Growth factors regulate the survival and fate of cells derived from human neurospheres (original) (raw)

• Gage, F.H. Mammalian neural stem cells. Science 287, 443–448 (2000).
  Article Google Scholar
• McKay, R.D.G. Stem cells in the central nervous system. Science 276, 66–71 (1997).
  Article CAS Google Scholar
• Reynolds, B.A. & Weiss, S. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev. Biol. 175, 1–13 (1996).
  Article CAS Google Scholar
• Svendsen, C.N. & Caldwell, M.A. Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation. Prog. Brain Res. 127, 13–24 (2000).
  Article CAS Google Scholar
• Flax, J.D. et al. Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign antigens. Nat. Biotechnol. 16, 1033–1039 (1998).
  Article CAS Google Scholar
• Quinn, S.M. et al. Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord. J. Neurosci. Res. 57, 590–602 (1999).
  Article CAS Google Scholar
• Svendsen, C.N. et al. Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Exp. Neurol. 137, 376–388 (1996).
  Article CAS Google Scholar
• Svendsen, C.N. et al. A new method for the rapid and long term growth of human neural precursor cells. J. Neurosci. Methods 85, 141–152 (1998).
  Article CAS Google Scholar
• Carpenter, M.K. et al. In vitro expansion of a multipotent population of human neural progenitor cells. Exp. Neurol. 158, 265–278 (1999).
  Article CAS Google Scholar
• Vescovi, A.L. et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Exp. Neurol. 156, 71–83 (1999).
  Article CAS Google Scholar
• Svendsen, C.N. et al. Restricted growth potential of rat neural precursors as compared to mouse. Dev. Brain Res. 99, 253–258 (1997).
  Article CAS Google Scholar
• Ostenfeld, T. et al. Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation. Exp. Neurol. 164, 215–226 (2000).
  Article CAS Google Scholar
• Hefti, F. Pharmacology of neurotrophic factors. Annu. Rev. Pharmacol. Toxicol. 37, 239–267 (1997).
  Article CAS Google Scholar
• Ip, N.Y. et al. Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal culture. J. Neurosci. 11, 3124–3134 (2000).
  Article Google Scholar
• Johe, K.K. et al. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Devel. 10, 3129–3140 (1996).
  Article CAS Google Scholar
• Yeh, H.J. et al. PDGF A-chain gene is expressed by mammalian neurons during development and in maturity. Cell 64, 209–216 (1991).
  Article CAS Google Scholar
• Williams, B.P. et al. A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells. Neuron 18, 553–562 (1997).
  Article CAS Google Scholar
• Greene, L.A. & Kaplan, D.R. Early events in neurotrophin signalling via Trk and p75 receptors. Curr. Opin. Neurobiol. 5, 579–587 (1995).
  Article CAS Google Scholar
• Dudek, H. et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661–665 (1997).
  Article CAS Google Scholar
• Piper, D.R. et al. Immunocytochemical and physiological characterization of a population of cultured human neural precursors. J. Neurophysiol. 84, 534–548 (2000).
  Article CAS Google Scholar
• Kornack, D.R. & Rakic, P. Radial and horizontal deployment of clonally related cells in the primate neocortex: relationship to distinct mitotic lineages. Neuron 15, 311–321 (1995).
  Article CAS Google Scholar
• Emerich, D.F. et al. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioural deficits and striatal degeneration in a rodent model of Huntington's disease. J. Neurosci. 16, 5168–5181 (1996).
  Article CAS Google Scholar
• Larkfors, L. Lindsay, R.M. & Alderson, R.F. Characterization of the responses of Purkinje cells to neurotrophin treatment. J. Neurochem. 66, 1362–1373 (1996).
  Article CAS Google Scholar
• Galli, R. et al. Regulation of neuronal differentiation in human CNS stem cell progeny by leukemia inhibitory factor. Dev. Neurosci. 22, 86–95 (2000).
  Article CAS Google Scholar
• Bonni, A. et al. Regulation of gliogenesis in the central nervous system by JAK/STAT signalling pathway. Science 278, 477–483 (1997).
  Article CAS Google Scholar
• Lindvall, O. Neural transplantation: a hope for patients with Parkinson's disease. NeuroReport 8, iii–x (1997).
  Article CAS Google Scholar
• Freed, C.R. et al. Transplantaion of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 344, 710–719 (2001)
  Article CAS Google Scholar
• Studer, L., Tabar, V. & McKay, R.D.G. Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Nat. Neurosci. 1, 290–295 (1998).
  Article CAS Google Scholar
• Wagner, J. et al. Induction of midbrain dopaminergic phenotype in _Nurr_1-overexpressing neural stem cells by type1 astrocytes. Nat. Biotechnol. 17, 653–659 (1999).
  Article CAS Google Scholar
• Sakurada, K. et al. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development 126, 4017–4026 (1999).
  CAS PubMed Google Scholar
• Ling, Z.-D. et al. Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines. Exp. Neurol. 149, 411–423 (1997).
  Article Google Scholar
• Bjorklund, A. & Lindvall, O. Self-repair in the brain. Nature 405, 892–895 (2000).
  Article CAS Google Scholar
• Ciesielski-Treska, J. et al. Chromogranin A induces a neurotoxic phenotype in brain microglial cells. J. Biol Chem. 273, 14339–14346 (1998).
  Article CAS Google Scholar