DNA repair is limiting for haematopoietic stem cells during ageing (original) (raw)

• Weissman, I. L. Stem cells: units of development, units of regeneration, and units in evolution. Cell 100, 157–168 (2000)
  Article CAS Google Scholar
• Park, Y. & Gerson, S. L. DNA repair defects in stem cell function and aging. Annu. Rev. Med. 56, 495–508 (2005)
  Article CAS Google Scholar
• Wang, Y., Schulte, B. A., LaRue, A. C., Ogawa, M. & Zhou, D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood 107, 358–366 (2006)
  Article CAS Google Scholar
• Khanna, K. K. & Jackson, S. P. DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genet. 27, 247–254 (2001)
  Article CAS Google Scholar
• Karanjawala, Z. E., Murphy, N., Hinton, D. R., Hsieh, C. L. & Lieber, M. R. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr. Biol. 12, 397–402 (2002)
  Article CAS Google Scholar
• Weterings, E. & van Gent, D. C. The mechanism of non-homologous end-joining: a synopsis of synapsis. DNA Repair (Amst.) 3, 1425–1435 (2004)
  Article CAS Google Scholar
• Lieber, M. R., Ma, Y., Pannicke, U. & Schwarz, K. Mechanism and regulation of human non-homologous DNA end-joining. Nature Rev. Mol. Cell Biol. 4, 712–720 (2003)
  Article CAS Google Scholar
• Ito, K. et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431, 997–1002 (2004)
  Article ADS CAS Google Scholar
• Sedelnikova, O. A. et al. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nature Cell Biol. 6, 168–170 (2004)
  Article CAS Google Scholar
• Bender, C. F. et al. Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev. 16, 2237–2251 (2002)
  Article CAS Google Scholar
• Dumble, M. et al. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood 109, 1736–1742 (2006)
  Article Google Scholar
• Buck, D. et al. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 124, 287–299 (2006)
  Article CAS Google Scholar
• Ahnesorg, P., Smith, P. & Jackson, S. P. XLF interacts with the XRCC4–DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 124, 301–313 (2006)
  Article CAS Google Scholar
• Riballo, E. et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to γ-H2AX foci. Mol. Cell 16, 715–724 (2004)
  Article CAS Google Scholar
• Hsu, H. L., Gilley, D., Blackburn, E. H. & Chen, D. J. Ku is associated with the telomere in mammals. Proc. Natl Acad. Sci. USA 96, 12454–12458 (1999)
  Article ADS CAS Google Scholar
• d’Adda di Fagagna, F. et al. Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr. Biol. 11, 1192–1196 (2001)
  Article Google Scholar
• Barnes, D. E., Stamp, G., Rosewell, I., Denzel, A. & Lindahl, T. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr. Biol. 8, 1395–1398 (1998)
  Article CAS Google Scholar
• Frank, K. M. et al. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 396, 173–177 (1998)
  Article ADS CAS Google Scholar
• O’Driscoll, M. et al. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol. Cell 8, 1175–1185 (2001)
  Article Google Scholar
• Ben-Omran, T. I., Cerosaletti, K., Concannon, P., Weitzman, S. & Nezarati, M. M. A patient with mutations in DNA Ligase IV: clinical features and overlap with Nijmegen breakage syndrome. Am. J. Med. Genet. A. 137, 283–287 (2005)
  Article Google Scholar
• van der Burg, M. et al. A new type of radiosensitive TBNK severe combined immunodeficiency caused by a LIG4 mutation. J. Clin. Invest. 116, 137–145 (2006)
  Article CAS Google Scholar
• Enders, A. et al. A severe form of human combined immunodeficiency due to mutations in DNA ligase IV. J. Immunol. 176, 5060–5068 (2006)
  Article CAS Google Scholar
• Toita, N. et al. Epstein–Barr virus-associated B-cell lymphoma in a patient with DNA ligase IV (LIG4) syndrome. Am. J. Med. Genet. A 143, 742–745 (2007)
  Article Google Scholar
• Gruhn, B. et al. Successful bone marrow transplantation in a patient with DNA ligase IV deficiency and bone marrow failure. Orphanet J. Rare Dis. 2, 5 (2007)
  Article Google Scholar
• Sekiguchi, J. M. & Ferguson, D. O. DNA double-strand break repair: a relentless hunt uncovers new prey. Cell 124, 260–262 (2006)
  Article CAS Google Scholar
• Nelms, K. A. & Goodnow, C. C. Genome-wide ENU mutagenesis to reveal immune regulators. Immunity 15, 409–418 (2001)
  Article CAS Google Scholar
• Quwailid, M. M. et al. A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm. Genome 15, 585–591 (2004)
  Article CAS Google Scholar
• Grawunder, U. et al. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388, 492–495 (1997)
  Article ADS CAS Google Scholar
• Girard, P. M., Kysela, B., Harer, C. J., Doherty, A. J. & Jeggo, P. A. Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Hum. Mol. Genet. 13, 2369–2376 (2004)
  Article CAS Google Scholar
• Okada, S. et al. In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood 80, 3044–3050 (1992)
  CAS Google Scholar
• Morrison, S. J., Wandycz, A. M., Akashi, K., Globerson, A. & Weissman, I. L. The aging of hematopoietic stem cells. Nature Med. 2, 1011–1016 (1996)
  Article CAS Google Scholar
• Rossi, D. J. et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc. Natl Acad. Sci. USA 102, 9194–9199 (2005)
  Article ADS CAS Google Scholar
• Bhattacharya, D., Rossi, D. J., Bryder, D. & Weissman, I. L. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J. Exp. Med. 203, 73–85 (2006)
  Article CAS Google Scholar
• Hasty, P. & Vijg, J. Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell 3, 55–65 (2004)
  Article CAS Google Scholar
• Cheng, T. et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287, 1804–1808 (2000)
  Article ADS CAS Google Scholar
• Hock, H. et al. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 431, 1002–1007 (2004)
  Article ADS CAS Google Scholar
• Orelio, C. & Dzierzak, E. Bcl-2 expression and apoptosis in the regulation of hematopoietic stem cells. Leuk. Lymphoma 48, 16–24 (2007)
  Article CAS Google Scholar
• Becker, K. A., Stein, J. L., Lian, J. B., van Wijnen, A. J. & Stein, G. S. Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells. J. Cell. Physiol. 210, 517–526 (2007)
  Article CAS Google Scholar
• Marchetti, C. et al. Identification of a novel motif in DNA ligases exemplified by DNA ligase IV. DNA Repair (Amst.) 5, 788–798 (2006)
  Article CAS Google Scholar
• Cabuy, E., Newton, C., Roberts, T., Newbold, R. & Slijepcevic, P. Identification of subpopulations of cells with differing telomere lengths in mouse and human cell lines by flow FISH. Cytometry A 62, 150–161 (2004)
  Article Google Scholar
• Rodrigues, N. P. et al. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood 106, 477–484 (2005)
  Article CAS Google Scholar
• Vinuesa, C. G. et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435, 452–458 (2005)
  Article ADS CAS Google Scholar