticleCASPubMed Google Scholar
Arikawa, T., Omura, K. & Morita, I. Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells. J. Cell. Physiol.200, 400–406 (2004). ArticleCASPubMed Google Scholar
Matsumoto, H. et al. Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice. J. Biol. Chem.277, 29260–29267 (2002). This study shows that COX2-derived prostaglandins coordinate VEGF and angiopoietin signalling during angiogenesis in the mouse deciduum — a process that is required for the establishment of pregnancy. ArticleCASPubMed Google Scholar
Paria, B. C. & Dey, S. K. Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors. Proc. Natl Acad. Sci. USA87, 4756–4760 (1990). ArticleCASPubMedPubMed Central Google Scholar
Leach, R. E. et al. Pre-eclampsia and expression of heparin-binding EGF-like growth factor. Lancet360, 1215–1219 (2002). ArticleCASPubMed Google Scholar
National Institutes of Health. Stem Cells: Scientific Progress and Future Research Directions. Stem Cell Information [online], http://stemcells.nih.gov/info/scireport (2001).
Gardner, R. L. Specification of embryonic axes begins before cleavage in normal mouse development. Development128, 839–847 (2001). CASPubMed Google Scholar
Fujimori, T., Kurotaki, Y., Miyazaki, J. & Nabeshima, Y. Analysis of cell lineage in two- and four-cell mouse embryos. Development130, 5113–5122 (2003). ArticleCASPubMed Google Scholar
Piotrowska, K., Wianny, F., Pedersen, R. A. & Zernicka-Goetz, M. Blastomeres arising from the first cleavage division have distinguishable fates in normal mouse development. Development128, 3739–3748 (2001). CASPubMed Google Scholar
Piotrowska, K. & Zernicka-Goetz, M. Role for sperm in spatial patterning of the early mouse embryo. Nature409, 517–521 (2001). ArticleCASPubMed Google Scholar
Gardner, R. L. The early blastocyst is bilaterally symmetrical and its axis of symmetry is aligned with the animal–vegetal axis of the zygote in the mouse. Development124, 289–301 (1997). This article proposes the concept of the embryonic axis and cell polarity during mouse preimplantation development. The ongoing debate on this subject is further highlighted in references 89–92,96,101,107 and 108. CASPubMed Google Scholar
Piotrowska-Nitsche, K., Perea-Gomez, A., Haraguchi, S. & Zernicka-Goetz, M. Four-cell stage mouse blastomeres have different developmental properties. Development132, 479–490 (2005). ArticleCASPubMed Google Scholar
Piotrowska-Nitsche, K. & Zernicka-Goetz, M. Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo. Mech. Dev.122, 487–500 (2005). ArticleCASPubMed Google Scholar
Plusa, B. et al. The first cleavage of the mouse zygote predicts the blastocyst axis. Nature434, 391–395 (2005). ArticleCASPubMed Google Scholar
Surani, M. A. & Barton, S. C. Spatial distribution of blastomeres is dependent on cell division order and interactions in mouse morulae. Dev. Biol.102, 335–343 (1984). ArticleCASPubMed Google Scholar
Garbutt, C. L., Johnson, M. H. & George, M. A. When and how does cell division order influence cell allocation to the inner cell mass of the mouse blastocyst? Development100, 325–332 (1987). CASPubMed Google Scholar
Alarcon, V. B. & Marikawa, Y. Unbiased contribution of the first two blastomeres to mouse blastocyst development. Mol. Reprod. Dev.72, 354–361 (2005). ArticleCASPubMed Google Scholar
Chroscicka, A., Komorowski, S. & Maleszewski, M. Both blastomeres of the mouse 2-cell embryo contribute to the embryonic portion of the blastocyst. Mol. Reprod. Dev.68, 308–312 (2004). ArticleCASPubMed Google Scholar
Motosugi, N., Bauer, T., Polanski, Z., Solter, D. & Hiiragi, T. Polarity of the mouse embryo is established at blastocyst and is not prepatterned. Genes Dev.19, 1081–1092 (2005). ArticleCASPubMedPubMed Central Google Scholar
Rossant, J. & Tam, P. P. Emerging asymmetry and embryonic patterning in early mouse development. Dev. Cell7, 155–164 (2004). ArticleCASPubMed Google Scholar
Zernicka-Goetz, M. First cell fate decisions and spatial patterning in the early mouse embryo. Semin. Cell Dev. Biol.15, 563–572 (2004). ArticleCASPubMed Google Scholar
Plusa, B., Grabarek, J. B., Piotrowska, K., Glover, D. M. & Zernicka-Goetz, M. Site of the previous meiotic division defines cleavage orientation in the mouse embryo. Nature Cell Biol.4, 811–815 (2002). ArticleCASPubMed Google Scholar
Plusa, B., Piotrowska, K. & Zernicka-Goetz, M. Sperm entry position provides a surface marker for the first cleavage plane of the mouse zygote. Genesis32, 193–198 (2002). ArticlePubMed Google Scholar
Davies, T. J. & Gardner, R. L. The plane of first cleavage is not related to the distribution of sperm components in the mouse. Hum. Reprod.17, 2368–2379 (2002). ArticleCASPubMed Google Scholar
Hiiragi, T. & Solter, D. First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei. Nature430, 360–364 (2004). ArticleCASPubMed Google Scholar
Louvet-Vallee, S., Vinot, S. & Maro, B. Mitotic spindles and cleavage planes are oriented randomly in the two-cell mouse embryo. Curr. Biol.15, 464–469 (2005). ArticleCASPubMed Google Scholar
Ain, R., Dai, G., Dunmore, J. H., Godwin, A. R. & Soares, M. J. A prolactin family paralog regulates reproductive adaptations to a physiological stressor. Proc. Natl Acad. Sci. USA101, 16543–16548 (2004). ArticleCASPubMedPubMed Central Google Scholar
Cheon, Y. P. et al. A genomic approach to identify novel progesterone receptor regulated pathways in the uterus during implantation. Mol. Endocrinol.16, 2853–2871 (2002). ArticleCASPubMed Google Scholar
Reese, J. et al. Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation. J. Biol. Chem.276, 44137–44145 (2001). ArticleCASPubMed Google Scholar
Reyzer, M. L. & Caprioli, R. M. MALDI mass spectrometry for direct tissue analysis: a new tool for biomarker discovery. J. Proteome Res.4, 1138–1142 (2005). ArticleCASPubMed Google Scholar
Ralston, A. & Rossant, J. Genetic regulation of stem cell origins in the mouse embryo. Clin. Genet.68, 106–112 (2005). ArticleCASPubMed Google Scholar
Branford, W. W., Benson, G. V., Ma, L., Maas, R. L. & Potter, S. S. Characterization of Hoxa-10/Hoxa-11 transheterozygotes reveals functional redundancy and regulatory interactions. Dev. Biol.224, 373–387 (2000). ArticleCASPubMed Google Scholar
Mericskay, M., Kitajewski, J. & Sassoon, D. Wnt5a is required for proper epithelial–mesenchymal interactions in the uterus. Development131, 2061–2072 (2004). ArticleCASPubMed Google Scholar
Shindo, T. et al. ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function. J. Clin. Invest.105, 1345–1352 (2000). ArticleCASPubMedPubMed Central Google Scholar
Simmen, R. C. et al. Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene. J. Biol. Chem.279, 29286–29294 (2004). ArticleCASPubMed Google Scholar
Fowler, K. J. et al. Uterine dysfunction and genetic modifiers in centromere protein B-deficient mice. Genome Res10, 30–41 (2000). CASPubMedPubMed Central Google Scholar
Panda, D. K. et al. Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc. Natl. Acad Sci. USA98, 7498–7503 (2001). ArticleCASPubMedPubMed Central Google Scholar
Baker, J. et al. Effects of an Igf1 gene null mutation on mouse reproduction. Mol. Endocrinol.10, 903–918 (1996). CASPubMed Google Scholar
Smith, C. L. et al. Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction. Mol. Cell Biol.22, 525–535 (2002). ArticleCASPubMedPubMed Central Google Scholar
Yoshizawa, T. et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nature Genet.16, 391–396 (1997). ArticleCASPubMed Google Scholar
Igakura, T. et al. A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Dev. Biol.194, 152–165 (1998). ArticleCASPubMed Google Scholar
Kuno, N. et al. Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily. FEBS Lett.425, 191–194 (1998). ArticleCASPubMed Google Scholar
Barak, Y. et al. Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer. Proc. Natl Acad. Sci USA99, 303–308 (2002). ArticleCASPubMed Google Scholar
Robb, L. et al. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nature Med4, 303–308 (1998). ArticleCASPubMed Google Scholar
Bilinski, P., Roopenian, D. & Gossler, A. Maternal IL-11Rα function is required for normal decidua and fetoplacental development in mice. Genes Dev.12, 2234–2243 (1998). ArticleCASPubMedPubMed Central Google Scholar
Meissner, A. & Jaenisch, R. Generation of nuclear transfer-derived pluripotent ES cells from cloned _Cdx2_-deficient blastocysts. Nature439, 212–215 (2006). ArticleCASPubMed Google Scholar
Niwa, H. et al. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell123, 917–929 (2005). ArticleCASPubMed Google Scholar
Gore, A. V. et al. The zebrafish dorsal axis is apparent at the four-cell stage. Nature438, 1030–1035 (2005). ArticleCASPubMed Google Scholar