HIV-1 and interferons: who's interfering with whom? (original) (raw)

• Faria, N. R. et al. HIV epidemiology. The early spread and epidemic ignition of HIV-1 in human populations. Science 346, 56–61 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• D'Arc, M. et al. Origin of the HIV-1 group O epidemic in western lowland gorillas. Proc. Natl Acad. Sci. USA 112, E1343–E1352 (2015).
  Article CAS PubMed Google Scholar
• Takeuchi, O. & Akira, S. Pattern recognition receptors and inflammation. Cell 140, 805–820 (2010).
  Article CAS PubMed Google Scholar
• Rotger, M. et al. Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals. PLoS Pathog. 6, e1000781 (2010). This study characterizes the gene expression profile abnormalities of the CD4+ T cells of patients with HIV-1 infection according to plasma viral load.
  Article CAS PubMed PubMed Central Google Scholar
• Hyrcza, M. D. et al. Distinct transcriptional profiles in ex vivo CD4+ and CD8+ T cells are established early in human immunodeficiency virus type 1 infection and are characterized by a chronic interferon response as well as extensive transcriptional changes in CD8+ T cells. J. Virol. 81, 3477–3486 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Sedaghat, A. R. et al. Chronic CD4+ T-cell activation and depletion in human immunodeficiency virus type 1 infection: type I interferon-mediated disruption of T-cell dynamics. J. Virol. 82, 1870–1883 (2008).
  Article CAS PubMed Google Scholar
• Chelbi-Alix, M. K. & Wietzerbin, J. Interferon, a growing cytokine family: 50 years of interferon research. Biochimie 89, 713–718 (2007).
  Article CAS PubMed Google Scholar
• Prokunina-Olsson, L. et al. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nature Genet. 45, 164–171 (2013).
  Article CAS PubMed Google Scholar
• Takaoka, A. & Yanai, H. Interferon signalling network in innate defence. Cell. Microbiol. 8, 907–922 (2006).
  Article CAS PubMed Google Scholar
• McNab, F., Mayer-Barber, K., Sher, A., Wack, A. & O'Garra, A. Type I interferons in infectious disease. Nature Rev. Immunol. 15, 87–103 (2015).
  Article CAS Google Scholar
• de Veer, M. J. et al. Functional classification of interferon-stimulated genes identified using microarrays. J. Leukoc. Biol. 69, 912–920 (2001).
  CAS PubMed Google Scholar
• MacMicking, J. D. Interferon-inducible effector mechanisms in cell-autonomous immunity. Nature Rev. Immunol. 12, 367–382 (2012).
  Article CAS Google Scholar
• Schoggins, J. W. Interferon-stimulated genes: roles in viral pathogenesis. Curr. Opin. Virol. 6, 40–46 (2014).
  Article CAS PubMed Google Scholar
• Schoggins, J. W. et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472, 481–485 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Liu, S. Y., Sanchez, D. J., Aliyari, R., Lu, S. & Cheng, G. Systematic identification of type I and type II interferon-induced antiviral factors. Proc. Natl Acad. Sci. USA 109, 4239–4244 (2012).
  Article CAS PubMed Google Scholar
• Schoggins, J. W. et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 505, 691–695 (2014).
  Article CAS PubMed Google Scholar
• Goubau, D., Deddouche, S. & Reis e Sousa, C. Cytosolic sensing of viruses. Immunity 38, 855–869 (2013).
  Article CAS PubMed Google Scholar
• Gao, D. et al. Cyclic GMP–AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341, 903–906 (2013). This study identifies cGAS as an important sensor of HIV.
  Article CAS PubMed Google Scholar
• Monroe, K. M. et al. IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science 343, 428–432 (2014).
  Article CAS PubMed Google Scholar
• Lahaye, X. et al. The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells. Immunity 39, 1132–1142 (2013).
  Article CAS PubMed Google Scholar
• Rasaiyaah, J. et al. HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature 503, 402–405 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Jakobsen, M. R. et al. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proc. Natl Acad. Sci. USA 110, E4571–E4580 (2013).
  Article CAS PubMed Google Scholar
• Matreyek, K. A. & Engelman, A. Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes. Viruses 5, 2483–2511 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Unterholzner, L. et al. IFI16 is an innate immune sensor for intracellular DNA. Nature Immunol. 11, 997–1004 (2010).
  Article CAS Google Scholar
• Doitsh, G. et al. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature 505, 509–514 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Doitsh, G. et al. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell 143, 789–801 (2010). This paper reports that the majority of CD4+ T cells depleted from HIV-1-infected tissues are abortively infected resting cells that die via IFI16-dependent pyroptosis.
  Article CAS PubMed PubMed Central Google Scholar
• Beignon, A. S. et al. Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor–viral RNA interactions. J. Clin. Invest. 115, 3265–3275 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Lepelley, A. et al. Innate sensing of HIV-infected cells. PLoS Pathog. 7, e1001284 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Blasius, A. L. & Beutler, B. Intracellular Toll-like receptors. Immunity 32, 305–315 (2010).
  Article CAS PubMed Google Scholar
• Li, G. et al. Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice. PLoS Pathog. 10, e1004291 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Bruel, T. et al. Plasmacytoid dendritic cell dynamics tune interferon-alfa production in SIV-infected cynomolgus macaques. PLoS Pathog. 10, e1003915 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Kader, M. et al. Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS Pathog. 9, e1003530 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Tsang, J. et al. HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation. AIDS 23, 2255–2263 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee-Kirsch, M. A. & Lieberman, J. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nature Immunol. 11, 1005–1013 (2010).
  Article CAS Google Scholar
• Manel, N. & Littman, D. R. Hiding in plain sight: how HIV evades innate immune responses. Cell 147, 271–274 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Pertel, T. et al. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 472, 361–365 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Galao, R. P., Le Tortorec, A., Pickering, S., Kueck, T. & Neil, S. J. Innate sensing of HIV-1 assembly by tetherin induces NFκB-dependent proinflammatory responses. Cell Host Microbe 12, 633–644 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Galao, R. P., Pickering, S., Curnock, R. & Neil, S. J. Retroviral retention activates a Syk-dependent HemITAM in human tetherin. Cell Host Microbe 16, 291–303 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Neil, S. & Bieniasz, P. Human immunodeficiency virus, restriction factors, and interferon. J. Interferon Cytokine Res. 29, 569–580 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Yan, N. & Chen, Z. J. Intrinsic antiviral immunity. Nature Immunol. 13, 214–222 (2012).
  Article CAS Google Scholar
• Sheehy, A. M., Gaddis, N. C., Choi, J. D. & Malim, M. H. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418, 646–650 (2002).
  Article CAS PubMed Google Scholar
• Stremlau, M. et al. The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys. Nature 427, 848–853 (2004).
  Article CAS PubMed Google Scholar
• Laguette, N. et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 474, 654–657 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Hrecka, K. et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 474, 658–661 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Neil, S. J., Zang, T. & Bieniasz, P. D. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 451, 425–430 (2008).
  Article CAS PubMed Google Scholar
• Van Damme, N. et al. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe 3, 245–252 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Malim, M. H. & Bieniasz, P. D. HIV restriction factors and mechanisms of evasion. Cold Spring Harb. Perspect. Med. 2, a006940 (2012). This paper provides an overview of HIV restriction factors.
  Article CAS PubMed PubMed Central Google Scholar
• Schaller, T., Goujon, C. & Malim, M. H. AIDS/HIV. HIV interplay with SAMHD1. Science 335, 1313–1314 (2012).
  Article CAS PubMed Google Scholar
• Goldstone, D. C. et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 480, 379–382 (2011).
  Article CAS PubMed Google Scholar
• Lahouassa, H. et al. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nature Immunol. 13, 223–228 (2011).
  Article CAS Google Scholar
• Ryoo, J. et al. The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Nature Med. 20, 936–941 (2014).
  Article CAS PubMed Google Scholar
• Kirchhoff, F. Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses. Cell Host Microbe 8, 55–67 (2010).
  Article CAS PubMed Google Scholar
• Sharp, P. M. & Hahn, B. H. Origins of HIV and the AIDS pandemic. Cold Spring Harb. Perspect. Med. 1, a006841 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Yu, X. et al. Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif–Cul5–SCF complex. Science 302, 1056–1060 (2003).
  Article CAS PubMed Google Scholar
• Guo, Y. et al. Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif. Nature 505, 229–233 (2014).
  Article CAS PubMed Google Scholar
• Neil, S. J. The antiviral activities of tetherin. Curr. Top. Microbiol. Immunol. 371, 67–104 (2013).
  CAS PubMed Google Scholar
• Diamond, T. L. et al. Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J. Biol. Chem. 279, 51545–51553 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Pillai, S. K. et al. Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo. Proc. Natl Acad. Sci. USA 109, 3035–3040 (2012).
  Article CAS PubMed Google Scholar
• Armitage, A. E. et al. Conserved footprints of APOBEC3G on hypermutated human immunodeficiency virus type 1 and human endogenous retrovirus HERV-K(HML2) sequences. J. Virol. 82, 8743–8761 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Wood, N. et al. HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC. PLoS Pathog. 5, e1000414 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Kim, E. Y. et al. Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection. PLoS Pathog. 10, e1004281 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Albin, J. S. & Harris, R. S. Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics. Expert Rev. Mol. Med. 12, e4 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Neil, S. J., Sandrin, V., Sundquist, W. I. & Bieniasz, P. D. An interferon-α-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein. Cell Host Microbe 2, 193–203 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Ho, D. D. et al. Recombinant human interferon alfa-A suppresses HTLV-III replication in vitro. Lancet 326, 602–604 (1985).
  Article Google Scholar
• Kornbluth, R. S., Oh, P. S., Munis, J. R., Cleveland, P. H. & Richman, D. D. Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro. J. Exp. Med. 169, 1137–1151 (1989).
  Article CAS PubMed Google Scholar
• Shirazi, Y. & Pitha, P. M. Alpha interferon inhibits early stages of the human immunodeficiency virus type 1 replication cycle. J. Virol. 66, 1321–1328 (1992).
  CAS PubMed PubMed Central Google Scholar
• Meylan, P. R., Guatelli, J. C., Munis, J. R., Richman, D. D. & Kornbluth, R. S. Mechanisms for the inhibition of HIV replication by interferons-α, -β, and -γ in primary human macrophages. Virology 193, 138–148 (1993).
  Article CAS PubMed Google Scholar
• Goujon, C. & Malim, M. H. Characterization of the alpha interferon-induced postentry block to HIV-1 infection in primary human macrophages and T cells. J. Virol. 84, 9254–9266 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Cheney, K. M. & McKnight, A. Interferon-α mediates restriction of human immunodeficiency virus type-1 replication in primary human macrophages at an early stage of replication. PLoS ONE 5, e13521 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Goujon, C. et al. Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. Nature 502, 559–562 (2013).
  Article CAS PubMed Google Scholar
• Liu, Z. et al. The interferon-inducible MxB protein inhibits HIV-1 infection. Cell Host Microbe 14, 398–410 (2013).
  Article CAS PubMed Google Scholar
• Kane, M. et al. MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature 502, 563–566 (2013). References 70–72 describe the anti-HIV-1 activities of MX2.
  Article CAS PubMed PubMed Central Google Scholar
• Melen, K. et al. Human MxB protein, an interferon-α-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope. J. Biol. Chem. 271, 23478–23486 (1996).
  Article CAS PubMed Google Scholar
• Goujon, C. et al. Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor. J. Virol. 88, 9017–9026 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Fricke, T. et al. MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1. Retrovirology 11, 68 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Fribourgh, J. L. et al. Structural insight into HIV-1 restriction by MxB. Cell Host Microbe 16, 627–638 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Compton, A. A. et al. IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread. Cell Host Microbe 16, 736–747 (2014).
  Article CAS PubMed Google Scholar
• Tartour, K. et al. IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity. Retrovirology 11, 103 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Lu, J. et al. The IFITM proteins inhibit HIV-1 infection. J. Virol. 85, 2126–2137 (2011).
  Article CAS PubMed Google Scholar
• Li, M. et al. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature 491, 125–128 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Alsharifi, M., Mullbacher, A. & Regner, M. Interferon type I responses in primary and secondary infections. Immunol. Cell Biol. 86, 239–245 (2008).
  Article CAS PubMed Google Scholar
• Sandler, N. G. et al. Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression. Nature 511, 601–605 (2014). This paper highlights the importance of type I interferons in the control of acute SIV infection.
  Article CAS PubMed PubMed Central Google Scholar
• Stacey, A. R. et al. Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J. Virol. 83, 3719–3733 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Parrish, N. F. et al. Phenotypic properties of transmitted founder HIV-1. Proc. Natl Acad. Sci. USA 110, 6626–6633 (2013).
  Article CAS PubMed Google Scholar
• Fenton-May, A. E. et al. Relative resistance of HIV-1 founder viruses to control by interferon-α. Retrovirology 10, 146 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Lane, H. C. et al. Interferon-α in patients with asymptomatic human immunodeficiency virus (HIV) infection: a randomized, placebo-controlled trial. Ann. Intern. Med. 112, 805–811 (1990).
  Article CAS PubMed Google Scholar
• Torriani, F. J. et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients. N. Engl. J. Med. 351, 438–450 (2004).
  Article CAS PubMed Google Scholar
• Neumann, A. et al. Differential antiviral effect of PEG-interferon-α-2b on HIV and HCV in the treatment of HIV/HCV co-infected patients. AIDS 21, 1855–1865 (2007).
  Article CAS PubMed Google Scholar
• Asmuth, D. M. et al. Safety, tolerability, and mechanisms of antiretroviral activity of pegylated interferon alfa-2a in HIV-1-monoinfected participants: a Phase II clinical trial. J. Infect. Dis. 201, 1686–1696 (2010). This study clearly characterizes the effect of IFNα therapy on HIV-1 plasma viral load in patients infected with HIV-1.
  Article CAS PubMed PubMed Central Google Scholar
• Hubbard, J. J. et al. Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon alfa-2a. J. Infect. Dis. 205, 1443–1447 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Sarasin-Filipowicz, M. et al. Interferon signaling and treatment outcome in chronic hepatitis C. Proc. Natl Acad. Sci. USA 105, 7034–7039 (2008).
  Article CAS PubMed Google Scholar
• Vanderford, T. H. et al. Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation. Blood 119, 5750–5757 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Azzoni, L. et al. Pegylated interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration. J. Infect. Dis. 207, 213–222 (2013).
  Article CAS PubMed Google Scholar
• Sun, H. et al. Hepatitis C therapy with interferon-α and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients. J. Infect. Dis. 209, 1315–1320 (2014).
  Article CAS PubMed Google Scholar
• Barouch, D. H. & Deeks, S. G. Immunologic strategies for HIV-1 remission and eradication. Science 345, 169–174 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Hardy, G. A. et al. Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers. PLoS ONE 8, e56527 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Herbeuval, J. P. et al. CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis. Blood 106, 3524–3531 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Douek, D. C., Roederer, M. & Koup, R. A. Emerging concepts in the immunopathogenesis of AIDS. Annu. Rev. Med. 60, 471–484 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Marshall, H. D., Urban, S. L. & Welsh, R. M. Virus-induced transient immune suppression and the inhibition of T cell proliferation by type I interferon. J. Virol. 85, 5929–5939 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Marshall, H. D. & Kaech, S. M. Regulating the diverse outcomes of interferon's interference. Trends Immunol. 35, 353–354 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Fraietta, J. A. et al. Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection. PLoS Pathog. 9, e1003658 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Bosinger, S. E. et al. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J. Clin. Invest. 119, 3556–3572 (2009).
  CAS PubMed PubMed Central Google Scholar
• Jacquelin, B. et al. Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J. Clin. Invest. 119, 3544–3555 (2009).
  CAS PubMed PubMed Central Google Scholar
• Harris, L. D. et al. Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques. J. Virol. 84, 7886–7891 (2010). References 102–104 identify the differences in the type I IFN responses of pathogenic and non-pathogenic NHP models following SIV infection.
  Article CAS PubMed PubMed Central Google Scholar
• Jacquelin, B. et al. Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-α during primary SIVagm infection. PLoS Pathog. 10, e1004241 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Best, S., Le Tissier, P., Towers, G. & Stoye, J. P. Positional cloning of the mouse retrovirus restriction gene Fv1. Nature 382, 826–829 (1996).
  Article CAS PubMed Google Scholar
• Paolini, R., Bernardini, G., Molfetta, R. & Santoni, A. NK cells and interferons. Cytokine Growth Factor Rev. http://dx.doi.org/10.1016/j.cytogfr.2014.11.003 (2014).
• Swann, J. B. et al. Type I IFN contributes to NK cell homeostasis, activation, and antitumor function. J. Immunol. 178, 7540–7549 (2007).
  Article CAS PubMed Google Scholar
• Zanoni, I. et al. IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions. Cell Rep. 4, 1235–1249 (2013).
  Article CAS PubMed Google Scholar
• Kolumam, G. A., Thomas, S., Thompson, L. J., Sprent, J. & Murali-Krishna, K. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J. Exp. Med. 202, 637–650 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Bahl, K., Huebner, A., Davis, R. J. & Welsh, R. M. Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to Toll-like receptor agonists. J. Virol. 84, 4866–4877 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Srivastava, S., Koch, M. A., Pepper, M. & Campbell, D. J. Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J. Exp. Med. 211, 961–974 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Le Bon, A. et al. Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 14, 461–470 (2001).
  Article CAS PubMed Google Scholar
• Hervas-Stubbs, S. et al. Direct effects of type I interferons on cells of the immune system. Clin. Cancer Res. 17, 2619–2627 (2011).
  Article CAS PubMed Google Scholar