Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance (original) (raw)

• Blackburn, E.H. Switching and signaling at the telomere. Cell 106, 661–673. (2001).
  Article CAS Google Scholar
• Rodier, F., Kim, S.H., Nijjar, T., Yaswen, P. & Campisi, J. Cancer and aging: the importance of telomeres in genome maintenance. Int. J. Biochem. Cell Biol. 37, 977–990 (2005).
  Article CAS Google Scholar
• Blasco, M.A. Telomere length, stem cells and aging. Nature Chem. Biol. 3, 640–649 (2007).
  Article CAS Google Scholar
• Blasco, M.A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25–34. (1997).
  Article CAS Google Scholar
• Lee, H.W. et al. Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569–574 (1998).
  Article CAS Google Scholar
• Chong, L. et al. A human telomeric protein. Science 270, 1663–1667 (1995).
  Article CAS Google Scholar
• van Steensel, B. & de Lange, T. Control of telomere length by the human telomeric protein Trf1. Nature 385, 740–743 (1997).
  Article CAS Google Scholar
• de Lange, T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19, 2100–2110 (2005).
  Article CAS Google Scholar
• Smith, S., Giriat, I., Schmitt, A. & de Lange, T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282, 1484–1487. (1998).
  Article CAS Google Scholar
• Kim, S.H., Kaminker, P. & Campisi, J. TIN2, a new regulator of telomere length in human cells. Nature Genet. 23, 405–412. (1999).
  Article CAS Google Scholar
• Zhou, X.Z. & Lu, K.P. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107, 347–359 (2001).
  Article CAS Google Scholar
• Lee, T.H., Perrem, K., Harper, J.W., Lu, K.P. & Zhou, X.Z. F-box protein Fbx4 targets Pin2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. J. Biol. Chem. 281, 759–768 (2006).
  Article CAS Google Scholar
• Chang, W., Dynek, J.N. & Smith, S. TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes Dev. 17, 1328–1333 (2003).
  Article CAS Google Scholar
• Lu, K.P., Hanes, S.D. & Hunter, T. A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380, 544–547 (1996).
  Article CAS Google Scholar
• Shen, M., Haggblom, C., Vogt, M., Hunter, T. & Lu, K.P. Characterization and cell cycle regulation of related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis. Proc. Natl Acad. Sci. USA 94, 13618–13623 (1997).
  Article CAS Google Scholar
• Yaffe, M.B. et al. Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism. Science 278, 1957–1960 (1997).
  Article CAS Google Scholar
• Shen, M., Stukenberg, P.T., Kirschner, M.W. & Lu, K.P. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 12, 706–720 (1998).
  Article CAS Google Scholar
• Lu, P.J., Wulf, G., Zhou, X.Z., Davies, P. & Lu, K.P. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature 399, 784–788 (1999).
  Article CAS Google Scholar
• Lu, P.J., Zhou, X.Z., Shen, M. & Lu, K.P. A function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283, 1325–1328 (1999).
  Article CAS Google Scholar
• Liou, Y.C. et al. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc. Natl Acad. Sci. USA 99, 1335–1340 (2002).
  Article CAS Google Scholar
• Zheng, H. et al. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature 419, 849–853 (2002).
  Article CAS Google Scholar
• Liou, Y.-C. et al. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424, 556–561 (2003).
  Article CAS Google Scholar
• Lu, K.P. & Zhou, X.Z. The prolyl isomerase Pin1: a pivotal new twist in phosphorylation signalling and human disease. Nature Rev. Mol. Cell Biol. 8, 904–916 (2007).
  Article CAS Google Scholar
• Ryo, A. et al. Pin1 is an E2F target gene essential for the Neu/Ras-induced transformation of mammary epithelial cells. Mol. Cell. Biol. 22, 5281–5295 (2002).
  Article CAS Google Scholar
• Atchison, F.W., Capel, B. & Means, A.R. Pin1 regulates the timing of mammalian primordial germ cell proliferation. Development 130, 3579–3586. (2003).
  Article CAS Google Scholar
• Pastorino, L. et al. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production. Nature 440, 528–534 (2006).
  Article CAS Google Scholar
• Kishi, S., Wulf, G., Nakamura, M. & Lu, K.P. Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells containing short telomeres and is down-regulated in breast tumors. Oncogene 20, 1497–1508 (2001).
  Article CAS Google Scholar
• Nakamura, M. et al. A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle. Curr. Biol. 11, 1512–1516 (2001).
  Article CAS Google Scholar
• Zhou, X.Z., Perrem, K. & Lu, K.P. Role of Pin2/TRF1 in telomere maintenance and cell cycle control. J. Cell. Biochem. 89, 19–37 (2003).
  Article CAS Google Scholar
• Lim, J. et al. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J. Clin. Invest. 118, 1877–1889 (2008).
  Article CAS Google Scholar
• Cristofari, G. & Lingner, J. Telomere length homeostasis requires that telomerase levels are limiting. EMBO J. 25, 565–574 (2006).
  Article CAS Google Scholar
• Milyavsky, M. et al. Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res. 63, 7147–7157 (2003).
  CAS PubMed Google Scholar
• Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S. & Reddel, R.R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240–4248 (1995).
  Article CAS Google Scholar
• Pinton, P. et al. Protein kinase C β and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science 315, 659–663 (2007).
  Article CAS Google Scholar
• Sultana, R. et al. Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiol. Aging 27, 918–925 (2006).
  Article CAS Google Scholar
• Panossian, L.A. et al. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol. Aging 24, 77–84 (2003).
  Article CAS Google Scholar
• Loayza, D. & De Lange, T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 423, 1013–1018 (2003).
  Article CAS Google Scholar
• Rufer, N., Dragowska, W., Thornbury, G., Roosnek, E. & Lansdorp, P.M. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nature Biotechnol. 16, 743–747. (1998).
  Article CAS Google Scholar
• Chiang, Y.J. et al. Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Mol. Cell Biol. 24, 7024–7031 (2004).
  Article CAS Google Scholar
• Hemann, M.T. & Greider, C.W. G-strand overhangs on telomeres in telomerase-deficient mouse cells. Nucleic Acids Res. 27, 3964–3969 (1999).
  Article CAS Google Scholar