Antigen decoding by T lymphocytes: from synapses to fate determination (original) (raw)

• Dustin, M. L. & Cooper, J. A. The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nature Immunol. 1, 23–29 (2000).
  Article CAS Google Scholar
• Bromley, S. K. et al. The immunological synapse. Annu. Rev. Immunol. 19, 375–396 (2001).
  Article CAS PubMed Google Scholar
• Valitutti, S., Dessing, M., Aktories, K., Gallati, H. & Lanzavecchia, A. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181, 577–584 (1995).
  Article CAS PubMed Google Scholar
• Beeson, C. et al. Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface. J. Exp. Med. 184, 777–782 (1996).
  Article CAS PubMed Google Scholar
• Hudrisier, D. et al. The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement. J. Immunol. 161, 553–562 (1998).
  CAS PubMed Google Scholar
• Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221–227 (1999).
  Article CAS PubMed Google Scholar
• Valitutti, S., Muller, S., Cella, M., Padovan, E. & Lanzavecchia, A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148–151 (1995).
  Article CAS PubMed Google Scholar
• Valitutti, S., Muller, S., Dessing, M. & Lanzavecchia, A. Signal extinction and T cell repolarization in T helper cell-antigen-presenting cell conjugates. Eur. J. Immunol. 26, 2012–2016 (1996).
  Article CAS PubMed Google Scholar
• Valitutti, S. & Lanzavecchia, A. Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol. Today 18, 299–304 (1997).
  Article CAS PubMed Google Scholar
• Viola, A. & Lanzavecchia, A. T cell activation determined by T cell receptor number and tunable thresholds. Science 273, 104–106 (1996).
  Article CAS PubMed Google Scholar
• Weber, S., Traunecker, A., Oliveri, F., Gerhard, W. & Karjalainen, K. Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor. Nature 356, 793–796 (1992).
  Article CAS PubMed Google Scholar
• Davis, M. M. et al. Ligand recognition by αß T cell receptors. Annu. Rev. Immunol. 16, 523–544 (1998).
  Article CAS PubMed Google Scholar
• Itoh, Y., Hemmer, B., Martin, R. & Germain, R. N. Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events. J. Immunol. 162, 2073–2080 (1999).
  CAS PubMed Google Scholar
• Kalergis, A. M. et al. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nature Immunol. 2, 229–234 (2001).
  Article CAS Google Scholar
• Viola, A. et al. Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering. J. Exp. Med. 186, 1775–1779 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Madrenas, J., Chau, L. A., Smith, J., Bluestone, J. A. & Germain, R. N. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185, 219–229 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Chau, L. A., Bluestone, J. A. & Madrenas, J. Dissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor. J. Exp. Med. 187, 1699–1709 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Kupfer, A. & Singer, S. J. Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. Annu. Rev. Immunol. 7, 309–337 (1989).
  Article CAS PubMed Google Scholar
• Monks, C. R., Freiberg, B. A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82–86 (1998).
  Article CAS PubMed Google Scholar
• Reichert, P., Reinhardt, R. L., Ingulli, E. & Jenkins, M. K. Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells. J. Immunol. 166, 4278–4281 (2001).
  Article CAS PubMed Google Scholar
• Johnson, K. G., Bromley, S. K., Dustin, M. L. & Thomas, M. L. A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. Proc. Natl Acad. Sci. USA 97, 10138–10143 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Leupin, O., Zaru, R., Laroche, T., Muller, S. & Valitutti, S. Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes. Curr. Biol. 10, 277–280 (2000).
  Article CAS PubMed Google Scholar
• Davis, S. J. & van der Merwe, P. A. The structure and ligand interactions of CD2: implications for T-cell function. Immunol. Today 17, 177–187 (1996).
  Article CAS PubMed Google Scholar
• Shaw, A. S. & Dustin, M. L. Making the T cell receptor go the distance: a topological view of T cell activation. Immunity 6, 361–369 (1997).
  Article CAS PubMed Google Scholar
• Wild, M. K. et al. Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex. J. Exp. Med. 190, 31–41 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Wulfing, C. & Davis, M. M. A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 282, 2266–2269 (1998).
  Article CAS PubMed Google Scholar
• Viola, A., Schroeder, S., Sakakibara, Y. & Lanzavecchia, A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283, 680–682 (1999).
  Article CAS PubMed Google Scholar
• Rozelle, A. L. et al. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr. Biol. 10, 311–320 (2000).
  Article CAS PubMed Google Scholar
• Sykulev, Y., Joo, M., Vturina, I., Tsomides, T. J. & Eisen, H. N. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 4, 565–571 (1996).
  Article CAS PubMed Google Scholar
• Delon, J. et al. CD8 expression allows T cell signaling by monomeric peptide-MHC complexes. Immunity 9, 467–473 (1998).
  Article CAS PubMed Google Scholar
• Lanzavecchia, A., Iezzi, G. & Viola, A. From TCR engagement to T cell activation: a kinetic view of T cell behavior. Cell 96, 1–4 (1999).
  Article CAS PubMed Google Scholar
• Arcaro, A. et al. Essential role of CD8 palmitoylation in CD8 coreceptor function. J Immunol 165, 2068–2076 (2000).
  Article CAS PubMed Google Scholar
• Xavier, R., Brennan, T., Li, Q., McCormack, C. & Seed, B. Membrane compartmentation is required for efficient T cell activation. Immunity 8, 723–732 (1998).
  Article CAS PubMed Google Scholar
• Montixi, C. et al. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J. 17, 5334–5348 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Janes, P. W., Ley, S. C. & Magee, A. I. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol. 147, 447–461 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Delon, J. & Germain, R. N. Information transfer at the immunological synapse. Curr. Biol. 10, 923–933 (2000).
  Article Google Scholar
• Krummel, M. F., Sjaastad, M. D., Wulfing, C. & Davis, M. M. Differential clustering of CD4 and CD3ζ during T cell recognition. Science 289, 1349–1352 (2000).
  Article CAS PubMed Google Scholar
• Krangel, M. S. Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation. J. Exp. Med. 165, 1141–1159 (1987).
  Article CAS PubMed Google Scholar
• Minami, Y., Samelson, L. E. & Klausner, R. D. Internalization and cycling of the T cell antigen receptor. Role of protein kinase C. J. Biol. Chem. 262, 13342–13347 (1987).
  CAS PubMed Google Scholar
• Dietrich, J. et al. Molecular characterization of the di-leucine-based internalization motif of the T cell receptor. J. Biol. Chem. 271, 11441–11448 (1996).
  Article CAS PubMed Google Scholar
• Salio, M., Valitutti, S. & Lanzavecchia, A. Agonist-induced T cell receptor down-regulation: molecular requirements and dissociation from T cell activation. Eur. J. Immunol. 27, 1769–1773 (1997).
  Article CAS PubMed Google Scholar
• Valitutti, S., Muller, S., Salio, M. & Lanzavecchia, A. Degradation of T cell receptor (TCR)-CD3-ζ complexes after antigenic stimulation. J. Exp. Med. 185, 1859–1864 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Cenciarelli, C. et al. Activation-induced ubiquitination of the T cell antigen receptor. Science 257, 795–797 (1992).
  Article CAS PubMed Google Scholar
• Lupher, M. L., Rao, N., Eck, M. J. & Band, H. The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction. Immunol. Today 20, 375–382 (1999).
  Article CAS PubMed Google Scholar
• Chiang, Y. J. et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403, 216–220 (2000).
  Article CAS PubMed Google Scholar
• Bachmaier, K. et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403, 211–216 (2000).
  Article CAS PubMed Google Scholar
• D'Oro, U., Vacchio, M. S., Weissman, A. M. & Ashwell, J. D. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity 7, 619–628 (1997).
  Article CAS PubMed Google Scholar
• Penna, D. et al. Degradation of ZAP-70 following antigenic stimulation in human T lymphocytes: role of calpain proteolytic pathway. J. Immunol. 163, 50–56 (1999).
  CAS PubMed Google Scholar
• Liu, H., Rhodes, M., Wiest, D. L. & Vignali, D. A. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity 13, 665–675 (2000).
  Article CAS PubMed Google Scholar
• Iezzi, G., Karjalainen, K. & Lanzavecchia, A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8, 89–95 (1998).
  Article CAS PubMed Google Scholar
• Viola, A., Linkert, S. & Lanzavecchia, A. A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low-affinity ligands, but does not affect triggering by high-affinity anti-CD3 antibodies. Eur. J. Immunol. 27, 3080–3083 (1997).
  Article CAS PubMed Google Scholar
• Bachmann, M. F. et al. Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation. Eur. J. Immunol. 27, 2195–2203 (1997).
  Article CAS PubMed Google Scholar
• Preckel, T., Grimm, R., Marin, S. & Weltzien, H. U. Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptors. J. Exp. Med. 185, 1803–1813 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Huang, J. F. et al. TCR-Mediated internalization of peptide-MHC complexes acquired by T cells. Science 286, 952–954 (1999).
  Article CAS PubMed Google Scholar
• Hwang, I. et al. T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells. J. Exp. Med. 191, 1137–1148 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R. P. & Samelson, L. E. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92, 83–92 (1998).
  Article CAS PubMed Google Scholar
• Tuosto, L. & Acuto, O. CD28 affects the earliest signaling events generated by TCR engagement. Eur. J. Immunol. 28, 2131–2142 (1998).
  Article CAS PubMed Google Scholar
• Cai, Z. et al. Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells. J. Exp. Med. 185, 641–651 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Bachmann, M. F. et al. Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells. J. Exp. Med. 189, 1521–1530 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Tuosto, L. et al. Organization of plasma membrane functional rafts upon T cell activation. Eur. J. Immunol. 31, 345–349 (2001).
  Article CAS PubMed Google Scholar
• Schwartz, R. H. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71, 1065–1068 (1992).
  Article CAS PubMed Google Scholar
• Boise, L. H. et al. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity 3, 87–98 (1995).
  Article CAS PubMed Google Scholar
• Kundig, T. M. et al. Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity 5, 41–52 (1996).
  Article CAS PubMed Google Scholar
• Cantrell, D. A. & Smith, K. A. The interleukin-2 T-cell system: a new cell growth model. Science 224, 1312–1316 (1984).
  Article CAS PubMed Google Scholar
• Weiss, A., Shields, R., Newton, M., Manger, B. & Imboden, J. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. J. Immunol. 138, 2169–2176 (1987).
  CAS PubMed Google Scholar
• Crabtree, G. R. Contingent genetic regulatory events in T lymphocyte activation. Science 243, 355–361 (1989).
  Article CAS PubMed Google Scholar
• Zhao, K. et al. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell 95, 625–636 (1998).
  Article CAS PubMed Google Scholar
• van Stipdonk, M. J., Lemmens, E. E. & Schoenberger, S. P. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nature Immunol. 2, 423–429 (2001).
  Article CAS Google Scholar
• Gett, A. V. & Hodgkin, P. D. A cellular calculus for signal integration by T cells. Nature Immunol. 1, 239–244 (2000).
  Article CAS Google Scholar
• Lipsky, P. E. & Rosenthal, A. S. Macrophage-lymphocyte interaction. II. Antigen-mediated physical interactions between immune guinea pig lymph node lymphocytes and syngeneic macrophages. J. Exp. Med. 141, 138–154 (1975).
  Article CAS PubMed Google Scholar
• Inaba, K. & Steinman, R. M. Accessory cell-T lymphocyte interactions. Antigen-dependent and -independent clustering. J. Exp. Med. 163, 247–261 (1986).
  Article CAS PubMed Google Scholar
• Gunzer, M. et al. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13, 323–332 (2000).
  Article CAS PubMed Google Scholar
• Friedl, P. & Gunzer, M. Interaction of T cells with APCs: the serial encounter model. Trends Immunol. 22, 187–191 (2001).
  Article CAS PubMed Google Scholar
• Gretz, J. E., Anderson, A. O. & Shaw, S. Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex. Immunol. Rev. 156, 11–24 (1997).
  Article CAS PubMed Google Scholar
• Seder, R. A. & Paul, W. E. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 12, 635–673 (1994).
  Article CAS PubMed Google Scholar
• Abbas, A. K., Murphy, K. M. & Sher, A. Functional diversity of helper T lymphocytes. Nature 383, 787–793 (1996).
  Article CAS PubMed Google Scholar
• O'Garra, A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8, 275–283 (1998).
  Article CAS PubMed Google Scholar
• Sallusto, F., Mackay, C. R. & Lanzavecchia, A. The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol. 18, 593–620 (2000).
  Article CAS PubMed Google Scholar
• Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708–712 (1999).
  Article CAS PubMed Google Scholar
• Lanzavecchia, A. & Sallusto, F. Dynamics of T lymphocyte responses: intermediates, effectors and memory cells. Science 290, 92–97 (2000).
  Article CAS PubMed Google Scholar
• Langenkamp, A., Messi, M., Lanzavecchia, A. & Sallusto, F. Kinetics of dendritic cell activation: impact on priming of Th1, Th2 and nonpolarized T cells. Nature Immunol. 1, 311–316 (2000).
  Article CAS Google Scholar
• Iezzi, G., Scheidegger, D. & Lanzavecchia, A. Migration and function of antigen-primed nonpolarized T lymphocytes in vivo. J. Exp. Med. 193, 987–994 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T. & Jenkins, M. K. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410, 101–105 (2001).
  Article CAS PubMed Google Scholar
• Manjunath, N. et al. A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo. Proc. Natl Acad. Sci. USA 96, 13932–13937 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Masopust, D., Vezys, V., Marzo, A. L. & Lefrancois, L. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291, 2413–2417 (2001).
  Article CAS PubMed Google Scholar
• Champagne, P. et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 410, 106–111 (2001).
  Article CAS PubMed Google Scholar
• Mercado, R. et al. Early programming of T cell populations responding to bacterial infection. J. Immunol. 165, 6833–6839 (2000).
  Article CAS PubMed Google Scholar
• Kaech, S. M. & Ahmed, R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nature Immunol. 2, 415–422 (2001).
  Article CAS Google Scholar
• Ahmed, R. & Gray, D. Immunological memory and protective immunity: understanding their relation. Science 272, 54–60 (1996).
  Article CAS PubMed Google Scholar
• Sad, S. & Mosmann, T. R. Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype. J. Immunol. 153, 3514–3522 (1994).
  CAS PubMed Google Scholar
• Kurts, C., Kosaka, H., Carbone, F. R., Miller, J. F. & Heath, W. R. Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J. Exp. Med. 186, 239–245 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Morgan, D. J., Kreuwel, H. T. & Sherman, L. A. Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens. J. Immunol. 163, 723–727 (1999).
  CAS PubMed Google Scholar
• Boring, L. et al. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 100, 2552–2561 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Yoneyama, H. et al. Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease. J. Exp. Med. 193, 35–49 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Forster, R. et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99, 23–33 (1999).
  Article CAS PubMed Google Scholar
• Randolph, G. J., Inaba, K., Robbiani, D. F., Steinman, R. M. & Muller, W. A. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 11, 753–761 (1999).
  Article CAS PubMed Google Scholar
• Ingulli, E., Mondino, A., Khoruts, A. & Jenkins, M. K. In vivo detection of dendritic cell antigen presentation to CD4(+) T cells. J. Exp. Med. 185, 2133–2141 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Ruedl, C., Koebel, P., Bachmann, M., Hess, M. & Karjalainen, K. Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes. J. Immunol. 165, 4910–4916 (2000).
  Article CAS PubMed Google Scholar
• Kamath, A. T. et al. The development, maturation, and turnover rate of mouse spleen dendritic cell populations. J. Immunol. 165, 6762–6770 (2000).
  Article CAS PubMed Google Scholar
• Grufman, P., Wolpert, E. Z., Sandberg, J. K. & Karre, K. T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens. Eur. J. Immunol. 29, 2197–2204 (1999).
  Article CAS PubMed Google Scholar
• Kedl, R. M. et al. T cells compete for access to antigen-bearing antigen-presenting cells. J. Exp. Med. 192, 1105–1113 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Smith, A. L., Wikstrom, M. E. & Fazekas de St Groth, B. Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency. Immunity 13, 783–794 (2000).
  Article CAS PubMed Google Scholar
• Chen, W., Anton, L. C., Bennink, J. R. & Yewdell, J. W. Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses. Immunity 12, 83–93 (2000).
  Article CAS PubMed Google Scholar
• Tang, H. L. & Cyster, J. G. Chemokine up-regulation and activated T cell attraction by maturing dendritic cells. Science 284, 819–822 (1999).
  Article CAS PubMed Google Scholar
• Sallusto, F. et al. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur. J. Immunol. 29, 1617–1625 (1999).
  Article CAS PubMed Google Scholar
• McHeyzer-Williams, M. G. & Davis, M. M. Antigen-specific development of primary and memory T cells in vivo. Science 268, 106–111 (1995).
  Article CAS PubMed Google Scholar
• Moskophidis, D., Lechner, F., Pircher, H. & Zinkernagel, R. M. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362, 758–761 (1993).
  Article CAS PubMed Google Scholar