Pot1 and cell cycle progression cooperate in telomere length regulation (original) (raw)
de Lange, T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev.19, 2100–2110 (2005). ArticleCASPubMed Google Scholar
Riha, K., Heacock, M.L. & Shippen, D.E. The role of the nonhomologous end-joining DNA double-strand break repair pathway in telomere biology. Annu. Rev. Genet.40, 237–277 (2006). ArticleCASPubMed Google Scholar
O'Connor, M.S., Safari, A., Xin, H., Liu, D. & Songyang, Z. A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc. Natl. Acad. Sci. USA103, 11874–11879 (2006). ArticleCASPubMedPubMed Central Google Scholar
Wang, F. et al. The POT–TTP1 telomere complex is a telomerase processivity factor. Nature445, 506–510 (2007). ArticleCASPubMed Google Scholar
d'Adda di Fagagna, F. et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature426, 194–198 (2003). ArticleCASPubMed Google Scholar
Larrivee, M., LeBel, C. & Wellinger, R.J. The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev.18, 1391–1396 (2004). ArticleCASPubMedPubMed Central Google Scholar
Tseng, S.F., Lin, J.J. & Teng, S.C. The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation. Nucleic Acids Res.34, 6327–6336 (2006). ArticleCASPubMedPubMed Central Google Scholar
Wu, Y., Xiao, S. & Zhu, X-D. MRE11/RAD50/NBS1 and ATM function as co-mediators of TRF1 in telomere length control. Nat. Struct. Mol. Biol.14, 832–840 (2007). ArticleCASPubMed Google Scholar
Verdun, R.E. & Karlseder, J. Replication and protection of telomeres. Nature447, 924–931 (2007). ArticleCASPubMed Google Scholar
Hector, R.E. et al. Tel1p preferentially associates with short telomeres to stimulate their elongation. Mol. Cell27, 851–858 (2007). ArticleCASPubMed Google Scholar
Verdun, R.E., Crabbe, L., Haggblom, C. & Karlseder, J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol. Cell20, 551–561 (2005). ArticleCASPubMed Google Scholar
Verdun, R.E. & Karlseder, J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell127, 709–720 (2006). ArticleCASPubMed Google Scholar
Herbig, U., Jobling, W.A., Chen, B.P., Chen, D.J. & Sedivy, J.M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell14, 501–513 (2004). ArticleCASPubMed Google Scholar
Celli, G.B. & de Lange, T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat. Cell Biol.7, 712–718 (2005). ArticleCASPubMed Google Scholar
Baumann, P. & Cech, T.R. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science292, 1171–1175 (2001). ArticleCASPubMed Google Scholar
Hockemeyer, D., Daniels, J.P., Takai, H. & de Lange, T. Recent expansion of the telomeric complex in rodents: two distinct Pot1 proteins protect mouse telomeres. Cell126, 63–77 (2006). ArticleCASPubMed Google Scholar
Churikov, D., Wei, C. & Price, C.M. Vertebrate Pot1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection. Mol. Cell. Biol.26, 6971–6982 (2006). ArticleCASPubMedPubMed Central Google Scholar
Wu, L. et al. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell126, 49–62 (2006). ArticleCASPubMed Google Scholar
Zou, L. Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response. Genes Dev.21, 879–885 (2007). ArticleCASPubMed Google Scholar
Sarkaria, J.N. et al. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res.58, 4375–4382 (1998). CASPubMed Google Scholar
Bartek, J. & Lukas, J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell3, 421–429 (2003). ArticleCASPubMed Google Scholar
Kohn, E.A., Yoo, C.J. & Eastman, A. The protein kinase C inhibitor Go6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Res.63, 31–35 (2003). CASPubMed Google Scholar
Zachos, G., Rainey, M.D. & Gillespie, D.A. Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures. Mol. Cell. Biol.25, 563–574 (2005). ArticleCASPubMedPubMed Central Google Scholar
Gaestel, M. MAPKAP kinases—MKs—two's company, three's a crowd. Nat. Rev. Mol. Cell Biol.7, 120–130 (2006). ArticleCASPubMed Google Scholar
Reinhardt, H.C., Aslanian, A.S., Lees, J.A. & Yaffe, M.B. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell11, 175–189 (2007). ArticleCASPubMedPubMed Central Google Scholar
Jazayeri, A. et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol.8, 37–45 (2006). ArticleCASPubMed Google Scholar
Takao, N. et al. Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation. Oncogene18, 7002–7009 (1999). ArticleCASPubMed Google Scholar
Dodson, H. et al. Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J.23, 3864–3873 (2004). ArticleCASPubMedPubMed Central Google Scholar
Chen, Y.S. & Chk, Y. 1 in the DNA damage response: conserved roles from yeasts to mammals. DNA Repair (Amst.)3, 1025–1032 (2004). ArticleCAS Google Scholar
Wei, C., Skopp, R., Takata, M., Takeda, S. & Price, C.M. Effects of double-strand break repair proteins on vertebrate telomere structure. Nucleic Acids Res.30, 2862–2870 (2002). ArticleCASPubMedPubMed Central Google Scholar
Ye, J.Z. et al. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev.18, 1649–1654 (2004). ArticleCASPubMedPubMed Central Google Scholar
Liu, D. et al. PTOP interacts with POT1 and regulates its localization to telomeres. Nat. Cell Biol.6, 673–680 (2004). ArticleCASPubMed Google Scholar
van Steensel, B. & de Lange, T. Control of telomere length by the human telomeric protein TRF1. Nature385, 740–743 (1997). ArticleCASPubMed Google Scholar
Jacob, N.K., Lescasse, R., Linger, B.R. & Price, C.M. Tetrahymena Pot1a regulates telomere length and prevents activation of a cell cycle checkpoint. Mol Cell Biol27, 1592–1601 (2007). ArticleCASPubMed Google Scholar
Leung-Pineda, V., Ryan, C.E. & Piwnica-Worms, H. Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol. Cell. Biol.26, 7529–7538 (2006). ArticleCASPubMedPubMed Central Google Scholar
Lei, M., Zaug, A.J., Podell, E.R. & Cech, T.R. Switching human telomerase on and off with hPOT1 protein in vitro. J. Biol. Chem.280, 20449–20456 (2005). ArticleCASPubMed Google Scholar
Kelleher, C., Kurth, I. & Lingner, J. Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol. Cell. Biol.25, 808–818 (2005). ArticleCASPubMedPubMed Central Google Scholar
Hockemeyer, D., Sfeir, A.J., Shay, J.W., Wright, W.E. & de Lange, T. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J.24, 2667–2678 (2005). ArticleCASPubMedPubMed Central Google Scholar
Denchi, E.L. & de Lange, T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature448, 1068–1071 (2007). ArticleCASPubMed Google Scholar
Wei, C. & Price, C.M. Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1. Mol. Cell. Biol.24, 2091–2102 (2004). ArticleCASPubMedPubMed Central Google Scholar
Majka, J.N. & Burgers, P.M. Clamping the Mec1/ATR checkpoint kinase into action. Cell Cycle6, 1157–1160 (2007). ArticleCASPubMed Google Scholar
Karlseder, J. et al. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol.2, E240 (2004). ArticlePubMedPubMed Central Google Scholar
Smogorzewska, A. & de Lange, T. Regulation of telomerase by telomeric proteins. Annu. Rev. Biochem.73, 177–208 (2004). ArticleCASPubMed Google Scholar
Xin, H. et al. TPP1 is a homolog of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature445, 559–562 (2007). ArticleCASPubMed Google Scholar
Frank, C.J., Hyde, M. & Greider, C.W. Regulation of telomere elongation by the cyclin-dependent kinase CDK1. Mol. Cell24, 423–432 (2006). ArticleCASPubMed Google Scholar
Vodenicharov, M.D. & Wellinger, R.J. DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase. Mol. Cell24, 127–137 (2006). ArticleCASPubMed Google Scholar