Telomerase modulates expression of growth-controlling genes and enhances cell proliferation (original) (raw)
Stewart, S.A. & Weinberg, R.A. Senescence: does it all happen at the ends? Oncogene21, 627–630 (2002). ArticleCASPubMed Google Scholar
Granger, M.P., Wright, W.E. & Shay, J.W. Telomerase in cancer and aging. Crit. Rev. Oncol. Hematol.41, 29–40 (2002). ArticlePubMed Google Scholar
Hahn, W.C. et al. Creation of human tumour cells with defined genetic elements. Nature400, 464–468 (1999). ArticleCASPubMed Google Scholar
Artandi, S.E. et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl Acad. Sci. USA99, 8191–8196 (2002). ArticleCASPubMedPubMed Central Google Scholar
Gonzalez-Suarez, E. et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J.20, 2619–2630 (2001). ArticleCASPubMedPubMed Central Google Scholar
Stewart, S.A. et al. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc. Natl Acad. Sci. USA99, 12606–12611 (2002). ArticleCASPubMedPubMed Central Google Scholar
Blasco, M.A. Telomerase beyond telomeres. Nature Rev. Cancer2, 627–633 (2002). ArticleCAS Google Scholar
Gonzalez-Suarez, E., Samper, E., Flores, J.M. & Blasco, M.A. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nature Genet.26, 114–117 (2000). ArticleCASPubMed Google Scholar
Oh, H. et al. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc. Natl Acad. Sci. USA98, 10308–10313 (2001). ArticleCASPubMedPubMed Central Google Scholar
Stampfer, M.R. et al. Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor β growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc. Natl Acad. Sci. USA98, 4498–4503 (2001). ArticleCASPubMedPubMed Central Google Scholar
Bodnar, A.G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science279, 349–352 (1998). ArticleCASPubMed Google Scholar
Shay, J.W. & Bacchetti, S. A survey of telomerase activity in human cancer. Eur. J. Cancer33, 787–791 (1997). ArticleCASPubMed Google Scholar
Kiyono, T. et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature396, 84–88 (1998). ArticleCASPubMed Google Scholar
Valverius, E.M. et al. Transforming growth factor α production and epidermal growth factor receptor expression in normal and oncogene transformed human mammary epithelial cells. Mol. Endocrinol.3, 203–214 (1989). ArticleCASPubMed Google Scholar
Pavlidis, P. & Noble, W.S. Analysis of strain and regional variation in gene expression in mouse brain. Genome Biol.2, (cited 27 September 2001) http://genomebiology.com/2001/2/10/research/0042 (2001).
Shelton, D.N., Chang, E., Whittier, P.S., Choi, D. & Funk, W.D. Microarray analysis of replicative senescence. Curr. Biol.9, 939–945 (1999). ArticleCASPubMed Google Scholar
Kim, H. & Muller, W.J. The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis. Exp. Cell Res.253, 78–87 (1999). ArticleCASPubMed Google Scholar
Allan, A.L., Albanese, C., Pestell, R.G. & LaMarre, J. Activating transcription factor 3 induces DNA synthesis and expression of cyclin D1 in hepatocytes. J. Biol. Chem.276, 27272–27280 (2001). ArticleCASPubMed Google Scholar
Ishiguro, T. & Nagawa, H. Expression of the ATF3 gene on cell lines and surgically excised specimens. Oncol. Res.12, 181–183 (2000). ArticleCASPubMed Google Scholar
Reimold, A.M. et al. An essential role in liver development for transcription factor XBP-1. Genes Dev.14, 152–157 (2000). CASPubMedPubMed Central Google Scholar
Arend, W.P., Malyak, M., Guthridge, C.J. & Gabay, C. Interleukin-1 receptor antagonist: role in biology. Annu. Rev. Immunol.16, 27–55 (1998). ArticleCASPubMed Google Scholar
Brown, E.J. & Frazier, W.A. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol.11, 130–135 (2001). ArticleCASPubMed Google Scholar
Sargiannidou, I., Zhou, J. & Tuszynski, G.P. The role of thrombospondin-1 in tumor progression. Exp. Biol. Med.226, 726–733 (2001). ArticleCAS Google Scholar
Luparello, C. et al. Midregion parathyroid hormone-related protein inhibits growth and invasion in vitro and tumorigenesis in vivo of human breast cancer cells. J. Bone Miner. Res.16, 2173–2181 (2001). ArticleCASPubMed Google Scholar
Bates, S.E. et al. Expression of the transforming growth factor-α/epidermal growth factor receptor pathway in normal human breast epithelial cells. Endocrinology126, 596–607 (1990). ArticleCASPubMed Google Scholar
Hahn, W.C. et al. Inhibition of telomerase limits the growth of human cancer cells. Nature Med.5, 1164–1170 (1999). ArticleCASPubMed Google Scholar
Romanov, S.R. et al. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature409, 633–637 (2001). ArticleCASPubMed Google Scholar
Eisen, M.B., Spellman, P.T., Brown, P.O. & Botstein, D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl Acad. Sci. USA95, 14863–14868 (1998). ArticleCASPubMedPubMed Central Google Scholar