de Onis, M. & Habicht, J.P. Anthropometric reference data for international use: recommendations from a World Health Organisation Expert Committee. Am. J. Clin. Nutr.64, 650– 658 (1996). ArticleCAS Google Scholar
Comuzzie, A.G. et al. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nature Genet. 15, 273–276 (1997). ArticleCAS Google Scholar
Norman, R.A. et al. Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am. J. Hum. Genet. 62, 659–668 (1998). ArticleCAS Google Scholar
Krude, K. et al. Severe early onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genet.19, 155–157 (1998). ArticleCAS Google Scholar
Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature372, 425– 434 (1994). ArticleCAS Google Scholar
Chen, H. et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell84, 491–495 (1996). ArticleCAS Google Scholar
Naggert, J.K. et al. Hyperproinsulinemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nature Genet.10, 153–142 (1995). Article Google Scholar
Noben-Trauth, K., Naggert, J.K., North, M.A. & Nishina, P.M. A candidate gene for the mouse mutation tubby. Nature380, 534–538 (1996). ArticleCAS Google Scholar
Klebig, M.L., Wilkinson, J.E., Geisler, J.G. & Woychik, R.P. Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes and yellow fur. Proc. Natl Acad. Sci. USA92, 4728–4732 (1995). ArticleCAS Google Scholar
Montague, C.T. et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature387, 903–908 (1997). ArticleCAS Google Scholar
Clement, K. et al. Mutation in the human leptin receptor causes obesity and pituitary dysfunction. Nature392, 398– 401 (1998). ArticleCAS Google Scholar
Clement, K. et al. Indication for linkage of the human OB gene region with extreme obesity. Diabetes45, 687– 690 (1996). ArticleCAS Google Scholar
Reed, D.R. et al. Extreme obesity may be linked to markers flanking the human OB gene. Diabetes45, 691– 694 (1996). ArticleCAS Google Scholar
Norman, R.A., Bogardus, C. & Ravussin, E. Linkage between obesity and a marker near the tumour necrosis factor-* locus in Pima Indians. J. Clin. Invest.96, 158–162 (1995). ArticleCAS Google Scholar
Considine, R.V. et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J. Clin. Invest. 95, 2986–2988 (1995). ArticleCAS Google Scholar
Francke, S. et al. Genetic studies of the leptin receptor gene in morbidly obese French Caucasian families. Hum. Genet.100, 491–496 (1997). ArticleCAS Google Scholar
Norman, R.A. et al. Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians. Diabetes45, 1229–1232 (1996). ArticleCAS Google Scholar
Chagnon, Y.C., Perusse, L. & Bouchard, C. The human obesity gene map: the 1997 update. Obes. Res. 6, 76–92 (1998). ArticleCAS Google Scholar
Lander, E. & Kuglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet.11, 241–247 (1995). ArticleCAS Google Scholar
Meunier, F., Philippi, A., Martinez, M. & Demenais, F. Affected sib-pair tests for linkage: Type 1 errors with dependent sib-pairs. Genet. Epidemiol.14, 1107– 1111 (1997). ArticleCAS Google Scholar
Tiret, L. et al. Segregation analysis of height-adjusted weight with generation- and age-dependent effects: the Nancy Family Study. Genet. Epidemiol.9, 389–403 (1992). ArticleCAS Google Scholar
Considine, R.V. et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Eng. J. Med. 334, 292–295 (1996). ArticleCAS Google Scholar
O'Connell, J.R. & Weeks, D.E. The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recording and fuzzy inheritance. Nature Genet.11, 402–408 (1995). ArticleCAS Google Scholar
Kruglyak, L. & Lander, E.S. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am. J. Hum. Genet.57, 439–454 (1995). CASPubMedPubMed Central Google Scholar
Tran, L.D., Elston, R.C., Keats, B.J.B. & Wilson, A.F. Sib-pair linkage program (SIBPAL). in S.A.G.E. Statistical Analysis for Genetic Epidemiology, Release 2.2 (Louisiana State University, New Orleans, 1994).
Haseman, J.K. & Elston, R.C. The investigation of linkage between a quantitative trait and a marker locus. Behav. Genet.2, 3–19 (1972). ArticleCAS Google Scholar