Release of Adenine Nucleotide from Nerve Axons (original) (raw)

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• Published: 05 December 1964

Nature volume 204, pages 1000–1001 (1964)Cite this article

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Abstract

RECENT experiments have shown that adenine nucleotides antagonize the neural effects of calcium deficiency1 and procaine2. These findings suggest that adenine nucleotides play some part in normal axon physiology and, specifically, a nucleotide-protein complex in the excitable membrane of the axon has been postulated1,3. Nerve stimulation and certain alterations of the ionic environment may affect axon function by causing dissociation of this complex and, consequently, an increased rate of nucleotide release. In this communication we present evidence in support of this hypothesis.

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References

1. Okamoto, M., Askari, A., and Kuperman, A. S., J. Pharmacol., 144, 229 (1964).
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2. Kuperman, A. S., Okamoto, M., Beyer, A., and Volpert, W. A., Science, 144, 1222 (1964).
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3. Abood, L. G., Koketsu, K., and Miyamoto, S., Amer. J. Physiol., 20, 469 (1962).
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4. Koketsu, K., and Miyamoto, S., Nature, 189, 402 (1961).
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Authors and Affiliations

1. Department of Pharmacology, Cornell University Medical College, New York City
   ALBERT S. KUPERMAN, WILLIAM A. VOLPERT & MICHIKO OKAMOTO

Authors

1. ALBERT S. KUPERMAN
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2. WILLIAM A. VOLPERT
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3. MICHIKO OKAMOTO
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KUPERMAN, A., VOLPERT, W. & OKAMOTO, M. Release of Adenine Nucleotide from Nerve Axons.Nature 204, 1000–1001 (1964). https://doi.org/10.1038/2041000a0

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• Issue Date: 05 December 1964
• DOI: https://doi.org/10.1038/2041000a0

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