Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors (original) (raw)
Bhat NM, Bieber MM, Chapman CJ, Stevenson FK, Teng NN . Human antilipid A monoclonal antibodies bind to human B cells and the i antigen on cord red blood cells. J Immunol 1993; 151: 5011–5021. CASPubMed Google Scholar
Spellerberg MB, Chapman CJ, Mockridge CI, Isenberg DA, Stevenson FK . Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: a possible link between infection and lupus. Hum Antibodies Hybridomas 1995; 6: 52–56. ArticleCASPubMed Google Scholar
Li Y-C, Spellerberg MB, Stevenson FK, Capra JD, Potter KN . The I binding specificity of human IGHV4-34 (VH4.21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3. J Mol Biol 1996; 256: 577–589. ArticleCASPubMed Google Scholar
Thomas MD, Clough K, Melamed MD, Stevenson FK, Chapman CJ, Spellerberg MB et al. A human monoclonal antibody encoded by the V4-34 gene segment recognises melanoma-associated ganglioside via CDR3 and FWR1. Hum Antibodies 1999; 9: 95–106. ArticleCASPubMed Google Scholar
Potter KN, Hobby P, Klijn S, Stevenson FK, Sutton BJ . Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen. J Immunol 2002; 169: 3777–3782. ArticleCASPubMed Google Scholar
Silberstein LE, George A, Durdik JM, Kipps TJ . The V4-34 encoded anti-i autoantibodies recognize a large subset of human and mouse B-cells. Blood Cells Mol Dis 1996; 22: 126–138. ArticleCASPubMed Google Scholar
Pugh-Bernard AE, Silverman GJ, Cappione AJ, Villano ME, Ryan DH, Insel RA et al. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J Clin Invest 2001; 108: 1061–1070. ArticleCASPubMedPubMed Central Google Scholar
van Vollenhoven RF, Bieber MM, Powell MJ, Gupta PK, Bhat NM, Richards KL et al. VH4-34 encoded antibodies in systemic lupus erythematosus: a specific diagnostic marker that correlates with clinical disease characteristics. J Rheumatol 1999; 26: 1727–1733. CASPubMed Google Scholar
Cappione AJ, Pugh-Bernard AE, Anolik JH, Sanz I . Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes. J Immunol 2004; 172: 4298–4307. ArticleCASPubMed Google Scholar
Mockridge CI, Rahman A, Buchan S, Hamblin T, Isenberg DA, Stevenson FK et al. Common patterns of B cell perturbation and expanded V4-34 immunoglobulin gene usage in autoimmunity and infection. Autoimmunity 2004; 37: 9–15. ArticlePubMed Google Scholar
Bhat NM, Bieber MM, Yang YC, Leu YS, van Vollenhoven RF, Teng NN . B cell lymphoproliferative disorders and IGHV4-34 gene encoded antibodies. Hum Antibodies 2004; 13: 63–68. ArticleCASPubMed Google Scholar
Loomes LM, Uemura K, Childs RA, Paulson JC, Rogers GN, Scudder PR et al. Erythrocyte receptors for Mycoplasma pneumoniae are sialylated oligosaccharides of Ii antigen type. Nature 1984; 307: 560–563. ArticleCASPubMed Google Scholar
Chapman C, Spellerberg M, Hamblin T, Stevenson F . Pattern of usage of the VH4-21 gene by B lymphocytesin a patient with EBV infection indicates ongoing mutation and class switching. Ann N Y Acad Sci 1995; 764: 195–197. ArticleCASPubMed Google Scholar
Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, Allen SL et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998; 102: 1515–1525. CASPubMedPubMed Central Google Scholar
Ghia P, Stamatopoulos K, Belessi C, Moreno C, Stella S, Guida S et al. Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood 2005; 105: 1678–1685. ArticleCASPubMed Google Scholar
Widhopf II GF, Kipps TJ . Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells. J Immunol 2001; 166: 95–102. ArticleCASPubMed Google Scholar
Tobin G, Thunberg U, Johnson A, Eriksson I, Söderberg O, Karlsson K et al. Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood 2003; 15: 4952–4957. Article Google Scholar
Ghiotto F, Fais F, Valetto A, Albesiano E, Hashimoto S, Dono M et al. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest 2004; 113: 1008–1016. ArticleCASPubMedPubMed Central Google Scholar
Widhopf II GF, Rassenti LZ, Toy TL, Gribben JG, Wierda WG, Kipps TJ . Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 2004; 104: 2499–2504. ArticlePubMed Google Scholar
Messmer BT, Albesiano E, Efremov DG, Ghiotto F, Allen SL, Kolitz J et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med 2004; 200: 519–525. CASPubMedPubMed Central Google Scholar
Tobin G, Thunberg U, Karlsson K, Murray F, Laurell A, Willander K et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 2004; 104: 2879–2885. ArticleCASPubMed Google Scholar
Stamatopoulos K, Belessi C, Moreno C, Boudjograh M, Guida G, Smilevska T et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 2007; 109: 259–270. ArticleCASPubMed Google Scholar
Thorselius M, Krober A, Murray F, Thunberg U, Tobin G, Bühler A et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-utilizing chronic lymphocytic leukemia independent of geographical origin and mutational status. Blood 2006; 107: 2889–2894. ArticleCASPubMed Google Scholar
Murray F, Darzentas N, Hadzidimitriou A, Tobin G, Boudjogra M, Scielzo C et al. Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 2008; 111: 1524–1533. ArticleCASPubMed Google Scholar
Landgren O, Gridley G, Check D, Caporaso NE, Morris Brown L . Acquired immune-related and inflammatory conditions and subsequent chronic lymphocytic leukaemia. Br J Haematol 2007; 139: 791–798. ArticlePubMed Google Scholar
Landgren O, Rapkin JS, Caporaso NE, Mellemkjaer L, Gridley G, Goldin LR et al. Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia. Blood 2007; 109: 2198–2201. ArticleCASPubMedPubMed Central Google Scholar
Hatzi K, Catera R, Ferrarini M, Fischetti V, Herve M, Meffre E et al. B-cell chronic lymphocytic leukemia (B-CLL) cells express antibodies reactive with antigenic epitopes expressed on the surface of common bacteria. Blood 2006; 108: 25. Google Scholar
Lanemo Myhrinder A, Hellqvist E, Sidorova E, Söderberg A, Baxendale H, Dahle C et al. A new perspective: molecular motifs on oxidized-LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood 2008; 111: 3838–3848. ArticlePubMed Google Scholar
Hallek M, Cheson B, Catovsky D, Caligaris-Cappio F, Dighiero G, Dohner H et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008; 111: 5446–5456. ArticleCASPubMedPubMed Central Google Scholar
Lefranc MP, Giudicelli V, Kaas Q, Duprat E, Chastellan P, Coelho I et al. IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res 2005; 33: D593–D597. ArticleCASPubMed Google Scholar
Giudicelli V, Chaume D, Lefranc MP . IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis. Nucleic Acids Res 2004; 32: W435–W440. ArticleCASPubMedPubMed Central Google Scholar
Ghia P, Stamatopoulos K, Belessi C, Moreno C, Stilgenbauer S, Stevenson F et al. European Research Initiative on CLL. ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia. Leukemia 2007; 21: 1–3. ArticleCASPubMed Google Scholar
Espy MJ, Uhl JR, Sloan LM, Buckwalter SP, Jones MF, Vetter EA et al. Real-time PCR in clinical microbiology: applications for routine laboratory testing. Clin Microbiol Rev 2006; 19: 165–256. ArticleCASPubMedPubMed Central Google Scholar
Hudnall SD, Chen T, Allison P, Tyring SK, Heath A . Herpesvirus prevalence and viral load in healthy blood donors by quantitative real-time polymerase chain reaction. Transfusion 2008; 48: 1180–1187. ArticlePubMed Google Scholar
Ghia P, Guida G, Stella S, Gottardi D, Geuna M, Strola G et al. The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood 2003; 101: 1262–1269. ArticleCASPubMed Google Scholar
Athanasiadou A, Stamatopoulos K, Gaitatzi M, Stavroyianni N, Fassas A, Anagnostopoulos A . Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins. Haematologica 2008; 93: 473–474. ArticlePubMed Google Scholar
Pascual V, Victor K, Spellerberg M, Hamblin TJ, Stevenson FK, Capra JD . VH restriction among human cold agglutinins: the VH4-21 gene segment is required to encode anti-I and anti-i specificities. J Immunol 1992; 149: 2337–2344. CASPubMed Google Scholar
McClain T, Harley JB, James JA . The role of Epstein–Barr virus in systemic lupus erythematosus. Front Biosci 2001; 6: 137–147. Article Google Scholar
Poole BD, Scofield RH, Harley JB, James JA . Epstein–Barr virus and molecular mimicry in systemic lupus erythematosus. Autoimmunity 2006; 39: 63–70. ArticleCASPubMed Google Scholar
Bhat NM, Bieber MM, Spellerberg MB, Stevenson FK, Teng NN . Recognition of auto- and exoantigens by V4-34 gene encoded antibodies. Scand J Immunol 2000; 51: 134–140. ArticleCASPubMed Google Scholar
Milner EC, Anolik J, Cappione A, Sanz I . Human innate B cells: a link between host defense and autoimmunity? Springer Semin Immunopathol 2005; 26: 433–452. ArticleCASPubMedPubMed Central Google Scholar
Chaganti S, Ma CS, Bell AI, Croom-Carter D, Hislop AD, Tangye SG et al. Epstein–Barr virus persistence in the absence of conventional memory B cells: IgM+IgD+CD27+ B cells harbor the virus in X-linked lymphoproliferative disease patients. Blood 2008; 112: 672–679. ArticleCASPubMed Google Scholar
Krishnan MR, Jou NT, Marion TN . Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies. J Immunol 1996; 157: 2430–2439. CASPubMed Google Scholar
Jang YJ, Stollar BD . Anti-DNA antibodies: aspects of structure and pathogenicity. Cell Mol Life Sci 2003; 60: 309–320. ArticleCASPubMed Google Scholar
Li Y, Li H, Ni D, Weigert M . Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. J Exp Med 2002; 196: 1543–1552. ArticleCASPubMedPubMed Central Google Scholar
Li H, Jiang Y, Prak EL, Radic M, Weigert M . Editors and editing of anti-DNA receptors. Immunity 2001; 15: 947–957. ArticleCASPubMed Google Scholar
Olsen LR, Dessen A, Gupta D, Sabesan S, Sacchettini JC, Brewer CF . X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin. Biochemistry 1997; 36: 15073–15080. ArticleCASPubMed Google Scholar
Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002; 169: 1984–1992. ArticleCASPubMed Google Scholar
Nascimbeni M, Shin EC, Chiriboga L, Kleiner DE, Rehermann B . Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions. Blood 2004; 104: 478–486. ArticleCASPubMed Google Scholar