Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation (original) (raw)
Restifo, N. P., Dudley, M. E. & Rosenberg, S. A. Adoptive immunotherapy for cancer: harnessing the T cell response. Nature Rev. Immunol.12, 269–281 (2012) ArticleCAS Google Scholar
Rosenberg, S. A. et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin. Cancer Res.17, 4550–4557 (2011) ArticleCAS Google Scholar
Khong, H. T. & Restifo, N. P. Natural selection of tumor variants in the generation of “tumor escape” phenotypes. Nature Immunol.3, 999–1005 (2002) ArticleCAS Google Scholar
Matsushita, H. et al. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature482, 400–404 (2012) ArticleADSCAS Google Scholar
DuPage, M., Mazumdar, C., Schmidt, L. M., Cheung, A. F. & Jacks, T. Expression of tumour-specific antigens underlies cancer immunoediting. Nature482, 405–409 (2012) ArticleADSCAS Google Scholar
Willimsky, G. & Blankenstein, T. Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance. Nature437, 141–146 (2005) ArticleADSCAS Google Scholar
Boon, T., Coulie, P. G., Van den Eynde, B. J. & van der Bruggen, B. Human T cell responses against melanoma. Annu. Rev. Immunol.24, 175–208 (2006) ArticleCAS Google Scholar
Mellman, I., Coukos, G. & Dranoff, G. Cancer immunotherapy comes of age. Nature480, 480–489 (2011) ArticleADSCAS Google Scholar
Yee, C. et al. Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc. Natl Acad. Sci. USA99, 16168–16173 (2002) ArticleADSCAS Google Scholar
Dudley, M. E. et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science298, 850–854 (2002) ArticleADSCAS Google Scholar
Tormo, D. et al. Therapeutic efficacy of antigen-specific vaccination and toll-like receptor stimulation against established transplanted and autochthonous melanoma in mice. Cancer Res.66, 5427–5435 (2006) ArticleCAS Google Scholar
Landsberg, J. et al. Autochthonous primary and metastatic melanomas in Hgf-Cdk4R24C mice evade T-cell-mediated immune surveillance. Pigment Cell Melanoma Res.23, 649–660 (2010) ArticleCAS Google Scholar
Wölfel, T. et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science269, 1281–1284 (1995) ArticleADS Google Scholar
Kohlmeyer, J. et al. Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy. Cancer Res.69, 6265–6274 (2009) ArticleCAS Google Scholar
Gabrilovich, D. I., Ostrand-Rosenberg, S. & Bronte, V. Coordinated regulation of myeloid cells by tumours. Nature Rev. Immunol.12, 253–268 (2012) ArticleCAS Google Scholar
Kanik, A. B., Yaar, M. & Bhawan, J. p75 nerve growth factor receptor staining helps identify desmoplastic and neurotropic melanoma. J. Cutan. Pathol.23, 205–210 (1996) ArticleCAS Google Scholar
Lennerz, V. et al. The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. Proc. Natl Acad. Sci. USA102, 16013–16018 (2005) ArticleADSCAS Google Scholar
Morgan, R. A. et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science314, 126–129 (2006) ArticleADSCAS Google Scholar
Johnson, L. A. et al. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood114, 535–546 (2009) ArticleCAS Google Scholar
Robbins, P. F. et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J. Clin. Oncol.29, 917–924 (2011) Article Google Scholar
Vatakis, D. N. et al. Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells. Proc. Natl Acad. Sci. USA108, E1408–E1416 (2011) ArticleCAS Google Scholar
Corbière, V. et al. Antigen spreading contributes to MAGE vaccination-induced regression of melanoma metastases. Cancer Res.71, 1253–1262 (2011) Article Google Scholar
Pilon-Thomas, S., Mackay, A., Vohra, N. & Mule, J. J. Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma. J. Immunol.184, 3442–3449 (2010) ArticleCAS Google Scholar
Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med.366, 2443–2454 (2012) ArticleCAS Google Scholar
Brahmer, J. R. et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med.366, 2455–2465 (2012) ArticleCAS Google Scholar
Taube, J. M. et al. Colocalization of inflammatory response with B7-H1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci. Transl. Med.4, 127ra37 (2012) Article Google Scholar
Koebel, C. M. et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature450, 903–907 (2007) ArticleADSCAS Google Scholar
Schreiber, R. D., Old, L. J. & Smyth, M. J. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science331, 1565–1570 (2011) ArticleADSCAS Google Scholar
Boiko, A. D. et al. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature466, 133–137 (2010) ArticleADSCAS Google Scholar
Straussman, R. et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature487, 500–504 (2012) ArticleADSCAS Google Scholar
Tormo, D. et al. Rapid growth of invasive metastatic melanoma in carcinogen-treated HGF/SF-transgenic mice carrying an oncogenic CDK4 mutation. Am. J. Pathol.169, 665–672 (2006) ArticleCAS Google Scholar
Overwijk, W. W. et al. Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells. J. Exp. Med.198, 569–580 (2003) ArticleCAS Google Scholar
O’Rourke, M. G. et al. Dendritic cell immunotherapy for stage IV melanoma. Melanoma Res.17, 316–322 (2007) Article Google Scholar
Steitz, J. et al. Genetic immunization of mice with human tyrosinase-related protein 2: implications for the immunotherapy of melanoma. Int. J. Cancer86, 89–94 (2000) ArticleCAS Google Scholar
Britten, C. M. et al. The use of HLA-A*0201-transfected K562 as standard antigen-presenting cells for CD8+ T lymphocytes in IFN-γ ELISPOT assays. J. Immunol. Methods259, 95–110 (2002) ArticleCAS Google Scholar
R Development Core Team. R: A Language and Environment for Statistical Computing http://www.R-project.org (R Foundation for Statistical Computing, Austria, 2010)
Gentleman, R. C. et al. Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol.5, R80 (2004) Article Google Scholar
Dunning, M. J. et al. beadarray: R classes and methods for Illumina bead-based data. Bioinformatics23, 2183–2184 (2007) ArticleCAS Google Scholar
Huber, W. et al. Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics18, S96–S104 (2002) Article Google Scholar
Gilbert, H. N. Pollard, K. S., van der Laan, M. J. & Dudoit, S. Resampling-based multiple hypothesis testing. U. C. Berkeley Div. Biostatistics Working Paper Series Working Paper 249 (April 2009)
Bourgon, R. et al. Independent filtering increases detection power for high-throughput experiments. Proc. Natl Acad. Sci. USA107, 9546–9551 (2010) ArticleADSCAS Google Scholar
Falcon, S. & Gentleman, R. Using GOstats to test gene lists for GO term association. Bioinformatics23, 257–258 (2007) ArticleCAS Google Scholar
Supek, F. et al. REVIGO summarizes and visualizes long lists of Gene Ontology terms. PLoS ONE6, e21800 (2011) ArticleADSCAS Google Scholar