Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis (original) (raw)

• Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D . Global cancer statistics. CA Cancer J Clin 2011; 61: 69–90.
  Article PubMed Google Scholar
• Xu S, Witmer PD, Lumayag S, Kovacs B, Valle D . MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. J Biol Chem 2007; 282: 25053–25066.
  Article CAS PubMed Google Scholar
• Moskwa P, Buffa FM, Pan Y, Panchakshari R, Gottipati P, Muschel RJ et al. miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell 2011; 41: 210–220.
  Article CAS PubMed Google Scholar
• Stittrich AB, Haftmann C, Sgouroudis E, Kuhl AA, Hegazy AN, Panse I et al. The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol 2010; 11: 1057–1062.
  Article CAS PubMed Google Scholar
• Saus E, Soria V, Escaramis G, Vivarelli F, Crespo JM, Kagerbauer B et al. Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia. Hum Mol Genet 2010; 19: 4017–4025.
  Article CAS PubMed Google Scholar
• Guttilla IK, White BA . Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem 2009; 284: 23204–23216.
  Article CAS PubMed PubMed Central Google Scholar
• Sun Y, Fang R, Li C, Li L, Li F, Ye X et al. Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro. Biochem Biophys Res Commun 2010; 396: 501–507.
  Article CAS PubMed Google Scholar
• Segura MF, Hanniford D, Menendez S, Reavie L, Zou X, Alvarez-Diaz S et al. Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc Natl Acad Sci USA 2009; 106: 1814–1819.
  Article CAS PubMed PubMed Central Google Scholar
• Huynh C, Segura MF, Gaziel-Sovran A, Menendez S, Darvishian F, Chiriboga L et al. Efficient in vivo microRNA targeting of liver metastasis. Oncogene 2011; 30: 1481–1488.
  Article CAS PubMed Google Scholar
• Jiang L, Mao P, Song L, Wu J, Huang J, Lin C et al. miR-182 as a prognostic marker for glioma progression and patient survival. Am J Pathol 2010; 177: 29–38.
  Article PubMed PubMed Central Google Scholar
• Liu Z, Liu J, Segura MF, Shao C, Lee P, Gong Y et al. MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma. J Pathol 2012; 228: 204–215.
  Article CAS PubMed Google Scholar
• Callahan CA, Ofstad T, Horng L, Wang JK, Zhen HH, Coulombe PA et al. MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev 2004; 18: 2724–2729.
  Article CAS PubMed PubMed Central Google Scholar
• Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE . Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. J Cell Biol 2005; 168: 453–463.
  Article CAS PubMed PubMed Central Google Scholar
• Dawson JC, Timpson P, Kalna G, Machesky LM . Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells. Oncogene 2011; 31: 1781–1793.
  Article PubMed PubMed Central Google Scholar
• Mattila PK, Salminen M, Yamashiro T, Lappalainen P . Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. J Biol Chem 2003; 278: 8452–8459.
  Article CAS PubMed Google Scholar
• Woodings JA, Sharp SJ, Machesky LM . MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. Biochem J 2003; 371: 463–471.
  Article CAS PubMed PubMed Central Google Scholar
• Lin J, Liu J, Wang Y, Zhu J, Zhou K, Smith N et al. Differential regulation of cortactin and N-WASP-mediated actin polymerization by missing in metastasis (MIM) protein. Oncogene 2005; 24: 2059–2066.
  Article CAS PubMed Google Scholar
• Yamagishi A, Masuda M, Ohki T, Onishi H, Mochizuki N . A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. J Biol Chem 2004; 279: 14929–14936.
  Article CAS PubMed Google Scholar
• Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J et al. Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci 2011; 124: 1245–1255.
  Article CAS PubMed Google Scholar
• Lee YG, Macoska JA, Korenchuk S, Pienta KJ . MIM, a potential metastasis suppressor gene in bladder cancer. Neoplasia 2002; 4: 291–294.
  Article CAS PubMed PubMed Central Google Scholar
• Wang Y, Liu J, Smith E, Zhou K, Liao J, Yang GY et al. Downregulation of missing in metastasis gene (MIM) is associated with the progression of bladder transitional carcinomas. Cancer Invest 2007; 25: 79–86.
  Article PubMed Google Scholar
• Parr C, Jiang WG . Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer. Eur J Cancer 2009; 45: 1673–1683.
  Article CAS PubMed Google Scholar
• Liu K, Wang G, Ding H, Chen Y, Yu G, Wang J . Downregulation of metastasis suppressor 1(MTSS1) is associated with nodal metastasis and poor outcome in Chinese patients with gastric cancer. BMC Cancer 2010; 10: 428.
  Article PubMed PubMed Central Google Scholar
• Xie F, Ye L, Chen J, Wu N, Zhang Z, Yang Y et al. The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance. J Transl Med 2011; 9: 95.
  Article PubMed PubMed Central Google Scholar
• Nixdorf S, Grimm MO, Loberg R, Marreiros A, Russell PJ, Pienta KJ et al. Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines. Cancer Lett 2004; 215: 209–220.
  Article CAS PubMed Google Scholar
• Ma S, Guan XY, Lee TK, Chan KW . Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma. Hum Pathol 2007; 38: 1201–1206.
  Article CAS PubMed Google Scholar
• Wang D, Xu MR, Wang T, Li T, Zhu J . MTSS1 overexpression correlates with poor prognosis in colorectal cancer. J Gastrointest Surg 2011; 15: 1205–1212.
  Article PubMed Google Scholar
• Bompard G, Sharp SJ, Freiss G, Machesky LM . Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. J Cell Sci 2005; 118: 5393–5403.
  Article CAS PubMed Google Scholar
• Du P, Ye L, Ruge F, Yang Y, Jiang WG . Metastasis suppressor-1, MTSS1, acts as a putative tumour suppressor in human bladder cancer. Anticancer Res 2011; 31: 3205–3212.
  CAS PubMed Google Scholar
• Xie F, Ye L, Ta M, Zhang L, Jiang WG . MTSS1: a multifunctional protein and its role in cancer invasion and metastasis. Front Biosci 2011; 3: 621–631.
  Article Google Scholar
• Aslakson CJ, Miller FR . Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 1992; 52: 1399–1405.
  CAS PubMed Google Scholar
• Lu X, Bennet B, Mu E, Rabinowitz J, Kang Y . Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model. J Biol Chem 2010; 285: 9317–9321.
  Article CAS PubMed PubMed Central Google Scholar
• Strickland LB, Dawson PJ, Santner SJ, Miller FR . Progression of premalignant MCF10AT generates heterogeneous malignant variants with characteristic histologic types and immunohistochemical markers. Breast Cancer Res Treat 2000; 64: 235–240.
  Article CAS PubMed Google Scholar
• Santner SJ, Dawson PJ, Tait L, Soule HD, Eliason J, Mohamed AN et al. Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells. Breast Cancer Res Treat 2001; 65: 101–110.
  Article CAS PubMed Google Scholar
• Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordon-Cardo C et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003; 3: 537–549.
  Article CAS PubMed Google Scholar
• Friedman RC, Farh KK, Burge CB, Bartel DP . Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19: 92–105.
  Article CAS PubMed PubMed Central Google Scholar
• Krek A, Grun D, Poy MN, Wolf R, Rosenberg L, Epstein EJ et al. Combinatorial microRNA target predictions. Nat Genet 2005; 37: 495–500.
  Article CAS PubMed Google Scholar
• Hicks DG, Yoder BJ, Short S, Tarr S, Prescott N, Crowe JP et al. Loss of breast cancer metastasis suppressor 1 protein expression predicts reduced disease-free survival in subsets of breast cancer patients. Clin Cancer Res 2006; 12: 6702–6708.
  Article CAS PubMed PubMed Central Google Scholar
• Acharya PS, Majumdar S, Jacob M, Hayden J, Mrass P, Weninger W et al. Fibroblast migration is mediated by CD44-dependent TGF beta activation. J Cell Sci 2008; 121: 1393–1402.
  Article CAS PubMed Google Scholar
• Sahai E, Marshall CJ . RHO-GTPases and cancer. Nat Rev Cancer 2002; 2: 133–142.
  Article PubMed Google Scholar
• Li H, Kloosterman W, Fekete DM . MicroRNA-183 family members regulate sensorineural fates in the inner ear. J Neurosci 2010; 30: 3254–3263.
  Article CAS PubMed PubMed Central Google Scholar
• Gokhale A, Kunder R, Goel A, Sarin R, Moiyadi A, Shenoy A et al. Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway. J Cancer Res Ther 2010; 6: 521–529.
  Article CAS PubMed Google Scholar
• Hall A . The cytoskeleton and cancer. Cancer Metastasis Rev 2009; 28: 5–14.
  Article PubMed Google Scholar
• Ebert MS, Neilson JR, Sharp PA . MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 2007; 4: 721–726.
  Article CAS PubMed Google Scholar
• Rajnicek AM, Foubister LE, McCaig CD . Temporally and spatially coordinated roles for Rho, Rac, Cdc42 and their effectors in growth cone guidance by a physiological electric field. J Cell Sci 2006; 119: 1723–1735.
  Article CAS PubMed Google Scholar
• Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F et al. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009; 15: 9–20.
  Article CAS PubMed PubMed Central Google Scholar
• Sethi N, Dai X, Winter CG, Kang Y . Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 2011; 19: 192–205.
  Article CAS PubMed PubMed Central Google Scholar