- van Leeuwen, J. E. & Samelson, L. E. T cell antigen-receptor signal transduction. Curr. Opin. Immunol. 11, 242–248 (1999).
Article Google Scholar
- Braun, J., Sha'afi, R. I. & Unanue, E. R. Crosslinking by ligands to surface immunoglobulin triggers mobilization of intracellular 45Ca2+ in B lymphocytes. J. Cell Biol. 82, 755–766 (1979).
Article CAS Google Scholar
- Hoth, M. & Penner, R. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 355, 353–356 (1992).
Article CAS Google Scholar
- Turner, H. & Kinet, J. P. Signalling through the high-affinity IgE receptor Fc epsilonRI. Nature 402, 24–30 (1999).
Article Google Scholar
- Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C. & Healy, J. I. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 386, 855–858 (1997).
Article CAS Google Scholar
- Teague, T. K. et al. Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc. Natl Acad. Sci. USA 96, 12691–12696 (1999).
Article CAS Google Scholar
- Berridge, M. J. Inositol trisphosphate and calcium signalling. Nature 361, 315–325 (1993).
Article CAS Google Scholar
- Putney, J. W., Jr. A model for receptor-regulated calcium entry. Cell Calcium 7, 1–12 (1986).
Article CAS Google Scholar
- Clapham, D. E. Intracellular calcium. Replenishing the stores. Nature 375, 634–635 (1995).
Article CAS Google Scholar
- Parekh, A. B. & Penner, R. Store depletion and calcium influx. Physiol. Rev. 77, 901–930 (1997).
Article CAS Google Scholar
- Putney, J. W. & Ribeiro, C. M. P. Signaling pathways between the plasma membrane and endoplasmic reticulum calcium stores. Cell Mol. Life Sci. 57, 1272–1286 (2000).
Article CAS Google Scholar
- Putney, J. W. “Kissin' cousins”: intimate plasma membrane-ER interactions underlie capacitative calcium entry. Cell 99, 5–8 (1999).
Article CAS Google Scholar
- Okamura, H. & Rao, A. Transcriptional regulation in lymphocytes. Curr. Opin. Cell. Biol., in press (2001).
- Crabtree, G. R. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. Cell 96, 611–614 (1999).
Article CAS Google Scholar
- Kiani, A., Rao, A. & Aramburu, J. Manipulating immune responses with immunosuppressive agents that target NFAT. Immunity 12, 359–372 (2000).
Article CAS Google Scholar
- Timmerman, L. A., Clipstone, N. A., Ho, S. N., Northrop, J. P. & Crabtree, G. R. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature 383, 837–840 (1996).
Article CAS Google Scholar
- Loh, C. et al. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J. Biol. Chem. 271, 10884–10891 (1996).
Article CAS Google Scholar
- Dolmetsch, R. E., Xu, K. & Lewis, R. S. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392, 933–936 (1998).
Article CAS Google Scholar
- Li, W., Llopis, J., Whitney, M., Zlokarnik, G. & Tsien, R. Y. Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature 392, 936–941 (1998).
Article CAS Google Scholar
- Feske, S. et al. Severe combined immunodeficiency due to defective binding of the nuclear factor of activated T cells in T lymphocytes of two male siblings. Eur. J. Immunol. 26, 2119–2126 (1996).
Article CAS Google Scholar
- Feske, S., Draeger, R., Peter, H. H., Eichmann, K. & Rao, A. The duration of nuclear residence of NFAT determines the pattern of cytokine expression in human SCID T Cells. J. Immunol. 165, 297–305 (2000).
Article CAS Google Scholar
- Feske, S., Draeger, R., Peter, H. H. & Rao, A. Impaired NFAT regulation and its role in a severe combined immunodeficiency. Immunobiology 202, 134–151 (2000).
Article CAS Google Scholar
- Hofer, A. M., Fasolato, C. & Pozzan, T. Capacitative Ca2+ entry is closely linked to the filling state of internal Ca2+ stores: a study using simultaneous measurements of ICRAC and intraluminal [Ca2+]. J. Cell Biol. 140, 325–334 (1998).
Article CAS Google Scholar
- Thastrup, O., Cullen, P. J., Drobak, B. K., Hanley, M. R. & Dawson, A. P. Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. Proc. Natl Acad. Sci. USA 87, 2466–2470 (1990).
Article CAS Google Scholar
- Gonzalez, J. E. & Tsien, R. Y. Improved indicators of cell membrane potential that use fluorescence resonance energy transfer. Chem. Biol. 4, 269–277 (1997).
Article CAS Google Scholar
- Gonzalez, J. E. & Tsien, R. Y. Voltage sensing by fluorescence resonance energy transfer in single cells. Biophys. J. 69, 1272–1280 (1995).
Article CAS Google Scholar
- DeRisi, J. L. & Iyer, V. R. Genomics and array technology. Curr. Opin. Oncol. 11, 76–79 (1999).
Article CAS Google Scholar
- Alizadeh, A. A. et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, 503–511 (2000).
Article CAS Google Scholar
- Rogge, L. et al. Transcript imaging of the development of human T helper cells using oligonucleotide arrays. Nature Genet. 25, 96–101 (2000).
Article CAS Google Scholar
- Alizadeh, A. et al. The Lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes. Cold Spring Harb. Symp. Quant. Biol. 64, 71–78 (1999).
Article CAS Google Scholar
- Schlesier, M. et al. Primary severe immunodeficiency due to impaired signal transduction in T cells. Immunodeficiency 4, 133–136 (1993).
CAS PubMed Google Scholar
- Montell, C. New light on Trp and Trpl. Mol. Pharmacol. 52, 755–763 (1997).
Article CAS Google Scholar
- Putney, J. W. & McKay, R. R. Capacitative calcium entry channels. Bioessays 21, 38–46 (1999).
Article Google Scholar
- Ma, H. T.et al. Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels. Science 287, 1647–1651 (2000).
Article CAS Google Scholar
- Boulay, C. et al. Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry. Proc. Natl Acad. Sci. USA 96, 14955–14960 (1999).
Article CAS Google Scholar
- Kiselyov, K., Mignery, G. A., Zhu, M. X. & Muallem, S. The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels. Mol. Cell 4, 423–429 (1999).
Article CAS Google Scholar
- Partiseti, M. et al. The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency. J. Biol. Chem. 269, 32327–32335 (1994).
CAS PubMed Google Scholar
- Le Deist, F. et al. A primary T-cell immunodeficiency associated with defective transmembrane calcium influx. Blood 85, 1053–1062 (1995).
CAS PubMed Google Scholar
- Fanger, C. M., Hoth, M., Crabtree, G. R. & Lewis, R. S. Characterization of T cell mutants with defects in capacitative calcium entry. Genetic evidence for the physiological roles of crac channels. J. Cell Biol. 131, 655–667 (1995).
Article CAS Google Scholar
- Serafini, A. T. et al. Isolation of mutant T lymphocytes with defects in capacitative calcium entry. Immunity 3, 239–250 (1995).
Article CAS Google Scholar
- Rao, A., Luo, C. & Hogan, P. G. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15, 707–747 (1997).
Article CAS Google Scholar
- Aramburu, J., Rao, A. & Klee, C. B. Calcineurin: from structure to function. Curr. Top. Cell Regul. 36, 237–295 (2000).
Article CAS Google Scholar
- Tokumitsu, H., Enslen, H. & Soderling, T. R. Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase. J. Biol. Chem. 270, 19320–19324 (1995).
Article CAS Google Scholar
- Carrion, A. M., Link, W. A., Ledo, F., Mellstrom, B. & Naranjo, J. R. DREAM is a Ca2+-regulated transcriptional repressor. Nature 398, 80–84 (1999).
Article CAS Google Scholar
- McKinsey, T. A., Zhang, C. L., Lu, J. R. & Olson, E. N. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408, 106–111 (2000).
Article CAS Google Scholar
- Youn, H. D., Grozinger, C. M. & Liu, J. O. Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4. J. Biol. Chem. 275, 22563–22567 (2000).
Article CAS Google Scholar
- Youn, H. D., Sun, L., Prywes, R. & Liu, J. O. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Science 286, 790–793 (1999).
Article CAS Google Scholar
- Wang, D. Z., McCaffrey, P. G. & Rao, A. The cyclosporin-sensitive transcription factor NFATp is expressed in several classes of cells in the immune system. Ann. NY Acad. Sci. 766, 182–194 (1995).
Article CAS Google Scholar
- Grynkiewicz, G., Poenie, M. & Tsien, R. Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440–3450 (1985).
CAS Google Scholar
- Chuvpilo, S. et al. Alternative polyadenylation events contribute to the induction of NF- ATc in effector T cells. Immunity 10, 261–269 (1999).
Article CAS Google Scholar