Linkage disequilibrium in the human genome (original) (raw)
Sachidanandam, R. et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature409, 928–933 (2001). ArticleADSCAS Google Scholar
Kruglyak, L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nature Genet.22, 139–144 (1999). ArticleCAS Google Scholar
Dunning, A. M. et al. The extent of linkage disequilibrium in four populations with distinct demographic histories. Am. J. Hum. Genet.67, 1544–1554 (2000). ArticleCAS Google Scholar
Abecasis, G. R. et al. Extent and distribution of linkage disequilibrium in three genomic regions. Am. J. Hum. Genet.68, 191–197 (2001). ArticleCAS Google Scholar
Taillon-Miller, P. et al. Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28. Nature Genet.25, 324–328 (2000). ArticleCAS Google Scholar
Collins, A., Lonjou, C. & Morton, N. E. Genetic epidemiology of single-nucleotide polymorphisms. Proc. Natl Acad. Sci. USA96, 15173–15177 (1999). ArticleADSCAS Google Scholar
Goddard, K. A. B., Hopkins, P. J., Hall, J. M. & Witte, J. S. Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations. Am. J. Hum. Genet.66, 216–234 (2000). ArticleCAS Google Scholar
Watterson, G. A. & Guess, H. A. Is the most frequent allele the oldest? Theor. Pop. Biol.11, 141–160 (1977). ArticleCAS Google Scholar
Lander, E. S. The new genomics: global views of biology. Science274, 536–539 (1996). ArticleADSCAS Google Scholar
Schneider, S., Kueffler, J. M., Roessli, D. & Excoffier, L. Arlequin (ver. 2.0): A software for population genetic data analysis (Genetics and Biometry Laboratory, Univ. Geneva, Switzerland, 2000).
Lewontin, R. C. On measures of gametic disequilibrium. Genetics120, 849–852 (1988). CAS Google Scholar
Jorde, L. B. Linkage disequilibrium and the search for complex disease genes. Genome Res.10, 1435–1444 (2000). ArticleCAS Google Scholar
Hudson, R. R. in Oxford Surveys in Evolutionary Biology (eds Futuyma, D. J. & Antonovics, J.) 1–44 (Oxford Univ. Press, Oxford, 1990). Google Scholar
Clark, A. G. et al. Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. Am. J. Hum. Genet.63, 595–612 (1998). ArticleCAS Google Scholar
Hartl, D. L. & Clark, A. G. Principles of Population Genetics (Sinauer, Massachusetts, 1997). Google Scholar
Chakraborty, R. & Weiss, K. M. Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci. Proc. Natl Acad. Sci. USA85, 9119–9123 (1988). ArticleADSCAS Google Scholar
Eaves, I. A. et al. The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes. Nature Genet.25, 320–322 (2000). ArticleCAS Google Scholar
Goldstein, D. B., Ruiz Linares, A., Cavalli-Sforza, L. L. & Feldman, M. W. Genetic absolute dating based on microsatellites and the origin of modern humans. Proc. Natl Acad. Sci. USA92, 6723–6727 (1995). ArticleADSCAS Google Scholar
Tishkoff, S. A. et al. Global patterns of linkage disequilibrium at the CD4 locus and modern human origins. Science271, 1380–1387 (1996). ArticleADSCAS Google Scholar
Tishkoff, S. A. et al. Short tandem-repeat polymorphism/Alu haplotype variation at the PLAT locus: Implications for modern human origins. Am. J. Hum. Genet.67, 901–925 (2000). ArticleCAS Google Scholar
Kidd, J. R. et al. Haplotypes and linkage disequilibrium at the phenylalanine hydroxylase locus, PAH, in a global representation of populations. Am. J. Hum. Genet.66, 1882–1899 (2000). ArticleCAS Google Scholar
Mateu, E. et al. Worldwide genetic analysis of the CFTR region. Am. J. Hum. Genet.68, 103–117 (2001). ArticleCAS Google Scholar
Housley, R. A., Gamble, C. S., Street, M. & Pettitt, P. Radiocarbon evidence for the Late glacial human recolonisation of northern Europe. Proc. Prehist. Soc.63, 25–54 (1994). Article Google Scholar
Richards, M. et al. Tracing European founder lineages in the Near Eastern mtDNA pool. Am. J. Hum. Genet.67, 1251–1276 (2000). ArticleCAS Google Scholar
Reich, D. E. & Goldstein, D. B. Genetic evidence for a Paleolithic human population expansion in Africa. Proc. Natl Acad. Sci. USA95, 8119–8123 (1998). ArticleADSCAS Google Scholar
Ingman, M., Kaessmann, H., Pääbo, S. & Gyllensten, U. Mitochondrial genome variation and the origin of modern humans. Nature408, 708–713 (2000). ArticleADSCAS Google Scholar
Altshuler, D., Daly, M. & Kruglyak, L. Guilt by association. Nature Genet.26, 135–137 (2000). ArticleCAS Google Scholar
Cargill, M. et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nature Genet.22, 231–238 (1999). ArticleCAS Google Scholar
Nickerson, D. B., Tobe, V. O. & Taylor, S. L. PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based sequencing. Nucleic Acids Res.25, 2745–2751 (1997). ArticleCAS Google Scholar
Ross, P., Hall, L., Smirnov, I. & Haff, L. High level multiplex genotyping by MALDI-TOF mass spectroscopy. Nature Biotech.16, 1347–1351 (1998). ArticleCAS Google Scholar
Chen, X., Levine, L. & Kwok, P. Y. Fluorescence polarization in homogenous nucleic acid analysis. Genome Res.9, 492–498 (1999). CAS Google Scholar
Lindblad-Toh, K. et al. Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nature Genet.24, 381–386 (2000). ArticleCAS Google Scholar
Excoffier, L. & Slatkin, M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol. Biol. Evol.12, 921–927 (1995). CAS Google Scholar
Broman, K. W., Murray, J. C., Sheffield, V. C., White, R. L. & Weber, J. L. Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am. J. Hum. Genet.63, 861–689 (1998). ArticleCAS Google Scholar
Lander, E. S. et al. Initial sequencing and analysis of the human genome. Nature409, 860–921.