A YY1–INO80 complex regulates genomic stability through homologous recombination–based repair (original) (raw)

• Khanna, K.K. & Jackson, S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27, 247–254 (2001).
  Article CAS Google Scholar
• van Gent, D.C., Hoeijmakers, J.H. & Kanaar, R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2, 196–206 (2001).
  Article CAS Google Scholar
• Sung, P. & Klein, H. Mechanism of homologous recombination: mediators and helicases take on regulatory functions. Nat. Rev. Mol. Cell Biol. 7, 739–750 (2006).
  Article CAS Google Scholar
• Jasin, M. Homologous repair of DNA damage and tumorigenesis: the BRCA connection. Oncogene 21, 8981–8993 (2002).
  Article CAS Google Scholar
• Moynahan, M.E. The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans. Oncogene 21, 8994–9007 (2002).
  Article CAS Google Scholar
• Fritsch, O., Benvenuto, G., Bowler, C., Molinier, J. & Hohn, B. The INO80 protein controls homologous recombination in Arabidopsis thaliana. Mol. Cell 16, 479–485 (2004).
  Article CAS Google Scholar
• Tsukuda, T., Fleming, A.B., Nickoloff, J.A. & Osley, M.A. Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae. Nature 438, 379–383 (2005).
  Article CAS Google Scholar
• Morrison, A.J. et al. INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell 119, 767–775 (2004).
  Article CAS Google Scholar
• Jin, J. et al. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. J. Biol. Chem. 280, 41207–41212 (2005).
  Article CAS Google Scholar
• Shen, X., Mizuguchi, G., Hamiche, A. & Wu, C. A chromatin remodelling complex involved in transcription and DNA processing. Nature 406, 541–544 (2000).
  Article CAS Google Scholar
• van Attikum, H., Fritsch, O., Hohn, B. & Gasser, S.M. Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. Cell 119, 777–788 (2004).
  Article CAS Google Scholar
• van Attikum, H. & Gasser, S.M. The histone code at DNA breaks: a guide to repair? Nat. Rev. Mol. Cell Biol. 6, 757–765 (2005).
  Article CAS Google Scholar
• Donohoe, M.E. et al. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol. Cell. Biol. 19, 7237–7244 (1999).
  Article CAS Google Scholar
• Brown, J.L., Fritsch, C., Mueller, J. & Kassis, J.A. The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing. Development 130, 285–294 (2003).
  Article CAS Google Scholar
• Atchison, L., Ghias, A., Wilkinson, F., Bonini, N. & Atchison, M.L. Transcription factor YY1 functions as a PcG protein in vivo. EMBO J. 22, 1347–1358 (2003).
  Article CAS Google Scholar
• Brown, J.L., Mucci, D., Whiteley, M., Dirksen, M.L. & Kassis, J.A. The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Mol. Cell 1, 1057–1064 (1998).
  Article CAS Google Scholar
• Sui, G. et al. Yin Yang 1 is a negative regulator of p53. Cell 117, 859–872 (2004).
  Article CAS Google Scholar
• Gronroos, E., Terentiev, A.A., Punga, T. & Ericsson, J. YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. Proc. Natl. Acad. Sci. USA 101, 12165–12170 (2004).
  Article Google Scholar
• Affar el, B. et al. Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol. Cell. Biol. 26, 3565–3581 (2006).
  Article Google Scholar
• D'Andrea, A.D. & Grompe, M. The Fanconi anaemia/BRCA pathway. Nat. Rev. Cancer 3, 23–34 (2003).
  Article CAS Google Scholar
• German, J. Bloom syndrome: a mendelian prototype of somatic mutational disease. Medicine (Baltimore) 72, 393–406 (1993).
  Article CAS Google Scholar
• Auerbach, A.D. & Wolman, S.R. Susceptibility of Fanconi's anaemia fibroblasts to chromosome damage by carcinogens. Nature 261, 494–496 (1976).
  Article CAS Google Scholar
• Scully, R. & Livingston, D.M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429–432 (2000).
  Article CAS Google Scholar
• Patel, K.J. et al. Involvement of Brca2 in DNA repair. Mol. Cell 1, 347–357 (1998).
  Article CAS Google Scholar
• Elledge, S.J. Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664–1672 (1996).
  Article CAS Google Scholar
• Manke, I.A. et al. MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol. Cell 17, 37–48 (2005).
  Article CAS Google Scholar
• Groisman, R. et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 113, 357–367 (2003).
  Article CAS Google Scholar
• Shi, Y. et al. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 422, 735–738 (2003).
  Article CAS Google Scholar
• Cai, Y. et al. YY1 functions with INO80 to activate transcription. Nat. Struct. Mol. Biol. 14, 872–874 (2007).
  Article CAS Google Scholar
• Taccioli, G.E. et al. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265, 1442–1445 (1994).
  Article CAS Google Scholar
• Allen, C., Kurimasa, A., Brenneman, M.A., Chen, D.J. & Nickoloff, J.A. DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc. Natl. Acad. Sci. USA 99, 3758–3763 (2002).
  Article CAS Google Scholar
• Blunt, T. et al. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813–823 (1995).
  Article CAS Google Scholar
• Schildkraut, E., Miller, C.A. & Nickoloff, J.A. Gene conversion and deletion frequencies during double-strand break repair in human cells are controlled by the distance between direct repeats. Nucleic Acids Res. 33, 1574–1580 (2005).
  Article CAS Google Scholar
• Gaffney, E.V. et al. Established lines of SV40-transformed human amnion cells. Cancer Res. 30, 1668–1676 (1970).
  CAS PubMed Google Scholar
• Labrecque, S. & Matlashewski, G.J. Viability of wild type p53-containing and p53-deficient tumor cells following anticancer treatment: the use of human papillomavirus E6 to target p53. Oncogene 11, 387–392 (1995).
  CAS PubMed Google Scholar
• Allen, C., Halbrook, J. & Nickoloff, J.A. Interactive competition between homologous recombination and non-homologous end joining. Mol. Cancer Res. 1, 913–920 (2003).
  CAS PubMed Google Scholar
• Tsaneva, I.R., Muller, B. & West, S.C. ATP-dependent branch migration of Holliday junctions promoted by the RuvA and RuvB proteins of E. coli. Cell 69, 1171–1180 (1992).
  Article CAS Google Scholar
• Parsons, C.A., Tsaneva, I., Lloyd, R.G. & West, S.C. Interaction of Escherichia coli RuvA and RuvB proteins with synthetic Holliday junctions. Proc. Natl. Acad. Sci. USA 89, 5452–5456 (1992).
  Article CAS Google Scholar
• Iwasaki, H., Takahagi, M., Nakata, A. & Shinagawa, H. Escherichia coli RuvA and RuvB proteins specifically interact with Holliday junctions and promote branch migration. Genes Dev. 6, 2214–2220 (1992).
  Article CAS Google Scholar
• Klymenko, T. et al. A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev. 20, 1110–1122 (2006).
  Article CAS Google Scholar
• Bugreev, D.V., Mazina, O.M. & Mazin, A.V. Rad54 protein promotes branch migration of Holliday junctions. Nature 442, 590–593 (2006).
  Article CAS Google Scholar
• Ingleston, S.M. et al. Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae. Eur. J. Biochem. 269, 1525–1533 (2002).
  Article CAS Google Scholar
• Lisby, M. & Rothstein, R. DNA damage checkpoint and repair centers. Curr. Opin. Cell Biol. 16, 328–334 (2004).
  Article CAS Google Scholar
• Lisby, M., Rothstein, R. & Mortensen, U.H. Rad52 forms DNA repair and recombination centers during S phase. Proc. Natl. Acad. Sci. USA 98, 8276–8282 (2001).
  Article CAS Google Scholar
• Gao, H., Chen, X.B. & McGowan, C.H. Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells. Mol. Biol. Cell 14, 4826–4834 (2003).
  Article CAS Google Scholar
• Sui, G. & Shi, Y. Gene silencing by a DNA vector-based RNAi technology. Methods Mol. Biol. 309, 205–218 (2005).
  CAS PubMed Google Scholar
• Savage, J.R. Classification and relationships of induced chromosomal structual changes. J. Med. Genet. 13, 103–122 (1976).
  Article CAS Google Scholar
• Ikura, T. et al. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 102, 463–473 (2000).
  Article CAS Google Scholar
• Karow, J.K., Constantinou, A., Li, J.L., West, S.C. & Hickson, I.D. The Bloom's syndrome gene product promotes branch migration of holliday junctions. Proc. Natl. Acad. Sci. USA 97, 6504–6508 (2000).
  Article CAS Google Scholar
• Kaplan, D.L. & O'Donnell, M. RuvA is a sliding collar that protects Holliday junctions from unwinding while promoting branch migration. J. Mol. Biol. 355, 473–490 (2006).
  Article CAS Google Scholar