- Slattery, M. et al. Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins. Cell 147, 1270–1282 (2011).
CAS PubMed PubMed Central Google Scholar
- Stark, G. & Darnell, J. The JAK–STAT pathway at twenty. Immunity 36, 503–514 (2012).
CAS PubMed PubMed Central Google Scholar
- Kodadek, T., Sikder, D. & Nalley, K. Keeping transcriptional activators under control. Cell 127, 261–264 (2006).
CAS PubMed Google Scholar
- Young, N. et al. High throughput characterization of combinatorial histone codes. Mol. Cell Proteom. 8, 2266–2284 (2009).
CAS Google Scholar
- Strahl, B. & Allis, C. The language of covalent histone modifications. Nature 403, 41–45 (2000).
CAS PubMed Google Scholar
- Cheung, P., Allis, C. & Sassone-Corsi, P. Signaling to chromatin through histone modifications. Cell 103, 263–271 (2000).
CAS PubMed Google Scholar
- Greer, E. et al. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature 479, 365–436 (2011).
CAS PubMed PubMed Central Google Scholar
- Schreiber, S. & Bernstein, B. Signaling network model of chromatin. Cell 111, 771–778 (2002).
CAS PubMed Google Scholar
- Bao, Y. Chromatin response to DNA double-strand break damage. Epigenomics 3, 307–328 (2011).
CAS PubMed Google Scholar
- Conaway, J. W. Introduction to theme “Chromatin, epigenetics, and transcription”. Annu. Rev. Biochem. 81, 61–64 (2012).
CAS PubMed Google Scholar
- Greer, E. & Shi, Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nature Rev. Genet. 13, 343–400 (2012).
CAS PubMed Google Scholar
- Spitale, R., Tsai, M.-C. & Chang, H. RNA templating the epigenome: long noncoding RNAs as molecular scaffolds. Epigenetics 6, 539–582 (2011).
CAS PubMed PubMed Central Google Scholar
- Iberg, A. et al. Arginine methylation of the histone H3 tail impedes effector binding. J. Biol. Chem. 283, 3006–3016 (2008).
CAS PubMed Google Scholar
- Guccione, E. et al. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature 449, 933–940 (2007). This paper was among the first to describe how methylation of one histone tail residue can directly influence the deposition and read-out of an adjacent methylation event.
CAS PubMed Google Scholar
- Hyllus, D. et al. PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev. 21, 3369–3449 (2007).
CAS PubMed PubMed Central Google Scholar
- Eustermann, S. et al. Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin. Nature Struct. Mol. Biol. 18, 777–859 (2011).
CAS Google Scholar
- Qiu, Y. et al. Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes Dev. 26, 1376–1467 (2012).
CAS PubMed PubMed Central Google Scholar
- Suganuma, T. & Workman, J. Signals and combinatorial functions of histone modifications. Annu. Rev. Biochem. 80, 473–572 (2011).
CAS PubMed Google Scholar
- Taverna, S., Li, H., Ruthenburg, A., Allis, C. & Patel, D. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nature Struct. Mol. Biol. 14, 1025–1065 (2007).
CAS Google Scholar
- Ruthenburg, A. et al. Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell 145, 692–706 (2011). Describes how BPTF (bromodomain PHD finger transcription factor; which harbours multiple reader domains) can simultaneously bind two activating histone marks on different histone tails. Provided an early example of a multivalent histone tail read-out.
CAS PubMed PubMed Central Google Scholar
- Alabert, C. & Groth, A. Chromatin replication and epigenome maintenance. Nature Rev. Mol. Cell Biol. 13, 153–167 (2012).
CAS Google Scholar
- Ripperger, J. & Merrow, M. Perfect timing: epigenetic regulation of the circadian clock. FEBS Lett. 585, 1406–1411 (2011).
CAS PubMed Google Scholar
- Zee, B., Levin, R., Dimaggio, P. & Garcia, B. Global turnover of histone post-translational modifications and variants in human cells. Epigenetics Chromatin 3, 22 (2010).
CAS PubMed PubMed Central Google Scholar
- Barth, T. & Imhof, A. Fast signals and slow marks: the dynamics of histone modifications. Trends Biochem. Sci. 35, 618–644 (2010).
CAS PubMed Google Scholar
- Banerjee, T. & Chakravarti, D. A peek into the complex realm of histone phosphorylation. Mol. Cell. Biol. 31, 4858–4931 (2011).
CAS PubMed PubMed Central Google Scholar
- Baek, S. When signaling kinases meet histones and histone modifiers in the nucleus. Mol. Cell 42, 274–358 (2011).
CAS PubMed Google Scholar
- Wei, Y., Yu, L., Bowen, J., Gorovsky, M. & Allis, C. Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell 97, 99–208 (1999).
CAS PubMed Google Scholar
- Cheung, P. et al. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol. Cell 5, 905–920 (2000).
CAS PubMed Google Scholar
- Thomson, S., Clayton, A. & Mahadevan, L. Independent dynamic regulation of histone phosphorylation and acetylation during immediate–early gene induction. Mol. Cell 8, 1231–1272 (2001).
CAS PubMed Google Scholar
- Vicent, G. et al. Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3. Mol. Cell 24, 367–448 (2006).
CAS PubMed Google Scholar
- Zippo, A. et al. Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell 138, 1122–1136 (2009).
CAS PubMed Google Scholar
- Dawson, M. et al. JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin. Nature 461, 819–822 (2009).
CAS PubMed PubMed Central Google Scholar
- Liokatis, S. et al. Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events. Nature Struct. Mol. Biol. 19, 819–823 (2012). Describes the hierarchy of histone tail phosphorylation events and the crosstalk with adjacent modifications.
CAS Google Scholar
- Metzger, E. et al. Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4. Nature 464, 792–798 (2010).
CAS PubMed Google Scholar
- Lau, P. & Cheung, P. Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing. Proc. Natl Acad. Sci. USA 108, 2801–2807 (2011).
CAS PubMed PubMed Central Google Scholar
- Yang, W. et al. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150, 685–696 (2012).
CAS PubMed PubMed Central Google Scholar
- Avraham, R. & Yarden, Y. Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nature Rev. Mol. Cell Biol. 12, 104–121 (2011).
CAS Google Scholar
- Xiong, S., Salazar, G., Patrushev, N. & Alexander, R. FoxO1 mediates an autofeedback loop regulating SIRT1 expression. J. Biol. Chem. 286, 5289–5388 (2011).
CAS PubMed Google Scholar
- Latham, J., Chosed, R., Wang, S. & Dent, S. Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination. Cell 146, 709–728 (2011). The first description of the crosstalk between marks on histones and non-histone proteins as a true 'signalling-out event.
CAS PubMed PubMed Central Google Scholar
- Lu, C. & Thompson, C. Metabolic regulation of epigenetics. Cell Metab. 16, 9–17 (2012).
CAS PubMed PubMed Central Google Scholar
- Melvin, A. & Rocha, S. Chromatin as an oxygen sensor and active player in the hypoxia response. Cell. Signal. 24, 35–78 (2012).
CAS PubMed PubMed Central Google Scholar
- Zhou, X. et al. Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer Res. 70, 4214–4235 (2010).
CAS PubMed PubMed Central Google Scholar
- Chowdhury, R. et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 12, 463–469 (2011).
CAS PubMed PubMed Central Google Scholar
- Lu, C. et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 483, 474–478 (2012). Shows how increased levels of 2-hydroxyglutarate, resulting from mutations in isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 that are found in cancers, block demethylase activity to prevent differentiation.
CAS PubMed PubMed Central Google Scholar
- Shimazu, T. et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339, 211–214 (2013).
CAS PubMed Google Scholar
- Fujiki, R. et al. GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature 459, 455–464 (2009).
CAS PubMed Google Scholar
- Fujiki, R. et al. GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature 480, 557–617 (2011).
CAS PubMed PubMed Central Google Scholar
- Hanover, J., Krause, M. & Love, D. Bittersweet memories: linking metabolism to epigenetics through _O_-GlcNAcylation. Nature Rev. Mol. Cell Biol. 13, 312–333 (2012).
CAS Google Scholar
- Kaelin, W. Jr. Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb. Symp. Quant. Biol. 76, 335–345 (2011).
CAS PubMed PubMed Central Google Scholar
- Sassone-Corsi, P. Physiology. When metabolism and epigenetics converge. Science 339, 148–150 (2013).
CAS PubMed Google Scholar
- Yang, X.-J. & Seto, E. Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol. Cell 31, 449–510 (2008).
CAS PubMed PubMed Central Google Scholar
- Cha, T.-L. et al. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 310, 306–310 (2005).
CAS PubMed Google Scholar
- Nacerddine, K. et al. Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J. Clin. Invest. 122, 1920–1952 (2012).
CAS PubMed PubMed Central Google Scholar
- Huang, W.-C. & Chen, C.-C. Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. Mol. Cell. Biol. 25, 6592–7194 (2005).
CAS PubMed PubMed Central Google Scholar
- Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6–21 (2002).
CAS PubMed Google Scholar
- stève, P.-O. et al. A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nature Struct. Mol. Biol. 18, 42–50 (2011).
Google Scholar
- Hervouet, E. et al. Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells. PLoS ONE 5, e11333 (2010).
PubMed PubMed Central Google Scholar
- Arita, K., Ariyoshi, M., Tochio, H., Nakamura, Y. & Shirakawa, M. Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature 455, 818–821 (2008).
CAS PubMed Google Scholar
- Avvakumov, G. et al. Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. Nature 455, 822–825 (2008).
CAS PubMed Google Scholar
- Hashimoto, H. et al. The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature 455, 826–829 (2008).
CAS PubMed PubMed Central Google Scholar
- Hennessy, B., Smith, D., Ram, P., Lu, Y. & Mills, G. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nature Rev. Drug Discov. 4, 988–1992 (2005).
CAS Google Scholar
- Bernstein, B. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315–326 (2006).
CAS PubMed Google Scholar
- Svotelis, A. et al. H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERα ligand dependency. EMBO J. 30, 3947–3961 (2011).
CAS PubMed PubMed Central Google Scholar
- Creyghton, M. et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc. Natl Acad. Sci. USA 107, 21931–21936 (2010).
CAS PubMed PubMed Central Google Scholar
- Visel, A. et al. ChIP–seq accurately predicts tissue-specific activity of enhancers. Nature 457, 854–858 (2009).
CAS PubMed PubMed Central Google Scholar
- Hargreaves, D. & Crabtree, G. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res. 21, 396–420 (2011).
CAS PubMed PubMed Central Google Scholar
- Forcales, S. et al. Signal-dependent incorporation of MyoD–BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex. EMBO J. 31, 301–317 (2012).
CAS PubMed Google Scholar
- Palacios, D. et al. TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration. Cell Stem Cell 7, 455–524 (2010).
CAS PubMed PubMed Central Google Scholar
- Bedford, M. & Clarke, S. Protein arginine methylation in mammals: who, what, and why. Mol. Cell 33, 1–13 (2009).
CAS PubMed PubMed Central Google Scholar
- Zhao, Q. et al. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nature Struct. Mol. Biol. 16, 304–315 (2009).
CAS Google Scholar
- Liu, F. et al. JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell 19, 283–377 (2011).
CAS PubMed PubMed Central Google Scholar
- Levy, D. et al. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nature Immunol. 12, 29–65 (2011).
CAS Google Scholar
- Day, J. & Sweatt, J. Epigenetic mechanisms in cognition. Neuron 70, 813–842 (2011).
CAS PubMed PubMed Central Google Scholar
- Maze, I., Noh, K.-M. & Allis, C. Histone regulation in the CNS: basic principles of epigenetic plasticity. Neuropsychopharmacology 38, 3–22 (2012).
PubMed PubMed Central Google Scholar
- West, A. & Greenberg, M. Neuronal activity-regulated gene transcription in synapse development and cognitive function. Cold Spring Harb. Persp. Biol. 3, a005744 (2011).
Google Scholar
- Okuno, H. Regulation and function of immediate-early genes in the brain: beyond neuronal activity markers. Neurosci. Res. 69, 175–261 (2011).
CAS PubMed Google Scholar
- Tagami, H., Ray-Gallet, D., Almouzni, G. & Nakatani, Y. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell 116, 51–112 (2004).
CAS PubMed Google Scholar
- Michod, D. et al. Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron 74, 122–157 (2012). Demonstrates that storage of a cellular experience in neurons is partly mediated through marking activity-induced genes with histone variant H3.3.
CAS PubMed PubMed Central Google Scholar
- Ng, R. & Gurdon, J. Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. Nature Cell Biol. 10, 102–111 (2008).
CAS PubMed Google Scholar
- Su, D. et al. Structural basis for recognition of H3K56-acetylated histone H3–H4 by the chaperone Rtt106. Nature 483, 104–111 (2012).
CAS PubMed PubMed Central Google Scholar
- Chang, Y. et al. MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nature Commun. 2, 533 (2011).
Google Scholar
- Fischle, W., Wang, Y. & Allis, C. Binary switches and modification cassettes in histone biology and beyond. Nature 425, 475–484 (2003).
CAS PubMed Google Scholar
- Nicodeme, E. et al. Suppression of inflammation by a synthetic histone mimic. Nature 468, 1119–1123 (2010). This clinically important paper shows that a histone-mimic compound (I-BET) that binds the acetylated Lys residues in the binding pocket of BRD2, BRD3 and BRD4 can prevent inflammation-induced gene expression in vitro and in vivo.
CAS PubMed PubMed Central Google Scholar
- Marazzi, I. et al. Suppression of the antiviral response by an influenza histone mimic. Nature 483, 428–433 (2012).
CAS PubMed PubMed Central Google Scholar
- Chin, H. et al. Automethylation of G9a and its implication in wider substrate specificity and HP1 binding. Nucleic Acids Res. 35, 7313–7336 (2007).
CAS PubMed PubMed Central Google Scholar
- Sampath, S. et al. Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol. Cell 27, 596–1204 (2007).
CAS PubMed Google Scholar
- Tachibana, M. et al. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3–K9. Genes Dev. 19, 815–826 (2005).
CAS PubMed PubMed Central Google Scholar
- Kim, H. et al. p53 requires an intact C-terminal domain for DNA binding and transactivation. J. Mol. Biol. 415, 843–897 (2012).
CAS PubMed Google Scholar
- Huang, J. et al. p53 is regulated by the lysine demethylase LSD1. Nature 449, 105–113 (2007).
CAS PubMed Google Scholar
- Chuikov, S. et al. Regulation of p53 activity through lysine methylation. Nature 432, 353–413 (2004).
CAS PubMed Google Scholar
- West, L. & Gozani, O. Regulation of p53 function by lysine methylation. Epigenomics 3, 361–370 (2011).
CAS PubMed Google Scholar
- Kruse, J.-P. & Gu, W. Modes of p53 regulation. Cell 137, 609–631 (2009).
CAS PubMed PubMed Central Google Scholar
- Cui, G. et al. PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nature Struct. Mol. Biol. 19, 916–924 (2012).
CAS Google Scholar
- Badeaux, A. et al. Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. J. Biol. Chem. 287, 429–466 (2012).
CAS PubMed Google Scholar
- Park, S. et al. Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53. J. Biol. Chem. 287, 11151–11214 (2012).
CAS PubMed PubMed Central Google Scholar
- Brookes, E. & Pombo, A. Modifications of RNA polymerase II are pivotal in regulating gene expression states. EMBO Rep. 10, 1213–1219 (2009).
CAS PubMed PubMed Central Google Scholar
- Levine, M. Paused RNA polymerase II as a developmental checkpoint. Cell 145, 502–513 (2011).
CAS PubMed PubMed Central Google Scholar
- Hsin, J.-P., Sheth, A. & Manley, J. RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3′ end processing. Science 334, 683–689 (2011).
CAS PubMed PubMed Central Google Scholar
- Mayer, A. et al. CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II. Science 336, 1723–1728 (2012).
CAS PubMed Google Scholar
- Ranuncolo, S., Ghosh, S., Hanover, J., Hart, G. & Lewis, B. Evidence of the involvement of _O_-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. J. Biol. Chem. 287, 23549–23561 (2012).
CAS PubMed PubMed Central Google Scholar
- Sims, R. et al. The C-terminal domain of RNA polymerase II is modified by site-specific methylation. Science 332, 99–202 (2011).
CAS PubMed PubMed Central Google Scholar
- Yang, Y. et al. TDRD3 is an effector molecule for arginine-methylated histone marks. Mol. Cell 40, 1016–1023 (2010).
CAS PubMed PubMed Central Google Scholar
- Canani, R. et al. Epigenetic mechanisms elicited by nutrition in early life. Nutr. Res. Rev. 24, 198–403 (2011).
CAS PubMed Google Scholar
- Symonds, M., Sebert, S., Hyatt, M. & Budge, H. Nutritional programming of the metabolic syndrome. Nature Rev. Endocrinol. 5, 604–614 (2009).
CAS Google Scholar
- Walker, C. & Ho, S.-M. Developmental reprogramming of cancer susceptibility. Nature Rev. Cancer 12, 479–565 (2012).
CAS Google Scholar
- Trollope, A. et al. Stress, epigenetic control of gene expression and memory formation. Exp. Neurol. 233, 3–14 (2012).
CAS PubMed Google Scholar
- Zovkic, I. & Sweatt, J. Epigenetic mechanisms in learned fear: implications for PTSD. Neuropsychopharmacology 38, 77–93 (2012).
PubMed PubMed Central Google Scholar
- Kantojärvi, K. et al. Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample. Psychiatr. Genet. 20, 102–108 (2010).
PubMed Google Scholar
- Wang, K.-S., Liu, X., Zhang, Q., Wu, L.-Y. & Zeng, M. Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. J. Neural Transm. 119, 425–433 (2012).
CAS PubMed Google Scholar
- Iwase, S. et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell 128, 1077–1088 (2007).
CAS PubMed Google Scholar
- Ounap, K. et al. A novel c.2T > C mutation of the KDM5C/JARID1C gene in one large family with X-linked intellectual disability. Eur. J. Med. Genet. 55, 178–184 (2012).
PubMed Google Scholar
- Kleefstra, T. et al. Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability. Am. J. Hum. Genet. 91, 73–82 (2012).
CAS PubMed PubMed Central Google Scholar
- O'Roak, B. et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 485, 246–250 (2012).
CAS PubMed PubMed Central Google Scholar
- Laumonnier, F. et al. Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate. J. Med. Genet. 42, 780–786 (2005).
CAS PubMed PubMed Central Google Scholar
- Ong, C.-T. & Corces, V. Enhancer function: new insights into the regulation of tissue-specific gene expression. Nature Rev. Genet. 12, 283–293 (2011).
CAS PubMed Google Scholar
- Boeke, J. et al. Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1. PLoS ONE 5, e10042 (2010).
PubMed PubMed Central Google Scholar
- Chi, Y. et al. Identification of CDK2 substrates in human cell lysates. Genome Biol. 9, R149 (2008).
PubMed PubMed Central Google Scholar
- Liu, H. et al. Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint. Nature 467, 343–346 (2010).
CAS PubMed PubMed Central Google Scholar
- Wu, S. et al. Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev. 24, 2531–2542 (2010).
CAS PubMed PubMed Central Google Scholar
- Spektor, T., Congdon, L., Veerappan, C. & Rice, J. The UBC9 E2 SUMO conjugating enzyme binds the PR-Set7 histone methyltransferase to facilitate target gene repression. PLoS ONE 6, e22785 (2011).
CAS PubMed PubMed Central Google Scholar
- Chen, S. et al. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nature Cell Biol. 12, 1108–1122 (2010).
CAS PubMed Google Scholar
- Wei, Y. et al. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nature Cell Biol. 13, 87–181 (2011).
CAS PubMed Google Scholar
- Baba, A. et al. PKA-dependent regulation of the histone lysine demethylase complex PHF2–ARID5B. Nature Cell Biol. 13, 668–743 (2011).
PubMed Google Scholar
- Liu, W. et al. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature 466, 508–512 (2010).
CAS PubMed PubMed Central Google Scholar
- Feng, Q. et al. Biochemical control of CARM1 enzymatic activity by phosphorylation. J. Biol. Chem. 284, 36167–36241 (2009).
CAS PubMed PubMed Central Google Scholar
- Higashimoto, K., Kuhn, P., Desai, D., Cheng, X. & Xu, W. Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc. Natl Acad. Sci. USA 104, 12318–12323 (2007).
CAS PubMed PubMed Central Google Scholar
- Estève P. O. et al. Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells. Proc. Natl Acad. Sci. USA 106, 5076–5081 (2009)
PubMed PubMed Central Google Scholar
- Lee, B. & Muller M. T. SUMOylation enhances DNA methyltransferase 1 activity. Biochem. J. 421, 449–461 (2009)
CAS PubMed Google Scholar
- Sugiyama Y. et al. The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1δ/ɛ. Biochem J. 427, 489–497 (2010)
CAS PubMed Google Scholar
- Lavoie G. & St-Pierre Y. Phosphorylation of human DNMT1: implication of cyclin-dependent kinases. Biochem. Biophys. Res. Commun. 409, 187–192 (2011)
CAS PubMed Google Scholar
- Bourachot, B., Yaniv, M. & Muchardt, C. Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation. EMBO J. 22, 6505–6515 (2003).
CAS PubMed PubMed Central Google Scholar
- Galisson, F. et al. A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells. Mol Cell Proteomics 10, M110.004796 (2011).
PubMed Google Scholar
- Hsiao, H.-H., Meulmeester, E., Frank, B., Melchior, F. & Urlaub, H. “ChopNSpice, ” a mass spectrometric approach that allows identification of endogenous small ubiquitin-like modifier-conjugated peptides. Mol. Cell Proteom. 8, 2664–2675 (2009).
CAS Google Scholar