Stress signalling pathways that impair prefrontal cortex structure and function (original) (raw)
Fuster, J. M. The Prefrontal Cortex (Academic Press, 2008). This is the most recent edition of a classic and eloquent book on the PFC. Google Scholar
Goldman-Rakic, P. S. The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive. Philos. Trans. R. Soc. Lond. B Biol. Sci.351, 1445–1453 (1996). CASPubMed Google Scholar
Thompson-Schill, S. L. et al. Effects of frontal lobe damage on interference effects in working memory. Cogn. Affect. Behav. Neurosci.2, 109–120 (2002). PubMed Google Scholar
Aron, A. R., Robbins, T. W. & Poldrack, R. A. Inhibition and the right inferior frontal cortex. Trends Cogn. Sci.8, 170–177 (2004). PubMed Google Scholar
Buschman, T. J. & Miller, E. K. Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices. Science315, 1860–1862 (2007). CASPubMed Google Scholar
Gazzaley, A. et al. Functional interactions between prefrontal and visual association cortex contribute to top-down modulation of visual processing. Cereb. Cortex17 (Suppl. 1), i125–i135 (2007). PubMed Google Scholar
Robbins, T. W. From arousal to cognition: the integrative position of the prefrontal cortex. Prog. Brain Res.126, 469–483 (2000). This review brings together important information on prefrontal circuits and how they are modulated. CASPubMed Google Scholar
Lee, D. & Seo, H. Mechanisms of reinforcement learning and decision making in the primate dorsolateral prefrontal cortex. Ann. NY Acad. Sci.1104, 108–122 (2007). PubMed Google Scholar
Modirrousta, M. & Fellows, L. K. Dorsal medial prefrontal cortex plays a necessary role in rapid error prediction in humans. J. Neurosci.28, 14000–14005 (2008). CASPubMedPubMed Central Google Scholar
Broadbent, D. Decision and Stress (Academic, London, 1971). This is a classic book on the effects of stress on cognitive function. Google Scholar
Hockey, G. R. J. Effect of loud noise on attentional selectivity. Q. J. Exp. Psychol.22, 28–36 (1970). Google Scholar
Hartley, L. R. & Adams, R. G. Effect of noise on the Stroop test. J. Exp. Psychol.102, 62–66 (1974). CASPubMed Google Scholar
Arnsten, A. F. T. The biology of feeling frazzled. Science280, 1711–1712 (1998). CASPubMed Google Scholar
Elliott, A. E. & Packard, M. G. Intra-amygdala anxiogenic drug infusion prior to retrieval biases rats towards the use of habit memory. Neurobiol. Learn. Mem.90, 616–623 (2008). CASPubMed Google Scholar
Glass, D. C., Reim, B. & Singer, J. E. Behavioral consequences of adaptation to controllable and uncontrollable noise. J. Exp. Social Psychol.7, 244–257 (1971). Google Scholar
Minor, T. R., Jackson, R. L. & Maier, S. F. Effects of task-irrelevant cues and reinforcement delay on choice-escape learning following inescapable shock: evidence for a deficit in selective attention. J. Exp. Psychol. Anim. Behav. Process.10, 543–556 (1984). CASPubMed Google Scholar
Qin, S., Hermans, E. J., van Marle, H. J. F., Lou, J. & Fernandez, G. Acute psychological stress reduces working memory-related activity in the dorsolateral prefrontal cortex. Biol. Psychiatry (in the press).
Dolcos, F. & McCarthy, G. Brain systems mediating cognitive interference by emotional distraction. J. Neurosci.26, 2072–2079 (2006). CASPubMedPubMed Central Google Scholar
Alexander, J. K., Hillier, A., Smith, R. M., Tivarus, M. E. & Beversdorf, D. Q. Beta-adrenergic modulation of cognitive flexibility during stress. J. Cogn. Neurosci.19, 468–478 (2007). PubMed Google Scholar
Luethi, M., Meier, B. & Sandi, C. Stress effects on working memory, explicit memory, and implicit memory for neutral and emotional stimuli in healthy men. Front. Behav. Neurosci. 15 Jan 2009 (doi:10.3389/neuro.08.005.2008).
Sinha, R., Lacadie, C. M., Skudlarski, P. & Wexler, B. E. Neural circuits underlying emotional distress in humans. Ann. NY Acad. Sci.1032, 254–257 (2004). PubMed Google Scholar
Li, C. S. & Sinha, R. Inhibitory control and emotional stress regulation: neuroimaging evidence for frontal-limbic dysfunction in psycho-stimulant addiction. Neurosci. Biobehav. Rev.32, 581–597 (2008). This paper relates prefrontal dysfunction during stress to substance abuse. PubMed Google Scholar
Liston, C., McEwen, B. S. & Casey, B. J. Psychosocial stress reversibly disrupts prefrontal processing and attentional control. Proc. Natl Acad. Sci. USA106, 912–917 (2009). This paper includes data on how chronic stress weakens prefrontal connectivity in both human subjects and rats exposed to chronic stress. CASPubMedPubMed Central Google Scholar
Mazure, C. M. (ed.) Does Stress Cause Psychiatric Illness? (American Psychiatric Press, Washington DC, 1995). This book gives many examples of how stress worsens mental illness. Google Scholar
Mazure, C. M. & Maciejewski, P. K. A model of risk for major depression: effects of life stress and cognitive style vary by age. Depress. Anxiety17, 26–33 (2003). PubMed Google Scholar
Southwick, S., Rasmusson, A., Barron, X. & Arnsten, A. F. T. in Neuropsychology of PTSD: Biological, Cognitive and Clinical Perspectives (eds Vasterling, J. J. & Brewin, C. R.) 27–58 (Guilford Publications, New York, 2005). Google Scholar
Breier, A., Wolkowitz, O. & Pickar, D. in Schizophrenia Research Vol. 1 (eds Tamminga, C. & Schult, S.) (Raven, New York, 1991). Google Scholar
Dohrenwend, B. P., Shrout, P. E., Link, B. G., Skodol, A. E. & Stueve, A. in Does Stress Cause Psychiatric Illness? (ed. Mazure, C. M.) 43–65 (American Psychiatric Press, Washington DC, 1995). Google Scholar
Hammen, C. & Gitlin, M. Stress reactivity in bipolar patients and its relation to prior history of disorder. Am. J. Psychiatry154, 856–857 (1997). CASPubMed Google Scholar
Amat, J., Paul, E., Zarza, C., Watkins, L. R. & Maier, S. F. Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex. J. Neurosci.26, 13264–13272 (2006). This study showed that it is the PFC that ascertains (rightly or wrongly) whether we are in control over a stressor. The PFC suppresses the brainstem stress response even when the perceived control is only an illusion. CASPubMedPubMed Central Google Scholar
Diorio, D., Viau, V. & Meaney, M. J. The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. J. Neurosci.13, 3839–3847 (1993). CASPubMedPubMed Central Google Scholar
Murphy, B. L., Arnsten, A. F. T., Goldman-Rakic, P. S. & Roth, R. H. Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proc. Natl Acad. Sci. USA93, 1325–1329 (1996). CASPubMedPubMed Central Google Scholar
Arnsten, A. F. T. & Goldman-Rakic, P. S. Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism. Arch. Gen. Psychiatry55, 362–369 (1998). CASPubMed Google Scholar
Shansky, R. M., Rubinow, K., Brennan, A. & Arnsten, A. F. The effects of sex and hormonal status on restraint-stress-induced working memory impairment. Behav. Brain Funct.2, 8 (2006). PubMedPubMed Central Google Scholar
McEwen, B. S. Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann. NY Acad. Sci.1032, 1–7 (2004). PubMed Google Scholar
Cahill, L. & McGaugh, J. L. Modulation of memory storage. Curr. Opin. Neurobiol.6, 237–242 (1996). CASPubMed Google Scholar
Quirk, G. J. & Mueller, D. Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology33, 56–72 (2008). PubMed Google Scholar
Kim, J. J. & Yoon, K. S. Stress: metaplastic effects in the hippocampus. Trends Neurosci.21, 505–509 (1998). CASPubMed Google Scholar
Packard, M. G. & Teather, L. A. Amygdala modulation of multiple memory systems: hippocampus and caudate-putamen. Neurobiol. Learn. Mem.69, 163–203 (1998). CASPubMed Google Scholar
Goldman-Rakic, P. S. Cellular basis of working memory. Neuron14, 477–485 (1995). This paper describes the microcircuits that underlie spatial working memory, summarizing both their anatomy and their physiology. CASPubMed Google Scholar
Funahashi, S., Bruce, C. J. & Goldman-Rakic, P. S. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J. Neurophysiol.61, 331–349 (1989). CASPubMed Google Scholar
Aston-Jones, G., Rajkowski, J. & Cohen, J. Role of locus coeruleus in attention and behavioral flexibility. Biol. Psychiatry46, 1309–1320 (1999). CASPubMed Google Scholar
Schultz, W. The phasic reward signal of primate dopamine neurons. Adv. Pharmacol.42, 686–690 (1998). CASPubMed Google Scholar
Matsumoto, M. & Hikosaka, O. Excitatory and inhibitory responses of midbrain dopamine neurons to cues predicting aversive stimuli. Soc. Neurosci. Abstr.691. 24 (2008). Google Scholar
Roth, R. H., Tam, S.-Y., Ida, Y., Yang, J.-X. & Deutch, A. Y. Stress and the mesocorticolimbic dopamine systems. Ann. NY Acad. Sci.537, 138–147 (1988). CASPubMed Google Scholar
Finlay, J. M., Zigmond, M. J. & Abercrombie, E. D. Increased dopamine and norepinephrine release in medial prefrontal cortex induced by acute and chronic stress: effects of diazepam. Neuroscience64, 619–628 (1995). CASPubMed Google Scholar
Deutch, A. Y. & Roth, R. H. The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog. Brain Res.85, 367–403 (1990). This paper summarizes the numerous biochemical studies of dopamine release in the PFC during stress exposure. CASPubMed Google Scholar
Lewis, D. A., Cambell, M. J., Foote, S. L., Goldstein, M. & Morrison, J. H. The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific. J. Neurosci.282, 317–330 (1987). Google Scholar
McCormick, D. A., Pape, H. C. & Williamson, A. Actions of norepinephrine in the cerebral cortex and thalamus: implications for function of the central noradrenergic system. Prog. Brain Res.88, 293–305 (1991). CASPubMed Google Scholar
Seamans, J. K., Durstewitz, D., Christie, B. R., Stevens, C. F. & Sejnowski, T. J. Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons. Proc. Natl Acad. Sci. USA98, 301–306 (2001). CASPubMed Google Scholar
Arnsten, A. F. T. Through the looking glass:differential noradrenergic modulation of prefrontal cortical function. Neural Plast.7, 133–146 (2000). CASPubMedPubMed Central Google Scholar
Arnsten, A. F. T. & Goldman-Rakic, P. S. Alpha-2 adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science230, 1273–1276 (1985). CASPubMed Google Scholar
Li, B.-M. & Mei, Z.-T. Delayed response deficit induced by local injection of the alpha-2 adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys. Behav. Neural Biol.62, 134–139 (1994). CASPubMed Google Scholar
Birnbaum, S. G., Gobeske, K. T., Auerbach, J., Taylor, J. R. & Arnsten, A. F. T. A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in prefrontal cortex. Biol. Psychiatry46, 1266–1274 (1999). CASPubMed Google Scholar
Ramos, B. et al. The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys. Biol. Psychiatry58, 894–900 (2005). CASPubMed Google Scholar
Cai, J. X., Ma, Y., Xu, L. & Hu, X. Reserpine impairs spatial working memory performance in monkeys: reversal by the alpha-2 adrenergic agonist clonidine. Brain Res.614, 191–196 (1993). CASPubMed Google Scholar
Mao, Z.-M., Arnsten, A. F. T. & Li, B.-M. Local infusion of alpha-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys. Biol. Psychiatry46, 1259–1265 (1999). CASPubMed Google Scholar
Ramos, B., Stark, D., Verduzco, L., van Dyck, C. H. & Arnsten, A. F. T. Alpha-2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals. Learn. Mem.13, 770–776 (2006). CASPubMedPubMed Central Google Scholar
Li, B.-M., Mao, Z.-M., Wang, M. & Mei, Z.-T. Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys. Neuropsychopharmacology21, 601–610 (1999). CASPubMed Google Scholar
Wang, M. et al. α2A-adrenoceptor stimulation strengthens working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell129, 397–410 (2007). CASPubMed Google Scholar
Birnbaum, S. B. et al. Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science306, 882–884 (2004). CASPubMed Google Scholar
Arnsten, A. F. T., Mathew, R., Ubriani, R., Taylor, J. R. & Li, B.-M. α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function. Biol. Psychiatry45, 26–31 (1999). CASPubMed Google Scholar
Taylor, F. & Raskind, M. A. The α1-adrenergic antagonist prazosin improves sleep and nightmares in civilian trauma posttraumatic stress disorder. J. Clin. Psychopharmacol.22, 82–85 (2002). CASPubMed Google Scholar
Raskind, M. A. et al. Prazosin reduces nightmares and other PTSD symptoms in combat veterans: a placebo-controlled study. Am. J. Psychiatry160, 371–373 (2003). PubMed Google Scholar
Arnsten, A. F. T. & Goldman-Rakic, P. S. Stress impairs prefrontal cortex cognitive function in monkeys: role of dopamine. Soc. Neurosci. Abstr.16, 164 (1990). Google Scholar
Sawaguchi, T. & Goldman-Rakic, P. S. D1 dopamine receptors in prefrontal cortex: involvement in working memory. Science251, 947–950 (1991). CASPubMed Google Scholar
Zahrt, J., Taylor, J. R., Mathew, R. G. & Arnsten, A. F. T. Supranormal stimulation of dopamine D1 receptors in the rodent prefrontal cortex impairs spatial working memory performance. J. Neurosci.17, 8528–8535 (1997). CASPubMedPubMed Central Google Scholar
Vijayraghavan, S. et al. Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neurosci.10, 376–384 (2007). CASPubMed Google Scholar
Druzin, M. Y., Kurzina, N. P., Malinina, E. P. & Kozlov, A. P. The effects of local application of D2 selective dopaminergic drugs into the medial prefrontal cortex of rats in a delayed spatial choice task. Behav. Brain Res.109, 99–111 (2000). CASPubMed Google Scholar
Gibbs, S. E. & D'Esposito, M. A functional MRI study of the effects of bromocriptine, a dopamine receptor agonist, on component processes of working memory. Psychopharmacology180, 644–653 (2005). CASPubMed Google Scholar
Wang, M., Vijayraghavan, S. & Goldman-Rakic, P. S. Selective D2 receptor actions on the functional circuitry of working memory. Science303, 853–856 (2004). CASPubMed Google Scholar
Kimberg, D. Y., D'Esposito, M. & Farah, M. J. Effects of bromocriptine on human subjects depend on working memory capacity. Neuroreport8, 3581–3585 (1997). CASPubMed Google Scholar
Egan, M. F. et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc. Natl Acad. Sci. USA98, 6917–6922 (2001). CASPubMedPubMed Central Google Scholar
Mattay, V. S. et al. Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc. Natl Acad. Sci. USA100, 6186–6191 (2003). CASPubMedPubMed Central Google Scholar
Papaleo, F. et al. Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice. J. Neurosci.28, 8709–8723 (2008). CASPubMedPubMed Central Google Scholar
Roozendaal, B., McReynolds, J. R. & McGaugh, J. L. The basolateral amygdala interacts with the medial prefrontal cortex in regulating glucocorticoid effects on working memory impairment. J. Neurosci.24, 1385–1392 (2004). CASPubMedPubMed Central Google Scholar
Lupien, S. J., Gillin, C. J. & Hauger, R. L. Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans. Behav. Neurosci.113, 420–430 (1999). CASPubMed Google Scholar
Grundemann, D., Schechinger, B., Rappold, G. A. & Schomig, E. Molecular identification of the cortisone-sensitive extraneuronal catecholamine transporter. Nature Neurosci.1, 349–351 (1998). CASPubMed Google Scholar
Ferry, B., Roozendaal, B. & McGaugh, J. L. Basolateral amygdala noradrenergic influences on memory storage are mediated by an interaction between β- and α-1-adrenoceptors. J. Neurosci.19, 5119–5123 (1999). CASPubMedPubMed Central Google Scholar
Roozendaal, B., Quirarte, G. L. & McGaugh, J. L. Glucocorticoids interact with the basolateral amygdala β-adrenoceptor–cAMP/cAMP/PKA system in influencing memory consolidation. Eur. J. Neurosci.15, 553–560 (2002). PubMed Google Scholar
Goldstein, L. E., Rasmusson, A. M., Bunney, S. B. & Roth, R. H. Role of the amygdala in the coordination of behavioral, neuroendocrine and prefrontal cortical monoamine responses to psychological stress in the rat. J. Neurosci.16, 4787–4798 (1996). CASPubMedPubMed Central Google Scholar
Hopkins, W. F. & Johnston, D. Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus. J. Neurophys.59, 667–687 (1988). CAS Google Scholar
Hu, H. et al. Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell131, 160–173 (2007). CASPubMed Google Scholar
Foote, S. L., Freedman, F. E. & Oliver, A. P. Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex. Brain Res.86, 229–242 (1975). CASPubMed Google Scholar
Waterhouse, B. D., Moises, H. C. & Woodward, D. J. Noradrenergic modulation of somatosensory cortical neuronal responses to iontophoretically applied putative transmitters. Exp. Neurol.69, 30–49 (1980). CASPubMed Google Scholar
Waterhouse, B. D., Moises, H. C. & Woodward, D. J. Alpha-receptor-mediated facilitation of somatosensory cortical neuronal responses to excitatory synaptic inputs and iontophoretically applied acetylcholine. Neuropharmacology20, 907–920 (1981). CASPubMed Google Scholar
Wickens, J. R., Horvitz, J. C., Costa, R. M. & Killcross, S. Dopaminergic mechanisms in actions and habits. J. Neurosci.27, 8181–8183 (2007). CASPubMedPubMed Central Google Scholar
Runyan, J. D., Moore, A. N. & Dash, P. K. A role for prefrontal calcium-sensitive protein phosphatase and kinase activities in working memory. Learn. Mem.12, 103–110 (2005). PubMedPubMed Central Google Scholar
Hagenston, A. M., Fitzpatrick, J. S. & Yeckel, M. F. mGluR-mediated calcium waves that invade the soma regulate firing in layer V medial prefrontal cortical pyramidal neurons. Cereb. Cortex18, 407–423 (2008). PubMed Google Scholar
Runyan, J. D. & Dash, P. K. Distinct prefrontal molecular mechanisms for information storage lasting seconds versus minutes. Learn. Mem.12, 232–238 (2005). This important study demonstrated that distinct memory processes can be modulated in very different ways, even in the same brain region. PubMedPubMed Central Google Scholar
Bos, J. L. Epac proteins: multi-purpose cAMP targets. Trends Biochem. Sci.31, 680–686 (2006). CASPubMed Google Scholar
Wahl-Schott, C. & Biel, M. HCN channels: structure, cellular regulation and physiological function. Cell. Mol. Life Sci.66, 470–494 (2009). CASPubMed Google Scholar
Chen, S., Wang, J. & Siegelbaum, S. A. Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. J. Gen. Physiol.117, 491–504 (2001). CASPubMedPubMed Central Google Scholar
George, M. S., Abbott, L. F. & Siegelbaum, S. A. Hyperpolarization-activated HCN channels inhibit subthreshold EPSPs through voltage-dependent interactions with M-type K+ channels. Nature Neurosci. (in the press). This important new study used both computational modelling and physiology to explain how HCN channels can shunt incoming synaptic inputs.
Delmas, P. & Brown, D. A. Pathways modulating neural KCNG/M (Kv7) potassium channels. Nature Rev. Neurosci.6, 850–862 (2005). CAS Google Scholar
Taylor, J. R., Birnbaum, S. G., Ubriani, R. & Arnsten, A. F. T. Activation of protein kinase A in prefrontal cortex impairs working memory performance. J. Neurosci.19, RC23 (1999). CASPubMedPubMed Central Google Scholar
Soulsby, M. D. & Wojcikiewicz, R. J. The type III inositol 1,4,5-trisphosphate receptor is phosphorylated by cAMP-dependent protein kinase at three sites. Biochem. J.392, 493–497 (2005). CASPubMedPubMed Central Google Scholar
Ferguson, G. D. & Storm, D. R. Why calcium-stimulated adenylyl cyclases? Physiology19, 271–276 (2004). CASPubMed Google Scholar
Partridge, L. D., Swandulla, D. & Muller, T. H. Modulation of calcium-activated non-specific cation currents by cyclic AMP-dependent phosphorylation in neurons of Helix. J. Physiol.429, 131–145 (1990). CASPubMedPubMed Central Google Scholar
Soboloff, J. et al. TRPC channels: integrators of multiple cellular signals. Handb. Exp. Pharmacol.179, 575–591 (2007). CAS Google Scholar
Haj-Dahmane, S. & Andrade, R. Ionic mechanism of the slow afterdepolarization induced by muscarinic receptor activation in rat prefrontal cortex. J. Neurophysiol.80, 1197–1210 (1998). CASPubMed Google Scholar
Tegner, J., Compte, A. & Wang, X. J. The dynamical stability of reverberatory neural circuits. Biol. Cybern.87, 471–481 (2002). PubMed Google Scholar
Han, J. Z., Lin, W., Lou, S. J., Qiu, J. & Chen, Y. Z. A rapid, nongenomic action of glucocorticoids in rat B103 neuroblastoma cells. Biochim. Biophys. Acta1591, 21–27 (2002). CASPubMed Google Scholar
Holmes, A. & Wellman, C. L. Stress-induced prefrontal reorganization and executive dysfunction in rodents. Neurosci. Biobehav. Rev. 6 Dec 2008 (doi:10.1016/j.neubiorev.2008.11.005). Google Scholar
Radley, J. J. et al. Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. Cereb. Cortex16, 313–320 (2006). PubMed Google Scholar
Michelsen, K. A. et al. Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex. BMC Neurosci.8, 107 (2007). PubMedPubMed Central Google Scholar
Liston, C. et al. Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting. J. Neurosci.26, 7870–7874 (2006). CASPubMedPubMed Central Google Scholar
Cerqueira, J. J., Mailliet, F., Almeida, O. F., Jay, T. M. & Sousa, N. The prefrontal cortex as a key target of the maladaptive response to stress. J. Neurosci.27, 2781–2787 (2007). CASPubMedPubMed Central Google Scholar
Radley, J. J. et al. Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress. Exp. Neurol.196, 199–203 (2005). PubMed Google Scholar
Brown, S. M., Henning, S. & Wellman, C. L. Mild, short-term stress alters dendritic morphology in rat medial prefrontal cortex. Cereb. Cortex15, 1714–1722 (2005). PubMed Google Scholar
Izquierdo, A., Wellman, C. L. & Holmes, A. Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice. J. Neurosci.26, 5733–5738 (2006). CASPubMedPubMed Central Google Scholar
Vyas, A., Mitra, R., Shankaranarayana Rao, B. S. & Chattarji, S. Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. J. Neurosci.22, 6810–6818 (2002). CASPubMedPubMed Central Google Scholar
Shansky, R. M., Hamo, C., Hof, P. R., McEwen, B. S. & Morrison, J. H. Stress-induced dendritic remodeling in the prefrontal cortex is circuit specific. Cereb. Cortex 4 Feb 2009 (doi:10.1093/cercor/bhp003). This study shows that not all prefrontal neurons respond similarly to stress, and that there are distinct changes based on the circuits involved. PubMedPubMed Central Google Scholar
Miner, L. H. et al. Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex. J. Neurosci.26, 1571–1578 (2006). CASPubMedPubMed Central Google Scholar
Mizoguchi, K. et al. Chronic stress induces impairment of spatial working memory due to prefrontal dopaminergic dysfunction. J. Neurosci.20, 1568–1575 (2000). CASPubMedPubMed Central Google Scholar
Wellman, C. L. Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. J. Neurobiol.49, 245–253 (2001). CASPubMed Google Scholar
Liu, R. J. & Aghajanian, G. K. Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy. Proc. Natl Acad. Sci. USA105, 359–364 (2008). CASPubMedPubMed Central Google Scholar
Zhu, M. Y., Wang, W. P., Huang, J. & Regunathan, S. Chronic treatment with glucocorticoids alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels. J. Neurochem.103, 1811–1820 (2007). CASPubMedPubMed Central Google Scholar
Gourley, S. L., Kedves, A. T., Olausson, P. & Taylor, J. R. A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF. Neuropsychopharmacology34, 707–716 (2009). CASPubMed Google Scholar
Lin, Y. et al. Sex differences in the effects of acute and chronic stress and recovery after long-term stress on stress-related brain regions of rats. Cereb. Cortex 10 Dec 2008 (doi:10.1093/cercor/bhn225). PubMedPubMed Central Google Scholar
Murmu, M. S. et al. Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy. Eur. J. Neurosci.24, 1477–1487 (2006). PubMed Google Scholar
Pascual, R. & Zamora-León, S. P. Effects of neonatal maternal deprivation and postweaning environmental complexity on dendritic morphology of prefrontal pyramidal neurons in the rat. Acta Neurobiol. Exp. (Wars.)67, 471–479 (2007). Google Scholar
Parker, K. J., Buckmaster, C. L., Justus, K. R., Schatzberg, A. F. & Lyons, D. M. Mild early life stress enhances prefrontal-dependent response inhibition in monkeys. Biol. Psychiatry57, 848–855 (2005). PubMed Google Scholar
Patel, P. D., Katz, M., Karssen, A. M. & Lyons, D. M. Stress-induced changes in corticosteroid receptor expression in primate hippocampus and prefrontal cortex. Psychoneuroendocrinology33, 360–367 (2008). CASPubMedPubMed Central Google Scholar
Meaney, M. J. et al. Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Dev. Neurosci.18, 49–72 (1996). CASPubMed Google Scholar
Lupien, S. J., McEwen, B. S., Gunnar, M. R. & Heim, C. Effects of stress throughout the lifespan on brain, behaviour and cognition. Nature Rev. Neurosci. 29 Apr 2009 (doi:10.1038/nrn2639). CASPubMed Google Scholar
Kim-Cohen, J. et al. MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis. Mol. Psychiatry11, 903–913 (2006). CASPubMed Google Scholar
Millar, J. K. et al. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science310, 1187–1191 (2005). CASPubMed Google Scholar
Millar, J. K. et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum. Mol. Genet.9, 1415–1423 (2000). CASPubMed Google Scholar
Cannon, T. D. et al. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch. Gen. Psychiatry62, 1205–1213 (2005). CASPubMed Google Scholar
Ishizuka, K., Paek, M., Kamiya, A. & Sawa, A. A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Biol. Psychiatry59, 1189–1197 (2006). CASPubMed Google Scholar
Kirkpatrick, B. et al. DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex. J. Comp. Neurol.497, 436–450 (2006). PubMed Google Scholar
Paspalas, C. D., Selemon, L. D. & Arnsten, A. F. Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex. Cereb. Cortex 19 Jan 2009 (doi:10.1093/cercor/bhn235). PubMedPubMed Central Google Scholar
Mirnics, K., Middleton, F. A., Stanwood, G. D., Lewis, D. A. & Levitt, P. Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol. Psychiatry6, 293–301 (2001). CASPubMed Google Scholar
Erdely, H. A., Tamminga, C. A., Roberts, R. C. & Vogel, M. W. Regional alterations in RGS4 protein in schizophrenia. Synapse59, 472–479 (2006). CASPubMed Google Scholar
Chowdari, K. V. et al. Association and linkage analyses of RGS4 polymorphisms in schizophrenia. Hum. Mol. Genet.11, 1373–1380 (2002). CASPubMed Google Scholar
Morris, D. W. et al. Confirming RGS4 as a susceptibility gene for schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet.125, 150–153 (2004). Google Scholar
Baum, A. E. et al. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol. Psychiatry13, 197–207 (2008). CASPubMed Google Scholar
Manji, H. K. & Lenox, R. H. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness. Biol. Psychiatry46, 1328–1351 (1999). CASPubMed Google Scholar
Arnsten, A. F. T. & Manji, H. K. Mania: a rational neurobiology. Future Neurol.3, 125–131 (2008). Google Scholar
Blumberg, H. P. et al. Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study. Biol. Psychiatry59, 611–618 (2006). CASPubMed Google Scholar
Bearden, C. E. et al. Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Biol. Psychiatry62, 7–16 (2007). CASPubMedPubMed Central Google Scholar
Moore, G. J., Bebchuk, J. M., Wilds, I. B., Chen, G. & Manji, H. K. Lithium-induced increase in human brain gray matter. The Lancet356, 1241–1242 (2000). CAS Google Scholar
Bremner, J. D. Neuroimaging studies in post-traumatic stress disorder. Curr. Psychiatry Rep.4, 254–263 (2002). PubMed Google Scholar
Southwick, S. M. et al. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol. Psychiatry46, 1192–1204 (1999). CASPubMed Google Scholar
Morey, R. A. et al. The role of trauma-related distractors on neural systems for working memory and emotion processing in posttraumatic stress disorder. J. Psychiatr. Res.43, 809–817 (2009). PubMed Google Scholar
Wang, L. et al. Prefrontal mechanisms for executive control over emotional distraction are altered in major depression. Psychiatry Res.163, 143–155 (2008). PubMedPubMed Central Google Scholar
Hayward, C. & Sanborn, K. Puberty and the emergence of gender differences in psychopathology. J. Adolesc. Health30, 49–58 (2002). PubMed Google Scholar
Shansky, R. M. et al. Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction. Mol. Psychiatry9, 531–538 (2004). CASPubMed Google Scholar
Jentsch, J. D., Roth, R. H. & Taylor, J. R. Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action. Prog. Brain Res.126, 433–453 (2000). CASPubMed Google Scholar
Markovac, J. & Goldstein, G. W. Picomolar concentrations of lead stimulate brain protein kinase C. Nature334, 71–73 (1988). CASPubMed Google Scholar
Morgan, R. E. et al. Early lead exposure produces lasting changes in sustained attention, response initiation, and reactivity to errors. Neurotoxicol. Teratol.23, 519–531 (2001). CASPubMed Google Scholar
Cecil, K. M. et al. Decreased brain volume in adults with childhood lead exposure. PLoS Med.5, e112 (2008). PubMedPubMed Central Google Scholar
Nevin, R. How lead exposure relates to temporal changes in IQ, violent crime, and unwed pregnancy. Environ. Res.83, 1–22 (2000). CASPubMed Google Scholar
Wright, J. P. et al. Association of prenatal and childhood blood lead concentrations with criminal arrests in early adulthood. PLoS Med.5, e101 (2008). PubMedPubMed Central Google Scholar
Woolley, D. E. A perspective of lead poisoning in antiquity and the present. Neurotoxicology5, 353–361 (1984). This paper describes how the fall of the Roman Empire probably involved lead poisoning, a topic of immediate relevance to crime and inappropriate social behaviours in today's society. CASPubMed Google Scholar
Brozoski, T., Brown, R. M., Rosvold, H. E. & Goldman, P. S. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science205, 929–931 (1979). This is the landmark paper that first showed that catecholamines are essential to dorsolateral prefrontal working memory abilities. Although the paper focused on dopamine, it is now known that noradrenaline also has an essential role. CASPubMed Google Scholar
Bland, S. T. et al. Stressor controllability modulates stress-induced dopamine and serotonin efflux and morphine-induced serotonin efflux in the medial prefrontal cortex. Neuropsychopharmacology28, 1589–1596 (2003). CASPubMed Google Scholar
Clarke, H. F., Walker, S. C., Dalley, J. W., Robbins, T. W. & Roberts, A. C. Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific. Cereb. Cortex17, 18–27 (2007). CASPubMed Google Scholar
Holmes, A. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neurosci. Biobehav. Rev.32, 1293–1314 (2008). CASPubMedPubMed Central Google Scholar
Williams, G. V., Rao, S. G. & Goldman-Rakic, P. S. The physiological role of 5-HT2A receptors in working memory. J. Neurosci.22, 2843–2854 (2002). CASPubMedPubMed Central Google Scholar
Boulougouris, V., Glennon, J. C. & Robbins, T. W. Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in rats. Neuropsychopharmacology33, 2007–2019 (2008). CASPubMed Google Scholar
Goldman-Rakic, P. S. in Handbook of Physiology, The Nervous System, Higher Functions of the Brain Vol. V (ed. Plum, F.) 373–417 (American Physiological Society, Bethesda, 1987). This classic paper describes the parallel anatomical circuits that underlie representational knowledge. Google Scholar
Price, J. L. & Amaral, D. G. An autoradiographic study of the projections of the central nucleus of the monkey amygdala. J. Neurosci.1, 1242–1259 (1981). CASPubMedPubMed Central Google Scholar
Price, J. L., Carmichael, S. T. & Drevets, W. C. Networks related to the orbital and medial prefrontal cortex; a substrate for emotional behavior? Prog. Brain Res.107, 523–536 (1996). CASPubMed Google Scholar
Ghashghaei, H. T. & Barbas, H. Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience115, 1261–1279 (2002). CASPubMed Google Scholar
Simons, J. S., Henson, R. N., Gilbert, S. J. & Fletcher, P. C. Separate forms of realty monitoring by the anterior prefrontal cortex. J. Cogn. Neurosci.20, 447–457 (2008). PubMedPubMed Central Google Scholar
Debiec, J. & LeDoux, J. E. Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD. Ann. NY Acad. Sci.1071, 521–524 (2006). CASPubMed Google Scholar