Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry (original) (raw)

References

  1. Knoblich, J.A. Asymmetric cell division during animal development. Nature Rev. Mol. Cell Biol. 2, 11–20 (2001).
    Article CAS Google Scholar
  2. Doe, C.Q. & Bowerman, B. Asymmetric cell division: fly neuroblast meets worm zygote. Curr. Opin. Cell Biol. 13, 68–75 (2001).
    Article CAS Google Scholar
  3. Ohshiro, T., Yagami, T., Zhang, C. & Matsuzaki, F. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408, 593–596 (2000).
    Article CAS Google Scholar
  4. Peng, C.Y., Manning, L., Albertson, R. & Doe, C.Q. The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408, 596–600 (2000).
    Article CAS Google Scholar
  5. Mathew, D. et al. Recruitment of Scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr. Biol. 12, 531–539 (2002).
    Article CAS Google Scholar
  6. Strand, D. et al. A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2–12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain. Oncogene 11, 291–301 (1995).
    CAS PubMed Google Scholar
  7. Bilder, D., Li, M. & Perrimon, N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289, 113–116 (2000).
    Article CAS Google Scholar
  8. Kraut, R., Chia, W., Jan, L.Y., Jan, Y.N. & Knoblich, J.A. Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383, 50–55 (1996).
    Article CAS Google Scholar
  9. Schober, M., Schaefer, M. & Knoblich, J.A. Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature 402, 548–551 (1999).
    Article CAS Google Scholar
  10. Petronczki, M. & Knoblich, J.A. DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nature Cell Biol. 3, 43–49 (2001).
    Article CAS Google Scholar
  11. Wodarz, A., Ramrath, A., Grimm, A. & Knust, E. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J. Cell Biol. 150, 1361–1374 (2000).
    Article CAS Google Scholar
  12. Schaefer, M., Shevchenko, A. & Knoblich, J.A. A protein complex containing Inscuteable and the Gα-binding protein Pins orients asymmetric cell divisions in Drosophila. Curr. Biol. 10, 353–362 (2000).
    Article CAS Google Scholar
  13. Schaefer, M., Petronczki, M., Dorner, D., Forte, M. & Knoblich, J.A. Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell 107, 183–194 (2001).
    Article CAS Google Scholar
  14. Wodarz, A., Ramrath, A., Kuchinke, U. & Knust, E. Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature 402, 544–547 (1999).
    Article CAS Google Scholar
  15. Brenman, J.E. et al. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. J. Neurosci. 18, 8805–8813 (1998).
    Article CAS Google Scholar
  16. Niethammer, M. et al. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. Neuron 20, 693–707 (1998).
    Article CAS Google Scholar
  17. Matsumine, A. et al. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 272, 1020–1023 (1996).
    Article CAS Google Scholar
  18. Hanada, T., Lin, L., Tibaldi, E.V., Reinherz, E.L. & Chishti, A.H. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. J. Biol. Chem. 275, 28774–28784 (2000).
    Article CAS Google Scholar
  19. Gomes, J.E. et al. The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos. Development 128, 4301–4314 (2001).
    CAS PubMed Google Scholar
  20. Guertin, D.A., Trautmann, S. & McCollum, D. Cytokinesis in eukaryotes. Microbiol. Mol. Biol. Rev. 66, 155–178 (2002).
    Article CAS Google Scholar
  21. Parmentier, M.L. et al. Rapsynoid/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila. J. Neurosci. (Online) 20, RC84 (2000).
    Article CAS Google Scholar
  22. Koh, Y.H., Popova, E., Thomas, U., Griffith, L.C. & Budnik, V. Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation. Cell 98, 353–363 (1999).
    Article CAS Google Scholar
  23. Morin, X., Daneman, R., Zavortink, M. & Chia, W. A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila. Proc. Natl Acad. Sci. USA 98, 15050–15055 (2001).
    Article CAS Google Scholar
  24. Bilder, D. & Perrimon, N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403, 676–680 (2000).
    Article CAS Google Scholar
  25. Broadus, J. & Doe, C.Q. Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts. Curr. Biol. 7, 827–835 (1997).
    Article CAS Google Scholar
  26. Zito, K., Fetter, R.D., Goodman, C.S. & Isacoff, E.Y. Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg. Neuron 19, 1007–1016 (1997).
    Article CAS Google Scholar
  27. Spana, E.P. & Doe, C.Q. The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development 121, 3187–3195 (1995).
    CAS PubMed Google Scholar
  28. Vaessin, H. et al. prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell 67, 941–953 (1991).
    Article CAS Google Scholar
  29. Cai, Y., Chia, W. & Yang, X. A family of snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions. EMBO J. 20, 1704–1714 (2001).
    Article CAS Google Scholar

Download references