Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I (original) (raw)

References

  1. Ingham, P. W. & McMahon, A. P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15, 3059–3087 (2001)
    Article CAS Google Scholar
  2. Briscoe, J. & Ericson, J. The specification of neuronal identity by graded Sonic Hedgehog signalling. Semin. Cell Dev. Biol. 10, 353–362 (1999)
    Article CAS Google Scholar
  3. Strigini, M. & Cohen, S. M. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124, 4697–4705 (1997)
    CAS PubMed Google Scholar
  4. Vervoort, M., Crozatier, M., Valle, D. & Vincent, A. The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing. Curr. Biol. 9, 632–639 (1999)
    Article CAS Google Scholar
  5. Jiang, J. & Struhl, G. Protein kinase A and Hedgehog signalling in Drosophila limb development. Cell 80, 563–572 (1995)
    Article CAS Google Scholar
  6. Li, W., Ohlmeyer, J. T., Lane, M. E. & Kalderon, D. Function of protein kinase A in hedghehog signal transduction and Drosophila imaginal disc development. Cell 80, 553–562 (1995)
    Article CAS Google Scholar
  7. Pan, D. & Rubin, G. M. cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543–552 (1995)
    Article CAS Google Scholar
  8. Lepage, T., Cohen, S. M., Diaz-Benjumea, F. J. & Parkhurst, S. M. Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373, 711–715 (1995)
    Article ADS CAS Google Scholar
  9. Wang, G., Wang, B. & Jiang, J. Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev. 13, 2828–2837 (1999)
    Article CAS Google Scholar
  10. Price, M. A. & Kalderon, D. Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. Development 126, 4331–4339 (1999)
    CAS PubMed Google Scholar
  11. Jia, J. et al. Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416, 548–552 (2002)
    Article ADS CAS Google Scholar
  12. Price, M. A. & Kalderon, D. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell 108, 823–835 (2002)
    Article CAS Google Scholar
  13. Jiang, J. Degrading Ci: who is Cul-pable? Genes Dev. 16, 2315–2321 (2002)
    Article CAS Google Scholar
  14. Ohlmeyer, J. T. & Kalderon, D. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396, 749–753 (1998)
    Article ADS CAS Google Scholar
  15. Denef, N., Neubuser, D., Perez, L. & Cohen, S. M. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102, 521–531 (2000)
    Article CAS Google Scholar
  16. Ohlmeyer, J. T. & Kalderon, D. Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 11, 2250–2258 (1997)
    Article CAS Google Scholar
  17. Kalderon, D. & Rubin, G. M. Isolation and characterization of Drosophila cAMP-dependent protein kinase genes. Genes Dev. 2, 1539–1556 (1988)
    Article CAS Google Scholar
  18. Alcedo, J., Ayzenzon, M., von Ohlen, T., Noll, M. & Hooper, J. E. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell 86, 221–232 (1996)
    Article CAS Google Scholar
  19. van-den-Heuval, M. & Ingham, P. W. smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382, 547–551 (1996)
    Article ADS Google Scholar
  20. Kemp, B. E. & Pearson, R. B. Protein kinase recognition sequence motifs. Trends Biochem. Sci. 15, 342–346 (1990)
    Article CAS Google Scholar
  21. Umphress, J. L., Tuazon, P. T., Chen, C. J. & Traugh, J. A. Determinants on simian virus 40 large T antigen are important for recognition and phosphorylation by casein kinase I. Eur. J. Biochem. 203, 239–243 (1992)
    Article CAS Google Scholar
  22. Chijiwa, T. et al. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, _N_-[2-(_p_-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J. Biol. Chem. 265, 5267–5272 (1990)
    CAS PubMed Google Scholar
  23. Chijiwa, T., Hagiwara, M. & Hidaka, H. A newly synthesized selective casein kinase I inhibitor, _N_-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis. J. Biol. Chem. 264, 4924–4927 (1989)
    CAS PubMed Google Scholar
  24. Lum, L. et al. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299, 2039–2045 (2003)
    Article ADS CAS Google Scholar
  25. Kennerdell, J. R. & Carthew, R. W. Heritable gene silencing in Drosophila using double-stranded RNA. Nature Biotechnol. 18, 896–898 (2000)
    Article CAS Google Scholar
  26. Zhu, A. J., Zheng, L., Suyama, K. & Scott, M. P. Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev. 17, 1240–1252 (2003)
    Article CAS Google Scholar
  27. Calleja, M., Moreno, E., Pelaz, S. & Morata, G. Visualization of gene expression in living adult Drosophila. Science 274, 252–255 (1996)
    Article ADS CAS Google Scholar
  28. Jia, J., Tong, C. & Jiang, J. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its carboxyl-terminal tail. Genes Dev. 17, 2709–2720 (2003)
    Article CAS Google Scholar
  29. Motzny, C. K. & Holmgren, R. The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev. 52, 137–150 (1995)
    Article CAS Google Scholar
  30. Lum, L. et al. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol. Cell 12, 1261–1274 (2003)
    Article CAS Google Scholar

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