Nuclear reprogramming and pluripotency (original) (raw)
Gurdon, J. B. & Byrne, J. A. The first half-century of nuclear transplantation. Proc. Natl Acad. Sci. USA100, 8048–8052 (2003). ADSCASPubMedPubMed Central Google Scholar
Wakayama, T., Perry, A. C., Zuccotti, M., Johnson, K. R. & Yanagimachi, R. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature394, 369–374 (1998). ADSCASPubMed Google Scholar
Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J. & Campbell, K. H. Viable offspring derived from fetal and adult mammalian cells. Nature385, 810–813 (1997). ArticleADSCASPubMed Google Scholar
Hochedlinger, K. et al. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev.18, 1875–1885 (2004). CASPubMedPubMed Central Google Scholar
Hochedlinger, K. & Jaenisch, R. Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature415, 1035–1038 (2002). ADSCASPubMed Google Scholar
Eggan, K. et al. Mice cloned from olfactory sensory neurons. Nature428, 44–49 (2004). ADSCASPubMed Google Scholar
Li, L., Connelly, M. C., Wetmore, C., Curran, T. & Morgan, J. I. Mouse embryos cloned from brain tumors. Cancer Res.63, 2733–2736 (2003). CASPubMed Google Scholar
Li, J., Ishii, T., Feinstein, P. & Mombaerts, P. Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Nature428, 393–399 (2004). ADSCASPubMed Google Scholar
Rideout, W. M., Hochedlinger, K., Kyba, M., Daley, G. Q. & Jaenisch, R. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell109, 17–27 (2002). CASPubMed Google Scholar
Tamashiro, K. L. et al. Cloned mice have an obese phenotype not transmitted to their offspring. Nature Med.8, 262–267 (2002). CASPubMed Google Scholar
Ogonuki, N. et al. Early death of mice cloned from somatic cells. Nature Genet.30, 253–254 (2002). CASPubMed Google Scholar
Briggs, R. & King, T. J. Changes in the nuclei of differentiating endoderm cells as revealed by nuclear transplantation. J. Morphol.100, 269–311 (1957). Google Scholar
Cheong, H. T., Takahashi, Y. & Kanagawa, H. Birth of mice after transplantation of early cell-cycle-stage embryonic nuclei into enucleated oocytes. Biol. Reprod.48, 958–963 (1993). CASPubMed Google Scholar
Hiiragi, T. & Solter, D. Reprogramming is essential in nuclear transfer. Mol. Reprod. Dev.70, 417–421 (2005). CASPubMed Google Scholar
Eggan, K. et al. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc. Natl Acad. Sci. USA98, 6209–6214 (2001). ADSCASPubMedPubMed Central Google Scholar
Rideout, W. M. et al. Generation of mice from wild-type and targeted ES cells by nuclear cloning. Nature Genet.24, 109–110 (2000). CASPubMed Google Scholar
Wakayama, T. & Yanagimachi, R. Cloning of male mice from adult tail-tip cells. Nature Genet.22, 127–128 (1999). CASPubMed Google Scholar
Ogura, A. et al. Production of male cloned mice from fresh, cultured, and cryopreserved immature Sertoli cells. Biol. Reprod.62, 1579–1584 (2000). CASPubMed Google Scholar
Inoue, K. et al. Generation of cloned mice by direct nuclear transfer from natural killer T cells. Curr. Biol.15, 1114–1118 (2005). CASPubMed Google Scholar
Blelloch, R. et al. Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells published online 18 May 2006 (doi:10.1634/stemcells.2006-0050).
Inoue, K. et al. Inefficient reprogramming of the haematopoietic stem cell genome following nuclear transfer. J. Cell Sci.119, 1985–1991 (2006). CASPubMed Google Scholar
Ng, R. K. & Gurdon, J. B. Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proc. Natl Acad. Sci. USA102, 1957–1962 (2005). ADSCASPubMedPubMed Central Google Scholar
Kohda, T. et al. Variation in gene expression and aberrantly regulated chromosome regions in cloned mice. Biol. Reprod.73, 1302–1311 (2005). CASPubMed Google Scholar
Humpherys, D. et al. Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc. Natl Acad. Sci. USA99, 12889–12894 (2002). ADSCASPubMedPubMed Central Google Scholar
Jaenisch, R. Human cloning — the science and ethics of nuclear transplantation. N. Engl. J. Med.351, 2787–2791 (2004). CASPubMed Google Scholar
Munsie, M. J. et al. Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei. Curr. Biol.10, 989–992 (2000). CASPubMed Google Scholar
Brambrink, T., Hochedlinger, K., Bell, G. & Jaenisch, R. ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. Proc. Natl Acad. Sci. USA103, 933–938 (2006). ADSCASPubMedPubMed Central Google Scholar
Cibelli, J. B. et al. Somatic cell nuclear transfer in humans: pronuclear and early embryonic development. J. Regen. Med.2, 25–31 (2001). Google Scholar
Chen, Y. et al. Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes. Cell Res.13, 251–263 (2003). ADSPubMed Google Scholar
Dey, R., Barrientos, A. & Moraes, C. T. Functional constraints of nuclear–mitochondrial DNA interactions in xenomitochondrial rodent cell lines. J. Biol. Chem.275, 31520–31527 (2000). CASPubMed Google Scholar
Simerly, C. et al. Molecular correlates of primate nuclear transfer failures. Science300, 297 (2003). PubMed Google Scholar
Simerly, C. et al. Embryogenesis and blastocyst development after somatic cell nuclear transfer in nonhuman primates: overcoming defects caused by meiotic spindle extraction. Dev. Biol.276, 237–252 (2004). CASPubMed Google Scholar
Meng, L., Ely, J. J., Stouffer, R. L. & Wolf, D. P. Rhesus monkeys produced by nuclear transfer. Biol. Reprod.57, 454–459 (1997). CASPubMed Google Scholar
Blau, H. M. & Blakely, B. T. Plasticity of cell fate: insights from heterokaryons. Semin. Cell Dev. Biol.10, 267–272 (1999). CASPubMed Google Scholar
Miller, R. A. & Ruddle, F. H. Pluripotent teratocarcinoma–thymus somatic cell hybrids. Cell9, 45–55 (1976). CASPubMed Google Scholar
Tada, M. et al. Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells. Dev. Dyn.227, 504–510 (2003). CASPubMed Google Scholar
Tada, M., Tada, T., Lefebvre, L., Barton, S. C. & Surani, M. A. Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells. EMBO J.16, 6510–6520 (1997). CASPubMedPubMed Central Google Scholar
Tada, M., Takahama, Y., Abe, K., Nakatsuji, N. & Tada, T. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr. Biol.11, 1553–1558 (2001). CASPubMed Google Scholar
Cowan, C. A., Atienza, J., Melton, D. A. & Eggan, K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science309, 1369–1373 (2005). ADSCASPubMed Google Scholar
Yu, J., Vodyanik, M. A., He, P., Slukvin, I. I. & Thomson, J. A. Human embryonic stem cells reprogram myeloid precursors following cell–cell fusion. Stem Cells24, 168–176 (2005). PubMed Google Scholar
Rousset, J. P., Bucchini, D. & Jami, J. Hybrids between F9 nullipotent teratocarcinoma and thymus cells produce multidifferentiated tumors in mice. Dev. Biol.96, 331–336 (1983). CASPubMed Google Scholar
Oshima, R. G., McKerrow, J. & Cox, D. Murine embryonal carcinoma hybrids: decreased ability to spontaneously differentiate as a dominant trait. J. Cell Physiol.109, 195–204 (1981). CASPubMed Google Scholar
Do, J. T. & Scholer, H. R. Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells22, 941–949 (2004). CASPubMed Google Scholar
Byrne, J. A., Simonsson, S., Western, P. S. & Gurdon, J. B. Nuclei of adult mammalian somatic cells are directly reprogrammed to oct-4 stem cell gene expression by amphibian oocytes. Curr. Biol.13, 1206–1213 (2003). CASPubMed Google Scholar
Simonsson, S. & Gurdon, J. DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nature Cell Biol.6, 984–990 (2004). CASPubMed Google Scholar
Kikyo, N., Wade, P. A., Guschin, D., Ge, H. & Wolffe, A. P. Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI. Science289, 2360–2362 (2000). ADSCASPubMed Google Scholar
Hansis, C., Barreto, G., Maltry, N. & Niehrs, C. Nuclear reprogramming of human somatic cells by Xenopus egg extract requires BRG1. Curr. Biol.14, 1475–1480 (2004). CASPubMed Google Scholar
Lemaitre, J. M., Danis, E., Pasero, P., Vassetzky, Y. & Mechali, M. Mitotic remodeling of the replicon and chromosome structure. Cell123, 787–801 (2005). CASPubMed Google Scholar
Gurdon, J. The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. J. Embryol. Exp. Morphol.10, 622–640 (1962). CASPubMed Google Scholar
Taranger, C. K. et al. Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. Mol. Biol. Cell16, 5719–5735 (2005). CASPubMedPubMed Central Google Scholar
Hakelien, A. M., Landsverk, H. B., Robl, J. M., Skalhegg, B. S. & Collas, P. Reprogramming fibroblasts to express T-cell functions using cell extracts. Nature Biotechnol.20, 460–466 (2002). CAS Google Scholar
Raff, M. Adult stem cell plasticity: fact or artifact? Annu. Rev. Cell Dev. Biol.19, 1–22 (2003). CASPubMed Google Scholar
Andrews, P. W. From teratocarcinomas to embryonic stem cells. Phil. Trans. R. Soc. Lond. B357, 405–417 (2002). Google Scholar
Evans, M. J. & Kaufman, M. H. Establishment in culture of pluripotential cells from mouse embryos. Nature292, 154–156 (1981). ADSCASPubMed Google Scholar
Martin, G. R. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl Acad. Sci. USA78, 7634–7638 (1981). ADSCASPubMedPubMed Central Google Scholar
Matsui, Y., Zsebo, K. & Hogan, B. L. Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. Cell70, 841–847 (1992). CASPubMed Google Scholar
Resnick, J. L., Bixler, L. S., Cheng, L. & Donovan, P. J. Long-term proliferation of mouse primordial germ cells in culture. Nature359, 550–551 (1992). ADSCASPubMed Google Scholar
Labosky, P. A., Barlow, D. P. & Hogan, B. L. Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. Development120, 3197–3204 (1994). CASPubMed Google Scholar
Tada, T. et al. Epigenotype switching of imprintable loci in embryonic germ cells. Dev. Genes Evol.207, 551–561 (1998). CASPubMed Google Scholar
Rossant, J. & McBurney, M. W. The developmental potential of a euploid male teratocarcinoma cell line after blastocyst injection. J. Embryol. Exp. Morphol.70, 99–112 (1982). CASPubMed Google Scholar
Stewart, C. L., Gadi, I. & Bhatt, H. Stem cells from primordial germ cells can reenter the germ line. Dev. Biol.161, 626–628 (1994). CASPubMed Google Scholar
Stewart, T. A. & Mintz, B. Recurrent germ-line transmission of the teratocarcinoma genome from the METT-1 culture line to progeny in vivo. J. Exp. Zool.224, 465–469 (1982). CASPubMed Google Scholar
Durcova-Hills, G., Adams, I. R., Barton, S. C., Surani, M. A. & McLaren, A. The role of exogenous FGF-2 on the reprogramming of primordial germ cells into pluripotent stem cells. Stem Cells (in the press).
Niwa, H., Miyazaki, J. & Smith, A. G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genet.24, 372–376 (2000). CASPubMed Google Scholar
Chung, Y. et al. Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres. Nature439, 216–219 (2005). ADSPubMed Google Scholar
Kanatsu-Shinohara, M. et al. Generation of pluripotent stem cells from neonatal mouse testis. Cell119, 1001–1012 (2004). CASPubMed Google Scholar
Guan, K. et al. Pluripotency of spermatogonial stem cells from adult mouse testis. Nature440, 1199–1203 (2006). ADSCASPubMed Google Scholar
Zwaka, T. P. & Thomson, J. A. A germ cell origin of embryonic stem cells? Development132, 227–233 (2005). CASPubMed Google Scholar
Jiang, Y. et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature418, 41–49 (2002). ADSCASPubMed Google Scholar
Kogler, G. et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J. Exp. Med.200, 123–135 (2004). PubMedPubMed Central Google Scholar
Snow, M. H. L. Gastrulation in the mouse: growth and regionalization of the epiblast. J. Embryol. Exp. Morphol.42, 293–303 (1977). Google Scholar
Yamazaki, Y. et al. Adult mice cloned from migrating primordial germ cells. Proc. Natl Acad. Sci. USA102, 11361–11366 (2005). ADSCASPubMedPubMed Central Google Scholar
Hajkova, P. et al. Epigenetic reprogramming in mouse primordial germ cells. Mech. Dev.117, 15–23 (2002). CASPubMed Google Scholar
Lee, J. et al. Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells. Development129, 1807–1817 (2002). CASPubMed Google Scholar
Hernandez, L., Kozlov, S., Piras, G. & Stewart, C. L. Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formation. Proc. Natl Acad. Sci. USA100, 13344–13349 (2003). ADSCASPubMedPubMed Central Google Scholar
Holm, T. M. et al. Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell8, 275–285 (2005). CASPubMed Google Scholar
Chambers, I. & Smith, A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene23, 7150–7160 (2004). CASPubMed Google Scholar
Li, X., Kato, Y. & Tsunoda, Y. Comparative analysis of development-related gene expression in mouse preimplantation embryos with different developmental potential. Mol. Reprod. Dev.72, 152–160 (2005). CASPubMed Google Scholar
Bortvin, A. et al. Incomplete reactivation of _Oct4_-related genes in mouse embryos cloned from somatic nuclei. Development130, 1673–1680 (2003). CASPubMed Google Scholar
Boiani, M., Eckardt, S., Scholer, H. R. & McLaughlin, K. J. Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev.16, 1209–1219 (2002). CASPubMedPubMed Central Google Scholar
Boyer, L. A. et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell122, 947–956 (2005). CASPubMedPubMed Central Google Scholar
Loh, Y. H. et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nature Genet.38, 431–440 (2006). CASPubMed Google Scholar
Ringrose, L. & Paro, R. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu. Rev. Genet.38, 413–443 (2004). CASPubMed Google Scholar
Lee, T. I. et al. Control of developmental regulators by polycomb in human embryonic stem cells. Cell125, 301–313 (2006). CASPubMedPubMed Central Google Scholar
Boyer, L. A. et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature441, 349–353 (2006). ADSCASPubMed Google Scholar
Bernstein, B. E. et al. Epigenetic landscape in embryonic stem cells. Cell125, 315–326 (2006). CASPubMed Google Scholar
Xie, H., Ye, M., Feng, R. & Graf, T. Stepwise reprogramming of B cells into macrophages. Cell117, 663–676 (2004). CASPubMed Google Scholar
Nutt, S. L., Heavey, B., Rolink, A. G. & Busslinger, M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature401, 556–562 (1999). ADSCASPubMed Google Scholar
Baba, Y., Garrett, K. P. & Kincade, P. W. Constitutively active β-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors. Immunity23, 599–609 (2005). CASPubMedPubMed Central Google Scholar
Kondo, T. & Raff, M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science289, 1754–1757 (2000). ADSCASPubMed Google Scholar
Bachoo, R. M. et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell1, 269–277 (2002). CASPubMed Google Scholar
Hochedlinger, K., Yamada, Y., Beard, C. & Jaenisch, R. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell121, 465–477 (2005). CASPubMed Google Scholar
Chambers, I. et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell113, 643–655 (2003). CASPubMed Google Scholar
Li, E., Bestor, T. H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell69, 915–926 (1992). CASPubMed Google Scholar
Wakayama, S. et al. Establishment of male and female nuclear transfer embryonic stem cell lines from different mouse strains and tissues. Biol. Reprod.72, 932–936 (2005). CASPubMed Google Scholar
Hubner, K. et al. Derivation of oocytes from mouse embryonic stem cells. Science300, 1251–1256 (2003). ADSPubMed Google Scholar
Lacham-Kaplan, O., Chy, H. & Trounson, A. Testicular cell conditioned medium supports differentiation of embryonic stem cells into ovarian structures containing oocytes. Stem Cells24, 266–273 (2006). PubMed Google Scholar