Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA (original) (raw)
Dorsett, Y. & Tuschl, T. siRNAs: applications in functional genomics and potential as therapeutics. Nat. Rev. Drug Discovery3, 318–329 (2004). ArticleCAS Google Scholar
Alexopoulou, L., Czopik Holt, A., Medzhitov, R. & Flavell, R. Recognition of double-stranded RNA and activation of NF-κB by toll-like receptor 3. Nature413, 732–738 (2001). ArticleCAS Google Scholar
Heil, F. et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science303, 1526–1529 (2004). ArticleCAS Google Scholar
Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science303, 1529–1531 (2004). ArticleCAS Google Scholar
Lund, J.M. et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl Acad. Sci. USA101, 5598–5603 (2004). ArticleCAS Google Scholar
Sioud, M. & Sorensen, D.R. Cationic liposome-mediated delivery of siRNA in adult mice. Biochem. Biophys. Res. Commun.312, 1220–1225 (2003). ArticleCAS Google Scholar
Karikó, K., Bhuyan, P., Capodici, J. & Weissman, D. Small interfering RNAs mediate sequence-independent gene supression and induce immune activation by signaling through toll-like receptor-3. J. Immunol.172, 6545–6549 (2004). Article Google Scholar
Fu, S.W. et al. Correlation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancer. Breast Cancer Res.5, R82–R87 (2003). ArticleCAS Google Scholar
Hornung, V., Rothenfusser, S., Britsch, S., Krug, A. & Jahrsdörfer, B. Quantitative expression of Toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol.168, 4531–4537 (2002). ArticleCAS Google Scholar
Kadowaki, N. et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial agents. J. Exp. Med.194, 863–869 (2001). ArticleCAS Google Scholar
Asselin-Paturel, C., Brizard, G., Pin, J-J., Brière, F. & Trinchieri, G. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J. Immunol.171, 6466–6477 (2003). ArticleCAS Google Scholar
Dzionek, A. et al. BDCA-2, BDCA-3 and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol.165, 6037–6046 (2000). ArticleCAS Google Scholar
Jego, G. et al. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity19, 225–234 (2003). ArticleCAS Google Scholar
Heil, F. et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur. J. Immunol.33, 2987–2997 (2003). ArticleCAS Google Scholar
Lee, J. et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc. Natl. Acad. Sci. USA100, 6646–6651 (2003). ArticleCAS Google Scholar
Yi, A.K. et al. CpG motifs in bacterial DNA activate leukocytes through the pH- dependent generation of reactive oxygen species. J. Immunol.160, 4755–4761 (1998). CASPubMed Google Scholar
Hacker, H. et al. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J.17, 6230–6240 (1998). ArticleCAS Google Scholar
Leadbetter, E.A. et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature416, 603–607 (2002). ArticleCAS Google Scholar
Hornung, V. et al. Replication-dependent potent IFN-α induction in human plasmacytoid dendritic cells by a single stranded RNA virus. J. Immunol.173, 5935–5943 (2004). ArticleCAS Google Scholar
Weber, S.M. & Levitz, S.M. Chloroquine interferes with lipopolysaccharide-induced TNF-α gene expression by a non-lysosomotropic mechanism. J. Immunol.165, 1534–1540 (2000). ArticleCAS Google Scholar
Soutschek, J. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature432, 173–178 (2004). ArticleCAS Google Scholar
Heidel, J.D., Hu, S., Lui, X.F., Triche, T.J. & Davis, M.E. Lack of interferon response in animals to naked siRNAs. Nat. Biotechnol.22, 1579–1582 (2004). ArticleCAS Google Scholar
Saunders, L.R. & Barber, G.N. The dsRNA binding protein family: critical roles, diverse cellular functions. FASEB J.17, 961–983 (2003). ArticleCAS Google Scholar
Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H. & Williams, B.R.G. Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol.5, 834–839 (2003). ArticleCAS Google Scholar
Bridge, A.J. et al. Induction of an interferon response by RNAi vectors in mammalian cells. Nat. Genet.34, 263–264 (2003). ArticleCAS Google Scholar
Kim, D.-H. et al. Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat. Biotechnol.22, 321–325 (2004). ArticleCAS Google Scholar
Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors. Annu. Rev. Immunol.21, 335–376 (2003). ArticleCAS Google Scholar
Krieg, A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol.20, 709–760 (2002). ArticleCAS Google Scholar
Jeffs, L. et al. A scalable, extrusion free method for efficient liposomal encapsulation of plasmid DNA. Pharm. Res.22, 362–372 (2005). ArticleCAS Google Scholar