Frequent inactivation of A20 in B-cell lymphomas (original) (raw)

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Gene Expression Omnibus

Data deposits

The copy number data as well as the raw microarray data will be accessible from the GEO (http://ncbi.nlm.nih.gov/geo/) with the accession number GSE12906.

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Acknowledgements

This work was supported by the Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, by the 21st century centre of excellence program ‘Study on diseases caused by environment/genome interactions’, and by Grant-in-Aids from the Ministry of Education, Culture, Sports, Science and Technology of Japan and from the Ministry of Health, Labor and Welfare of Japan for the 3rd-term Comprehensive 10-year Strategy for Cancer Control. We also thank Y. Ogino, E. Matsui and M. Matsumura for their technical assistance.

Author Contributions M.Ka., K.N. and M.S. performed microarray experiments and subsequent data analyses. M.Ka., Y.C., K.Ta., J.T., J.N., M.I., A.T. and Y.K. performed mutation analysis of A20. M.Ka., S.Mu., M.S., Y.C. and Y.Ak. conducted functional assays of mutant A20. Y.S., K.Ta., Y.As., H.M., M.Ku., S.Mo., S.C., Y.K., K.To. and Y.I. prepared tumour specimens. I.K., K.O., A.N., H.N. and T.N. conducted in vivo tumorigenicity experiments in NOG/SCID mice. T.I., Y.H., T.Y., Y.K. and S.O. designed overall studies, and S.O. wrote the manuscript. All authors discussed the results and commented on the manuscript.

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Authors and Affiliations

1. Department of,, Cancer Genomics Project,
   Motohiro Kato, Masashi Sanada, Junko Takita, Yuyan Chen, Kumi Nakazaki, Satsuki Muto, Azusa Tamura, Mitsuru Iio & Seishi Ogawa
2. Pediatrics,,
   Motohiro Kato, Junko Takita, Yuyan Chen & Takashi Igarashi
3. Cell Therapy and Transplantation Medicine, and,,
   Junko Takita & Shigeru Chiba
4. Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan ,
   Kumi Nakazaki & Mineo Kurokawa
5. Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 4-1-8, Honcho, Kawaguchi-shi, Saitama 332-0012, Japan ,
   Masashi Sanada, Kumi Nakazaki & Seishi Ogawa
6. Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan,
   Itaru Kato, Akira Niwa & Tatsutoshi Nakahata
7. Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan,
   Yasuharu Sato & Tadashi Yoshino
8. Division of Pathology, The Cancer Institute of Japanese Foundation for Cancer Research, Japan, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan,
   Kengo Takeuchi & Yuichi Ishikawa
9. Hematology Division, Hospital, and,
   Junko Nomoto, Yoshitaka Asakura, Kensei Tobinai & Yukio Kobayashi
10. Early Oncogenesis Research Project, Research Institute, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan ,
    Koji Okamoto & Hitoshi Nakagama
11. Division of Immunology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan,
    Yoshiki Akatsuka
12. Gunma Children’s Medical Center, 779 Shimohakoda, Hokkitsu-machi, Shibukawa 377-8577, Japan ,
    Yasuhide Hayashi
13. Division of Hematology, Internal Medicine, Showa University Fujigaoka Hospital, 1-30, Fujigaoka, Aoba-ku, Yokohama-shi, Kanagawa 227-8501, Japan,
    Hiraku Mori
14. Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan,
    Shigeo Mori

Authors

1. Motohiro Kato
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2. Masashi Sanada
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3. Itaru Kato
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4. Yasuharu Sato
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5. Junko Takita
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6. Kengo Takeuchi
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7. Akira Niwa
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8. Yuyan Chen
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9. Kumi Nakazaki
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10. Junko Nomoto
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11. Yoshitaka Asakura
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12. Satsuki Muto
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13. Azusa Tamura
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14. Mitsuru Iio
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15. Yoshiki Akatsuka
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16. Yasuhide Hayashi
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17. Hiraku Mori
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18. Takashi Igarashi
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19. Mineo Kurokawa
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20. Shigeru Chiba
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21. Shigeo Mori
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22. Yuichi Ishikawa
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23. Koji Okamoto
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24. Kensei Tobinai
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25. Hitoshi Nakagama
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26. Tatsutoshi Nakahata
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27. Tadashi Yoshino
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28. Yukio Kobayashi
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29. Seishi Ogawa
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Corresponding authors

Correspondence toYukio Kobayashi or Seishi Ogawa.

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Kato, M., Sanada, M., Kato, I. et al. Frequent inactivation of A20 in B-cell lymphomas.Nature 459, 712–716 (2009). https://doi.org/10.1038/nature07969

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• Received: 17 September 2008
• Accepted: 03 March 2009
• Published: 03 May 2009
• Issue Date: 04 June 2009
• DOI: https://doi.org/10.1038/nature07969